ATE178491T1 - Zyklische adhäsionsinhibitoren - Google Patents

Zyklische adhäsionsinhibitoren

Info

Publication number: ATE178491T1
Authority: AT; Austria
Prior art keywords: gly; cyclo; phe; asp; arg
Prior art date: 1992-07-06

Application number

AT93110232T

Other languages

English (en)

Inventor

Alfred Dr Jonczyk

Guenter Dr Hoelzemann

Brunhilde Dr Felding-Habermann

Guido Dr Melzer

Beate Diefenbach

David A Dr Cheresh

Horst Prof Dr Kessler

Marion Dr Gurrath

Gerhard Dr Mueller

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-06

Filing date

1993-06-26

Publication date

1999-04-15

1993-06-26 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1999-04-15 Application granted granted Critical

1999-04-15 Publication of ATE178491T1 publication Critical patent/ATE178491T1/de

Links

239000003112 inhibitor Substances 0.000 title abstract 2
YYQUWEHEBOMRPH-NYUBLWNDSA-N 2-[(2s,5r,8s,11s)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid Chemical compound N1C(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H]1CC1=CC=CC=C1 YYQUWEHEBOMRPH-NYUBLWNDSA-N 0.000 abstract 1
OJOVBVONXDWCFW-CBHOWOPOSA-N 2-[(2s,5r,8s,11s,14s)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-14-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid Chemical compound N1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C(C)C)NC(=O)[C@H]1CC1=CC=CC=C1 OJOVBVONXDWCFW-CBHOWOPOSA-N 0.000 abstract 1
108010069514 Cyclic Peptides Proteins 0.000 abstract 1
102000001189 Cyclic Peptides Human genes 0.000 abstract 1
230000021164 cell adhesion Effects 0.000 abstract 1
108010083321 cyclic(arginyl-alanyl-aspartyl-phenylalanyl-valyl) Proteins 0.000 abstract 1
108010028542 cyclic(arginyl-glycyl-aspartyl-phenylalanyl-leucyl-glycyl) Proteins 0.000 abstract 1
108010050963 cyclo(arginyl-glycyl-aspartyl-phenylalanyl-valyl) Proteins 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Physical Education & Sports Medicine (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Rheumatology (AREA)
Toxicology (AREA)
Zoology (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT93110232T 1992-07-06 1993-06-26 Zyklische adhäsionsinhibitoren ATE178491T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US90936792A	1992-07-06	1992-07-06
US2202493A	1993-02-24	1993-02-24

Publications (1)

Publication Number	Publication Date
ATE178491T1 true ATE178491T1 (de)	1999-04-15

Family

ID=26695386

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93110232T ATE178491T1 (de)	1992-07-06	1993-06-26	Zyklische adhäsionsinhibitoren

Country Status (19)

Country	Link
US (1)	US5866540A (de)
EP (1)	EP0578083B1 (de)
JP (2)	JP3803392B2 (de)
KR (1)	KR100261898B1 (de)
CN (1)	CN1065438C (de)
AT (1)	ATE178491T1 (de)
AU (2)	AU675946B2 (de)
CA (1)	CA2099541C (de)
CZ (1)	CZ283744B6 (de)
DE (1)	DE69324305T2 (de)
DK (1)	DK0578083T3 (de)
ES (1)	ES2131542T3 (de)
HU (1)	HU212572B (de)
MX (1)	MX9304035A (de)
NO (1)	NO307985B1 (de)
PL (1)	PL173785B1 (de)
SK (1)	SK282024B6 (de)
TW (1)	TW393319B (de)
UA (1)	UA43823C2 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5654267A (en) *	1988-12-20	1997-08-05	La Jolla Cancer Research Center	Cooperative combinations of ligands contained within a matrix
DE4310643A1 (de)	1993-04-01	1994-10-06	Merck Patent Gmbh	Cyclische Adhäsionsinhibitoren
US5753230A (en) *	1994-03-18	1998-05-19	The Scripps Research Institute	Methods and compositions useful for inhibition of angiogenesis
US5770565A (en) *	1994-04-13	1998-06-23	La Jolla Cancer Research Center	Peptides for reducing or inhibiting bone resorption
DE4415310A1 (de) *	1994-04-30	1995-11-02	Merck Patent Gmbh	Cyclopeptide
US6056958A (en) *	1994-12-09	2000-05-02	Dupont Pharmaceuticals	Method of treatment of arterial and venous thromboembolic disorders
US6492332B1 (en) *	1995-12-12	2002-12-10	Omeros Corporation	Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
DE4444260A1 (de) *	1994-12-13	1996-06-20	Hoechst Ag	Cyclohexapeptide und deren Mischungen, Verfahren zur Herstellung sowie deren Verwendung
US5780426A (en) *	1995-06-07	1998-07-14	Ixsys, Incorporated	Fivemer cyclic peptide inhibitors of diseases involving αv β3
US5767071A (en) *	1995-06-07	1998-06-16	Ixsys Incorporated	Sevenmer cyclic peptide inhibitors of diseases involving αv β3
US7053041B1 (en)	1996-05-31	2006-05-30	The Scripps Research Institute	Methods and compositions useful for inhibition of αvβ5mediated angiogenesis
JP4903921B2 (ja) *	1995-08-14	2012-03-28	ザスクリプスリサーチインスティチュート	αＶβ５仲介血管形成の阻止に有効な方法及び組成物
US5817750A (en) *	1995-08-28	1998-10-06	La Jolla Cancer Research Foundation	Structural mimics of RGD-binding sites
US6080719A (en) *	1996-02-23	2000-06-27	Hoechst Aktiengesellschaft	Cyclohexapeptides and their mixtures, a process for preparing them, and their use
DE19613933A1 (de) *	1996-04-06	1997-10-09	Merck Patent Gmbh	Cyclische Adhäsionsinhibitoren
RU2195312C2 (ru)	1996-05-31	2002-12-27	Дзе Скриппс Рисерч Инститьют	СПОСОБЫ И КОМПОЗИЦИИ, ИСПОЛЬЗУЕМЫЕ ДЛЯ ИНГИБИРОВАНИЯ αvβ5-ОПОСРЕДОВАННОГО АНГИОГЕНЕЗА
US6245809B1 (en)	1996-12-09	2001-06-12	Cor Therapeutics Inc.	Integrin antagonists
DE19728524A1 (de) *	1997-07-04	1999-01-07	Merck Patent Gmbh	Cyclische Azapeptide
DE19736772A1 (de) *	1997-08-23	1999-02-25	Merck Patent Gmbh	Cyclopeptidderivate
US6852318B1 (en) *	1998-05-08	2005-02-08	The Regents Of The University Of California	Methods for detecting and inhibiting angiogenesis
WO1999065944A1 (en) *	1998-06-15	1999-12-23	Ixsys Incorporated	PEPTIDE INHIBITORS OF αVβ3 AND αVβ¿5?
AU756916B2 (en) *	1998-11-12	2003-01-23	Jcr Pharmaceuticals Co., Ltd.	Modulation of cell proliferative disorders by cyclic RGD
UA71608C2 (en) *	1999-03-11	2004-12-15	Merck Patent Gmbh	A method for producing the cyclic pentapeptide
EP1272507B1 (de)	2000-04-12	2005-06-29	Amersham Health AS	Integrinbindende peptidderivate
NO20004795D0 (no)	2000-09-26	2000-09-26	Nycomed Imaging As	Peptidbaserte forbindelser
US20030133972A1 (en) *	2000-10-11	2003-07-17	Targesome, Inc.	Targeted multivalent macromolecules
US20030129223A1 (en) *	2000-10-11	2003-07-10	Targesome, Inc.	Targeted multivalent macromolecules
US20030082103A1 (en) *	2000-10-11	2003-05-01	Targesome, Inc.	Targeted therapeutic lipid constructs having cell surface targets
US20040029788A1 (en) *	2000-11-01	2004-02-12	Hans-Markus Bender	Methods and compositions for the treatment of diseases of the eye
SI1381382T1 (sl)	2000-11-01	2009-04-30	Merck Patent Gmbh	Postopki in sestavki za zdravljenje oäśesnih bolezni
KR100932827B1 (ko)	2001-07-10	2009-12-21	지이 헬스케어 에이에스	펩티드계 화합물
US7597907B2 (en) *	2004-11-05	2009-10-06	Trustees Of The University Of Pennsylvania	Antioxidant polymer nanocarriers for use in preventing oxidative injury
US7605056B2 (en)	2005-05-31	2009-10-20	Semiconductor Energy Laboratory Co., Ltd.	Method of manufacturing a semiconductor device including separation by physical force
US7927629B2 (en) *	2007-10-27	2011-04-19	The Trustees Of The University Of Pennsylvania	Method and compositions for polymer nanocarriers containing therapeutic molecules
US8568786B2 (en) *	2007-10-27	2013-10-29	The Trustees Of The Universtiy Of Pennsylvania	Method and compositions for polymer nanocarriers containing therapeutic molecules
RU2555357C2 (ru) *	2008-04-08	2015-07-10	Мерк Патент Гмбх	Композиции, содержащие циклические пептиды, и способы их применения
CN102265158A (zh)	2008-12-23	2011-11-30	通用电气健康护理有限公司	99mTc肽基化合物作为骨髓成像剂的应用
US9220771B2 (en) *	2010-07-16	2015-12-29	Merck Patent Gmbh	Peptide for use in the treatment of breast cancer and/or bone metastases
PL2892540T3 (pl) *	2012-09-06	2018-12-31	Mcpharma Biotech Inc.	Leczenie biegunki i biegunki po odsadzeniu przy pomocy opornej skrobi ziemniaczanej
WO2018200368A1 (en) *	2017-04-24	2018-11-01	The Regents Of The University Of California	Cell permeable cyclic peptide scaffolds
US11965041B2 (en) *	2017-09-19	2024-04-23	Technische Universitaet Muenchen	N-methylated cyclic peptides and their prodrugs
KR102213196B1 (ko) *	2018-05-08	2021-02-05	주식회사 메디폴리머	클릭화학 반응을 통해 필러 또는 약물전달체로 사용하기 위한 주사제형 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2945680B2 (ja) *	1988-09-09	1999-09-06	旭硝子株式会社	ペプチド誘導体およびその用途
EP0410537A1 (de) *	1989-07-28	1991-01-30	Merck & Co. Inc.	Fibrinogen-Rezeptor-Antagonisten
CA2079606A1 (en) *	1990-04-06	1991-10-07	Michael D. Pierschbacher	Method and composition for treating thrombosis
US5192746A (en) *	1990-07-09	1993-03-09	Tanabe Seiyaku Co., Ltd.	Cyclic cell adhesion modulation compounds

1993
- 1993-06-18 UA UA93002630A patent/UA43823C2/uk unknown
- 1993-06-24 JP JP15346293A patent/JP3803392B2/ja not_active Expired - Lifetime
- 1993-06-26 DK DK93110232T patent/DK0578083T3/da active
- 1993-06-26 AT AT93110232T patent/ATE178491T1/de active
- 1993-06-26 EP EP93110232A patent/EP0578083B1/de not_active Expired - Lifetime
- 1993-06-26 ES ES93110232T patent/ES2131542T3/es not_active Expired - Lifetime
- 1993-06-26 DE DE69324305T patent/DE69324305T2/de not_active Expired - Lifetime
- 1993-06-30 CZ CZ931315A patent/CZ283744B6/cs not_active IP Right Cessation
- 1993-07-02 CA CA002099541A patent/CA2099541C/en not_active Expired - Lifetime
- 1993-07-05 KR KR1019930012550A patent/KR100261898B1/ko not_active IP Right Cessation
- 1993-07-05 PL PL93299559A patent/PL173785B1/pl unknown
- 1993-07-05 MX MX9304035A patent/MX9304035A/es unknown
- 1993-07-05 HU HU9301950A patent/HU212572B/hu unknown
- 1993-07-05 NO NO932439A patent/NO307985B1/no not_active IP Right Cessation
- 1993-07-06 SK SK706-93A patent/SK282024B6/sk not_active IP Right Cessation
- 1993-07-06 AU AU41796/93A patent/AU675946B2/en not_active Expired
- 1993-07-06 CN CN93108015A patent/CN1065438C/zh not_active Expired - Lifetime
- 1993-08-18 TW TW082106697A patent/TW393319B/zh not_active IP Right Cessation
1995
- 1995-01-04 US US08/368,760 patent/US5866540A/en not_active Expired - Lifetime
1997
- 1997-02-13 AU AU12687/97A patent/AU1268797A/en not_active Abandoned
2004
- 2004-05-06 JP JP2004137652A patent/JP4192114B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
NO307985B1 (no)	2000-07-03
CN1084408A (zh)	1994-03-30
JPH06293659A (ja)	1994-10-21
CA2099541A1 (en)	1994-01-07
NO932439L (no)	1994-01-07
JP4192114B2 (ja)	2008-12-03
KR940001900A (ko)	1994-02-16
US5866540A (en)	1999-02-02
UA43823C2 (uk)	2002-01-15
PL299559A1 (en)	1994-03-21
CA2099541C (en)	2009-08-25
DK0578083T3 (da)	1999-10-18
AU1268797A (en)	1997-03-20
SK282024B6 (sk)	2001-10-08
HUT66348A (en)	1994-11-28
NO932439D0 (no)	1993-07-05
DE69324305D1 (de)	1999-05-12
MX9304035A (es)	1994-04-29
DE69324305T2 (de)	1999-11-04
JP2004224803A (ja)	2004-08-12
CZ131593A3 (en)	1994-02-16
EP0578083A2 (de)	1994-01-12
ES2131542T3 (es)	1999-08-01
AU4179693A (en)	1994-01-13
TW393319B (en)	2000-06-11
HU9301950D0 (en)	1993-09-28
JP3803392B2 (ja)	2006-08-02
CZ283744B6 (cs)	1998-06-17
KR100261898B1 (ko)	2000-07-15
AU675946B2 (en)	1997-02-27
SK70693A3 (en)	1994-02-02
PL173785B1 (pl)	1998-04-30
EP0578083A3 (de)	1994-08-03
HU212572B (en)	1996-08-29
EP0578083B1 (de)	1999-04-07
CN1065438C (zh)	2001-05-09

Publication	Publication Date	Title
ATE178491T1 (de)	1999-04-15	Zyklische adhäsionsinhibitoren
DK0572166T3 (da)	1997-09-01	Hidtil ukendte 7beta-substitueret-4-aza-5beta-androstan-3-oner som 5beta-reduktaseinhibitorer
ATE267164T1 (de)	2004-06-15	9-(substituiertes glycyl)amido-6-(substituiert)-5-hydroxy-6-deoxy etracycline
DK0778277T3 (da)	2003-10-27	Substituerede heterocycliske derivater som CRF antagonister
FI933568A (fi)	1994-02-14	9-((substituerad glycyl)amido)-6-demetyl-6-deoxitetracykliner
NO302568B1 (no)	1998-03-23	Nye 7-(substituerte)-8-(substituerte)-9-(substituert amino)-6-demetyl-6-deoksy-tetracykliner, farmasöytiske blandinger inneholdende disse og mellomprodukter i fremstillingen av dem
NO932869L (no)	1994-02-14	7-(substituerte)-9-((substituerte glycyl)amido)-6-demetyl-6-deoksytetracykliner
DE69312218D1 (de)	1997-08-21	Redistribution von organischen Polycarbonatzusammensetzungen
DE68908248D1 (de)	1993-09-16	Kathodische elektrotauchlackierungszusammensetzungen.
AR005999A1 (es)	1999-07-21	Nuevos derivados de eritromicina, su procedimiento de preparacion, composiciones farmaceuticas y medicamentos
DK0513675T3 (da)	1996-09-30	Hidtil ukendt peptidforbindelse samt fremgangsmåde til fremstilling deraf
NO944406L (no)	1995-01-19	Nye 7 e inhibitorer
FI954556A0 (fi)	1995-09-26	Syklisiä yhdisteitä, jotka ovat käyttökelpoisia verihiutaleen glykoproteiinin IIb/IIIa inhibiittoreina
NO303783B1 (no)	1998-08-31	Substituerte aminofosfonatderivater og farmas°ytiske preparater derav
DE69406766D1 (de)	1997-12-18	Polyoxymetalate-Gruppen enthaltende Organosiloxan-Zusammensetzungen
AU1634288A (en)	1988-11-24	Cyclic anticoagulant peptides
DE69315062D1 (de)	1997-12-11	Triazol-ring enthaltende phosphonsäurederivate als herbizide
FI921948A (fi)	1992-11-04	Nya 2-merkaptometylen-tetrahydronaftalen- och indan-2-karboxamidderivat anvaendbara som enkefalinasinhibitorer
DK1260222T3 (da)	2006-02-27	Farmaceutiske præparater indeholdende hidtil ukendte iso-butenyl-substituerede taxaner
ES2091571T3 (es)	1996-11-01	Nuevos derivados peptidicos activos en los procesos de adhesion celular, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ITMI922332A0 (it)	1992-10-09	Composizioni farmaceutiche per la somministrazione di paratormone, suoi frammenti biologicamente attivi o peptidi correlati per via rettale