FI921948A - Nya 2-merkaptometylen-tetrahydronaftalen- och indan-2-karboxamidderivat anvaendbara som enkefalinasinhibitorer - Google Patents
Nya 2-merkaptometylen-tetrahydronaftalen- och indan-2-karboxamidderivat anvaendbara som enkefalinasinhibitorer Download PDFInfo
- Publication number
- FI921948A FI921948A FI921948A FI921948A FI921948A FI 921948 A FI921948 A FI 921948A FI 921948 A FI921948 A FI 921948A FI 921948 A FI921948 A FI 921948A FI 921948 A FI921948 A FI 921948A
- Authority
- FI
- Finland
- Prior art keywords
- mercaptomethylene
- tetrahydronaphthalene
- enkefalinasinhibitorer
- carboxamiderives
- nya
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69563591A | 1991-05-03 | 1991-05-03 | |
US69563591 | 1991-05-03 | ||
US07/860,572 US5252601A (en) | 1991-05-03 | 1992-04-03 | 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors |
US86057292 | 1992-04-03 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI921948A0 FI921948A0 (fi) | 1992-04-30 |
FI921948A true FI921948A (fi) | 1992-11-04 |
FI111252B FI111252B (fi) | 2003-06-30 |
Family
ID=27105626
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI921948A FI111252B (fi) | 1991-05-03 | 1992-04-30 | Menetelmä terapeuttisesti käyttökelpoisten tetrahydronaftaleenijohdannaisten valmistamiseksi |
Country Status (17)
Country | Link |
---|---|
US (1) | US5252601A (fi) |
EP (1) | EP0516980B1 (fi) |
JP (1) | JP3291631B2 (fi) |
KR (1) | KR100237949B1 (fi) |
AT (1) | ATE136884T1 (fi) |
AU (1) | AU649807B2 (fi) |
CA (1) | CA2067408C (fi) |
DE (1) | DE69209892T2 (fi) |
DK (1) | DK0516980T3 (fi) |
ES (1) | ES2089281T3 (fi) |
FI (1) | FI111252B (fi) |
GR (1) | GR3019685T3 (fi) |
HU (1) | HU211730B (fi) |
IE (1) | IE72082B1 (fi) |
IL (1) | IL101743A (fi) |
NO (1) | NO178334C (fi) |
NZ (1) | NZ242521A (fi) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT750631E (pt) * | 1994-02-14 | 2000-07-31 | Merrell Pharma Inc | Novos derivados de dissulfureto de mercapto-aacetilamido-1,3,4,5-tetra-hidro-benzo¬c)azepin-3-ona uteis como inibidores de encefalinase e ace |
HUT74584A (en) * | 1994-02-14 | 1997-01-28 | Merrell Pharma Inc | Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them |
CA2183314C (en) * | 1994-02-14 | 1999-08-31 | Gary A. Flynn | Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2480747A1 (fr) * | 1980-04-17 | 1981-10-23 | Roques Bernard | Derives d'acides amines et leur application therapeutique |
DE3467754D1 (de) * | 1983-10-03 | 1988-01-07 | Squibb & Sons Inc | Enkephalinase inhibitors |
US4973585A (en) * | 1986-06-13 | 1990-11-27 | Merrell Dow Pharmaceuticals | Tricyclic lactams active as antihypertensive agents |
KR880007441A (ko) * | 1986-12-11 | 1988-08-27 | 알렌 제이.스피겔 | 스피로-치환된 글루타르아미드 이뇨제 |
JPH02231464A (ja) * | 1988-02-26 | 1990-09-13 | Tanabe Seiyaku Co Ltd | インダンオキシ酢酸誘導体 |
EP0361365A1 (en) * | 1988-09-30 | 1990-04-04 | E.R. SQUIBB & SONS, INC. | Aminobenzoic and aminocyclohexane-carboylic acid compounds, compositions, and their method of use |
ZA902661B (en) * | 1989-04-10 | 1991-01-30 | Schering Corp | Mercapto-acyl amino acids |
AU7168091A (en) * | 1989-12-22 | 1991-07-24 | Schering Corporation | Mercaptocycloacyl aminoacid endopeptidase inhibitors |
-
1992
- 1992-04-03 US US07/860,572 patent/US5252601A/en not_active Expired - Fee Related
- 1992-04-27 AU AU15168/92A patent/AU649807B2/en not_active Ceased
- 1992-04-28 NZ NZ242521A patent/NZ242521A/en not_active IP Right Cessation
- 1992-04-28 CA CA002067408A patent/CA2067408C/en not_active Expired - Fee Related
- 1992-04-30 FI FI921948A patent/FI111252B/fi not_active IP Right Cessation
- 1992-04-30 IL IL10174392A patent/IL101743A/en not_active IP Right Cessation
- 1992-04-30 EP EP92107464A patent/EP0516980B1/en not_active Expired - Lifetime
- 1992-04-30 HU HU9201474A patent/HU211730B/hu not_active IP Right Cessation
- 1992-04-30 AT AT92107464T patent/ATE136884T1/de not_active IP Right Cessation
- 1992-04-30 DK DK92107464.7T patent/DK0516980T3/da active
- 1992-04-30 ES ES92107464T patent/ES2089281T3/es not_active Expired - Lifetime
- 1992-04-30 NO NO921706A patent/NO178334C/no unknown
- 1992-04-30 DE DE69209892T patent/DE69209892T2/de not_active Expired - Fee Related
- 1992-05-01 JP JP13763192A patent/JP3291631B2/ja not_active Expired - Fee Related
- 1992-05-01 KR KR1019920007436A patent/KR100237949B1/ko not_active IP Right Cessation
- 1992-07-01 IE IE921408A patent/IE72082B1/en not_active IP Right Cessation
-
1996
- 1996-04-19 GR GR960401064T patent/GR3019685T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
HUT65256A (en) | 1994-05-02 |
IE72082B1 (en) | 1997-03-12 |
NO178334B (no) | 1995-11-27 |
ES2089281T3 (es) | 1996-10-01 |
DK0516980T3 (da) | 1996-05-13 |
FI111252B (fi) | 2003-06-30 |
JPH05208952A (ja) | 1993-08-20 |
IE921408A1 (en) | 1992-11-04 |
DE69209892T2 (de) | 1996-11-14 |
NO921706L (no) | 1992-11-04 |
GR3019685T3 (en) | 1996-07-31 |
HU211730B (en) | 1995-12-28 |
IL101743A0 (en) | 1992-12-30 |
NZ242521A (en) | 1994-04-27 |
NO921706D0 (no) | 1992-04-30 |
AU1516892A (en) | 1992-11-05 |
JP3291631B2 (ja) | 2002-06-10 |
US5252601A (en) | 1993-10-12 |
ATE136884T1 (de) | 1996-05-15 |
DE69209892D1 (de) | 1996-05-23 |
KR100237949B1 (ko) | 2000-01-15 |
CA2067408A1 (en) | 1992-11-04 |
IL101743A (en) | 1996-05-14 |
AU649807B2 (en) | 1994-06-02 |
FI921948A0 (fi) | 1992-04-30 |
HU9201474D0 (en) | 1992-07-28 |
KR920021504A (ko) | 1992-12-18 |
CA2067408C (en) | 2003-07-15 |
NO178334C (no) | 1996-03-06 |
EP0516980A1 (en) | 1992-12-09 |
EP0516980B1 (en) | 1996-04-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Transfer of assignment of patent |
Owner name: AVENTIS INC. Free format text: AVENTIS INC. |
|
MA | Patent expired |