ATE127851T1 - Verbesserte zusammensetzung, vorrichtung und verfahren zur untersuchung einer peroxidativ aktiven substanz. - Google Patents
Verbesserte zusammensetzung, vorrichtung und verfahren zur untersuchung einer peroxidativ aktiven substanz.Info
- Publication number
- ATE127851T1 ATE127851T1 AT90123922T AT90123922T ATE127851T1 AT E127851 T1 ATE127851 T1 AT E127851T1 AT 90123922 T AT90123922 T AT 90123922T AT 90123922 T AT90123922 T AT 90123922T AT E127851 T1 ATE127851 T1 AT E127851T1
- Authority
- AT
- Austria
- Prior art keywords
- active substance
- indicator
- peroxidatively active
- assay
- improved
- Prior art date
Links
- 239000013543 active substance Substances 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000003556 assay Methods 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- DHCLVCXQIBBOPH-UHFFFAOYSA-N Glycerol 2-phosphate Chemical compound OCC(CO)OP(O)(O)=O DHCLVCXQIBBOPH-UHFFFAOYSA-N 0.000 abstract 1
- 102000001554 Hemoglobins Human genes 0.000 abstract 1
- 108010054147 Hemoglobins Proteins 0.000 abstract 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- HFACYLZERDEVSX-UHFFFAOYSA-N benzidine Chemical compound C1=CC(N)=CC=C1C1=CC=C(N)C=C1 HFACYLZERDEVSX-UHFFFAOYSA-N 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- CMPQUABWPXYYSH-UHFFFAOYSA-N phenyl phosphate Chemical compound OP(O)(=O)OC1=CC=CC=C1 CMPQUABWPXYYSH-UHFFFAOYSA-N 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- -1 phosphorus compound Chemical class 0.000 abstract 1
- 239000002824 redox indicator Substances 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 210000002700 urine Anatomy 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/521—Single-layer analytical elements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- G01N33/725—Haemoglobin using peroxidative activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
- C12Q2326/10—Benzidines
- C12Q2326/12—3,3',5,5'-Tetramethylbenzidine, i.e. TMB
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/904—Oxidation - reduction indicators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/472,295 US5318894A (en) | 1990-01-30 | 1990-01-30 | Composition, device and method of assaying for peroxidatively active substances |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE127851T1 true ATE127851T1 (de) | 1995-09-15 |
Family
ID=23874919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90123922T ATE127851T1 (de) | 1990-01-30 | 1990-12-12 | Verbesserte zusammensetzung, vorrichtung und verfahren zur untersuchung einer peroxidativ aktiven substanz. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5318894A (de) |
| EP (1) | EP0444263B1 (de) |
| JP (1) | JP2922003B2 (de) |
| KR (1) | KR0163793B1 (de) |
| AT (1) | ATE127851T1 (de) |
| AU (1) | AU623038B2 (de) |
| CA (1) | CA2025803A1 (de) |
| DE (1) | DE69022393T2 (de) |
| DK (1) | DK0444263T3 (de) |
| ES (1) | ES2078934T3 (de) |
| GR (1) | GR3017415T3 (de) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5830765A (en) * | 1993-09-22 | 1998-11-03 | Ranpak Corp. | Feline urinary tract disease-detecting paper cat litter and method |
| US5567621A (en) * | 1993-07-14 | 1996-10-22 | Shimadzu Corporation | Method of and apparatus for analyzing nitrogen compound and phosphorus compound contained in water |
| US5702955A (en) * | 1995-05-22 | 1997-12-30 | Bayer Corporation | Ascorbate resistant detection of hydrogen peroxide |
| CA2168625A1 (en) * | 1996-02-01 | 1997-08-02 | Francois Rousseau | Method and device for specifically detecting myoglobin using a non-discriminating peroxidase-sensitive assay |
| US5885789A (en) * | 1997-03-20 | 1999-03-23 | Stc Technologies Incorporated | Solution-based assay for peroxidatively-active substances in bodily fluids |
| SE9602818D0 (sv) * | 1996-07-19 | 1996-07-19 | Pharmacia & Upjohn Ab | Colored composition |
| EP1000358B1 (de) | 1997-07-15 | 2003-04-02 | Kem-En-Tec A/S | Vorgefärbte 3,3',5,5'-tetramethylbenzidin-substrate zum nachweis von enzymaktivität |
| US6121050A (en) * | 1997-08-29 | 2000-09-19 | Han; Chi-Neng Arthur | Analyte detection systems |
| CA2249778A1 (en) * | 1997-12-15 | 1999-06-15 | Bayer Corporation | Competitive apo-peroxidase assay |
| ES2143434B1 (es) | 1998-09-16 | 2000-12-16 | Cerrato Paula Jimenez | Pañal con indicadores sensibles al estado de la orina que lo impregna visualiazables desde el exterior. |
| US6001656A (en) * | 1998-09-28 | 1999-12-14 | Bayer Corporation | Method for the detection of creatinine |
| US6689618B1 (en) | 2000-04-03 | 2004-02-10 | Shuenn Tzong Chen | Method and test strip of detecting oxidizing adulterant in urine |
| US6743597B1 (en) | 2000-06-13 | 2004-06-01 | Lifescan, Inc. | Compositions containing a urea derivative dye for detecting an analyte and methods for using the same |
| WO2002090930A2 (en) * | 2001-05-09 | 2002-11-14 | Biofx Laboratories, Inc. | Stabilizing peroxides with stannous halides |
| JP4618932B2 (ja) * | 2001-05-28 | 2011-01-26 | 株式会社同仁化学研究所 | 塩素濃度の測定用組成物 |
| US7459127B2 (en) * | 2002-02-26 | 2008-12-02 | Siemens Healthcare Diagnostics Inc. | Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces |
| US20030170905A1 (en) * | 2002-03-05 | 2003-09-11 | Alexander Kamyshny | Diagnostic beads for the detection of blood in animal excreta and a method for production thereof |
| US7094354B2 (en) * | 2002-12-19 | 2006-08-22 | Bayer Healthcare Llc | Method and apparatus for separation of particles in a microfluidic device |
| US7125711B2 (en) * | 2002-12-19 | 2006-10-24 | Bayer Healthcare Llc | Method and apparatus for splitting of specimens into multiple channels of a microfluidic device |
| US7435381B2 (en) * | 2003-05-29 | 2008-10-14 | Siemens Healthcare Diagnostics Inc. | Packaging of microfluidic devices |
| US20080257754A1 (en) * | 2003-06-27 | 2008-10-23 | Pugia Michael J | Method and apparatus for entry of specimens into a microfluidic device |
| US20040265171A1 (en) * | 2003-06-27 | 2004-12-30 | Pugia Michael J. | Method for uniform application of fluid into a reactive reagent area |
| US20040265172A1 (en) * | 2003-06-27 | 2004-12-30 | Pugia Michael J. | Method and apparatus for entry and storage of specimens into a microfluidic device |
| US7347617B2 (en) * | 2003-08-19 | 2008-03-25 | Siemens Healthcare Diagnostics Inc. | Mixing in microfluidic devices |
| CN101193584A (zh) * | 2005-02-28 | 2008-06-04 | 普雷姆德股份有限公司 | 用于非侵入性测定皮肤组织胆固醇的方法和设备 |
| US8304254B2 (en) * | 2007-05-02 | 2012-11-06 | Siemens Healthcare Diagnostics Inc. | Piezo dispensing of a diagnostic liquid onto a reagent surface |
| JP5422108B2 (ja) | 2007-10-16 | 2014-02-19 | 栄研化学株式会社 | ヘムタンパク質の安定化方法及び保存溶液 |
| CA2623328A1 (en) * | 2008-02-28 | 2009-08-28 | Francois Mestrallet | Mammalian disease detection system |
| US20130202499A1 (en) * | 2012-01-31 | 2013-08-08 | Kimberly-Clark Worldwide, Inc. | Composition and Sensor for Detecting Occult Blood |
| WO2015027176A1 (en) | 2013-08-22 | 2015-02-26 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
| WO2015109136A2 (en) | 2014-01-16 | 2015-07-23 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
| US9091682B1 (en) | 2014-05-01 | 2015-07-28 | Steven M Hacker | Tissue specimen bottle with color indicator in lid verifying and confirming presence of human tissue or blood contained in specimen bottle |
| CN107454903B (zh) * | 2015-02-26 | 2021-01-01 | 索尼公司 | 包含共轭基团的水溶性荧光或着色染料 |
| KR102646956B1 (ko) | 2015-02-26 | 2024-03-14 | 소니그룹주식회사 | 페닐에티닐나프탈렌 염료 및 이의 사용 방법 |
| WO2016183185A1 (en) | 2015-05-11 | 2016-11-17 | Sony Corporation | Ultra bright dimeric or polymeric dyes |
| DE102016203335A1 (de) * | 2016-03-01 | 2017-09-07 | Axagarius Gmbh & Co. Kg | Test zur Bestimmung einer Basen-Konzentration |
| US11434377B2 (en) | 2016-04-01 | 2022-09-06 | Sony Corporation | Ultra bright dimeric or polymeric dyes with rigid spacing groups |
| KR102773661B1 (ko) | 2016-04-01 | 2025-02-27 | 소니그룹주식회사 | 초휘도 이량체성 또는 중합체성 염료 |
| RU2753706C2 (ru) | 2016-04-06 | 2021-08-20 | Сони Корпорейшн | Ультраяркие димерные или полимерные красители со спейсерными линкерными группами |
| WO2017196954A1 (en) | 2016-05-10 | 2017-11-16 | Sony Corporation | Ultra bright polymeric dyes with peptide backbones |
| WO2017197014A2 (en) | 2016-05-10 | 2017-11-16 | Sony Corporation | Compositions comprising a polymeric dye and a cyclodextrin and uses thereof |
| KR102526802B1 (ko) | 2016-05-11 | 2023-05-02 | 소니그룹주식회사 | 초고명도 이량체성 또는 중합체성 염료 |
| EP3464477A1 (de) | 2016-06-06 | 2019-04-10 | Sony Corporation | Ionische polymere mit fluoreszierenden oder gefärbten reportergruppen |
| US12018159B2 (en) | 2016-07-29 | 2024-06-25 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes and methods for preparation of the same |
| WO2019071208A1 (en) | 2017-10-05 | 2019-04-11 | Sony Corporation | PROGRAMMABLE POLYMERIC MEDICAMENTS |
| US11931419B2 (en) | 2017-11-16 | 2024-03-19 | Sony Group Corporation | Programmable polymeric drugs |
| US12076407B2 (en) | 2018-01-12 | 2024-09-03 | Sony Group Corporation | Polymers with rigid spacing groups comprising biologically active compounds |
| JP2021510698A (ja) | 2018-01-12 | 2021-04-30 | ソニー株式会社 | 生物学的に活性な化合物を含むホスホアルキルリボースポリマー |
| EP4137818A1 (de) | 2018-03-19 | 2023-02-22 | Sony Group Corporation | Verwendung von zweiwertigen metallen zur verstärkung von fluoreszenten signalen |
| CN112119083B (zh) | 2018-03-21 | 2024-05-24 | 索尼公司 | 具有连接体基团的聚合串联染料 |
| JP7580689B2 (ja) | 2018-06-27 | 2024-11-12 | ソニーグループ株式会社 | デオキシリボースを含むリンカー基を有するポリマー色素 |
| WO2020139767A1 (en) * | 2018-12-28 | 2020-07-02 | Beckman Coulter, Inc. | Methods for enhanced detection of hemoglobin |
| KR102718543B1 (ko) | 2019-09-26 | 2024-10-18 | 소니그룹주식회사 | 링커 그룹을 갖는 중합체성 탠덤 염료 |
| CN111239124A (zh) * | 2020-03-06 | 2020-06-05 | 中国药科大学 | 一种利用二硫化铂的过氧化氢比色检测法 |
| CN113533704A (zh) * | 2021-06-21 | 2021-10-22 | 南京市第一医院 | 一种呕吐物隐血检测装置及方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE220142C (de) * | 1908-11-27 | 1910-03-16 | ||
| DE2235127C2 (de) * | 1972-07-18 | 1974-08-08 | Boehringer Mannheim Gmbh, 6800 Mannheim | Diagnostisches Mittel zum Nachweis von Blut und anderen peroxidatisch wirksamen Substanzen in Körperflüssigkeiten |
| JPS6010261B2 (ja) * | 1975-07-31 | 1985-03-15 | 和光純薬工業株式会社 | 潜血検出用組成物 |
| NL7610608A (nl) * | 1976-09-24 | 1978-03-29 | Akzo Nv | Werkwijze voor het stabiliseren van peroxidase- -bevattende composities. |
| US4288541A (en) * | 1979-10-15 | 1981-09-08 | Miles Laboratories, Inc. | Ascorbate resistant composition, test device and method for detecting a component in a liquid test sample |
| US4251223A (en) * | 1979-12-17 | 1981-02-17 | Miles Laboratories, Inc. | Sensitizers for peroxidative activity tests |
| US4310626A (en) * | 1980-06-02 | 1982-01-12 | Miles Laboratories, Inc. | Interference-resistant composition, device and method for determining a peroxidatively active substance in a test sample |
| US4587220A (en) * | 1983-03-28 | 1986-05-06 | Miles Laboratories, Inc. | Ascorbate interference-resistant composition, device and method for the determination of peroxidatively active substances |
| JPS6066994A (ja) * | 1983-09-19 | 1985-04-17 | Wako Pure Chem Ind Ltd | 発色試液の安定化方法 |
| US4615982A (en) * | 1984-12-11 | 1986-10-07 | Lawrence Paul J | Fecal occult blood test |
-
1990
- 1990-01-30 US US07/472,295 patent/US5318894A/en not_active Expired - Lifetime
- 1990-09-20 CA CA002025803A patent/CA2025803A1/en not_active Abandoned
- 1990-09-28 AU AU63661/90A patent/AU623038B2/en not_active Ceased
- 1990-12-12 EP EP90123922A patent/EP0444263B1/de not_active Expired - Lifetime
- 1990-12-12 AT AT90123922T patent/ATE127851T1/de not_active IP Right Cessation
- 1990-12-12 ES ES90123922T patent/ES2078934T3/es not_active Expired - Lifetime
- 1990-12-12 DE DE69022393T patent/DE69022393T2/de not_active Expired - Lifetime
- 1990-12-12 DK DK90123922.8T patent/DK0444263T3/da active
-
1991
- 1991-01-28 KR KR1019910001367A patent/KR0163793B1/ko not_active Expired - Lifetime
- 1991-01-29 JP JP3026714A patent/JP2922003B2/ja not_active Expired - Lifetime
-
1994
- 1994-01-27 US US08/187,384 patent/US5362633A/en not_active Expired - Lifetime
-
1995
- 1995-09-14 GR GR950402354T patent/GR3017415T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5362633A (en) | 1994-11-08 |
| JP2922003B2 (ja) | 1999-07-19 |
| EP0444263B1 (de) | 1995-09-13 |
| CA2025803A1 (en) | 1991-07-31 |
| KR910014703A (ko) | 1991-08-31 |
| US5318894A (en) | 1994-06-07 |
| DE69022393D1 (de) | 1995-10-19 |
| GR3017415T3 (en) | 1995-12-31 |
| DK0444263T3 (da) | 1995-12-04 |
| ES2078934T3 (es) | 1996-01-01 |
| JPH04213063A (ja) | 1992-08-04 |
| EP0444263A1 (de) | 1991-09-04 |
| AU623038B2 (en) | 1992-04-30 |
| KR0163793B1 (ko) | 1999-03-30 |
| DE69022393T2 (de) | 1996-03-28 |
| AU6366190A (en) | 1991-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |