AR222828A1 - Procedimiento para la preparacion de 2,3,4,5-tetrahidro-6-feniltio-1h-3-benzazepinas y sus sales - Google Patents

Procedimiento para la preparacion de 2,3,4,5-tetrahidro-6-feniltio-1h-3-benzazepinas y sus sales

Info

Publication number: AR222828A1
Authority: AR; Argentina
Prior art keywords: feniltio; benzazepinas; tetrahidro; salts; procedure
Prior art date: 1978-07-07

Application number

AR277218A

Other languages

English (en)

Spanish (es)

Original Assignee

Smithkline Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-07-07

Filing date

1979-07-06

Publication date

1981-06-30

1979-07-06 Application filed by Smithkline Corp filed Critical Smithkline Corp

1981-06-30 Application granted granted Critical

1981-06-30 Publication of AR222828A1 publication Critical patent/AR222828A1/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/022—Boron compounds without C-boron linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Anesthesiology (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)

AR277218A 1978-07-07 1979-07-06 Procedimiento para la preparacion de 2,3,4,5-tetrahidro-6-feniltio-1h-3-benzazepinas y sus sales AR222828A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US92261378A	1978-07-07	1978-07-07

Publications (1)

Publication Number	Publication Date
AR222828A1 true AR222828A1 (es)	1981-06-30

Family

ID=25447325

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AR277218A AR222828A1 (es)	1978-07-07	1979-07-06	Procedimiento para la preparacion de 2,3,4,5-tetrahidro-6-feniltio-1h-3-benzazepinas y sus sales

Country Status (24)

Country	Link
EP (2)	EP0007070B1 (fr)
JP (1)	JPS5511584A (fr)
AR (1)	AR222828A1 (fr)
AU (1)	AU525789B2 (fr)
CA (1)	CA1115271A (fr)
CS (1)	CS213381B2 (fr)
DD (1)	DD147355A5 (fr)
DE (1)	DE2964530D1 (fr)
DK (1)	DK156001C (fr)
ES (3)	ES482281A1 (fr)
FI (1)	FI67215C (fr)
GR (1)	GR69675B (fr)
HU (1)	HU179315B (fr)
IE (1)	IE48654B1 (fr)
IL (1)	IL57532A (fr)
IT (1)	IT1193190B (fr)
JO (1)	JO1273B1 (fr)
NO (1)	NO152213C (fr)
NZ (1)	NZ190745A (fr)
PH (1)	PH15754A (fr)
PL (1)	PL216908A1 (fr)
PT (1)	PT69855A (fr)
SU (1)	SU1029827A3 (fr)
ZA (1)	ZA792785B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3119874A1 (de)	1981-05-19	1982-12-09	Dr. Karl Thomae Gmbh, 7950 Biberach	"benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4469634A (en) *	1982-07-29	1984-09-04	Smithkline Beckman Corporation	Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines
US4652642A (en) *	1984-08-23	1987-03-24	Smithkline Beckman Corporation	Azidobenzazepines
US4683229A (en) *	1986-03-17	1987-07-28	Smithkline Beckman Corporation	6-halo-9-alkenyleneoxy-3-alkyl-2,3,4,5-tetrahydro-(1H-3)-benzazepines and their use as selective alpha-adrenergic receptor antagonists
US6384079B1 (en)	1986-12-23	2002-05-07	Tristrata Technology, Incorporated	Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging
US5942250A (en) *	1986-12-23	1999-08-24	Tristrata Technology, Inc.	Compositions and methods for enhancing the topical effects of sunscreen agents
GB9119467D0 (en) *	1991-09-12	1991-10-23	Smithkline Beecham Corp	Chemical compounds
GB9708805D0 (en)	1997-05-01	1997-06-25	Smithkline Beecham Plc	Compounds
GB9810876D0 (en)	1998-05-20	1998-07-22	Smithkline Beecham Plc	Compounds
CZ20011270A3 (cs)	1998-10-08	2001-09-12	Smithkline Beecham Plc	Tetrahydrobenzazepinové deriváty vhodné jako modulátory dopaminových receptorů D3
US6953787B2 (en)	2002-04-12	2005-10-11	Arena Pharmaceuticals, Inc.	5HT2C receptor modulators
AU2003273969A1 (en) *	2002-10-07	2004-04-23	Glaxo Group Limited	Sulfonamide derivatives as antipsychotic agents
SI2332921T1 (sl)	2003-06-17	2016-06-30	Arena Pharmaceuticals, Inc.	8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazapin hidroklorid
JP4782003B2 (ja)	2003-06-17	2011-09-28	アリーナファーマシューティカルズ，インコーポレイテッド	５ｈｔ２ｃレセプター関連疾患の処置に有用なベンズアゼピン誘導体
NZ549009A (en) *	2004-02-25	2010-08-27	Lilly Co Eli	6-substituted 2,3,4,5-tetrahydro-1H-benzo[D]azepines as 5-HT2C receptor agonists
NZ589756A (en)	2004-12-21	2012-05-25	Arena Pharm Inc	Method for the preparation of crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
KR101426850B1 (ko)	2004-12-23	2014-08-05	아레나 파마슈티칼스, 인크.	5ｈｔ２ｃ 수용체 조정물질 조성물 및 그의 사용 방법
EP2001852A2 (fr)	2006-04-03	2008-12-17	Arena Pharmaceuticals, Inc.	Procédés de préparation de 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine et produits intermédiaires associés
JP5404414B2 (ja)	2006-12-05	2014-01-29	アリーナファーマシューティカルズ，インコーポレイテッド	（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンおよびその中間体を調製するための方法
JP5491421B2 (ja)	2008-03-04	2014-05-14	アリーナファーマシューティカルズ，インコーポレイテッド	５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス
EP2443080A2 (fr)	2009-06-18	2012-04-25	Arena Pharmaceuticals, Inc.	Procédés pour la préparation d'agonistes du récepteur 5-ht<sb>2c</sb>
KR20130112848A (ko)	2010-06-02	2013-10-14	아레나 파마슈티칼스, 인크.	5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
CN103189360A (zh)	2010-09-01	2013-07-03	艾尼纳制药公司	5-ht2c激动剂的非吸湿性盐
EP2611427B1 (fr)	2010-09-01	2018-10-17	Arena Pharmaceuticals, Inc.	Formes galéniques à libération modifiée d'agonistes de 5-ht2c, utiles pour la gestion du poids
EP2939677A1 (fr)	2010-09-01	2015-11-04	Arena Pharmaceuticals, Inc.	Administration de lorcasérine à des individus avec une insuffisance rénale
MX2013002422A (es)	2010-09-01	2013-05-17	Arena Pharm Inc	Sales de lorcaserina con acidos opticamente activos.
UY34436A (es)	2012-10-09	2014-07-31	Arena Pharm Inc	Metodo de control del peso

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2520264A (en) *	1947-08-26	1950-08-29	Maltbie Lab Inc	Substituted 3, 1-benz-2, 3, 4, 5-tetrahydroazepines
US3483185A (en)	1966-08-16	1969-12-09	American Home Prod	N-substituted 2,3,4,5-tetrahydro-1h-3-benzazepines
CA974989A (en) *	1968-03-11	1975-09-23	Wallace And Tiernan Inc.	Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
US3671519A (en)	1969-07-14	1972-06-20	American Home Prod	N-substituted 2,3,4,5,-tetrahydro-1h-3-benzazepines
US3752892A (en)	1970-03-11	1973-08-14	Ciba Geigy Corp	Anorexigenic tetrahydrobenzazepine derivative method and composition thereof
US3716639A (en)	1970-03-11	1973-02-13	Ciba Geigy Corp	Anorexigenic tetrahydrobenzazepines
US4111957A (en) *	1977-02-02	1978-09-05	Smithkline Corporation	Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4108989A (en) *	1977-04-01	1978-08-22	Smithkline Corporation	2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diones

1979
- 1979-06-05 ZA ZA792785A patent/ZA792785B/xx unknown
- 1979-06-11 IL IL57532A patent/IL57532A/xx unknown
- 1979-06-15 NZ NZ190745A patent/NZ190745A/xx unknown
- 1979-06-28 JP JP8252779A patent/JPS5511584A/ja active Granted
- 1979-07-02 PH PH22728A patent/PH15754A/en unknown
- 1979-07-02 PT PT69855A patent/PT69855A/pt unknown
- 1979-07-02 CS CS794635A patent/CS213381B2/cs unknown
- 1979-07-02 DK DK278379A patent/DK156001C/da not_active IP Right Cessation
- 1979-07-03 GR GR59498A patent/GR69675B/el unknown
- 1979-07-03 CA CA331,022A patent/CA1115271A/fr not_active Expired
- 1979-07-03 AU AU48613/79A patent/AU525789B2/en not_active Ceased
- 1979-07-04 EP EP79102279A patent/EP0007070B1/fr not_active Expired
- 1979-07-04 DE DE7979102279T patent/DE2964530D1/de not_active Expired
- 1979-07-04 EP EP82105188A patent/EP0080012B1/fr not_active Expired
- 1979-07-05 FI FI792125A patent/FI67215C/fi not_active IP Right Cessation
- 1979-07-05 HU HU79SI1705A patent/HU179315B/hu unknown
- 1979-07-06 ES ES482281A patent/ES482281A1/es not_active Expired
- 1979-07-06 NO NO792267A patent/NO152213C/no unknown
- 1979-07-06 DD DD79214179A patent/DD147355A5/de unknown
- 1979-07-06 ES ES482282A patent/ES482282A1/es not_active Expired
- 1979-07-06 PL PL21690879A patent/PL216908A1/xx unknown
- 1979-07-06 AR AR277218A patent/AR222828A1/es active
- 1979-07-06 IT IT24165/79A patent/IT1193190B/it active
- 1979-07-06 ES ES482276A patent/ES482276A1/es not_active Expired
- 1979-07-06 SU SU792783746A patent/SU1029827A3/ru active
- 1979-07-07 JO JO19791273A patent/JO1273B1/en active
- 1979-08-08 IE IE1276/79A patent/IE48654B1/en unknown

Also Published As

Publication number	Publication date
JPS5511584A (en)	1980-01-26
ZA792785B (en)	1980-08-27
DK156001B (da)	1989-06-12
PT69855A (en)	1979-08-01
IE48654B1 (en)	1985-04-03
DK278379A (da)	1980-01-08
DD147355A5 (de)	1981-04-01
JPH0153271B2 (fr)	1989-11-13
IE791276L (en)	1980-01-07
IT7924165A0 (it)	1979-07-06
JO1273B1 (en)	1986-11-30
EP0007070B1 (fr)	1983-01-19
NZ190745A (en)	1981-01-23
HU179315B (en)	1982-09-28
AU525789B2 (en)	1982-12-02
IL57532A0 (en)	1979-10-31
IL57532A (en)	1982-08-31
EP0080012A1 (fr)	1983-06-01
NO152213B (no)	1985-05-13
CA1115271A (fr)	1981-12-29
FI792125A (fi)	1980-01-08
ES482282A1 (es)	1980-04-01
ES482276A1 (es)	1980-04-01
SU1029827A3 (ru)	1983-07-15
EP0080012B1 (fr)	1986-04-09
DE2964530D1 (en)	1983-02-24
NO792267L (no)	1980-01-08
CS213381B2 (en)	1982-04-09
AU4861379A (en)	1980-02-07
GR69675B (fr)	1982-07-07
FI67215C (fi)	1985-02-11
FI67215B (fi)	1984-10-31
DK156001C (da)	1989-11-06
NO152213C (no)	1985-08-28
EP0007070A1 (fr)	1980-01-23
ES482281A1 (es)	1980-04-01
IT1193190B (it)	1988-06-02
PH15754A (en)	1983-03-18
PL216908A1 (fr)	1980-08-11

Publication	Publication Date	Title
AR222828A1 (es)	1981-06-30	Procedimiento para la preparacion de 2,3,4,5-tetrahidro-6-feniltio-1h-3-benzazepinas y sus sales
MX6046E (es)	1984-10-11	Procedimiento para la preparacion de 4,5-diaril-2-nitro-imidazoles
ES481909A0 (es)	1980-11-01	Procedimiento para la preparacion de nuevas aril-3 eter-5 o-xazolidinonas-2
AR224495A1 (es)	1981-12-15	Procedimiento para la preparacion de derivados de 1-fenil-7,8-dihidroxi o 7,8-dialcanoiloxi-1,3,4,5-tetrahidro-1h-3-benzazepina y sus sales
AR229103A1 (es)	1983-06-15	Procedimiento para la preparacion de derivados de 3-aril-5-isotiazol y sus sales
ES496166A0 (es)	1982-05-01	Un procedimiento para la preparacion de acidos 6-b-hidroxialquilpenicilanicos y sus derivados.
ES482499A0 (es)	1980-12-01	Procedimiento para la preparacion de 2-cloro-6-nitroanilinas
ES494668A0 (es)	1981-08-16	Procedimiento para la preparacion de sales de la (+)-cate- quina
MX5375E (es)	1983-06-30	Procedimiento para la preparacion de n-(diaminofosfinil)-arilcarboxamidas
AR227882A1 (es)	1982-12-30	Procedimiento para la preparacion de nuevos derivados de pirido(1,2-a)pirimidina y sus sales
AR223069A1 (es)	1981-07-15	Polieterpoliaminas y sus sales,procedimiento para su preparacion y su empleo
MX6242E (es)	1985-01-28	Procedimiento para la preparacion de 1,2,3,5,tetrahidroimidazotienopirimidin-2-onas
AR227379A1 (es)	1982-10-29	Procedimiento para la preparacion de 1-aril-2-imidazolil vinileteres
MX4972E (es)	1983-01-26	Procedimiento mejorado para la preparacion de 7 beta-oxiimmino-acilcefalosporinas
ES498128A0 (es)	1982-06-16	Un procedimiento para la preparacion de aminopropenol y pro-pano nitrilos 2 sustituidos.
MX4649E (es)	1982-07-15	Procedimiento para la preparacion de n-cicloalquilmetil-2-fenilaminoimidazolinas-(2)-substituidas
AR220383A1 (es)	1980-10-31	Procedimiento para la preparacion de 2,3,5,6-tetracloropiridina y pentacloropiridina
AR226288A1 (es)	1982-06-30	Procedimiento para la produccion de nuevas 4-alquiltiofenoxi alquilaminas y sus sales
MX5685E (es)	1983-12-09	Procedimiento para la preparacion de 4,5-diaril-2-(tio-substituido)-pirrol
AR226180A1 (es)	1982-06-15	Procedimiento para la sintesis de acido 4,4'-dinitroestilben-2,2'-disulfonico y sus sales
ES485567A0 (es)	1980-11-01	Procedimiento para la preparacion de azolilcetales
MX6217E (es)	1984-12-21	Procedimiento para la preparacion de 4,1-benzoxazepinas y 4,1-benzotiazepinas
ES511329A0 (es)	1983-07-01	"procedimiento de preparacion de nuevos derivados imidazotiazoles y de sus sales".
ES484342A0 (es)	1980-11-01	Procedimiento para la preparacion de propenilensulfona
AR220561A1 (es)	1980-11-14	Procedimiento para preparar compuestos de 5,8-dihidro 3,2-b-1,8-naftiridina y sus sales