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AR091477A1 - Analogos de glucagon que presentan actividad de receptor de gip - Google Patents

Analogos de glucagon que presentan actividad de receptor de gip

Info

Publication number
AR091477A1
AR091477A1 ARP130102142A AR091477A1 AR 091477 A1 AR091477 A1 AR 091477A1 AR P130102142 A ARP130102142 A AR P130102142A AR 091477 A1 AR091477 A1 AR 091477A1
Authority
AR
Argentina
Prior art keywords
presenting
glucagon analogs
receiver activity
gip
gip receiver
Prior art date
Application number
Other languages
English (en)
Inventor
Dmarchi Richard
Original Assignee
Univ Indiana Res & Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Indiana Res & Tech Corp filed Critical Univ Indiana Res & Tech Corp
Publication of AR091477A1 publication Critical patent/AR091477A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En la presente se proporcionan análogos de glucagón que presentan actividad potente en el receptor de GIP y, como tales, están contemplados para el uso en el tratamiento de la diabetes y la obesidad. En ejemplos de realizaciones, el análogo de glucagón de la presente presenta una EC50 en el receptor de GIP (péptido insulinotrópico dependiente de glucosa) que está dentro de la gama nanomolar o picomolar. Composición.
ARP130102142 2012-06-21 2013-06-18 Analogos de glucagon que presentan actividad de receptor de gip AR091477A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261662868P 2012-06-21 2012-06-21
US201261716878P 2012-10-22 2012-10-22

Publications (1)

Publication Number Publication Date
AR091477A1 true AR091477A1 (es) 2015-02-04

Family

ID=48699335

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130102142 AR091477A1 (es) 2012-06-21 2013-06-18 Analogos de glucagon que presentan actividad de receptor de gip

Country Status (13)

Country Link
US (1) US9340600B2 (es)
EP (1) EP2864351B1 (es)
JP (1) JP6311708B2 (es)
KR (1) KR20150023013A (es)
CN (1) CN104583232B (es)
AR (1) AR091477A1 (es)
CA (1) CA2877358A1 (es)
ES (1) ES2602486T3 (es)
HK (1) HK1209764A1 (es)
MX (1) MX2014015558A (es)
RU (1) RU2015101697A (es)
TW (1) TWI599575B (es)
WO (1) WO2013192129A1 (es)

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CN104583232B (zh) 2018-04-13
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TWI599575B (zh) 2017-09-21
EP2864351B1 (en) 2016-08-10
JP2015521622A (ja) 2015-07-30
CA2877358A1 (en) 2013-12-27
MX2014015558A (es) 2015-03-05
ES2602486T3 (es) 2017-02-21
CN104583232A (zh) 2015-04-29
US20140011738A1 (en) 2014-01-09
TW201402598A (zh) 2014-01-16
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