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AR082663A2 - Procedimiento para sintetizar compuesto(s) relacionado(s) con camptotecina - Google Patents

Procedimiento para sintetizar compuesto(s) relacionado(s) con camptotecina

Info

Publication number
AR082663A2
AR082663A2 ARP110102927A ARP110102927A AR082663A2 AR 082663 A2 AR082663 A2 AR 082663A2 AR P110102927 A ARP110102927 A AR P110102927A AR P110102927 A ARP110102927 A AR P110102927A AR 082663 A2 AR082663 A2 AR 082663A2
Authority
AR
Argentina
Prior art keywords
compound
formula
group
produced
tms
Prior art date
Application number
ARP110102927A
Other languages
English (en)
Inventor
Seigo Sawada
Miyuki Uchida
Takanori Ogawa
Hiroyuki Nishiyama
Original Assignee
Yakult Honsha Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Kk filed Critical Yakult Honsha Kk
Publication of AR082663A2 publication Critical patent/AR082663A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/20—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/21—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C205/22—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring having one nitro groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se describe un procedimiento para preparar una cetona tricíclica, correspondiente a la parte CDE del anillo de la camptotecina (CPT), la cual es un material de partida para el clorhidrato de irinotecan y diversos tipos de derivados de camptotecina.Reivindicación 1: Un procedimiento para preparar una cetona tricíclica para sintetizar análogos de camptotecina, en donde a partir del compuesto de fórmula (1) (en donde TMS es un grupo trimetilsililo, y Me es un grupo metilo), o del compuesto de fórmula (2) (en donde TMS es un grupo trimetilsililo, y Me es un grupo metilo), se produce el compuesto de fórmula (3) (en donde TMS es un grupo trimetilsililo, y Me es un grupo metilo); y a partir del compuesto de fórmula (3), se produce el compuesto de fórmula (4) (en donde TMS es un grupo trimetilsililo, y Me es un grupo metilo); y a partir del compuesto de fórmula (4), se produce el compuesto de fórmula (5) (en donde TMS es un grupo trimetilsililo, Me es un grupo metilo, y Et es un grupo etilo); y a partir del compuesto de fórmula (5), se produce el compuesto de fórmula (6) (en donde TMS es un grupo trimetilsililo, Me es un grupo metilo, y Et es un grupo etilo); y a partir del compuesto de fórmula (6), se produce el compuesto de fórmula (7) (en donde TMS es un grupo trimetilsililo, Me es un grupo metilo, y Et es un grupo etilo); y a partir del compuesto de fórmula (7), se produce el compuesto de fórmula (8) (en donde Me es un grupo metilo, y Et es un grupo etilo); y a partir del compuesto de fórmula (8), se produce el compuesto de fórmula (9) (en donde Me es un grupo metilo, Et es un grupo etilo y Pr es un grupo propilo); y a partir del compuesto de fórmula (9), se obtiene el compuesto de fórmula (10) (en donde Et es un grupo etilo y Pr es un grupo propilo); y a partir del compuesto de fórmula (10), se produce el compuesto de fórmula (11) (en donde Et es un grupo etilo, y tBu es un grupo t-butilo); y a partir del compuesto de fórmula (11), se produce el compuesto de fórmula (12) (en donde Et es un grupo etilo), caracterizado porque la mejora comprende una etapa (i) para obtener el compuesto de fórmula (3) que comprende mezclar el compuesto de fórmula (1), un agente litiante, un reactivo de formilación y un reactivo de iodación.
ARP110102927A 2001-02-21 2011-08-11 Procedimiento para sintetizar compuesto(s) relacionado(s) con camptotecina AR082663A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001045430 2001-02-21
JP2001309322 2001-10-05

Publications (1)

Publication Number Publication Date
AR082663A2 true AR082663A2 (es) 2012-12-26

Family

ID=26609837

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP020100579A AR035684A1 (es) 2001-02-21 2002-02-20 Procedimiento para preparar 2'-amino-5'-hidroxipropiofenona, uso de la misma para la preparacion de analogos de camptotecina, procedimiento para prepararlos, compuestos intermediarios, procedimiento para preparar una cetona triciclica utilizada en la sintesis de analogos de camptotecina
ARP110102927A AR082663A2 (es) 2001-02-21 2011-08-11 Procedimiento para sintetizar compuesto(s) relacionado(s) con camptotecina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP020100579A AR035684A1 (es) 2001-02-21 2002-02-20 Procedimiento para preparar 2'-amino-5'-hidroxipropiofenona, uso de la misma para la preparacion de analogos de camptotecina, procedimiento para prepararlos, compuestos intermediarios, procedimiento para preparar una cetona triciclica utilizada en la sintesis de analogos de camptotecina

Country Status (23)

Country Link
US (2) US7126000B2 (es)
EP (1) EP1378505B1 (es)
JP (2) JP4210119B2 (es)
KR (2) KR100864692B1 (es)
CN (1) CN100408550C (es)
AR (2) AR035684A1 (es)
AU (1) AU2002237527B2 (es)
BG (2) BG108031A (es)
BR (1) BR0207470A (es)
CA (2) CA2683768C (es)
CZ (1) CZ20032470A3 (es)
EE (1) EE05361B1 (es)
HU (1) HUP0302755A3 (es)
IL (2) IL156949A0 (es)
MX (1) MXPA03007528A (es)
NO (2) NO328628B1 (es)
NZ (2) NZ527615A (es)
PL (2) PL217238B1 (es)
RO (2) RO122639B9 (es)
RU (1) RU2308447C2 (es)
SK (2) SK288149B6 (es)
TW (1) TWI245768B (es)
WO (1) WO2002066416A1 (es)

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Also Published As

Publication number Publication date
SK288073B6 (sk) 2013-05-03
AU2002237527B2 (en) 2007-01-04
NZ534374A (en) 2004-12-24
NO331656B1 (no) 2012-02-13
BR0207470A (pt) 2008-04-08
AR035684A1 (es) 2004-06-23
RO122639B1 (ro) 2009-10-30
US20040106830A1 (en) 2004-06-03
EE05361B1 (et) 2010-12-15
EP1378505A1 (en) 2004-01-07
HUP0302755A2 (hu) 2003-12-29
CZ20032470A3 (cs) 2004-02-18
PL218065B1 (pl) 2014-10-31
MXPA03007528A (es) 2003-12-11
NO328628B1 (no) 2010-04-12
NZ527615A (en) 2004-12-24
RU2308447C2 (ru) 2007-10-20
KR100864692B1 (ko) 2008-10-23
JP4210119B2 (ja) 2009-01-14
SK288149B6 (sk) 2013-12-02
RO125158A2 (ro) 2010-01-29
IL156949A (en) 2009-09-01
US7126000B2 (en) 2006-10-24
HUP0302755A3 (en) 2008-03-28
CN1492851A (zh) 2004-04-28
PL217238B1 (pl) 2014-06-30
TWI245768B (en) 2005-12-21
SK11472003A3 (sk) 2004-03-02
IL156949A0 (en) 2004-02-08
CA2683768C (en) 2013-05-28
PL399009A1 (pl) 2012-09-10
BG111453A (en) 2013-09-30
BG108031A (bg) 2005-04-30
KR20080012383A (ko) 2008-02-11
KR20030077631A (ko) 2003-10-01
PL363440A1 (en) 2004-11-15
CN100408550C (zh) 2008-08-06
CA2437702C (en) 2010-04-06
JP2008273952A (ja) 2008-11-13
CA2683768A1 (en) 2002-08-29
NO20033579D0 (no) 2003-08-13
RU2003128530A (ru) 2005-03-27
EE200300373A (et) 2003-10-15
NO20093402L (no) 2003-10-10
JPWO2002066416A1 (ja) 2004-09-24
US7378555B2 (en) 2008-05-27
EP1378505A4 (en) 2006-09-27
WO2002066416A1 (en) 2002-08-29
JP4805967B2 (ja) 2011-11-02
EP1378505B1 (en) 2014-11-05
RO122639B9 (ro) 2014-03-28
KR100858972B1 (ko) 2008-09-17
CA2437702A1 (en) 2002-08-29
US20070010674A1 (en) 2007-01-11
NO20033579L (no) 2003-10-10

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