AR081113A1 - Liberacion pulsatil de medicamentos desde un tapon de punctum - Google Patents
Liberacion pulsatil de medicamentos desde un tapon de punctumInfo
- Publication number
- AR081113A1 AR081113A1 ARP100103164A ARP100103164A AR081113A1 AR 081113 A1 AR081113 A1 AR 081113A1 AR P100103164 A ARP100103164 A AR P100103164A AR P100103164 A ARP100103164 A AR P100103164A AR 081113 A1 AR081113 A1 AR 081113A1
- Authority
- AR
- Argentina
- Prior art keywords
- punctum plug
- medicines
- pulsatile release
- pulsatile
- tube
- Prior art date
Links
- 230000000541 pulsatile effect Effects 0.000 title abstract 4
- 241000083513 Punctum Species 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 2
- 238000005538 encapsulation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00772—Apparatus for restoration of tear ducts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Anesthesiology (AREA)
- Surgery (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Prostheses (AREA)
- Biological Depolymerization Polymers (AREA)
Abstract
La presente solicitud describe los métodos y el aparato para proporcionar la liberacion pulsátil de agentes activos mediante un tapon de punctum insertado en un punto lagrimal. Se proporciona un tubo que se puede insertar en una cavidad de un tapon de punctum. Una o más unidades de administracion pulsátil se disponen en forma generalmente lineal dentro del tubo. Las unidades de administracion pulsátil incluyen un nucleo que comprende el agente activo y una capa de encapsulacion alrededor del nucleo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23847009P | 2009-08-31 | 2009-08-31 | |
US12/857,885 US8808257B2 (en) | 2009-08-31 | 2010-08-17 | Methods and apparatus for pulsatile release of medicaments from a punctal plug |
Publications (1)
Publication Number | Publication Date |
---|---|
AR081113A1 true AR081113A1 (es) | 2012-06-27 |
Family
ID=43625924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100103164A AR081113A1 (es) | 2009-08-31 | 2010-08-30 | Liberacion pulsatil de medicamentos desde un tapon de punctum |
Country Status (13)
Country | Link |
---|---|
US (2) | US8808257B2 (es) |
EP (1) | EP2473143A1 (es) |
JP (1) | JP5687276B2 (es) |
KR (1) | KR20120073242A (es) |
CN (1) | CN102481204A (es) |
AR (1) | AR081113A1 (es) |
AU (1) | AU2010286770B2 (es) |
BR (1) | BR112012004459A2 (es) |
CA (1) | CA2772566A1 (es) |
RU (1) | RU2539556C2 (es) |
SG (1) | SG178551A1 (es) |
TW (1) | TW201114456A (es) |
WO (1) | WO2011025766A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
EP3412260B1 (en) | 2009-05-18 | 2020-08-26 | Dose Medical Corporation | Drug eluting ocular implant |
US9475709B2 (en) | 2010-08-25 | 2016-10-25 | Lockheed Martin Corporation | Perforated graphene deionization or desalination |
US9301874B2 (en) * | 2011-05-06 | 2016-04-05 | Johnson & Johnson Vision Care, Inc. | Punctal plugs for controlled release of therapeutic agents |
US9877799B2 (en) * | 2011-06-10 | 2018-01-30 | Pharmaphd, Inc. | Regulated periodontal dispensing apparatus and multiple dose applicator with a semilunar valve |
TWI635855B (zh) * | 2012-02-29 | 2018-09-21 | 壯生和壯生視覺關懷公司 | 具有激能圍阻陣列之淚管塞 |
US10376845B2 (en) | 2016-04-14 | 2019-08-13 | Lockheed Martin Corporation | Membranes with tunable selectivity |
US9610546B2 (en) | 2014-03-12 | 2017-04-04 | Lockheed Martin Corporation | Separation membranes formed from perforated graphene and methods for use thereof |
US10653824B2 (en) | 2012-05-25 | 2020-05-19 | Lockheed Martin Corporation | Two-dimensional materials and uses thereof |
US9834809B2 (en) | 2014-02-28 | 2017-12-05 | Lockheed Martin Corporation | Syringe for obtaining nano-sized materials for selective assays and related methods of use |
US10696554B2 (en) | 2015-08-06 | 2020-06-30 | Lockheed Martin Corporation | Nanoparticle modification and perforation of graphene |
US9744617B2 (en) | 2014-01-31 | 2017-08-29 | Lockheed Martin Corporation | Methods for perforating multi-layer graphene through ion bombardment |
US9844757B2 (en) | 2014-03-12 | 2017-12-19 | Lockheed Martin Corporation | Separation membranes formed from perforated graphene and methods for use thereof |
TW201504140A (zh) | 2013-03-12 | 2015-02-01 | Lockheed Corp | 形成具有均勻孔尺寸之多孔石墨烯之方法 |
US10517759B2 (en) | 2013-03-15 | 2019-12-31 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
US9572918B2 (en) | 2013-06-21 | 2017-02-21 | Lockheed Martin Corporation | Graphene-based filter for isolating a substance from blood |
SG11201606287VA (en) | 2014-01-31 | 2016-08-30 | Lockheed Corp | Processes for forming composite structures with a two-dimensional material using a porous, non-sacrificial supporting layer |
WO2015116946A1 (en) | 2014-01-31 | 2015-08-06 | Lockheed Martin Corporation | Perforating two-dimensional materials using broad ion field |
JP6655610B2 (ja) | 2014-05-29 | 2020-02-26 | グローコス コーポレーション | 制御された薬物送達機能を備えるインプラント及びそれを使用する方法 |
MX2017002738A (es) | 2014-09-02 | 2017-08-02 | Lockheed Corp | Membranas de hemodialisis y hemofiltracion basadas en un material de membrana bidimensional y metodos que emplean las mismas. |
WO2017023376A1 (en) | 2015-08-05 | 2017-02-09 | Lockheed Martin Corporation | Perforatable sheets of graphene-based material |
WO2017040853A1 (en) | 2015-09-02 | 2017-03-09 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
US11564833B2 (en) * | 2015-09-25 | 2023-01-31 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
KR20190019907A (ko) | 2016-04-14 | 2019-02-27 | 록히드 마틴 코포레이션 | 자유-플로팅 방법을 사용한 대규모 이송을 위한 그래핀 시트 취급 방법 |
WO2017180134A1 (en) | 2016-04-14 | 2017-10-19 | Lockheed Martin Corporation | Methods for in vivo and in vitro use of graphene and other two-dimensional materials |
SG11201809016QA (en) | 2016-04-14 | 2018-11-29 | Lockheed Corp | Selective interfacial mitigation of graphene defects |
WO2017180139A1 (en) | 2016-04-14 | 2017-10-19 | Lockheed Martin Corporation | Two-dimensional membrane structures having flow passages |
EP3443329A4 (en) | 2016-04-14 | 2020-04-08 | Lockheed Martin Corporation | METHODS FOR PROVIDING IN SITU MONITORING AND CONTROL OF DEFECT TRAINING OR HEALING |
AU2017252294B2 (en) | 2016-04-20 | 2021-12-02 | Glaukos Corporation | Bioresorbable ocular drug delivery device |
KR20230150840A (ko) | 2021-02-24 | 2023-10-31 | 오큘라 테라퓨틱스, 인코포레이티드 | 소관내 데포 삽입 디바이스 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5098443A (en) * | 1989-03-23 | 1992-03-24 | University Of Miami | Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents |
US5017381A (en) | 1990-05-02 | 1991-05-21 | Alza Corporation | Multi-unit pulsatile delivery system |
US5260069A (en) | 1992-11-27 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Pulsatile particles drug delivery system |
MY125849A (en) | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems |
US6196993B1 (en) | 1998-04-20 | 2001-03-06 | Eyelab Group, Llc | Ophthalmic insert and method for sustained release of medication to the eye |
US6590588B2 (en) | 1998-05-29 | 2003-07-08 | Palm, Inc. | Wireless, radio-frequency communications using a handheld computer |
US6375972B1 (en) * | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
US20050129731A1 (en) * | 2003-11-03 | 2005-06-16 | Roland Horres | Biocompatible, biostable coating of medical surfaces |
WO2006014793A1 (en) | 2004-07-26 | 2006-02-09 | Clarity Corporation | Implantable device having reservoir with controlled release of medication and method of manufacturing the same |
US20080038317A1 (en) * | 2004-09-10 | 2008-02-14 | Chin-Ming Chang | Therapeutic Lacrimal Canalicular Inserts And Related Methods |
CN103393483B (zh) * | 2006-03-31 | 2016-08-24 | 玛提治疗有限公司 | 用于鼻泪系统的药物释放方法、结构及组合物 |
US20080045911A1 (en) | 2006-06-21 | 2008-02-21 | Borgia Maureen J | Punctal plugs for the delivery of active agents |
US9173773B2 (en) | 2006-06-21 | 2015-11-03 | Johnson & Johnson Vision Care, Inc. | Punctal plugs for the delivery of active agents |
US8617143B2 (en) | 2006-12-07 | 2013-12-31 | The Regents Of The University Of California | Therapeutic agent delivery systems and devices |
JP5555162B2 (ja) | 2007-09-07 | 2014-07-23 | キュー エル ティー インク. | 治療薬剤の持続放出のための薬物コア |
US8521273B2 (en) | 2008-01-29 | 2013-08-27 | Gilbert H. KLIMAN | Drug delivery devices, kits and methods therefor |
TWI542338B (zh) | 2008-05-07 | 2016-07-21 | 壯生和壯生視覺關懷公司 | 用於活性劑之控制釋放的眼用裝置 |
-
2010
- 2010-08-17 US US12/857,885 patent/US8808257B2/en active Active
- 2010-08-24 JP JP2012526900A patent/JP5687276B2/ja not_active Expired - Fee Related
- 2010-08-24 CA CA2772566A patent/CA2772566A1/en not_active Abandoned
- 2010-08-24 EP EP10748035A patent/EP2473143A1/en not_active Withdrawn
- 2010-08-24 SG SG2012012811A patent/SG178551A1/en unknown
- 2010-08-24 BR BR112012004459A patent/BR112012004459A2/pt not_active IP Right Cessation
- 2010-08-24 AU AU2010286770A patent/AU2010286770B2/en not_active Expired - Fee Related
- 2010-08-24 KR KR1020127007554A patent/KR20120073242A/ko not_active Application Discontinuation
- 2010-08-24 CN CN2010800395190A patent/CN102481204A/zh active Pending
- 2010-08-24 WO PCT/US2010/046442 patent/WO2011025766A1/en active Application Filing
- 2010-08-24 RU RU2012112548/14A patent/RU2539556C2/ru not_active IP Right Cessation
- 2010-08-30 TW TW099129021A patent/TW201114456A/zh unknown
- 2010-08-30 AR ARP100103164A patent/AR081113A1/es unknown
-
2013
- 2013-05-08 US US13/890,066 patent/US9125715B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US9125715B2 (en) | 2015-09-08 |
WO2011025766A1 (en) | 2011-03-03 |
CN102481204A (zh) | 2012-05-30 |
US8808257B2 (en) | 2014-08-19 |
TW201114456A (en) | 2011-05-01 |
KR20120073242A (ko) | 2012-07-04 |
RU2012112548A (ru) | 2013-10-10 |
US20130338611A1 (en) | 2013-12-19 |
EP2473143A1 (en) | 2012-07-11 |
BR112012004459A2 (pt) | 2016-05-10 |
SG178551A1 (en) | 2012-03-29 |
CA2772566A1 (en) | 2011-03-03 |
US20110054418A1 (en) | 2011-03-03 |
RU2539556C2 (ru) | 2015-01-20 |
JP5687276B2 (ja) | 2015-03-18 |
AU2010286770B2 (en) | 2015-04-09 |
JP2013502991A (ja) | 2013-01-31 |
AU2010286770A1 (en) | 2012-03-15 |
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Legal Events
Date | Code | Title | Description |
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FB | Suspension of granting procedure |