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WO2011111027A3 - Oral dispersible delayed release tablet formulation - Google Patents

Oral dispersible delayed release tablet formulation Download PDF

Info

Publication number
WO2011111027A3
WO2011111027A3 PCT/IB2011/051031 IB2011051031W WO2011111027A3 WO 2011111027 A3 WO2011111027 A3 WO 2011111027A3 IB 2011051031 W IB2011051031 W IB 2011051031W WO 2011111027 A3 WO2011111027 A3 WO 2011111027A3
Authority
WO
WIPO (PCT)
Prior art keywords
tablet
delayed release
mini
release tablet
tablet formulation
Prior art date
Application number
PCT/IB2011/051031
Other languages
French (fr)
Other versions
WO2011111027A2 (en
Inventor
Adel Penhasi
Maxim Gomberg
Tal Meisler
Janina Gauchman
Original Assignee
Dexcel Pharma Technologies Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dexcel Pharma Technologies Ltd. filed Critical Dexcel Pharma Technologies Ltd.
Publication of WO2011111027A2 publication Critical patent/WO2011111027A2/en
Publication of WO2011111027A3 publication Critical patent/WO2011111027A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

A formulation for delivery of a therapeutic agent to the small intestine which features a combination of a single delayed release mini-tablet for delivery to the gastrointestinal tract, surrounded by a fast disintegrating tablet layer which dissolves in the oral cavity. The oral disintegrating tablet which undergoes rapid disintegration in the oral cavity supports ease of swallowing and hence ease of administration of the mini-tablet, which is responsible for delayed release of a therapeutic agent in the small intestine. The mini-tablet preferably has a relatively small diameter, smaller than that of a regular tablet.
PCT/IB2011/051031 2010-03-11 2011-03-11 Oral dispersible delayed release tablet formulation WO2011111027A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31272210P 2010-03-11 2010-03-11
US61/312,722 2010-03-11
US33416410P 2010-05-12 2010-05-12
US61/334,164 2010-05-12

Publications (2)

Publication Number Publication Date
WO2011111027A2 WO2011111027A2 (en) 2011-09-15
WO2011111027A3 true WO2011111027A3 (en) 2012-03-01

Family

ID=44483952

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/051031 WO2011111027A2 (en) 2010-03-11 2011-03-11 Oral dispersible delayed release tablet formulation

Country Status (1)

Country Link
WO (1) WO2011111027A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8808736B2 (en) 2011-02-11 2014-08-19 Zx Pharma, Llc Enteric coated multiparticulate controlled release peppermint oil composition and related methods
PT2672981T (en) 2011-02-11 2018-06-21 Zx Pharma Llc Multiparticulate l-menthol formulations and related methods
US8911780B2 (en) 2011-02-11 2014-12-16 Zx Pharma, Llc Multiparticulate L-menthol formulations and related methods
AU2013387678B2 (en) 2013-04-23 2015-04-16 Sociétés des Produits Nestlé S.A. Enteric coated multiparticulate controlled release peppermint oil composition and related methods
CN103556501B (en) * 2013-10-30 2015-06-24 齐齐哈尔大学 Cation dyeing auxiliary of linen reactive dye, preparation method and application of cation dyeing auxiliary
KR102392313B1 (en) * 2014-09-03 2022-05-02 라이온 가부시키가이샤 Coated preparation and method for producing same
WO2016174664A1 (en) 2015-04-29 2016-11-03 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
CN108283000B (en) 2015-09-23 2021-04-13 凯瑞康宁生物工程（武汉）有限公司 Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
CN110724279B (en) * 2019-10-14 2022-04-22 浙江海洋大学 A kind of preparation method of temperature and pH sensitive guar gum/starch composite hydrogel
CN112156077B (en) * 2020-10-26 2023-01-24 上海纳为生物技术有限公司 N-acetylglucosamine tablet and preparation method thereof
EP4243633A1 (en) * 2020-11-13 2023-09-20 Sila S.P.A. Orally dispersible compound containing an ester or salt of n-butyric acid and process for production
EP4356904A1 (en) * 2022-10-19 2024-04-24 Sanovel Ilac Sanayi Ve Ticaret A.S. A capsule comprising lansoprazole

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020142034A1 (en) * 1998-05-18 2002-10-03 Toshihiro Shimizu Orally disintegrable tablets
EP1430888A1 (en) * 2001-09-28 2004-06-23 Sanwa Kagaku Kenkyusho Co., Ltd. Press-coated molded article undergoing quick disintegration
WO2007075980A2 (en) * 2005-12-20 2007-07-05 Teva Pharmaceutical Industries Ltd. Lansoprazole orally disintegrating tablets
WO2009060064A2 (en) * 2007-11-09 2009-05-14 Valpharma S.A. Pharmaceutical formulations for the oral administration of ppi

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0181966A1 (en) 1984-11-13 1986-05-28 Gist-Brocades N.V. Compression-coated dispersible tablets
JP2000516222A (en) 1996-08-15 2000-12-05 ロザン ファルマ ゲゼルシャフトミットベシュレンクテル ハフツング Oral pharmaceutical composition that is easy to swallow
US20040068000A1 (en) 2002-10-02 2004-04-08 Mintong Guo Compression coated tablets
US20070077300A1 (en) 2005-09-30 2007-04-05 Wynn David W Oral compositions containing a salivation inducing agent
FR2894475B1 (en) 2005-12-14 2008-05-16 Servier Lab ORODISPERSIBLE PHARMACEUTICAL COMPOSITION FOR OROMUCOSAL OR SUBLINGUAL ADMINISTRATION OF AGOMELATIN
AU2007266574A1 (en) 2006-06-01 2007-12-06 Dexcel Pharma Technologies Ltd. Multiple unit pharmaceutical formulation
ITMI20062290A1 (en) 2006-11-28 2008-05-29 Monteres S R L TABLETS STABLE WITH STORAGE BASED ON BENZIMIDAZOLE DERIVATIVES COATED WITH GASTRO-RESISTANT FILM

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020142034A1 (en) * 1998-05-18 2002-10-03 Toshihiro Shimizu Orally disintegrable tablets
EP1430888A1 (en) * 2001-09-28 2004-06-23 Sanwa Kagaku Kenkyusho Co., Ltd. Press-coated molded article undergoing quick disintegration
WO2007075980A2 (en) * 2005-12-20 2007-07-05 Teva Pharmaceutical Industries Ltd. Lansoprazole orally disintegrating tablets
WO2009060064A2 (en) * 2007-11-09 2009-05-14 Valpharma S.A. Pharmaceutical formulations for the oral administration of ppi

Also Published As

Publication number Publication date
WO2011111027A2 (en) 2011-09-15

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