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AR058956A1 - Derivados de tiofeno agonistas de receptores s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores. - Google Patents

Derivados de tiofeno agonistas de receptores s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores.

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Publication number
AR058956A1
AR058956A1 ARP070100083A ARP070100083A AR058956A1 AR 058956 A1 AR058956 A1 AR 058956A1 AR P070100083 A ARP070100083 A AR P070100083A AR P070100083 A ARP070100083 A AR P070100083A AR 058956 A1 AR058956 A1 AR 058956A1
Authority
AR
Argentina
Prior art keywords
hydroxy
ethyl
alkyl
represents hydrogen
och2
Prior art date
Application number
ARP070100083A
Other languages
English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37908151&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR058956(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR058956A1 publication Critical patent/AR058956A1/es

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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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Abstract

Reivindicacion 1: Un compuesto seleccionado del grupo que consiste en compuestos de tiofeno de la Formula (1), en donde A representa *-CO-CH=CH-,*-CO-CH2CH2-, *-CO-CH2-NH-,en donde los asteriscos indican el enlace que está unido al grupo tiofeno de la Formula (1); R1 representa hidrogeno, metilo, o trifluormetilo; R2 representa n-propilo, isobutilo, o ciclopropilmetilo; R3 representa hidrogeno, metilo, trifluormetilo, etilo, n-propilo, isopropilo, o isobutilo; R4 representa hidrogeno, alquilo C1-4, metoxi, o halogeno; R5 representa hidrogeno, alquilo C1-4, alcoxi C1-4, o halogeno; R6 representa hidroxi-alquilo C1-4, di-(hidroxi-alquil C1-)-alquilo C1-4, 2,3-dihidroxipropilo, -CH2-(CH2)n-NR61R62, -CH2-(CH2)n-NHCOR64, -CH2-(CH2)n- NHSO2R63, -(CH2)k-(CHR65)p-CHR66-CONR61R62, -(CH2)nCH(OH)-CH2-NR61R62, -(CH2)nCH(OH)-CH2-NHCOR64, -(CH2)nCH(OH)-CH2-NHSO2R63, -CO-NHR61, hidroxi, hidroxi-alcoxi C2-4, di-(hidroxi-alquil C1-4)-alcoxi C1-4, 1-glicerilo, 2,3-dihidroxipropoxi, 2- hidroxi-3-metoxi-propoxi, -OCH2-(CH2)mNR61 R62, -OCH2-(CH2)mNHCOR64, OCH2-(CH2)mNHSO2R63, -OCH2-CH(OH)-CH2-NR61R62, -OCH2-CH(OH)-CH2-NHCOR64, -OCH2-CH(OH)-CH2-NHSO2R63, -NR61R62, -NHCO-R64, o -SO2NH-R61; R61 representa hidrogeno, metilo, etilo, 2- hidroxietilo, 2-hidroxi-1-hidroximetil-etilo, 2,3-dihidroxi-propilo, 2-alcoxietilo C1-4, 3-hidroxipropilo, 3-alcoxipropilo C1-4, 2- aminoetilo, 2-(alquilamino C1-4)etilo, 2-(di-(alquil C1-4)amino)etilo, carboximetilo, alquilcarboximetilo C1-4, 2- carboxietilo, o 2-(alquilcarboxi C1- 4)etilo; R62 representa hidrogeno, o metilo; R63 representa metilo, etilo, 2-hidroxietilo, 2-metoxietilo, metilamino, etilamino, o dimetilamino; R64 representa hidroximetilo, aminometilo, metilaminometilo, dimetilaminometilo, 2-aminoetilo, o 2-metilamino-etilo; R65 representa hidrogeno; R66 representa hidrogeno o hidroxi; y en el caso que R66 represente hidroxi, R65 puede además representar hidroxi; m representa el entero 1 o 2; n representa 0, 1, o 2; k representa 0; p representa 0 o 1; y en el caso que p represente 1, k puede además representar 1; y R7 representa hidrogeno, alquilo C1-4, o halogeno; y las sales de los mismos.
ARP070100083A 2006-01-11 2007-01-09 Derivados de tiofeno agonistas de receptores s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores. AR058956A1 (es)

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