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BRPI0513672A - processo aperfeiçoado para a preparação de 2h-1-benzopiran-2metanol, (alfa). (alfa)' [iminobis (metileno)] bis [6-fluoro-3, 4-dihidro, [2r* [r* [r* (s*)]]]], composição farmacêutica, forma t1 amorfa, e processo para a preparação da forma t1 de hidrocloreto de nebivolol - Google Patents

processo aperfeiçoado para a preparação de 2h-1-benzopiran-2metanol, (alfa). (alfa)' [iminobis (metileno)] bis [6-fluoro-3, 4-dihidro, [2r* [r* [r* (s*)]]]], composição farmacêutica, forma t1 amorfa, e processo para a preparação da forma t1 de hidrocloreto de nebivolol

Info

Publication number
BRPI0513672A
BRPI0513672A BRPI0513672-5A BRPI0513672A BRPI0513672A BR PI0513672 A BRPI0513672 A BR PI0513672A BR PI0513672 A BRPI0513672 A BR PI0513672A BR PI0513672 A BRPI0513672 A BR PI0513672A
Authority
BR
Brazil
Prior art keywords
preparation
alpha
2methanol
iminobis
benzopyran
Prior art date
Application number
BRPI0513672-5A
Other languages
English (en)
Inventor
Rakesh Sheth
Srinivasarao Veeravenk Attanti
Hasmukh Mathurbhai Patel
Vinodkumar Gupta
Sunil Sadanand Nadkarni
Original Assignee
Torrent Pharmaceuticals Limita
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35653988&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0513672(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Torrent Pharmaceuticals Limita filed Critical Torrent Pharmaceuticals Limita
Publication of BRPI0513672A publication Critical patent/BRPI0513672A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCESSO APERFEIçOADO PARA A PREPARAçãO DE 2H-1-BENZOPIRAN-2-METANOL, a, a' ¢IMINOBIS (METILENO) ! BIS ¢6-FLUORO-3, 4-DIHIDRO-,¢2R* ¢R*¢R* (S*) ! ! ! !, COMPOSIçãO FARMACêUTICA, FORMA T1 AMORFA, E PROCESSO PARA A PREPARAçãO DA FORMA T1 DE HIDROCLORETO DE NEBIVOLOL A presente invenção proporciona um processo aperfeiçoado para a síntese de nebivolol ou de seus sais farmaceuticamente aceitáveis, mais particularmente o sal de hidrocloreto da fórmula (I). A presente invenção proporciona adicionalmente uma nova forma T1 de nebivolol e de seus sais farmaceuticamente aceitáveis. A presente invenção também proporciona as composições farmacêuticas e os processos para a preparação de uma forma de dosagem sólida oral de hidrocloreto de nebivolol da fórmula (I), sem o uso de agentes de umedecimento, e opcionalmente usando um aglutinante e/ou um desintegrante.
BRPI0513672-5A 2004-07-30 2005-08-01 processo aperfeiçoado para a preparação de 2h-1-benzopiran-2metanol, (alfa). (alfa)' [iminobis (metileno)] bis [6-fluoro-3, 4-dihidro, [2r* [r* [r* (s*)]]]], composição farmacêutica, forma t1 amorfa, e processo para a preparação da forma t1 de hidrocloreto de nebivolol BRPI0513672A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN811MU2004 2004-07-30
PCT/IN2005/000252 WO2006025070A2 (en) 2004-07-30 2005-08-01 Nebivolol and its pharmaceutically acceptable salts, process for preparation and pharmaceutical compositions of nebivolol

Publications (1)

Publication Number Publication Date
BRPI0513672A true BRPI0513672A (pt) 2008-05-13

Family

ID=35653988

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0513672-5A BRPI0513672A (pt) 2004-07-30 2005-08-01 processo aperfeiçoado para a preparação de 2h-1-benzopiran-2metanol, (alfa). (alfa)' [iminobis (metileno)] bis [6-fluoro-3, 4-dihidro, [2r* [r* [r* (s*)]]]], composição farmacêutica, forma t1 amorfa, e processo para a preparação da forma t1 de hidrocloreto de nebivolol

Country Status (16)

Country Link
US (2) US8604222B2 (pt)
EP (2) EP1737847B1 (pt)
JP (3) JP5757005B2 (pt)
KR (1) KR100896266B1 (pt)
CN (2) CN101006081B (pt)
AT (2) ATE397605T1 (pt)
AU (1) AU2005278782B2 (pt)
BR (1) BRPI0513672A (pt)
DE (1) DE602005007339D1 (pt)
ES (1) ES2307219T3 (pt)
HR (1) HRP20080297T3 (pt)
MX (1) MX2007000911A (pt)
PL (1) PL1737847T3 (pt)
RU (1) RU2378272C2 (pt)
WO (1) WO2006025070A2 (pt)
ZA (1) ZA200700765B (pt)

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EP2907809B1 (en) 2014-02-14 2018-08-22 Corden Pharma International GmbH Base-free process for the preparation of ketone intermediates usable for manufacture of nebivolol
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KR102203229B1 (ko) * 2016-01-08 2021-01-14 에리슨제약(주) 용출률이 개선된 네비보롤을 포함하는 약학적 조성물
WO2017119629A1 (ko) * 2016-01-08 2017-07-13 에리슨제약(주) 용출률이 개선된 네비보롤을 포함하는 약학적 조성물
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Also Published As

Publication number Publication date
EP1741712A2 (en) 2007-01-10
JP2008508258A (ja) 2008-03-21
JP5837975B2 (ja) 2015-12-24
JP2015057407A (ja) 2015-03-26
HRP20080297T3 (en) 2008-07-31
WO2006025070A2 (en) 2006-03-09
JP2013151550A (ja) 2013-08-08
ATE397605T1 (de) 2008-06-15
US20130296583A1 (en) 2013-11-07
EP1737847A2 (en) 2007-01-03
MX2007000911A (es) 2007-04-12
CN101862322A (zh) 2010-10-20
DE602005007339D1 (de) 2008-07-17
PL1737847T3 (pl) 2008-11-28
ES2307219T3 (es) 2008-11-16
JP5757005B2 (ja) 2015-07-29
RU2378272C2 (ru) 2010-01-10
RU2007106103A (ru) 2008-09-10
AU2005278782B2 (en) 2011-04-21
US8633241B2 (en) 2014-01-21
EP1741712A3 (en) 2007-04-04
CN101006081B (zh) 2011-02-09
ZA200700765B (en) 2008-11-26
WO2006025070A3 (en) 2006-10-12
KR20070062507A (ko) 2007-06-15
US8604222B2 (en) 2013-12-10
US20070259950A1 (en) 2007-11-08
ATE512961T1 (de) 2011-07-15
AU2005278782A1 (en) 2006-03-09
EP1741712B1 (en) 2011-06-15
KR100896266B1 (ko) 2009-05-08
CN101006081A (zh) 2007-07-25
EP1737847B1 (en) 2008-06-04

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