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AR036172A1 - 4-aminociclohexanoles sustituidos, medicamentos que los contienen, su uso para elaborar estos ultimos y proceso para la elaboracion de los mismos - Google Patents

4-aminociclohexanoles sustituidos, medicamentos que los contienen, su uso para elaborar estos ultimos y proceso para la elaboracion de los mismos

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Publication number
AR036172A1
AR036172A1 ARP020102649A ARP020102649A AR036172A1 AR 036172 A1 AR036172 A1 AR 036172A1 AR P020102649 A ARP020102649 A AR P020102649A AR P020102649 A ARP020102649 A AR P020102649A AR 036172 A1 AR036172 A1 AR 036172A1
Authority
AR
Argentina
Prior art keywords
substituted
unsubstituted
ch2r7
aryl
multiple form
Prior art date
Application number
ARP020102649A
Other languages
English (en)
Inventor
C Sundermann
H Hennies
W Englberger
S Wnendt
Original Assignee
Gruenenthal Gmbh
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Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of AR036172A1 publication Critical patent/AR036172A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
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    • A61P1/12—Antidiarrhoeals
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61P7/10—Antioedematous agents; Diuretics
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    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
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    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Heart & Thoracic Surgery (AREA)
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  • Nutrition Science (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

4-aminociclohexanoles sustituidos que tienen la fórmula general (1), en donde: R1 y R2 en forma independiente se seleccionan a partir de H; alquilo C1-8 o cicloalquilo C3-8, ya sea saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; arilo-, o heteroarilo, y sea no sustituido o sustituido en forma simple o múltiple; o arilo, cicloalquilo C3-8 o heteroarilo unido mediante alquileno C1-3, ya sea no sustituido o sustituido en forma simple o múltiple; en donde ni R1 ni R2 pueden ser H, o los restos R1 y R2 en forma conjunta forman un ciclo y significan CH2CH2OCH2CH2, CH2CH2NR5CH2CH2 ó (CH2)3-6, con R5 seleccionado a partir de H; alquilo C1-8 o cicloalquilo C3-8, ya sea saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; arilo-, o heteroarilo, ya sea no sustituido o sustituido en forma simple o múltiple; o arilo, cicloalquilo C3-8, o heteroarilo unido mediante alquileno C1-3, ya sea no sustituido o sustituido en forma simple o múltiple; R3 es seleccionado a partir de arilo o heteroarilo, ya sea no sustituido o sustituido en forma simple o múltiple; R4 se selecciona a partir de cicloalquilo C3-8, arilo o heteroarilo, no sustituido o sustituido en forma simple o múltiple; -CHR6R7, -CHR6-CH2R7, -CHR6-CH2-CH2R7, -CHR6-CH2-CH2-CH2R7, -C(Y)R7, -C(Y)-CH2R7, -C(Y)-CH2-CH2R7 ó -C(Y)-CH2-CH2-CH2R7; ó -R8-L-R9; con Y = O, S ó H2; con R6 seleccionado a partir de H; alquilo C1-7, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; o C(O)O-alquilo C1-6, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; y con R7 seleccionado a partir de H; cicloalquilo C3-8, arilo o heteroarilo, no sustituido o sustituido en forma simple o múltiple; con R8 seleccionado a partir de arilo o heteroarilo, no sustituido o sustituido en forma simple o múltiple; con L seleccionado a partir de -C(O)-NH-, -NH-C(O)-, -C(O)-O-, -O-C(O)-, -O-, -S- ó -S(O)2-; y con R9 seleccionado a partir de arilo o heteroarilo, no sustituido o sustituido en forma simple o múltiple; con la reserva que, (Factor de rechazo - Grupo 1) si R3 = fenilo, sustituido o no sustituido, y R4 = fenilo, sustituido o no sustituido, ó -CHR6R7, -CHR6-CH2R7, -CHR6-CH2-CH2R7, -CHR6-CH2-CH2-CH2R7, -C(Y)R7, -C(Y)-CH2R7, -C(Y)-CH2-CH2R7 ó -C(Y)-CH2-CH2-CH2R7 con Y = H2, R6 = H, alquilo C1-5, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple y/o R7 = H, cicloalquilo C3-8 o fenilo, ya sea sustituido o no sustituido, ni R1 ni R2 en forma independiente son alquilo C1-5; (Factor de rechazo - Grupo 2) si R3 = tiofenilo, sustituido o no sustituido, y R4 = -CH2-CH2-fenilo, los restos R1 y R2 no forman un ciclo ni significan (CH2)5; en la forma de su racemato; estereoisómeros puros, en especial enantiómeros y diastereómeros, o en la forma de mezclad de estereoisómeros, en especial de los enantiómeros y diasterómeros en una relación de mezcla arbitraria; en la forma producida o en la forma de sus ácidos o bases, como también de sus sales, en especial sales fisiológicamente tolerantes, o en la forma de sus solvatos, en especial de los hidratos. Medicamentos que comprenden al menos uno de los 4-aminociclohexanoles sustituidos de la fórmula general (1) y uso de estos últimos para elaborar dichos medicamentos. Proceso para elaborar los 4-aminociclohexanoles descriptos. Los compuestos de la fórmula general (1) son útiles para el tratamiento del dolor, estados de ansiedad, síndromes generados por o relacionados con el estrés, depresiones, epilepsia, mal de Alzheimer, demencia senil, disfunciones cognitivas generales y trastornos del aprendizaje.
ARP020102649A 2001-07-17 2002-07-15 4-aminociclohexanoles sustituidos, medicamentos que los contienen, su uso para elaborar estos ultimos y proceso para la elaboracion de los mismos AR036172A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10135636A DE10135636A1 (de) 2001-07-17 2001-07-17 Substituierte 4-Aminocyclohexanole

Publications (1)

Publication Number Publication Date
AR036172A1 true AR036172A1 (es) 2004-08-18

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ID=7692668

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ARP020102649A AR036172A1 (es) 2001-07-17 2002-07-15 4-aminociclohexanoles sustituidos, medicamentos que los contienen, su uso para elaborar estos ultimos y proceso para la elaboracion de los mismos

Country Status (18)

Country Link
US (1) US7183436B2 (es)
EP (1) EP1406858B1 (es)
JP (1) JP4208139B2 (es)
AR (1) AR036172A1 (es)
AT (1) ATE435197T1 (es)
AU (1) AU2002321215B2 (es)
CA (1) CA2453901C (es)
CY (1) CY1109361T1 (es)
DE (2) DE10135636A1 (es)
DK (1) DK1406858T3 (es)
ES (1) ES2329017T3 (es)
HU (1) HU228911B1 (es)
MX (1) MXPA04000446A (es)
PE (1) PE20030325A1 (es)
PL (1) PL208676B1 (es)
PT (1) PT1406858E (es)
SI (1) SI1406858T1 (es)
WO (1) WO2003008370A1 (es)

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DE10153346A1 (de) 2001-10-29 2004-04-22 Grünenthal GmbH Substituierte Indole
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AR071066A1 (es) 2008-03-27 2010-05-26 Gruenenthal Chemie Derivados de (hetero) aril-ciclohexano
CA2719736C (en) 2008-03-27 2016-02-09 Gruenenthal Gmbh Spiro(5.5)undecane derivatives
JP5529843B2 (ja) 2008-03-27 2014-06-25 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換シクロヘキシルジアミン
KR20120075500A (ko) 2008-03-27 2012-07-06 그뤼넨탈 게엠베하 치환된 4-아미노사이클로헥산 유도체
CA3011182A1 (en) * 2016-01-13 2017-07-20 Grunenthal Gmbh 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives

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JP2004534858A (ja) 2004-11-18
PE20030325A1 (es) 2003-04-03
HUP0401082A2 (hu) 2004-08-30
PT1406858E (pt) 2009-09-21
CY1109361T1 (el) 2014-07-02
HU228911B1 (en) 2013-06-28
DE50213651D1 (de) 2009-08-13
HUP0401082A3 (en) 2011-07-28
SI1406858T1 (sl) 2009-12-31
PL208676B1 (pl) 2011-05-31
US7183436B2 (en) 2007-02-27
DK1406858T3 (da) 2009-11-23
EP1406858B1 (de) 2009-07-01
AU2002321215B2 (en) 2007-08-02
DE10135636A1 (de) 2003-02-06
PL368050A1 (en) 2005-03-21
CA2453901A1 (en) 2003-01-30
ATE435197T1 (de) 2009-07-15
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EP1406858A1 (de) 2004-04-14
US20040236104A1 (en) 2004-11-25

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