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AR015168A1 - Compuesto herbicida 3-(1,2-benzisotiazol)-e isoxazol-5-il)-2,4-(1h,3h)-pirimidindiona o tiona o 3-(1,2-benzisotiazol)-e isoxazol-5-il)-4(3h)-pirimidinona o tiona, y procedimiento para preparar el compuesto 3-(1,2-benzisotiazol)-e isoxazol-5-il)-2,4-(1h,3h)-pirimidindiona o tiona - Google Patents

Compuesto herbicida 3-(1,2-benzisotiazol)-e isoxazol-5-il)-2,4-(1h,3h)-pirimidindiona o tiona o 3-(1,2-benzisotiazol)-e isoxazol-5-il)-4(3h)-pirimidinona o tiona, y procedimiento para preparar el compuesto 3-(1,2-benzisotiazol)-e isoxazol-5-il)-2,4-(1h,3h)-pirimidindiona o tiona

Info

Publication number
AR015168A1
AR015168A1 ARP980104611A ARP980104611A AR015168A1 AR 015168 A1 AR015168 A1 AR 015168A1 AR P980104611 A ARP980104611 A AR P980104611A AR P980104611 A ARP980104611 A AR P980104611A AR 015168 A1 AR015168 A1 AR 015168A1
Authority
AR
Argentina
Prior art keywords
groups
alkyl
isoxazol
halogen
benzisotiazol
Prior art date
Application number
ARP980104611A
Other languages
English (en)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of AR015168A1 publication Critical patent/AR015168A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Se proveen compuestos de 3-(1,2-benzisotiazol-e isoxazol-5-il)-2,4-(3H,1H)-pirimidindiona o tiona de la formula (I) y compuestos de 3-(1,2-benzisotiazol-eisoxazol-5-il)-4(3H)-pirimidinona o tiona de la formula (II), dondeR es alquilo C1-6,haloalquil o C1-6, cicloalquilo C3-7, alquenilo C3-6, alquinilo C3-6,bencilo, OR4 o NR5R6; R1 y R2 son independientemente hidrogeno, halogeno, alquilo C1-6, cicloalquilo C3-7, haloalquilo C1-6, alquenilo C3-6, haloalqueniloC3-6, alquinilo C3-6, OR7,S(O)nR8 o N R9R10, y cuando R1 y R2 tomados junto con el átomo al que están unidos, representan un anillo de 4-7 miembros saturados ono saturados opcionalmente interrumpido por oxígeno azufre o nitrogeno y opcionalmente sustituido con entre uno ytres grupo meti lo o uno o más átomos dehalogeno; R3 es halogeno o A2R11; X es hidrogeno, halogeno o alquilo C1-4; X1 es hidrogeno, halogeno, alquilo C1-4, haloalquilo C1-4, alcoxi C1-4 o haloalcoxiC1-4; Z es O o S(O)m<; Y es halogeno, ciano, R12,X2R12, X3R12, X2X3 R12 o X3X2R12; X2 es O, S(O)p o NR13; X3 es -C(=A3)-, -C(=NOR14)- o -C(=N-NR13R50)-; R4,R5, R6, R7, R8, R9, R10, R11 y R14 son cada uno independientemente hidrogeno, alquilo C1-6, cicloalquilo C3-7, alcoxialquilo C2-8, alqueniloC2-6, alquinilo obenc ilo C2-6; R12 es hidrogeno, un grupo alquilo C1-8, cicloalquilo C3-7, alquenilo C2-8, cicloalquenilo C5-6 o alquinilo C2-8, donde cada grupo estáopcionalmente sustituido con cualquier combinacion de uno a seis átomos dehalogeno, uno o tres grupos al coxi C1-20 opcionalmente sustituidos con un grupoalcoxi C1-6, benciloxi o alquitio C1-6, uno o dos grupos de NR15R16, entre uno o tres S(O)qR17, uno o dos grupos de ciano, un grupo tiociano, un grupoO(SO2)R17, un grupoO(NO2), uno o dos grupos C(O)R1 8, uno o dos grupos CO2R19, uno o dos grupos C(O)SR19, uno o dos grupos C(O)NR20R21, de uno a tres gruposX4R22, uno o dos grupos P(O)(OR23)2, uno o dos grupos Si(R24)3, un anillo de 4- a 10- miembros monocíclico obicíclicos fusionado heterocíclico o pcionalmentesustituido con cualquier combinacion de uno o dos grupos oxo, uno o dos grupos tioxo, uno a tres átomos de halogeno, uno a tres grupos de alquilo C1-4, uno a
ARP980104611A 1997-09-17 1998-09-16 Compuesto herbicida 3-(1,2-benzisotiazol)-e isoxazol-5-il)-2,4-(1h,3h)-pirimidindiona o tiona o 3-(1,2-benzisotiazol)-e isoxazol-5-il)-4(3h)-pirimidinona o tiona, y procedimiento para preparar el compuesto 3-(1,2-benzisotiazol)-e isoxazol-5-il)-2,4-(1h,3h)-pirimidindiona o tiona AR015168A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93145197A 1997-09-17 1997-09-17
US12883198A 1998-08-04 1998-08-04

Publications (1)

Publication Number Publication Date
AR015168A1 true AR015168A1 (es) 2001-04-18

Family

ID=26826981

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP980104611A AR015168A1 (es) 1997-09-17 1998-09-16 Compuesto herbicida 3-(1,2-benzisotiazol)-e isoxazol-5-il)-2,4-(1h,3h)-pirimidindiona o tiona o 3-(1,2-benzisotiazol)-e isoxazol-5-il)-4(3h)-pirimidinona o tiona, y procedimiento para preparar el compuesto 3-(1,2-benzisotiazol)-e isoxazol-5-il)-2,4-(1h,3h)-pirimidindiona o tiona
ARP990105578A AR021081A2 (es) 1997-09-17 1999-11-04 Un proceso para la preparacion de un compuesto intermediario para preparar compuestos herbicidas 3-(1,2-benzisotiazol) -e isoxazol-5-il) -2,4-(1h,3h)-pirimidindiona o tiona y 3-(1,2-benzisotiazol) -e isoxazol-5-il)-4(eh)- pirimidinona o tiona
ARP990105577A AR021500A2 (es) 1997-09-17 1999-11-04 Compuesto intermediario para preparar compuestos herbicidas 3-(1,2-benzisotiazol)-e isoxazol-5-il)-2,4-(1h,3h)-pirimidindiona o tiona y 3-(1,2-benzisotiazol)-e isoxazol-5-il)-4(3h)pirimidinona o tiona

Family Applications After (2)

Application Number Title Priority Date Filing Date
ARP990105578A AR021081A2 (es) 1997-09-17 1999-11-04 Un proceso para la preparacion de un compuesto intermediario para preparar compuestos herbicidas 3-(1,2-benzisotiazol) -e isoxazol-5-il) -2,4-(1h,3h)-pirimidindiona o tiona y 3-(1,2-benzisotiazol) -e isoxazol-5-il)-4(eh)- pirimidinona o tiona
ARP990105577A AR021500A2 (es) 1997-09-17 1999-11-04 Compuesto intermediario para preparar compuestos herbicidas 3-(1,2-benzisotiazol)-e isoxazol-5-il)-2,4-(1h,3h)-pirimidindiona o tiona y 3-(1,2-benzisotiazol)-e isoxazol-5-il)-4(3h)pirimidinona o tiona

Country Status (24)

Country Link
EP (1) EP0908457B1 (es)
JP (1) JP2001516758A (es)
KR (1) KR20010030612A (es)
CN (1) CN1273585A (es)
AR (3) AR015168A1 (es)
AT (1) ATE227721T1 (es)
AU (2) AU9392598A (es)
BG (1) BG104336A (es)
BR (1) BR9813017A (es)
CA (1) CA2246221A1 (es)
CZ (1) CZ2000861A3 (es)
DE (1) DE69809370T2 (es)
ES (1) ES2185118T3 (es)
HU (1) HUP0004477A3 (es)
IL (1) IL125947A0 (es)
MX (1) MXPA00002661A (es)
NZ (1) NZ331825A (es)
PL (1) PL339350A1 (es)
SK (1) SK3552000A3 (es)
TR (1) TR200000679T2 (es)
TW (1) TW474927B (es)
WO (1) WO1999014216A1 (es)
YU (1) YU15800A (es)
ZA (1) ZA988435B (es)

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HUP0201942A3 (en) * 1999-02-16 2002-12-28 Basf Ag Processes and intermediates for the preparation of 1,3-oxazin-6-ones and uracils
AR033365A1 (es) * 2000-04-17 2003-12-17 Basf Ag Compuestos benzisotiazol y benzisoxazol 3-heterociclicos sustituidos herbicidas
US20040097728A1 (en) * 2000-09-08 2004-05-20 Gerhard Hamprecht Method for producing anellated tetrahydro-{1h}-triazoles
HUP0401298A3 (en) 2001-08-30 2008-03-28 Alizyme Therapeutics Ltd Thieno [1,3] oxazin-4-ones with lipase inhibiting activity, process for their preparation and pharmaceutical compositions containing them
WO2003087072A1 (fr) * 2002-03-29 2003-10-23 Mochida Pharmaceutical Co., Ltd. Agent therapeutique destine a des troubles endotheliaux
EA010872B1 (ru) 2002-10-30 2008-12-30 Басф Акциенгезельшафт Бифункциональные фенилизо(тио)цианаты, способ и промежуточные продукты для их получения
BR112013029508B1 (pt) 2011-05-17 2022-05-03 Principia Biopharma, Inc. Composto, composição farmacêutica, e, uso do referido composto
US9376438B2 (en) 2011-05-17 2016-06-28 Principia Biopharma, Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
KR102027598B1 (ko) 2011-05-17 2019-10-01 프린시피아 바이오파마, 인코퍼레이티드 타이로신 키나아제 저해제
MX361815B (es) 2012-09-10 2018-12-17 Principia Biopharma Inc Compuestos pirazolopirimidinicos como inhibidores de cinasas.
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
DE102013226249A1 (de) * 2013-12-17 2015-06-18 Wacker Chemie Ag Polyetherreste aufweisende Organopolysiloxangele
US10092569B2 (en) 2014-02-21 2018-10-09 Principia Biopharma Inc. Salts and solid form of a BTK inhibitor
SG11201704808VA (en) 2014-12-18 2017-07-28 Principia Biopharma Inc Treatment of pemphigus
US20180305350A1 (en) 2015-06-24 2018-10-25 Principia Biopharma Inc. Tyrosine kinase inhibitors
IL263815B (en) 2016-06-29 2022-07-01 Principia Biopharma Inc Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
BR112020000085A2 (pt) * 2017-07-03 2020-07-07 Bayer Cropscience Aktiengesellschaft novos biciclos baseados em isotiazol, processos para sua preparação e seu uso como herbicidas e/ou reguladores de crescimento da planta.
CN109776302A (zh) * 2017-11-13 2019-05-21 中国科学院化学研究所 一种由木质素为甲基源制备重要化学品的方法
CA3154257A1 (en) 2019-10-14 2021-04-22 Principia Biopharma Inc. Methods for treating immune thrombocytopenia by administering (r)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
CN114276287B (zh) * 2021-12-27 2023-10-03 浙江工业大学 N-(取代苄氧基)酰胺类化合物及其制备方法和应用
CN116354953B (zh) * 2022-12-31 2024-07-16 西北农林科技大学 含苯并噻唑类化合物的除草组合物

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Also Published As

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ES2185118T3 (es) 2003-04-16
CN1273585A (zh) 2000-11-15
EP0908457B1 (en) 2002-11-13
CA2246221A1 (en) 1999-03-17
AR021081A2 (es) 2002-06-12
AU8423998A (en) 1999-04-01
HUP0004477A2 (hu) 2001-02-28
TR200000679T2 (tr) 2000-08-21
HUP0004477A3 (en) 2002-01-28
CZ2000861A3 (cs) 2000-08-16
DE69809370D1 (de) 2002-12-19
EP0908457A1 (en) 1999-04-14
PL339350A1 (en) 2000-12-18
MXPA00002661A (es) 2001-10-31
NZ331825A (en) 2000-04-28
SK3552000A3 (en) 2001-01-18
KR20010030612A (en) 2001-04-16
TW474927B (en) 2002-02-01
IL125947A0 (en) 1999-04-11
AU737864B2 (en) 2001-08-30
BR9813017A (pt) 2000-08-15
YU15800A (sh) 2002-11-15
WO1999014216A1 (en) 1999-03-25
JP2001516758A (ja) 2001-10-02
BG104336A (en) 2001-09-28
DE69809370T2 (de) 2003-03-27
ZA988435B (en) 2000-03-15
ATE227721T1 (de) 2002-11-15
AR021500A2 (es) 2002-07-24
AU9392598A (en) 1999-04-05

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