AR010129A1 - Compuestos aminicos sustituidos, procedimiento de preparacion y su aplicacion como analgesico - Google Patents
Compuestos aminicos sustituidos, procedimiento de preparacion y su aplicacion como analgesicoInfo
- Publication number
- AR010129A1 AR010129A1 ARP980101094A ARP980101094A AR010129A1 AR 010129 A1 AR010129 A1 AR 010129A1 AR P980101094 A ARP980101094 A AR P980101094A AR P980101094 A ARP980101094 A AR P980101094A AR 010129 A1 AR010129 A1 AR 010129A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- substituted
- cycloalkyl
- heterocyclyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/28—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by unsaturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Se describen compuestos amínicos sustituidos de la formula general (I), en la cual: R1 es H, OH, O-C1-6-alquilo, O-C3-7-cicloalquilo (siempre que R1 seadistinto de H, cuando R2 y R7 son iguales a H o un grupo OCH3 está sustituido en posicion 7); R2 es H (cuando R1 es distinto de H), OH, C1-6-alquilo, O-arilo, C2-6-alquenilen-arilo O-C3-7-cicloalquilo, Cl, F, F1-6-alcoxi, arilo, heterociclilo, C1-6-alquilo-heterociclilo, C1-6-alquil-arilo, 5,6,o 6,7-benzono sustituido, monosustituido o bisustituido con Cl, F, CF3, C1-6-alquilo, OH, (siempre que cuando R1 y R2 o R7 son H, R2 o R7 no son grupos CF3 y R2 oR7 en posicion 7 no representan un grupo OCH3); o R2 y R7 son conjuntamente -O-(CH2)(1-2)-O- (en las posiciones 5,6 o 6,7); R3es hidrogeno; R4 esC1-6-alquilo, o R3 conjuntamente con R4 son -(CH2)(1-4); R5 es C1-6-alquilo, C3-7-cicloalquilo; R6 es C1-6-alquilo, C1-6-alquil-arilo, C1-6-alquil-heterociclilo, -CH2-CH=C(R8)2, -(CH2-(C3-7)-cicloalquilo, C3-7-cicloalquilo;R7 es H (cuando R1 es distinto de H), OH, C1-6-alquilo, O-arilo, C2-6-alquenilen-arilo, O-C3-7-cicloalquilo, C1-6-alcoxi, Cl, F, arilo, heterociclilo, C1-6-alquil-heterociclilo, C1-6-alquil-arilo, 5,6- o 6,7-benzono sustituido, monosustituido o bisustituido con Cl, F, CF3, C1-6-alquilo, O- C1-6-alquilo, OH, (siempre que cuando R1 y R2 o R7 son H, R2 o R7 no son unradical CF3 y R2 o R7 en posicion 7 no son un grupo OCH3, y R8 es H o CH3, o sus sales farmacologicamente aceptables, y un procedimiento para supreparacion. Estos compuestos son aplicables como analgésicos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19710628 | 1997-03-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR010129A1 true AR010129A1 (es) | 2000-05-17 |
Family
ID=7823396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101094A AR010129A1 (es) | 1997-03-14 | 1998-03-11 | Compuestos aminicos sustituidos, procedimiento de preparacion y su aplicacion como analgesico |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6022895A (es) |
| EP (1) | EP0864559B1 (es) |
| JP (1) | JP4132189B2 (es) |
| KR (1) | KR100579428B1 (es) |
| CN (1) | CN1243721C (es) |
| AR (1) | AR010129A1 (es) |
| AT (1) | ATE218534T1 (es) |
| AU (1) | AU728501B2 (es) |
| CA (1) | CA2231975C (es) |
| CO (1) | CO4940510A1 (es) |
| CZ (1) | CZ295522B6 (es) |
| DE (2) | DE19805370A1 (es) |
| DK (1) | DK0864559T3 (es) |
| ES (1) | ES2178055T3 (es) |
| HK (1) | HK1015351A1 (es) |
| HU (1) | HU226060B1 (es) |
| IL (1) | IL123647A (es) |
| MY (1) | MY118828A (es) |
| NO (1) | NO311128B1 (es) |
| NZ (1) | NZ329951A (es) |
| PE (1) | PE59899A1 (es) |
| PL (1) | PL191727B1 (es) |
| PT (1) | PT864559E (es) |
| RU (1) | RU2197474C2 (es) |
| SI (1) | SI0864559T1 (es) |
| SK (1) | SK284279B6 (es) |
| UA (1) | UA56997C2 (es) |
| UY (1) | UY24919A1 (es) |
| ZA (1) | ZA982157B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19830105C1 (de) | 1998-07-06 | 2000-02-17 | Gruenenthal Gmbh | Acridinderivate |
| DE19963179B4 (de) * | 1999-12-27 | 2009-02-05 | Grünenthal GmbH | Substituierte 1- und 2-Naphthol-Mannichbasen |
| DE10033459A1 (de) * | 2000-07-10 | 2002-01-24 | Gruenenthal Gmbh | Cyclische substituierte Aminomethylverbindungen und diese Verbindungen enthaltende Arzeimittel |
| ATE347549T1 (de) | 2001-10-15 | 2006-12-15 | Janssen Pharmaceutica Nv | Neue substituierte 4-phenyl-4-(1h-imidazo-2-yl)- piperidin-derivate und ihre anwendung als selective delta-opioid-agonisten |
| DE10206403A1 (de) * | 2002-02-14 | 2003-08-28 | Gruenenthal Gmbh | Synthese von Beta-Aminoketonen |
| DE10206405A1 (de) * | 2002-02-14 | 2003-08-28 | Gruenenthal Gmbh | Synthese von substituierten Carbamidestern |
| CL2004000754A1 (es) * | 2003-04-11 | 2005-02-25 | Janssen Pharmaceutica Nv | Uso de compuestos derivados de 4-fenil-4-(1h-imidazol-2-il)piperidina, como agonistas delta-opioides no peptidicos, para preparar un medicamento util en prevenir o tratar trastornos del sistema nervioso central. |
| DE10341534A1 (de) * | 2003-09-09 | 2005-03-31 | Bayer Chemicals Ag | Difluoralkylaromaten |
| CN100549004C (zh) | 2003-10-01 | 2009-10-14 | 阿得罗公司 | 螺环杂环衍生物及其应用方法 |
| DE102004030099A1 (de) * | 2004-06-22 | 2006-01-12 | Grünenthal GmbH | Gesättigte und ungesättigte 3-Pyridyl-benzocycloalkylmethyl-amine als Serotonin- und/oder Noradrenalin-Reuptake-Hemmer und/oder µ-Opioidrezeptor-Modulatoren |
| WO2006023757A2 (en) * | 2004-08-19 | 2006-03-02 | University Of Virginia Patent Foundation | Novel tricyclic, bicyclic, monocyclic, and acyclic amines as potent sodium channel blocking agents |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| JP5090639B2 (ja) | 2005-11-18 | 2012-12-05 | 出光興産株式会社 | 芳香族アミン誘導体及びそれを用いた有機エレクトロルミネッセンス素子 |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| TWI401237B (zh) * | 2006-07-24 | 2013-07-11 | ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備 | |
| JP2010503669A (ja) | 2006-09-12 | 2010-02-04 | アドラー コーポレーション | 認知機能の強化のためのｎ含有スピロ化合物の使用 |
| TW200901961A (en) | 2007-02-16 | 2009-01-16 | Synta Pharmaceuticals Corp | Substituted fused-ring compounds for inflammation and immune-related uses |
| WO2012100423A1 (en) * | 2011-01-27 | 2012-08-02 | Eli Lilly And Company | Analgesic compounds, methods, and formulations |
| RU2538727C1 (ru) * | 2013-11-15 | 2015-01-10 | Закрытое акционерное общество "Институт экспериментальной фармакологии" | Анальгетическое средство пептидной структуры на основе тридекапептида, содержащего d-октааргининовый вектор |
| CN104844471B (zh) * | 2015-04-21 | 2017-05-03 | 苏州远智医药科技有限公司 | 一种作为dor受体拮抗剂的化合物 |
| CN109896991B (zh) * | 2017-12-08 | 2020-11-20 | 苏州远智医药科技有限公司 | 一种δ阿片受体拮抗剂及其用途和药物组合物 |
| JP7413048B2 (ja) | 2020-01-30 | 2024-01-15 | 三和シヤッター工業株式会社 | シャッターカーテン及びシャッターカーテンの梱包方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE623394A (es) * | ||||
| FR1578702A (es) * | 1961-10-10 | 1969-08-22 | ||
| DE1203247B (de) * | 1961-10-10 | 1965-10-21 | Koninklijke Pharma Fab Nv | Verfahren zur Herstellung von Diphenylalkenyl-aminen sowie deren nicht-toxischen Salzen |
| DE1149002B (de) * | 1961-10-19 | 1963-05-22 | Giulini Gmbh Geb | Verfahren zur Herstellung von blutdrucksteigernden Salzen von N, N-Dialkyl-2-aethyl-3, 3-diphenyl-propen-(2)-yl-aminen |
-
1998
- 1998-02-11 DE DE19805370A patent/DE19805370A1/de not_active Withdrawn
- 1998-02-19 ES ES98102853T patent/ES2178055T3/es not_active Expired - Lifetime
- 1998-02-19 SI SI9830137T patent/SI0864559T1/xx unknown
- 1998-02-19 EP EP98102853A patent/EP0864559B1/de not_active Expired - Lifetime
- 1998-02-19 AT AT98102853T patent/ATE218534T1/de active
- 1998-02-19 PT PT98102853T patent/PT864559E/pt unknown
- 1998-02-19 DE DE59804276T patent/DE59804276D1/de not_active Expired - Lifetime
- 1998-02-19 DK DK98102853T patent/DK0864559T3/da active
- 1998-03-09 UY UY24919A patent/UY24919A1/es not_active Application Discontinuation
- 1998-03-09 MY MYPI98001021A patent/MY118828A/en unknown
- 1998-03-11 US US09/038,033 patent/US6022895A/en not_active Expired - Lifetime
- 1998-03-11 CO CO98013443A patent/CO4940510A1/es unknown
- 1998-03-11 AR ARP980101094A patent/AR010129A1/es unknown
- 1998-03-12 NZ NZ329951A patent/NZ329951A/en unknown
- 1998-03-12 CA CA002231975A patent/CA2231975C/en not_active Expired - Fee Related
- 1998-03-12 CZ CZ1998755A patent/CZ295522B6/cs not_active IP Right Cessation
- 1998-03-12 UA UA98031284A patent/UA56997C2/uk unknown
- 1998-03-12 IL IL12364798A patent/IL123647A/en not_active IP Right Cessation
- 1998-03-12 SK SK333-98A patent/SK284279B6/sk not_active IP Right Cessation
- 1998-03-12 CN CNB981078680A patent/CN1243721C/zh not_active Expired - Fee Related
- 1998-03-12 PE PE1998000170A patent/PE59899A1/es not_active Application Discontinuation
- 1998-03-12 RU RU98105507/04A patent/RU2197474C2/ru active
- 1998-03-13 PL PL325322A patent/PL191727B1/pl not_active IP Right Cessation
- 1998-03-13 AU AU58408/98A patent/AU728501B2/en not_active Ceased
- 1998-03-13 ZA ZA982157A patent/ZA982157B/xx unknown
- 1998-03-13 JP JP06350098A patent/JP4132189B2/ja not_active Expired - Fee Related
- 1998-03-13 KR KR1019980008435A patent/KR100579428B1/ko not_active IP Right Cessation
- 1998-03-13 NO NO19981121A patent/NO311128B1/no unknown
- 1998-03-13 HU HU9800555A patent/HU226060B1/hu not_active IP Right Cessation
-
1999
- 1999-01-21 HK HK99100283A patent/HK1015351A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |