AR002279A1 - Composicion de vacuna contra la hepatitis b, proceso para la fabricacion de dicha composicion de vacuna, proceso para la fabricacion de un medicamento para la profilaxis o el tratamiento de infeccion de hepatitis, y proceso para la fabricacion de una composicion de vacuna para la induccion de anticuerpos neutralizantes en el rango de 10mu para hepatitis b en humanos - Google Patents
Composicion de vacuna contra la hepatitis b, proceso para la fabricacion de dicha composicion de vacuna, proceso para la fabricacion de un medicamento para la profilaxis o el tratamiento de infeccion de hepatitis, y proceso para la fabricacion de una composicion de vacuna para la induccion de anticuerpos neutralizantes en el rango de 10mu para hepatitis b en humanosInfo
- Publication number
- AR002279A1 AR002279A1 ARP960101469A AR10146996A AR002279A1 AR 002279 A1 AR002279 A1 AR 002279A1 AR P960101469 A ARP960101469 A AR P960101469A AR 10146996 A AR10146996 A AR 10146996A AR 002279 A1 AR002279 A1 AR 002279A1
- Authority
- AR
- Argentina
- Prior art keywords
- hepatitis
- manufacture
- vaccine composition
- prophylaxis
- treatment
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 208000006454 hepatitis Diseases 0.000 title abstract 4
- 231100000283 hepatitis Toxicity 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 229960005486 vaccine Drugs 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 230000003472 neutralizing effect Effects 0.000 title abstract 2
- 238000011321 prophylaxis Methods 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 238000002255 vaccination Methods 0.000 title 1
- 208000002672 hepatitis B Diseases 0.000 abstract 3
- 101000874347 Streptococcus agalactiae IgA FC receptor Proteins 0.000 abstract 2
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- SPSXSWRZQFPVTJ-ZQQKUFEYSA-N hepatitis b vaccine Chemical compound C([C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CC1N=CN=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)OC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](N)CCCNC(N)=N)C1=CC=CC=C1 SPSXSWRZQFPVTJ-ZQQKUFEYSA-N 0.000 abstract 1
- 229940124736 hepatitis-B vaccine Drugs 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical class O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a una composición de vacuna contra la hepatitis B que comprende un antígeno de hepatitis B conjuntamente con lípidoA monofosforilado 3-0-deacilado y fosfato de aluminio. El antígeno de hepatitis B esparticularme nte el antígeno superficial de hepatitis B. Talesformulaciones han mostrado tener propiedades inmunogénicas superiores en ensayos clínicos. La invención se refiere también a procedimientos para lafabricación de dicha composiciónde vacuna, de un medicamento para la profilaxis o el tratamiento de infecciones de hepatitis y de una vacuna para lainducción de anticuerpos neutralizantes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9503863.4A GB9503863D0 (en) | 1995-02-25 | 1995-02-25 | Vaccine compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR002279A1 true AR002279A1 (es) | 1998-03-11 |
Family
ID=10770292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960101469A AR002279A1 (es) | 1995-02-25 | 1996-02-22 | Composicion de vacuna contra la hepatitis b, proceso para la fabricacion de dicha composicion de vacuna, proceso para la fabricacion de un medicamento para la profilaxis o el tratamiento de infeccion de hepatitis, y proceso para la fabricacion de una composicion de vacuna para la induccion de anticuerpos neutralizantes en el rango de 10mu para hepatitis b en humanos |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US5972346A (es) |
| EP (1) | EP0810877B1 (es) |
| JP (1) | JP3881015B2 (es) |
| KR (1) | KR100365373B1 (es) |
| CN (1) | CN1101225C (es) |
| AP (1) | AP766A (es) |
| AR (1) | AR002279A1 (es) |
| AT (1) | ATE209045T1 (es) |
| AU (1) | AU695921B2 (es) |
| BG (1) | BG101851A (es) |
| BR (1) | BR9607458A (es) |
| CA (1) | CA2212552C (es) |
| CZ (1) | CZ288417B6 (es) |
| DE (1) | DE69617211T2 (es) |
| DK (1) | DK0810877T3 (es) |
| EA (1) | EA199700126A1 (es) |
| ES (1) | ES2166879T3 (es) |
| FI (1) | FI118118B (es) |
| GB (1) | GB9503863D0 (es) |
| HK (1) | HK1004117A1 (es) |
| HU (1) | HU224832B1 (es) |
| IL (1) | IL117249A (es) |
| MA (1) | MA23814A1 (es) |
| MX (1) | MX9706450A (es) |
| MY (1) | MY113428A (es) |
| NO (1) | NO319394B1 (es) |
| NZ (1) | NZ302674A (es) |
| OA (1) | OA10612A (es) |
| PL (1) | PL182679B1 (es) |
| PT (1) | PT810877E (es) |
| SA (1) | SA96160633B1 (es) |
| SK (1) | SK115097A3 (es) |
| TR (1) | TR199700849T1 (es) |
| TW (1) | TW467745B (es) |
| WO (1) | WO1996026741A1 (es) |
| ZA (1) | ZA961460B (es) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6620414B2 (en) * | 1992-03-27 | 2003-09-16 | Smithkline Beecham Biologicals (S.A.) | Hepatitis vaccines containing 3-0-deacylated monophoshoryl lipid A |
| FR2711670B1 (fr) | 1993-10-22 | 1996-01-12 | Pasteur Institut | Vecteur nucléotidique, composition le contenant et vaccin pour l'immunisation à l'encontre d'une hépatite. |
| US6488934B1 (en) * | 1995-02-25 | 2002-12-03 | Smithkline Beecham Biologicals S.A. | Hepatitis B vaccine |
| US20010014331A1 (en) * | 1996-11-07 | 2001-08-16 | Smithkline Beecham Biologicals S.A. | Acellular pertussis vaccine with diphthriae-and tetanus-toxoids |
| US20030049268A1 (en) | 1998-05-01 | 2003-03-13 | Smithkline Beecham Biologicals S.A. | Novel composition |
| GB9809507D0 (en) * | 1998-05-01 | 1998-07-01 | Smithkline Beecham Biolog | Novel composition |
| ES2272069T3 (es) | 1998-05-22 | 2007-04-16 | Ottawa Health Research Institute | Metodos y productos para inducir inmunidad en mucosas. |
| US6306404B1 (en) | 1998-07-14 | 2001-10-23 | American Cyanamid Company | Adjuvant and vaccine compositions containing monophosphoryl lipid A |
| EP1126876B1 (en) * | 1998-10-16 | 2007-03-21 | GlaxoSmithKline Biologicals S.A. | Adjuvant systems and vaccines |
| CU22871A1 (es) * | 1998-12-02 | 2003-10-21 | Ct Ingenieria Genetica Biotech | Formulaciones conteniendo partículas semejantes a virus como inmunopotenciadores por vía mucosal |
| EP1140155A4 (en) * | 1998-12-23 | 2004-11-03 | Merck & Co Inc | IMPROVED RECOMBINATION HEPATITIS B ENVELOPE ANTIGEN |
| EP2322210A1 (en) | 1999-04-19 | 2011-05-18 | GlaxoSmithKline Biologicals S.A. | Adjuvant composition comprising saponin and an immunostimulatory oligonucleotide |
| US6635261B2 (en) | 1999-07-13 | 2003-10-21 | Wyeth Holdings Corporation | Adjuvant and vaccine compositions containing monophosphoryl lipid A |
| CU23031A1 (es) * | 2002-01-24 | 2005-02-23 | Ct Ingenieria Genetica Biotech | Antigeno de superficie del virus de la hepatitis b como inmunopotenciador mucosal, formulaciones resultantes |
| AU2006215419B2 (en) * | 2005-02-16 | 2012-03-08 | Novartis Vaccines And Diagnostics, Inc. | Adjuvant composition comprising aluminium phosphate and 3D-MPL |
| AP2745A (en) * | 2005-08-02 | 2013-09-30 | Novartis Vaccines & Diagnostic | Reducing interference between oil-containing adjuvants and surfactant-containing antigens |
| NZ592713A (en) | 2005-11-04 | 2012-12-21 | Novartis Vaccines & Diagnostic | Adjuvanted influenza vaccines including a cytokine-inducing agents other than an agonist of Toll-Like Receptor 9 |
| US20090304742A1 (en) | 2005-11-04 | 2009-12-10 | Novartis Vaccines And Diagnostics Srl | Influenza vaccines with reduced amount of emulsion adjuvant |
| PT1951299E (pt) | 2005-11-04 | 2012-02-28 | Novartis Vaccines & Diagnostic | Vacinas contra a gripe que incluem combinações de adjuvantes particulados e imuno-potenciadores |
| EP2368572B1 (en) | 2005-11-04 | 2020-03-04 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| CN100415294C (zh) * | 2005-12-23 | 2008-09-03 | 中国农业大学 | 一种治疗和/或预防乙肝的药物 |
| KR20110110853A (ko) | 2006-01-27 | 2011-10-07 | 노파르티스 파르마 아게 | 적혈구응집소 및 기질 단백질을 함유한 인플루엔자 백신 |
| CA2646539A1 (en) | 2006-03-23 | 2007-09-27 | Novartis Ag | Imidazoquinoxaline compounds as immunomodulators |
| JP2009534303A (ja) | 2006-03-24 | 2009-09-24 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | 冷蔵しないインフルエンザワクチンの保存 |
| EP1862176A1 (de) * | 2006-05-31 | 2007-12-05 | Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH | Ein Verfahren zur Herstellung einer Impfzusammensetzung |
| EP1862177A1 (de) * | 2006-06-01 | 2007-12-05 | Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH | Ein Verfahren zur Herstellung einer Impfzusammensetzung |
| PT2054431E (pt) | 2006-06-09 | 2011-11-03 | Novartis Ag | Confórmeros de adesinas bacterianas |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| AU2007297178B2 (en) | 2006-09-11 | 2014-07-24 | Novartis Ag | Making influenza virus vaccines without using eggs |
| CA2671629C (en) | 2006-12-06 | 2017-08-15 | Novartis Ag | Vaccines including antigen from four strains of influenza virus |
| AU2008269439B2 (en) | 2007-06-27 | 2013-12-19 | Novartis Ag | Low-additive influenza vaccines |
| GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| AU2008339631B2 (en) | 2007-12-24 | 2014-07-24 | Novartis Ag | Assays for adsorbed influenza vaccines |
| AR077757A1 (es) | 2009-07-15 | 2011-09-21 | Novartis Ag | Composiciones de proteinas de fusion del virus sincicial respiratorio (rsv) y metodos para su preparacion |
| WO2012103361A1 (en) | 2011-01-26 | 2012-08-02 | Novartis Ag | Rsv immunization regimen |
| US9452212B2 (en) | 2011-04-14 | 2016-09-27 | Dynavax Technologies Corporation | Methods and compositions for eliciting an immune response against hepatitis B virus |
| HUE034673T2 (en) | 2011-05-13 | 2018-02-28 | Glaxosmithkline Biologicals Sa | Pre-fusion rsv f antigens |
| WO2016207853A2 (en) | 2015-06-26 | 2016-12-29 | Seqirus UK Limited | Antigenically matched influenza vaccines |
| US12128100B2 (en) | 2018-11-13 | 2024-10-29 | Variation Biotechnologies Inc. | Immunogenic compositions for treatment of Hepatitis B |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4912094B1 (en) * | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| DE69031556T2 (de) * | 1989-07-25 | 1998-05-14 | Smithkline Beecham Biologicals S.A., Rixensart | Antigene sowie Verfahren zu deren Herstellung |
| JP3307392B2 (ja) * | 1991-05-29 | 2002-07-24 | オリジン・メドシステムズ・インク | 内視鏡による手術用の器官後退装置 |
| MY111880A (en) * | 1992-03-27 | 2001-02-28 | Smithkline Beecham Biologicals S A | Hepatitis vaccines containing 3-0 deacylated monophosphoryl lipid a |
| ES2118963T3 (es) * | 1992-05-23 | 1998-10-01 | Smithkline Beecham Biolog | Vacunas combinadas, que contienen antigeno de superficie de la hepatitis b y otros antigenos. |
| ATE204762T1 (de) * | 1993-03-23 | 2001-09-15 | Smithkline Beecham Biolog | 3-0-deazylierte monophosphoryl lipid a enthaltende impfstoff-zusammensetzungen |
| GB9311536D0 (en) * | 1993-06-04 | 1993-07-21 | Unilever Plc | Hot soluble low density extractable food product |
-
1995
- 1995-02-25 GB GBGB9503863.4A patent/GB9503863D0/en active Pending
-
1996
- 1996-02-14 MY MYPI96000567A patent/MY113428A/en unknown
- 1996-02-15 KR KR1019970705880A patent/KR100365373B1/ko not_active IP Right Cessation
- 1996-02-15 EP EP96904814A patent/EP0810877B1/en not_active Expired - Lifetime
- 1996-02-15 CZ CZ19972674A patent/CZ288417B6/cs not_active IP Right Cessation
- 1996-02-15 ES ES96904814T patent/ES2166879T3/es not_active Expired - Lifetime
- 1996-02-15 AU AU48780/96A patent/AU695921B2/en not_active Ceased
- 1996-02-15 TR TR97/00849T patent/TR199700849T1/xx unknown
- 1996-02-15 CN CN96192146A patent/CN1101225C/zh not_active Expired - Fee Related
- 1996-02-15 SK SK1150-97A patent/SK115097A3/sk unknown
- 1996-02-15 EA EA199700126A patent/EA199700126A1/ru unknown
- 1996-02-15 CA CA002212552A patent/CA2212552C/en not_active Expired - Fee Related
- 1996-02-15 US US08/894,643 patent/US5972346A/en not_active Expired - Lifetime
- 1996-02-15 PL PL96321966A patent/PL182679B1/pl unknown
- 1996-02-15 PT PT96904814T patent/PT810877E/pt unknown
- 1996-02-15 BR BR9607458A patent/BR9607458A/pt not_active IP Right Cessation
- 1996-02-15 DE DE69617211T patent/DE69617211T2/de not_active Expired - Lifetime
- 1996-02-15 WO PCT/EP1996/000681 patent/WO1996026741A1/en active IP Right Grant
- 1996-02-15 AP APAP/P/1997/001060A patent/AP766A/en active
- 1996-02-15 JP JP52598896A patent/JP3881015B2/ja not_active Expired - Fee Related
- 1996-02-15 DK DK96904814T patent/DK0810877T3/da active
- 1996-02-15 HU HU9801242A patent/HU224832B1/hu not_active IP Right Cessation
- 1996-02-15 NZ NZ302674A patent/NZ302674A/xx not_active IP Right Cessation
- 1996-02-15 AT AT96904814T patent/ATE209045T1/de active
- 1996-02-22 AR ARP960101469A patent/AR002279A1/es active IP Right Grant
- 1996-02-23 IL IL11724996A patent/IL117249A/xx not_active IP Right Cessation
- 1996-02-23 ZA ZA961460A patent/ZA961460B/xx unknown
- 1996-02-23 MA MA24171A patent/MA23814A1/fr unknown
- 1996-02-26 TW TW085102154A patent/TW467745B/zh not_active IP Right Cessation
- 1996-03-02 SA SA96160633A patent/SA96160633B1/ar unknown
-
1997
- 1997-08-02 OA OA70066A patent/OA10612A/en unknown
- 1997-08-22 FI FI973457A patent/FI118118B/fi not_active IP Right Cessation
- 1997-08-22 MX MX9706450A patent/MX9706450A/es unknown
- 1997-08-22 NO NO19973873A patent/NO319394B1/no not_active IP Right Cessation
- 1997-08-25 BG BG101851A patent/BG101851A/xx unknown
-
1998
- 1998-04-28 HK HK98103600A patent/HK1004117A1/xx not_active IP Right Cessation
Also Published As
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