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EA200100701A1 - Белки наружной поверхности, их гены и их применение - Google Patents

Белки наружной поверхности, их гены и их применение

Info

Publication number
EA200100701A1
EA200100701A1 EA200100701A EA200100701A EA200100701A1 EA 200100701 A1 EA200100701 A1 EA 200100701A1 EA 200100701 A EA200100701 A EA 200100701A EA 200100701 A EA200100701 A EA 200100701A EA 200100701 A1 EA200100701 A1 EA 200100701A1
Authority
EA
Eurasian Patent Office
Prior art keywords
genes
application
surface proteins
vaccines
localized
Prior art date
Application number
EA200100701A
Other languages
English (en)
Other versions
EA009885B1 (ru
Inventor
Мартин Джон Глентон Хьюз
Джозеф Дэвид Сантанджело
Джонатан Дуглас Лэйн
Роберт Фелдман
Джоанн Кристин Мур
Пол Эверест
Ричард Джеймс Добсон
Кэролайн Джоанн Хенвуд
Гордон Дауган
Ребекка Керри Уилсон
Original Assignee
Майкросайенс Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9828346.8A external-priority patent/GB9828346D0/en
Priority claimed from GBGB9901233.8A external-priority patent/GB9901233D0/en
Priority claimed from GBGB9901234.6A external-priority patent/GB9901234D0/en
Priority claimed from GBGB9908321.4A external-priority patent/GB9908321D0/en
Priority claimed from GBGB9912036.2A external-priority patent/GB9912036D0/en
Priority claimed from GBGB9922596.3A external-priority patent/GB9922596D0/en
Application filed by Майкросайенс Лимитед filed Critical Майкросайенс Лимитед
Publication of EA200100701A1 publication Critical patent/EA200100701A1/ru
Publication of EA009885B1 publication Critical patent/EA009885B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1018—Carboxy- and carbamoyl transferases (2.1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Согласно данному изобретению идентифицирована серия генов Streptococcus группы B, продукты которых могут быть локализованы на наружной поверхности организма. Гены или их функциональные фрагменты могут быть пригодны для получения терапевтических средств, например вакцин для иммунизации пациентов, направленных против микробной инфекции.Отчет о международном поиске был опубликован 2001.09.20.
EA200100701A 1998-12-22 1999-12-22 Применение пептидов бактерий streptococcus группы b, кодирующего их полинуклеотида, вакцина и антитело EA009885B1 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB9828346.8A GB9828346D0 (en) 1998-12-22 1998-12-22 Protein and compositions containing it
GBGB9901233.8A GB9901233D0 (en) 1999-01-20 1999-01-20 Protein and compositions containing it
GBGB9901234.6A GB9901234D0 (en) 1999-01-20 1999-01-20 Protein and compositions containing it
GBGB9908321.4A GB9908321D0 (en) 1999-04-12 1999-04-12 Purine nucleoside phosphatase and compositions containing it
GBGB9912036.2A GB9912036D0 (en) 1999-05-24 1999-05-24 Glucose-6-phosphate isomerase and compositions containing it
GBGB9922596.3A GB9922596D0 (en) 1999-09-23 1999-09-23 Protein and compositions containing it
PCT/GB1999/004376 WO2000037490A2 (en) 1998-12-22 1999-12-22 Outer surface proteins, their genes, and their use

Publications (2)

Publication Number Publication Date
EA200100701A1 true EA200100701A1 (ru) 2001-12-24
EA009885B1 EA009885B1 (ru) 2008-04-28

Family

ID=27547330

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100701A EA009885B1 (ru) 1998-12-22 1999-12-22 Применение пептидов бактерий streptococcus группы b, кодирующего их полинуклеотида, вакцина и антитело

Country Status (24)

Country Link
US (3) US7217415B1 (ru)
EP (2) EP1574579A3 (ru)
JP (1) JP2002533065A (ru)
KR (4) KR100818815B1 (ru)
CN (3) CN1357045A (ru)
AP (1) AP2006003504A0 (ru)
AT (1) ATE297995T1 (ru)
AU (1) AU758722B2 (ru)
BR (1) BR9916473A (ru)
CA (1) CA2354843A1 (ru)
CZ (1) CZ20012174A3 (ru)
DE (1) DE69925866T2 (ru)
DK (1) DK1140994T3 (ru)
EA (1) EA009885B1 (ru)
ES (1) ES2241352T3 (ru)
HK (1) HK1039339A1 (ru)
HU (1) HUP0201022A3 (ru)
NO (1) NO20013101L (ru)
NZ (4) NZ512296A (ru)
OA (1) OA12425A (ru)
PL (1) PL351027A1 (ru)
PT (1) PT1140994E (ru)
SI (1) SI1140994T1 (ru)
WO (1) WO2000037490A2 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6890539B2 (en) * 1998-12-22 2005-05-10 Microscience, Ltd. Genes and proteins, and their use
JP2002533083A (ja) * 1998-12-22 2002-10-08 マイクロサイエンス リミテッド 遺伝子およびたんぱく質、およびそれらの用途
ATE297995T1 (de) * 1998-12-22 2005-07-15 Microscience Ltd Aussermembranproteine, ihre gene, und deren verwendung
EP2104512A2 (en) * 2006-12-21 2009-09-30 Emergent Product Development UK Limited Streptococcus proteins, and their use in vaccination
CN103060284A (zh) * 2012-10-31 2013-04-24 内蒙古民族大学 一种无乳链球菌pgk亚单位重组蛋白及其制备方法
CN110669711A (zh) * 2019-08-09 2020-01-10 中国水产科学研究院珠江水产研究所 基于pgk基因的重组乳酸乳球菌和无乳链球菌病疫苗

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0230777B1 (en) 1985-12-28 1991-04-10 Ohgen Research Laboratories Ltd., Antitumor protein gene of streptococcus pyogenes su, plasmids containing the gene, transformant cells harboring the plasmids, and process for producing the antitumor protein
US5328996A (en) * 1989-03-29 1994-07-12 University Of Florida Research Foundation, Inc. Bacterial plasmin receptors as fibrinolytic agents
EP0672123A1 (en) * 1992-01-08 1995-09-20 The Rockefeller University Multifunctional surface protein of streptococci
IL107458A0 (en) * 1992-11-02 1994-02-27 Gen Hospital Corp Conjugate vaccine against group b streptococcus
WO1994021685A1 (en) * 1993-03-19 1994-09-29 Gunnar Lindahl Protein rib, a cell surface protein that confers immunity to many strains of the group b streptococcus; process for purification of the protein, reagent kit and pharmaceutical composition
US6015889A (en) * 1993-03-19 2000-01-18 Gunnar Lindahl Protein rib, a cell surface protein that confers immunity to many strains of the group B streptococcus: process for purification of the protein, reagent kit and pharmaceutical composition
US6346392B1 (en) 1996-11-27 2002-02-12 Smithkline Beecham Corporation Polynucleotides encoding a novel glutamine transport ATP-binding protein
DK0942983T4 (en) * 1996-10-31 2014-12-01 Human Genome Sciences Inc Streptococcus pneumoniae antigens and vaccines
US7196164B2 (en) * 1997-07-08 2007-03-27 Human Genome Sciences, Inc. Secreted protein HHTLF25
US7129339B1 (en) * 1997-07-02 2006-10-31 Sanofi Pasteur Limited Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
US6800744B1 (en) * 1997-07-02 2004-10-05 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
US6380370B1 (en) * 1997-08-14 2002-04-30 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and therapeutics
US6165763A (en) * 1997-10-30 2000-12-26 Smithkline Beecham Corporation Ornithine carbamoyltransferase
US6248329B1 (en) * 1998-06-01 2001-06-19 Ramaswamy Chandrashekar Parasitic helminth cuticlin nucleic acid molecules and uses thereof
US6890539B2 (en) * 1998-12-22 2005-05-10 Microscience, Ltd. Genes and proteins, and their use
ATE297995T1 (de) * 1998-12-22 2005-07-15 Microscience Ltd Aussermembranproteine, ihre gene, und deren verwendung
JP2002533083A (ja) * 1998-12-22 2002-10-08 マイクロサイエンス リミテッド 遺伝子およびたんぱく質、およびそれらの用途
US6605709B1 (en) * 1999-04-09 2003-08-12 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Proteus mirabilis for diagnostics and therapeutics

Also Published As

Publication number Publication date
AU758722B2 (en) 2003-03-27
PL351027A1 (en) 2003-02-24
NZ542777A (en) 2007-11-30
DE69925866D1 (de) 2005-07-21
NO20013101D0 (no) 2001-06-21
AP2006003504A0 (en) 2006-02-28
WO2000037490A3 (en) 2001-09-20
EA009885B1 (ru) 2008-04-28
EP1574579A3 (en) 2006-02-22
WO2000037490A2 (en) 2000-06-29
DE69925866T2 (de) 2005-11-24
CA2354843A1 (en) 2000-06-29
HK1039339A1 (en) 2002-04-19
NZ525538A (en) 2004-10-29
ATE297995T1 (de) 2005-07-15
CN1357045A (zh) 2002-07-03
KR20080052527A (ko) 2008-06-11
US20060104990A1 (en) 2006-05-18
EP1574579A2 (en) 2005-09-14
US7217415B1 (en) 2007-05-15
OA12425A (en) 2006-04-18
NZ512296A (en) 2003-08-29
KR20010099885A (ko) 2001-11-09
PT1140994E (pt) 2005-11-30
CZ20012174A3 (cs) 2002-02-13
ES2241352T3 (es) 2005-10-16
BR9916473A (pt) 2002-01-15
KR20070027665A (ko) 2007-03-09
KR100866170B1 (ko) 2008-10-30
HUP0201022A3 (en) 2004-07-28
CN101486756A (zh) 2009-07-22
HUP0201022A2 (en) 2002-08-28
DK1140994T3 (da) 2005-08-15
AU1877900A (en) 2000-07-12
EP1140994A1 (en) 2001-10-10
KR20060096515A (ko) 2006-09-11
US20080226641A1 (en) 2008-09-18
NO20013101L (no) 2001-08-13
JP2002533065A (ja) 2002-10-08
EP1140994B1 (en) 2005-06-15
KR100818815B1 (ko) 2008-04-01
NZ552871A (en) 2008-11-28
CN1733800A (zh) 2006-02-15
SI1140994T1 (sl) 2005-12-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU