AP3597A - Imidazopyridazines as akt kinase inhibitors - Google Patents

Imidazopyridazines as akt kinase inhibitors

Info

Publication number: AP3597A
Authority: AP; ARIPO
Prior art keywords: imidazopyridazines; kinase inhibitors; akt kinase; akt; inhibitors
Prior art date: 2011-04-07

Application number

AP2013007215A

Other languages

English (en)

Other versions

AP2013007215A0 (en

Inventor

Lars Barfacker

William Johnston Scott

Andrea Hagebarth

Stuart Ince

Hartmut Rehwinkel

Oliver Politz

Roland Neuhaus

Hans Briem

Ulf Bomer

Original Assignee

Bayer Ip Gmbh

Bayer Pharma Aktiengellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-04-07

Filing date

2012-04-05

Publication date

2016-02-19

2012-04-05 Application filed by Bayer Ip Gmbh, Bayer Pharma Aktiengellschaft filed Critical Bayer Ip Gmbh

2013-10-31 Publication of AP2013007215A0 publication Critical patent/AP2013007215A0/xx

2016-02-19 Application granted granted Critical

2016-02-19 Publication of AP3597A publication Critical patent/AP3597A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Cosmetics (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AP2013007215A 2011-04-07 2012-04-05 Imidazopyridazines as akt kinase inhibitors AP3597A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201161472732P	2011-04-07	2011-04-07
PCT/EP2012/056300 WO2012136776A1 (en)	2011-04-07	2012-04-05	Imidazopyridazines as akt kinase inhibitors

Publications (2)

Publication Number	Publication Date
AP2013007215A0 AP2013007215A0 (en)	2013-10-31
AP3597A true AP3597A (en)	2016-02-19

Family

ID=45953129

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2013007215A AP3597A (en)	2011-04-07	2012-04-05	Imidazopyridazines as akt kinase inhibitors

Country Status (43)

Country	Link
US (2)	US9206185B2 (me)
EP (1)	EP2694510B1 (me)
JP (1)	JP5906303B2 (me)
KR (1)	KR20140022057A (me)
CN (1)	CN103596957B (me)
AP (1)	AP3597A (me)
AR (1)	AR087148A1 (me)
AU (1)	AU2012238589B2 (me)
BR (1)	BR112013025777A2 (me)
CA (1)	CA2832374A1 (me)
CL (1)	CL2013002878A1 (me)
CO (1)	CO6862145A2 (me)
CR (1)	CR20130515A (me)
CU (1)	CU24263B1 (me)
CY (1)	CY1117163T1 (me)
DK (1)	DK2694510T3 (me)
DO (1)	DOP2013000226A (me)
EA (1)	EA024890B1 (me)
EC (1)	ECSP13013008A (me)
ES (1)	ES2558780T3 (me)
GT (1)	GT201300238A (me)
HR (1)	HRP20160011T1 (me)
HU (1)	HUE026323T2 (me)
IL (1)	IL228567A0 (me)
JO (1)	JO3068B1 (me)
MA (1)	MA35016B1 (me)
ME (1)	ME02316B (me)
MX (1)	MX336865B (me)
NI (1)	NI201300105A (me)
PE (1)	PE20141380A1 (me)
PH (1)	PH12013502073A1 (me)
PL (1)	PL2694510T3 (me)
PT (1)	PT2694510E (me)
RS (1)	RS54480B1 (me)
SG (1)	SG193631A1 (me)
SI (1)	SI2694510T1 (me)
SM (1)	SMT201600001B (me)
TN (1)	TN2013000400A1 (me)
TW (1)	TWI535719B (me)
UA (1)	UA111739C2 (me)
UY (1)	UY34006A (me)
WO (1)	WO2012136776A1 (me)
ZA (1)	ZA201307223B (me)

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US9447049B2 (en)	2010-03-01	2016-09-20	University Of Tennessee Research Foundation	Compounds for treatment of cancer
PT3289876T (pt)	2008-06-16	2022-10-28	Univ Tennessee Res Found	Compostos para o tratamento do câncer
US9029408B2 (en)	2008-06-16	2015-05-12	Gtx, Inc.	Compounds for treatment of cancer
MX2012010115A (es)	2010-03-01	2013-02-26	Gtx Inc	Compuestos para el tratamiento de cancer.
US11084811B2 (en)	2010-03-01	2021-08-10	Oncternal Therapeutics, Inc.	Compounds for treatment of cancer
PT2694510E (pt) *	2011-04-07	2016-02-08	Bayer Pharma AG	Imidazopiridazinas como inibidores da akt quinase
CN104066736B (zh) *	2012-01-10	2017-03-08	拜耳知识产权有限责任公司	作为akt激酶抑制剂的取代的吡唑并嘧啶
CA2860723A1 (en) *	2012-01-10	2013-07-18	Bayer Intellectual Property Gmbh	Substituted imidazopyrazines as akt kinase inhibitors
ES2686730T3 (es) *	2012-11-30	2018-10-19	Novartis Ag	Composición farmacéutica novedosa
WO2014138279A1 (en) *	2013-03-05	2014-09-12	University Of Tennessee Research Foundation	Compounds for treatment of cancer
US20150352121A1 (en) *	2013-03-12	2015-12-10	Glaxosmithkline Llc	Combination
EP2968343A4 (en) *	2013-03-14	2016-11-02	Epizyme Inc	COMBINATION THERAPY FOR THE TREATMENT OF CANCER
CN105899512A (zh) *	2014-01-09	2016-08-24	拜耳医药股份公司	可用于治疗过度增殖性和/或血管生成疾病的酰胺基团取代的咪唑并哒嗪
WO2018098411A1 (en) *	2016-11-28	2018-05-31	Bristol-Myers Squibb Company	Gsk-3 inhibitors
EP3453706A1 (en)	2017-09-08	2019-03-13	Basf Se	Pesticidal imidazole compounds

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WO2011033265A1 (en) *	2009-09-18	2011-03-24	Almac Discovery Limited	Pharmaceutical compounds

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EP1268478B1 (en)	2000-03-31	2007-05-02	Ortho-McNeil Pharmaceutical, Inc.	Phenyl-substituted imidazopyridines
KR100830859B1 (ko)	2000-04-27	2008-05-21	아스텔라스세이야쿠 가부시키가이샤	이미다조피리딘 유도체 및 이를 함유하는 의약 조성물
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ATE512957T1 (de)	2003-04-24	2011-07-15	Merck Sharp & Dohme	Hemmer der akt aktivität
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DE602005026509D1 (de)	2004-04-09	2011-04-07	Merck Sharp & Dohme	Hemmer der akt aktivität
AU2005290081B2 (en)	2004-08-23	2010-12-02	Merck Sharp & Dohme Corp.	Inhibitors of Akt activity
US20070255064A1 (en)	2004-08-24	2007-11-01	Basf Aktiengesellschaft	Imidazolium-Methyl Sulfites for Use as Starting Compounds for Producing Ionic Liquids
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AU2009255358A1 (en)	2008-06-03	2009-12-10	Msd K.K.	Inhibitors of Akt activity
CA2726358A1 (en)	2008-06-03	2009-12-10	Merck Sharp & Dohme Corp.	Inhibitors of akt activity
AR074072A1 (es)	2008-11-11	2010-12-22	Lilly Co Eli	Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme
PA8854101A1 (es)	2008-12-18	2010-07-27	Ortho Mcneil Janssen Pharm	Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
EP2391623A4 (en)	2009-02-02	2012-09-05	Merck Sharp & Dohme	INHIBITORS OF AKT ACTIVITY
WO2010104933A1 (en)	2009-03-11	2010-09-16	Merck Sharp & Dohme Corp.	Inhibitors of akt activity
US8691825B2 (en)	2009-04-01	2014-04-08	Merck Sharp & Dohme Corp.	Inhibitors of AKT activity
AR076936A1 (es)	2009-06-02	2011-07-20	Vitae Pharmaceuticals Inc	Inhibidores de carbamato y urea de la 11 beta hidroxiesteroide deshidrogenasa 1
CA2804845A1 (en) *	2010-07-12	2012-01-19	Stuart Ince	Substituted imidazo[1,2-a]pyrimidines and -pyridines
CN103384670B (zh) *	2010-07-28	2016-05-25	拜耳知识产权有限责任公司	取代的咪唑并[1,2-b]哒嗪
PT2694510E (pt) *	2011-04-07	2016-02-08	Bayer Pharma AG	Imidazopiridazinas como inibidores da akt quinase

2012
- 2012-04-05 PT PT127139632T patent/PT2694510E/pt unknown
- 2012-04-05 PE PE2013002192A patent/PE20141380A1/es not_active Application Discontinuation
- 2012-04-05 JP JP2014503153A patent/JP5906303B2/ja not_active Expired - Fee Related
- 2012-04-05 ME MEP-2016-1A patent/ME02316B/me unknown
- 2012-04-05 US US14/007,427 patent/US9206185B2/en not_active Expired - Fee Related
- 2012-04-05 PL PL12713963T patent/PL2694510T3/pl unknown
- 2012-04-05 DK DK12713963.2T patent/DK2694510T3/en active
- 2012-04-05 AU AU2012238589A patent/AU2012238589B2/en not_active Ceased
- 2012-04-05 CN CN201280027994.5A patent/CN103596957B/zh not_active Expired - Fee Related
- 2012-04-05 RS RS20160005A patent/RS54480B1/en unknown
- 2012-04-05 SG SG2013072509A patent/SG193631A1/en unknown
- 2012-04-05 JO JOP/2012/0084A patent/JO3068B1/ar active
- 2012-04-05 MX MX2013011699A patent/MX336865B/es active IP Right Grant
- 2012-04-05 SI SI201230430T patent/SI2694510T1/sl unknown
- 2012-04-05 KR KR1020137029229A patent/KR20140022057A/ko not_active Withdrawn
- 2012-04-05 CA CA2832374A patent/CA2832374A1/en not_active Abandoned
- 2012-04-05 EP EP12713963.2A patent/EP2694510B1/en active Active
- 2012-04-05 BR BR112013025777A patent/BR112013025777A2/pt active Search and Examination
- 2012-04-05 AP AP2013007215A patent/AP3597A/xx active
- 2012-04-05 MA MA36290A patent/MA35016B1/fr unknown
- 2012-04-05 EA EA201301130A patent/EA024890B1/ru not_active IP Right Cessation
- 2012-04-05 HU HUE12713963A patent/HUE026323T2/en unknown
- 2012-04-05 WO PCT/EP2012/056300 patent/WO2012136776A1/en active Application Filing
- 2012-04-05 ES ES12713963.2T patent/ES2558780T3/es active Active
- 2012-04-05 PH PH1/2013/502073A patent/PH12013502073A1/en unknown
- 2012-04-05 CU CUP2013000135A patent/CU24263B1/es unknown
- 2012-04-06 TW TW101112356A patent/TWI535719B/zh not_active IP Right Cessation
- 2012-04-09 AR ARP120101200A patent/AR087148A1/es active Pending
- 2012-04-09 UY UY0001034006A patent/UY34006A/es not_active Application Discontinuation
- 2012-05-04 UA UAA201312894A patent/UA111739C2/uk unknown
2013
- 2013-09-26 ZA ZA2013/07223A patent/ZA201307223B/en unknown
- 2013-09-29 IL IL228567A patent/IL228567A0/en unknown
- 2013-10-03 TN TNP2013000400A patent/TN2013000400A1/fr unknown
- 2013-10-07 NI NI201300105A patent/NI201300105A/es unknown
- 2013-10-07 CO CO13237923A patent/CO6862145A2/es active IP Right Grant
- 2013-10-07 GT GT201300238A patent/GT201300238A/es unknown
- 2013-10-07 CL CL2013002878A patent/CL2013002878A1/es unknown
- 2013-10-07 CR CR20130515A patent/CR20130515A/es unknown
- 2013-10-07 DO DO2013000226A patent/DOP2013000226A/es unknown
- 2013-11-04 EC ECSP13013008 patent/ECSP13013008A/es unknown
2015
- 2015-07-06 US US14/792,205 patent/US9604989B2/en not_active Expired - Fee Related
2016
- 2016-01-05 SM SM201600001T patent/SMT201600001B/it unknown
- 2016-01-05 HR HRP20160011TT patent/HRP20160011T1/hr unknown
- 2016-01-08 CY CY20161100011T patent/CY1117163T1/el unknown

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2010091808A1 (en) *	2009-02-13	2010-08-19	Bayer Schering Pharma Aktiengesellschaft	Fused pyrimidines
WO2011033265A1 (en) *	2009-09-18	2011-03-24	Almac Discovery Limited	Pharmaceutical compounds

Also Published As

Publication number	Publication date
PH12013502073A1 (en)	2014-01-13
WO2012136776A1 (en)	2012-10-11
DOP2013000226A (es)	2013-11-15
CA2832374A1 (en)	2012-10-11
ZA201307223B (en)	2014-12-23
AU2012238589B2 (en)	2017-02-16
PE20141380A1 (es)	2014-10-18
ES2558780T3 (es)	2016-02-08
HUE026323T2 (en)	2016-05-30
TW201245204A (en)	2012-11-16
UA111739C2 (uk)	2016-06-10
PL2694510T3 (pl)	2016-03-31
CO6862145A2 (es)	2014-02-10
EA024890B1 (ru)	2016-10-31
US20140113901A1 (en)	2014-04-24
US9604989B2 (en)	2017-03-28
DK2694510T3 (en)	2016-01-18
CN103596957A (zh)	2014-02-19
RS54480B1 (en)	2016-06-30
JO3068B1 (ar)	2017-03-15
IL228567A0 (en)	2013-12-31
HRP20160011T1 (hr)	2016-02-12
CU20130135A7 (es)	2014-02-28
CN103596957B (zh)	2016-12-07
EP2694510B1 (en)	2015-10-14
EP2694510A1 (en)	2014-02-12
MX2013011699A (es)	2014-01-31
EA201301130A1 (ru)	2014-07-30
CU24263B1 (es)	2017-07-04
MA35016B1 (fr)	2014-04-03
TN2013000400A1 (en)	2015-03-30
GT201300238A (es)	2015-04-06
KR20140022057A (ko)	2014-02-21
SMT201600001B (it)	2016-02-25
NZ616270A (en)	2015-09-25
NI201300105A (es)	2014-07-14
CL2013002878A1 (es)	2014-05-02
PT2694510E (pt)	2016-02-08
AR087148A1 (es)	2014-02-26
ECSP13013008A (es)	2013-12-31
ME02316B (me)	2016-06-20
SG193631A1 (en)	2013-11-29
AP2013007215A0 (en)	2013-10-31
SI2694510T1 (sl)	2016-02-29
CR20130515A (es)	2013-12-04
BR112013025777A2 (pt)	2016-12-20
US20150368250A1 (en)	2015-12-24
CY1117163T1 (el)	2017-04-05
US9206185B2 (en)	2015-12-08
AU2012238589A1 (en)	2013-11-07
MX336865B (es)	2016-02-04
JP5906303B2 (ja)	2016-04-20
JP2014510127A (ja)	2014-04-24
UY34006A (es)	2012-10-31
TWI535719B (zh)	2016-06-01

Publication	Publication Date	Title
HK1222647A1 (zh)	2017-07-07	激酶抑制劑
HK1210775A1 (en)	2016-05-06	Imidazotriazinecarbonitriles useful as kinase inhibitors
PL2710007T3 (pl)	2020-06-01	Inhibitory kinazy
AP3597A (en)	2016-02-19	Imidazopyridazines as akt kinase inhibitors
EP2552208A4 (en)	2014-07-09	IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS
IL228103A0 (en)	2013-09-30	Amino-quinolines as kinase inhibitors
HK1199880A1 (en)	2015-07-24	Benzonitrile derivatives as kinase inhibitors
EP2552214A4 (en)	2013-10-16	PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS
EP2552211A4 (en)	2013-10-23	INDAZOLYL-PYRIMIDINE AS KINASEHEMMER
EP2685992A4 (en)	2014-09-10	AMINO-QUINOLINES AS KINASE INHIBITORS
IL229028A0 (en)	2013-12-31	Kinase inhibitors
HK1199873A1 (en)	2015-07-24	Kinase inhibitors
HK1201830A1 (en)	2015-09-11	Substituted imidazopyrazines as akt kinase inhibitors akt
SG11201500973WA (en)	2015-04-29	Amino-quinolines as kinase inhibitors
HK1201831A1 (en)	2015-09-11	Substituted pyrazolopyrimidines as akt kinase inhibitors akt