CL2013002878A1 - Compuestos derivados de 1-[4-(imidazo[1,2-b]piridazin-2-il)fenil]ciclobutanamida, inhibidores de quinasa akt (pi3k/akt); proceso de preparacion; composicion farmaceutica y uso en el tratamiento del cancer. - Google Patents
Compuestos derivados de 1-[4-(imidazo[1,2-b]piridazin-2-il)fenil]ciclobutanamida, inhibidores de quinasa akt (pi3k/akt); proceso de preparacion; composicion farmaceutica y uso en el tratamiento del cancer.Info
- Publication number
- CL2013002878A1 CL2013002878A1 CL2013002878A CL2013002878A CL2013002878A1 CL 2013002878 A1 CL2013002878 A1 CL 2013002878A1 CL 2013002878 A CL2013002878 A CL 2013002878A CL 2013002878 A CL2013002878 A CL 2013002878A CL 2013002878 A1 CL2013002878 A1 CL 2013002878A1
- Authority
- CL
- Chile
- Prior art keywords
- akt
- cancer treatment
- cyclobutanamide
- pyridazin
- pi3k
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- -1 1- [4- (imidazo [1,2-b] pyridazin-2-yl) phenyl] cyclobutanamide Chemical compound 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 239000002131 composite material Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000009826 neoplastic cell growth Effects 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
SE DESCRIBE UN COMPUESTO DE IMIDAZOPIRIDAZINAS DE FÓRMULA (1), CON ACTIVIDAD INHIBIDORA DE AKT ALTERNATIVOS, PARA TRATAMIENTO DEL CÁNCER, DONDE RL, R2, R3, R4, X E Y SON COMO SE DEFINE EN LA REIVINDICACIÓN 1. ADEMÁS, SE DESCRIBE EL PROCESO DE PREPARACIÓN DE LOS COMPUESTOS DE FÓRMULA (1) QUE COMPRENDE HACER REACCIONAR UN COMPUESTO DE FÓRMULA (II), DONDE LA TRANSFORMACIÓN A UN COMPUESTO DE FÓRMULA (1) SE LLEVA A CABO POR MEDIO DE¡ USO DE UNA REACCIÓN DE DESPROTECCIÓN APROPIADA; EL USO DE LOS COMPUESTOS PARA EL TRATAMIENTO DE NEOPLASIA BENIGNA O MALIGNA; Y LA COMPOSICIÓN QUE COMPRENDE POR LO MENOS UN COMPUESTO DE FÓRMULA (1).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161472732P | 2011-04-07 | 2011-04-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013002878A1 true CL2013002878A1 (es) | 2014-05-02 |
Family
ID=45953129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013002878A CL2013002878A1 (es) | 2011-04-07 | 2013-10-07 | Compuestos derivados de 1-[4-(imidazo[1,2-b]piridazin-2-il)fenil]ciclobutanamida, inhibidores de quinasa akt (pi3k/akt); proceso de preparacion; composicion farmaceutica y uso en el tratamiento del cancer. |
Country Status (43)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2962524C (en) | 2008-06-16 | 2020-07-14 | University Of Tennessee Research Foundation | (2-(1-h-indolyl)imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone useful for the treatment of cancer |
| US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
| US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
| KR20120130777A (ko) | 2010-03-01 | 2012-12-03 | 유니버시티 오브 테네시 리서치 파운데이션 | 암 치료용 화합물 |
| US11084811B2 (en) | 2010-03-01 | 2021-08-10 | Oncternal Therapeutics, Inc. | Compounds for treatment of cancer |
| KR20140022057A (ko) * | 2011-04-07 | 2014-02-21 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | Akt 키나제 억제제로서의 이미다조피리다진 |
| WO2013104610A1 (en) * | 2012-01-10 | 2013-07-18 | Bayer Intellectual Property Gmbh | Substituted imidazopyrazines as akt kinase inhibitors |
| ES2589955T3 (es) * | 2012-01-10 | 2016-11-17 | Bayer Intellectual Property Gmbh | Pirazolopirimidinas sustituidas como inhibidores de la quinasa Akt |
| JP6232443B2 (ja) * | 2012-11-30 | 2017-11-15 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | 新規な医薬組成物 |
| JP6835472B2 (ja) | 2013-03-05 | 2021-02-24 | ユニバーシティ オブ テネシー リサーチ ファウンデーション | 癌の処置のための組成物 |
| WO2014158467A1 (en) * | 2013-03-12 | 2014-10-02 | Glaxosmithkline Llc | Combination |
| EP2968343A4 (en) * | 2013-03-14 | 2016-11-02 | Epizyme Inc | COMBINATION THERAPY FOR THE TREATMENT OF CANCER |
| US10214545B2 (en) * | 2014-01-09 | 2019-02-26 | Bayer Pharma Aktiengesellschaft | Amido-substituted imidazopyridazines useful in the treatment of hyper-proliferative and/or angiogenesis disorders |
| KR102611539B1 (ko) * | 2016-11-28 | 2023-12-06 | 브리스톨-마이어스 스큅 컴퍼니 | Gsk-3 억제제 |
| EP3453706A1 (en) | 2017-09-08 | 2019-03-13 | Basf Se | Pesticidal imidazole compounds |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0017037A (pt) | 1999-12-23 | 2003-06-10 | Nitromed Inc | Inibidores de ciclooxigenase-2 nitrosados e nitrosilados, composições e métodos de uso |
| ES2286114T3 (es) | 2000-03-31 | 2007-12-01 | Ortho-Mcneil Pharmaceutical, Inc. | Imidazopiridina fenil-substituidos. |
| ES2244613T3 (es) | 2000-04-27 | 2005-12-16 | Astellas Pharma Inc. | Derivados de imidazopiridina. |
| US7169801B2 (en) | 2003-03-17 | 2007-01-30 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| CN1809354A (zh) | 2003-04-24 | 2006-07-26 | 麦克公司 | Akt活性抑制剂 |
| DE602004010680T2 (de) | 2003-07-30 | 2009-01-02 | Laboratorios S.A.L.V.A.T., S.A., Esplugues De Llobregat | Substituierte imidazopyrimidine zur prävention und behandlung von krebs |
| US7655649B2 (en) | 2004-04-09 | 2010-02-02 | Merck Sharp & Dohme Corp. | Inhibitors of Akt activity |
| US7544677B2 (en) | 2004-08-23 | 2009-06-09 | Merck & Co., Inc. | Inhibitors of Akt activity |
| US20070255064A1 (en) | 2004-08-24 | 2007-11-01 | Basf Aktiengesellschaft | Imidazolium-Methyl Sulfites for Use as Starting Compounds for Producing Ionic Liquids |
| JP2008524339A (ja) | 2004-12-15 | 2008-07-10 | メルク エンド カムパニー インコーポレーテッド | Ａｋｔ活性のインヒビター |
| WO2006125101A2 (en) | 2005-05-20 | 2006-11-23 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
| CA2610888C (en) | 2005-06-10 | 2011-02-08 | Merck & Co., Inc. | Inhibitors of akt activity |
| US20070049591A1 (en) | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Inhibitors of MAPK/Erk Kinase |
| PE20070978A1 (es) | 2006-02-14 | 2007-11-15 | Novartis Ag | COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks) |
| US7530313B2 (en) | 2006-05-12 | 2009-05-12 | Day & Zimmerman, Inc. | Self-destruct fuze delay mechanism |
| AR064010A1 (es) * | 2006-12-06 | 2009-03-04 | Merck & Co Inc | Inhibidores de la actividad de la akt |
| MX2009013213A (es) * | 2007-06-08 | 2010-03-30 | Abbott Lab | Indazoles 5-sustituidos 5-heteroarilo como inhibidores de cinasa. |
| TW200924761A (en) * | 2007-08-14 | 2009-06-16 | Bayer Schering Pharma Ag | Fused bicyclic imidazoles |
| NZ583267A (en) | 2007-08-14 | 2012-03-30 | Bayer Schering Pharma Ag | Fused bicyclic pyrimidines |
| CA2710458A1 (en) | 2007-12-21 | 2009-07-09 | Wyeth Llc | Imidazo [1,2-b] pyridazine compounds as modulators of liver x receptors |
| EP2303269B1 (en) | 2008-06-03 | 2014-07-30 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| WO2009148887A1 (en) | 2008-06-03 | 2009-12-10 | Merck & Co., Inc. | Inhibitors of akt activity |
| AR074072A1 (es) | 2008-11-11 | 2010-12-22 | Lilly Co Eli | Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme |
| PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
| EP2391623A4 (en) | 2009-02-02 | 2012-09-05 | Merck Sharp & Dohme | INHIBITORS OF AKT ACTIVITY |
| MX2011008583A (es) * | 2009-02-13 | 2011-12-12 | Bayer Pharma AG | Pirimidinas fusionadas. |
| EP2406250B1 (en) | 2009-03-11 | 2015-08-12 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| WO2010114780A1 (en) * | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| AR076936A1 (es) | 2009-06-02 | 2011-07-20 | Vitae Pharmaceuticals Inc | Inhibidores de carbamato y urea de la 11 beta hidroxiesteroide deshidrogenasa 1 |
| WO2011033265A1 (en) * | 2009-09-18 | 2011-03-24 | Almac Discovery Limited | Pharmaceutical compounds |
| JP5830094B2 (ja) * | 2010-07-12 | 2015-12-09 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 置換イミダゾ［１，２−ａ］ピリミジンおよび−ピリジン |
| CN103384670B (zh) | 2010-07-28 | 2016-05-25 | 拜耳知识产权有限责任公司 | 取代的咪唑并[1,2-b]哒嗪 |
| KR20140022057A (ko) * | 2011-04-07 | 2014-02-21 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | Akt 키나제 억제제로서의 이미다조피리다진 |
-
2012
- 2012-04-05 KR KR1020137029229A patent/KR20140022057A/ko not_active Withdrawn
- 2012-04-05 JO JOP/2012/0084A patent/JO3068B1/ar active
- 2012-04-05 ES ES12713963.2T patent/ES2558780T3/es active Active
- 2012-04-05 PL PL12713963T patent/PL2694510T3/pl unknown
- 2012-04-05 CA CA2832374A patent/CA2832374A1/en not_active Abandoned
- 2012-04-05 JP JP2014503153A patent/JP5906303B2/ja not_active Expired - Fee Related
- 2012-04-05 SI SI201230430T patent/SI2694510T1/sl unknown
- 2012-04-05 CN CN201280027994.5A patent/CN103596957B/zh not_active Expired - Fee Related
- 2012-04-05 CU CUP2013000135A patent/CU24263B1/es unknown
- 2012-04-05 PT PT127139632T patent/PT2694510E/pt unknown
- 2012-04-05 AP AP2013007215A patent/AP3597A/xx active
- 2012-04-05 PE PE2013002192A patent/PE20141380A1/es not_active Application Discontinuation
- 2012-04-05 SG SG2013072509A patent/SG193631A1/en unknown
- 2012-04-05 WO PCT/EP2012/056300 patent/WO2012136776A1/en active Application Filing
- 2012-04-05 RS RS20160005A patent/RS54480B1/en unknown
- 2012-04-05 HU HUE12713963A patent/HUE026323T2/en unknown
- 2012-04-05 DK DK12713963.2T patent/DK2694510T3/en active
- 2012-04-05 MX MX2013011699A patent/MX336865B/es active IP Right Grant
- 2012-04-05 EP EP12713963.2A patent/EP2694510B1/en active Active
- 2012-04-05 PH PH1/2013/502073A patent/PH12013502073A1/en unknown
- 2012-04-05 US US14/007,427 patent/US9206185B2/en not_active Expired - Fee Related
- 2012-04-05 AU AU2012238589A patent/AU2012238589B2/en not_active Ceased
- 2012-04-05 ME MEP-2016-1A patent/ME02316B/me unknown
- 2012-04-05 MA MA36290A patent/MA35016B1/fr unknown
- 2012-04-05 EA EA201301130A patent/EA024890B1/ru not_active IP Right Cessation
- 2012-04-05 BR BR112013025777A patent/BR112013025777A2/pt active Search and Examination
- 2012-04-06 TW TW101112356A patent/TWI535719B/zh not_active IP Right Cessation
- 2012-04-09 UY UY0001034006A patent/UY34006A/es not_active Application Discontinuation
- 2012-04-09 AR ARP120101200A patent/AR087148A1/es active Pending
- 2012-05-04 UA UAA201312894A patent/UA111739C2/uk unknown
-
2013
- 2013-09-26 ZA ZA2013/07223A patent/ZA201307223B/en unknown
- 2013-09-29 IL IL228567A patent/IL228567A0/en unknown
- 2013-10-03 TN TNP2013000400A patent/TN2013000400A1/fr unknown
- 2013-10-07 CR CR20130515A patent/CR20130515A/es unknown
- 2013-10-07 CO CO13237923A patent/CO6862145A2/es active IP Right Grant
- 2013-10-07 GT GT201300238A patent/GT201300238A/es unknown
- 2013-10-07 CL CL2013002878A patent/CL2013002878A1/es unknown
- 2013-10-07 NI NI201300105A patent/NI201300105A/es unknown
- 2013-10-07 DO DO2013000226A patent/DOP2013000226A/es unknown
- 2013-11-04 EC ECSP13013008 patent/ECSP13013008A/es unknown
-
2015
- 2015-07-06 US US14/792,205 patent/US9604989B2/en not_active Expired - Fee Related
-
2016
- 2016-01-05 SM SM201600001T patent/SMT201600001B/it unknown
- 2016-01-05 HR HRP20160011TT patent/HRP20160011T1/hr unknown
- 2016-01-08 CY CY20161100011T patent/CY1117163T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2013002878A1 (es) | Compuestos derivados de 1-[4-(imidazo[1,2-b]piridazin-2-il)fenil]ciclobutanamida, inhibidores de quinasa akt (pi3k/akt); proceso de preparacion; composicion farmaceutica y uso en el tratamiento del cancer. | |
| NI201100048A (es) | Aminotriazolopiridinas y su uso como inhibidores de la cinasa. | |
| CO6470845A2 (es) | Derivados de pirimidina novedosos y su uso en el tratamiento del cancer y enfermedades adicionales | |
| EA201200218A1 (ru) | Новые бициклические соединения мочевины | |
| ECSP11010880A (es) | Compuestos orgánicos | |
| BR112012029647A2 (pt) | novos derivados de pirimidinas | |
| ECSP15029636A (es) | Nuevos compuestos bicíclicos y su uso como agentes antibacterianos e inhibidores de beta-lactamasa | |
| UY33503A (es) | Imidazo [1,2-a]pirimidinas y piridinas sustituidas | |
| CL2011002115A1 (es) | Compuestos derivados de 5-fenil-1h-piridin-2-ona y 5-fenil-pirazin-2-ona, inhibidores de la tirosina-quinasa de bruton (btk); proceso de preparación de los compuestos, compuesto intermediario, composición farmacéutica y uso en el tratamiento de enfermedades inflamatorias y/o autoinmunes. | |
| DOP2011000260A (es) | Pirimidinas fusionadas | |
| EA201200102A1 (ru) | Соединения, применимые в качестве лекарственных средств | |
| PH12014500813A1 (en) | Novel [1,2,3] triazolo [4,5-d] pyrimidine derivatives as agonists of the cannabinoid receptor | |
| ECSP099480A (es) | Compuestos químicos 637: piridopirimidindionas como inhibidores de la pde4 | |
| MX2011008452A (es) | Derivados de triazolo [4,3-b] piridazina y sus usos para el cancer de prostata. | |
| MY184858A (en) | Substituted pyridopyrimidine compounds and their use as flt3 inhibitors | |
| MX2014012477A (es) | Inhibidores pirrolopirazona de tanquirasa. | |
| PA8843901A1 (es) | INHIBIDORES DE PIRIMIDINONA DE PI3K( ALFA) Y m TOR | |
| PH12014501026A1 (en) | [1, 2, 3]triazolo[4,5-d] pyrimidine derivatives as agonists of the cannabinoid receptor 2 agonists | |
| CR20150245A (es) | Proceso novedoso para la elaboración de compuestos para uso en el tratamiento de cáncer | |
| ECSP11010867A (es) | Compuestos novedosos de fenilamino-isonicotinamida | |
| CO6460764A2 (es) | [1,2,4] triazolo [4,3-b] piridazinas como ligandos del receptor de andrógenos | |
| MX376059B (es) | Compuestos de pirimidina substituidos y su uso como inhibidores de la tirosina cinasa del bazo (syk). | |
| PH12013500219A1 (en) | Compounds with antibacterial activity against clostridium | |
| NZ702073A (en) | Methanethione compounds having antiviral activity | |
| CU20100004A7 (es) | Derivados de morfolino pirimidina utilizados en enfermedades relacionadas con mtor quinasa y/o pi3k |