(Q28283445)

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Zinc-finger nucleases: the next generation emerges

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Europe PubMed Central

Zinc-finger nucleases: the next generation emerges (English)

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Toni Cathomen

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J Keith Joung

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publication date

July 2008

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Molecular Therapy

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16

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7

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1200-7

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Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century

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Gene targeting using zinc finger nucleases

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Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells

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Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

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Meganucleases and DNA double-strand break-induced recombination: perspectives for gene therapy

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Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain

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Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains

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Stimulation of homologous recombination through targeted cleavage by chimeric nucleases

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Mechanism and regulation of human non-homologous DNA end-joining

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Efficient gene targeting in Drosophila with zinc-finger nucleases

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Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases.

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Genetic therapies against HIV.

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Manipulating the mammalian genome by homologous recombination

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Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae

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Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells

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Double-strand breaks at the target locus stimulate gene targeting in embryonic stem cells

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Highly efficient endogenous human gene correction using designed zinc-finger nucleases

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HIV and the chemokine system: 10 years later

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Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases

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Targeted genome modifications using integrase-deficient lentiviral vectors.

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DNA recognition by Cys2His2 zinc finger proteins

1 reference

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Design and selection of novel Cys2His2 zinc finger proteins

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Drug discovery with engineered zinc-finger proteins

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Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins

1 reference

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Engineering polydactyl zinc-finger transcription factors

1 reference

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Towards therapeutic applications of engineered zinc finger proteins

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Custom DNA-binding proteins and artificial transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.114

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based on heuristic

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The design of functional DNA-binding proteins based on zinc finger domains.

1 reference

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Validated zinc finger protein designs for all 16 GNN DNA triplet targets

1 reference

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A zinc finger directory for high-affinity DNA recognition

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Zinc finger phage: affinity selection of fingers with new DNA-binding specificities

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based on heuristic

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Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions

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Building zinc fingers by selection: toward a therapeutic application

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Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences

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Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors

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Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors

1 reference

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based on heuristic

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Toward rules relating zinc finger protein sequences and DNA binding site preferences

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Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A

1 reference

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Human zinc fingers as building blocks in the construction of artificial transcription factors.

1 reference

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Designing transcription factor architectures for drug discovery.

1 reference

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Design, construction and in vitro testing of zinc finger nucleases.

1 reference

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Design, engineering, and characterization of zinc finger nucleases

1 reference

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Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly.

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Zinc Finger Tools: custom DNA-binding domains for transcription factors and nucleases

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Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool.

1 reference

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Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.114

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based on heuristic

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Enhancing Gene Targeting with Designed Zinc Finger Nucleases

1 reference

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based on heuristic

inferred from DOI database lookup

Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.114

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based on heuristic

inferred from DOI database lookup

Custom zinc-finger nucleases for use in human cells.

1 reference

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based on heuristic

inferred from DOI database lookup

Unexpected failure rates for modular assembly of engineered zinc fingers

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.114

7 January 2021

based on heuristic

inferred from DOI database lookup

Synergy between adjacent zinc fingers in sequence-specific DNA recognition

1 reference

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based on heuristic

inferred from DOI database lookup

Use of a zinc-finger consensus sequence framework and specificity rules to design specific DNA binding proteins

1 reference

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based on heuristic

inferred from DOI database lookup

Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions

1 reference

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A 2.2 A resolution crystal structure of a designed zinc finger protein bound to DNA

1 reference

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based on heuristic

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Comprehensive DNA recognition through concerted interactions from adjacent zinc fingers

1 reference

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based on heuristic

inferred from DOI database lookup

Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.114

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based on heuristic

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Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes

1 reference

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based on heuristic

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Rearrangement of side-chains in a Zif268 mutant highlights the complexities of zinc finger-DNA recognition

1 reference

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based on heuristic

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A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.114

7 January 2021

based on heuristic

inferred from DOI database lookup

A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter

1 reference

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based on heuristic

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Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection

1 reference

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based on heuristic

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DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases

1 reference

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based on heuristic

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The zinc finger nuclease monopoly.

1 reference

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based on heuristic

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Gene therapy. Putting the fingers on gene repair

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.114

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based on heuristic

inferred from DOI database lookup

Mammalian gene targeting with designed zinc finger nucleases

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.114

7 January 2021

based on heuristic

inferred from DOI database lookup

An improved zinc-finger nuclease architecture for highly specific genome editing

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.114

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based on heuristic

inferred from DOI database lookup

Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

1 reference

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based on heuristic

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Gene repair: pointing the finger at genetic disease

1 reference

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based on heuristic

inferred from DOI database lookup

Chimeric nucleases stimulate gene targeting in human cells

1 reference

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A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors

1 reference

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Profiling the DNA-binding specificities of engineered Cys2His2 zinc finger domains using a rapid cell-based method

1 reference

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based on heuristic

inferred from DOI database lookup

Adeno-associated virus vectors integrate at chromosome breakage sites

1 reference

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Induction of endogenous telomerase (hTERT) by c-Myc in WI-38 fibroblasts transformed with specific genetic elements

1 reference

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Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

1 reference

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inferred from DOI database lookup

Spectral karyotyping analysis of human and mouse chromosomes

1 reference

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based on heuristic

inferred from DOI database lookup

Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.114

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based on heuristic

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Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.114

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein assembly and DNA looping by the FokI restriction endonuclease

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.114

7 January 2021

based on heuristic

inferred from DOI database lookup

Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.114

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks

1 reference

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based on heuristic

inferred from DOI database lookup

Human Gene Targeting by Adeno-Associated Virus Vectors Is Enhanced by DNA Double-Strand Breaks

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.114

7 January 2021

based on heuristic

inferred from DOI database lookup

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

1 reference

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based on heuristic

inferred from DOI database lookup

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.114

7 January 2021

based on heuristic

inferred from DOI database lookup

AAV vector integration sites in mouse hepatocellular carcinoma.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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