(Q28307951)

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Michael C Holmes

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Jianbin Wang

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Dmitry Y Guschin

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Ya-Li Lee

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Igor Rupniewski

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Christian M Beausejour

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Nathaniel S Wang

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Kenneth A Kim

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Carl O Pabo

Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain

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language of work or name

English

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publication date

July 2007

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778-85

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cites work

1 reference

7 January 2021

A detailed study of the substrate specificity of a chimeric restriction enzyme.

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7 January 2021

Chimeric nucleases stimulate gene targeting in human cells

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7 January 2021

Enhancing Gene Targeting with Designed Zinc Finger Nucleases

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7 January 2021

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

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7 January 2021

Efficient gene targeting in Drosophila with zinc-finger nucleases

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7 January 2021

Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases

1 reference

7 January 2021

Homology-directed repair is a major double-strand break repair pathway in mammalian cells

1 reference

7 January 2021

High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition

1 reference

7 January 2021

Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions

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7 January 2021

Rearrangement of side-chains in a Zif268 mutant highlights the complexities of zinc finger-DNA recognition

1 reference

7 January 2021

A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites

1 reference

7 January 2021

Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences

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7 January 2021

Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection

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7 January 2021

Design and selection of novel Cys2His2 zinc finger proteins

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7 January 2021

A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter

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7 January 2021

Genome maintenance mechanisms for preventing cancer

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7 January 2021

Targeted mutagenesis using zinc-finger nucleases in Arabidopsis

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7 January 2021

High-frequency homologous recombination in plants mediated by zinc-finger nucleases.

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7 January 2021

Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells

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7 January 2021

FokI dimerization is required for DNA cleavage

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7 January 2021

FokI requires two specific DNA sites for cleavage

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7 January 2021

Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains

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7 January 2021

Binding of two zinc finger nuclease monomers to two specific sites is required for effective double-strand DNA cleavage

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7 January 2021

Purification and characterization of the FokI restriction endonuclease

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7 January 2021

Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity.

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7 January 2021

Engineered zinc finger proteins for controlling stem cell fate

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7 January 2021

Positive and negative regulation of endogenous genes by designed transcription factors

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7 January 2021

Heritable endogenous gene regulation in plants with designed polydactyl zinc finger transcription factors

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7 January 2021

Peptide 'Velcro': design of a heterodimeric coiled coil.

1 reference

7 January 2021

Remodeling domain interfaces to enhance heterodimer formation

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7 January 2021

Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library

1 reference

7 January 2021

Altering dimerization specificity by changes in surface electrostatics

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7 January 2021

Automated design of specificity in molecular recognition

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7 January 2021

Specificity versus stability in computational protein design

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7 January 2021

Structure of FokI has implications for DNA cleavage

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7 January 2021

Computational design of a new hydrogen bond network and at least a 300-fold specificity switch at a protein-protein interface

1 reference

7 January 2021

p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

1 reference

7 January 2021

Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage

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7 January 2021

Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways

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7 January 2021

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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7 January 2021

Megabase chromatin domains involved in DNA double-strand breaks in vivo

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7 January 2021

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

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7 January 2021

Computational redesign of endonuclease DNA binding and cleavage specificity

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7 January 2021

Isolation and characterization of new homing endonuclease specificities at individual target site positions

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7 January 2021

Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets

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7 January 2021

In vivo selection of engineered homing endonucleases using double-strand break induced homologous recombination

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7 January 2021

A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells

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7 January 2021

VMD: visual molecular dynamics

1 reference

7 January 2021

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

1 reference

7 January 2021

The role of metals in catalysis by the restriction endonuclease BamHI

1 reference

7 January 2021

Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector

1 reference

7 January 2021

Mutation detection using Surveyor nuclease

1 reference

7 January 2021

Computational redesign of protein-protein interaction specificity

1 reference

7 January 2021