AbstractTwo new flavonoid glycosides (I) and (II) are isolated along with eleven known compounds.
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Biomolecular recognition has been playing an important role in health care, pharmaceutical industry, environmental analysis, and broad biotechnology applications. In these cases, the detection of specific interactions between two... more
Biomolecular recognition has been playing an important role in health care, pharmaceutical industry, environmental analysis, and broad biotechnology applications. In these cases, the detection of specific interactions between two bio-logical molecules with affinity to each other is ...
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A new coumarin derivative, coumacasia (1) and eight known compounds, coumarin (2), cinnamaldehyde (3), 2-methoxycinnamaldehyde (4), 2-hydroxycinnamaldehyde (5), coniferaldehyde (6), cinnamic acid (7), 2-hydroxycinnamic acid (8), and... more
A new coumarin derivative, coumacasia (1) and eight known compounds, coumarin (2), cinnamaldehyde (3), 2-methoxycinnamaldehyde (4), 2-hydroxycinnamaldehyde (5), coniferaldehyde (6), cinnamic acid (7), 2-hydroxycinnamic acid (8), and cinnamic alcohol (9), were isolated from the methanol extract of Cinnamomum cassia. Their structures were elucidated by spectral data and by comparison with the reported literature. The cytotoxic activities of compounds 1-9 were evaluated with two human cancer cell lines, HL-60 and A-549. Compound 1 showed growth inhibitory effects in the HL-60 and A-549 cell lines with IC50 values of 8.2 +/- 0.5 and 11.3 +/- 1.1 microM, respectively. Compounds 3-6, and 8 exhibited moderate cytotoxicity with IC50 values ranging from 20.5 to 65.6 microM.
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ABSTRACT
Research Interests: Cell Cycle, Apoptosis, Molecular Mechanics, Signal Transduction, Estrogen Receptor, and 17 moreHumans, mTOR, Female, Lignans, Cell Death, Signal Transduction Pathway Models, Phosphorylation, Retinoblastoma, Epidermal Growth Factor Receptor, Cell Cycle Arrest, Cell Cycle Proteins, Protein Binding, SRC, Breast Cancer Cells, Cell Growth, Down-Regulation, and DNA fragmentation
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Research Interests: Free Radicals, Complementary and Alternative Medicine, Plant Biology, Ethnopharmacology, Pharmacognosy, and 22 moreMedicinal Plants, Free Radical, Antioxidants, Humans, Copper, ROOT, Methanol, Plant Roots, Lipid peroxidation, Gallic acid, Antioxidant Activity, Plant extracts, Alpha-Tocopherol, PBS, Thiobarbituric Acid Reactive Substance, Low Density Lipoprotein (LDL), Chlorogenic Acid, Quinic Acid, Malondialdehyde, Molecular Structure, Butylated hydroxytoluene, and Monosaccharides
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Research Interests: Inflammation, Macrophages, Lipopolysaccharide, Cell line, Mice, and 18 moreSeptic Shock, Nitric oxide, Animals, Lignans, Male, Sepsis, Fruit, Anti-inflammatory agents, Mitogen Activated Protein Kinase, European, Lipopolysaccharides, Acetic Acid, Nuclear Factor-kappaB, Active Ingredient, Vascular Permeability, Prostaglandin E2, Nitrites, and Gene Expression Regulation
Research Interests: Environmental Monitoring, Vietnam, Adolescent, Multidisciplinary, Adipose tissue, and 24 moreHumans, Pesticide, Pesticides, Female, Animals, Male, Fishes, Soils, Sol, Vegetables, Ducks, Contaminated soil, Middle Aged, Adult, Breast milk, Human Milk, Pollutant, Environmental Pollutants, Food Chain, Rate, Environment, Geologic Sediments, Soil Pollutants, and Aerial Application
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Three new phenolics:…
Research Interests: Organic Chemistry, Mass Spectrometry, Macrophages, Magnetic Resonance Spectroscopy, Food Microbiology, and 12 moreCell line, Mice, Nitric oxide, Animals, Anti-inflammatory agents, Phenols, Phenolic compound, Seeds, Myristica Fragrans, Anti Inflammatory Activity, Bioorganic and medicinal Chemistry, and Chemical Structure
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Research Interests: Vietnam, Dogs, Humans, Mice, Animals, and 5 moreLignans, Seeds, HeLa cells, Myristica Fragrans, and Cytotoxins
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Five flavonoids,... more
Five flavonoids, myricetin-3'-methylether 3-O-β-D: -galactopyranoside (1), myricetin-3',5'-dimethylether 3-O-β-D: -galactopyranoside (2), quercetin (3), kaempferol (4), and tamarixetin (5) were isolated from the buds of Cleistocalyx operculatus (Myrtaceae). The chemical structures of these compounds were determined on the basis of spectroscopic analyses, including 2D NMR. Their anti-Alzheimer effects were evaluated via acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. All five compounds 1-5 showed potential inhibitory activities against AChE with IC(50) values of 19.9, 37.8, 25.9, 30.4 and 22.3 μM, respectively, while compounds 1, 3, 4 and 5 also possessed BChE inhibitory activity with IC(50) values of 152.5, 177.8, 62.5, and 160.6 μM, respectively.
Research Interests: Drug Discovery, Magnetic Resonance Spectroscopy, Flavonoids, Acetylcholinesterase, Flowers, and 11 moreCholinesterase inhibitors, Liquid Chromatography / Electrospray Ionization Mass Spectrometry, Fourier transform infrared spectroscopy, Galactose Binding, Alzheimer Disease, Eugenia, Optical Rotation, Chemical Structure, Glycosides, Molecular Structure, and Butyrylcholinesterase
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Research Interests: Web search and Web Pages
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Page 1. 2392 Bull. Korean Chem. Soc. 2010, Vol. 31, No. 8 Notes DOI 10.5012/bkcs.2010.31. 8.2392 Flavonoids from Cleistocalyx operculatus Buds and their Cytotoxic Activity Byung Sun Min,* To Dao Cuong, Joo-Sang Lee, Mi Hee Woo, and Tran... more
Page 1. 2392 Bull. Korean Chem. Soc. 2010, Vol. 31, No. 8 Notes DOI 10.5012/bkcs.2010.31. 8.2392 Flavonoids from Cleistocalyx operculatus Buds and their Cytotoxic Activity Byung Sun Min,* To Dao Cuong, Joo-Sang Lee, Mi Hee Woo, and Tran Manh Hung ...