0721] Personality disorders and accentuated personality Temperament and character traits in patients with irritable colon Cengiz Karacaer, Esra Yazici, Alime Burcin Saykan, Atila Erol Sakarya University, Faculty of Medicine,... more
0721] Personality disorders and accentuated personality Temperament and character traits in patients with irritable colon Cengiz Karacaer, Esra Yazici, Alime Burcin Saykan, Atila Erol Sakarya University, Faculty of Medicine, Sakarya-Turkey e-mail address: dresrayazici@yahoo.com Objective: Irritable Bowel Syndrome (IBS) is a chronic, continuous or intermittent illness characterized by frequent and unexplained symptoms that include abdominal pain, bloating, and bowel disturbance. It is considered to be the most common gastrointestinal (GI) dysfunction with an estimated prevalence of 8-22% in general population. Though a number of biological triggers have been proposed for onset of IBS, it has also been suggested that psychological factors, particularly those associated with the process of somatization play an important role and may even act as markers of IBS onset. Recent studies have shown that subjects with IBS have higher levels of depression, anxiety and neuroticism as compared to...
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Background: Even though particularly bipolar depression and unipolar depression seem to be similar, they show differences in terms of the etiology, phenomenology, course, and treatment process. Bipolar depression is associated with mood... more
Background: Even though particularly bipolar depression and unipolar depression seem to be similar, they show differences in terms of the etiology, phenomenology, course, and treatment process. Bipolar depression is associated with mood lability, motor retardation, and hypersomnia to a larger extent. Early age of onset, a high frequency of depressive episodes, and history of bipolar disease in the family are suggestive of bipolar disorder (BD) rather than major depression. Bipolar and unipolar disorders are also associated with increased impulsivity during illness episodes. However, there is little information about impulsivity during euthymia in these mood disorders. The aim of this study was to illustrate the difference in impulsivity in euthymic bipolar and unipolar patients. Materials and Methods: Impulsivity was evaluated by the Barratt Impulsiveness Scale (BIS-11A), in 78 interepisode BD patients, 72 interepisode unipolar disorder patients, and 70 healthy controls. The diagnos...
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Objectives: Current treatment methods in alcohol and substance use disorders (ASUDs) cannot meet the demands of patients for many reasons. This situation may result in individuals with addiction seeking different approaches. This study... more
Objectives: Current treatment methods in alcohol and substance use disorders (ASUDs) cannot meet the demands of patients for many reasons. This situation may result in individuals with addiction seeking different approaches. This study aims to investigate nondrug methods used by individuals with ASUD to cope with their disorder and the factors that may be associated with it. Materials and Methods: The study was carried out on 103 volunteer patients who presented to a Training and Research Hospital alcohol substance treatment center. In the study, the God Attachment Inventory, the Addiction Profile Index-Practitioner Form, and the Non-Drug Treatment Questionnaire were used, and Structured Clinical Interview for DSM-IV (SCID-1) and Structured Clinical Interview for DSM-IV (SCID-2) psychiatric interviews were conducted. Result: In individuals with addiction, the rate of seeking any nondrug method was found to be 33%. To get rid of addiction, turning to religion was mostly preferred (24.3%). In terms of subheadings, self-help methods such as praying (17.4%) and engaging in sports (6.7%) were the most preferred. No relationship was found between the patients’ attachment style to God and personality disorder diagnoses and the frequency of seeking nondrug methods and the type of nondrug method. It has been found that there is a relationship between the severity of addiction and the use of nondrug methods. Conclusions: In addition to the medical approaches of patients with ASUD problems, it is observed that they attempt to cope using traditional and complementary methods and prefer the self-help methods among these methods. However, further studies are needed to investigate the contribution of these methods to current treatment methods.
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To compare and determine the relative effects of six of the variables (family functioning, self-esteem, obsessive-compulsive symptoms, depressive symptoms, locus of control and Body Mass Index-BMI) related to the etiology of eating... more
To compare and determine the relative effects of six of the variables (family functioning, self-esteem, obsessive-compulsive symptoms, depressive symptoms, locus of control and Body Mass Index-BMI) related to the etiology of eating disorders in predicting eating disorder symptoms and the general symptom index. Two hundred and ninety-two female college students completed the Rosenberg Self-Esteem Scale (RSES), the Family Assessment Device (FAD), the Eating Attitude Test (EAT), the Symptom Check List (SCL-90-R), Rotter's Internal-External Locus of Control Scale (RIELCS), and the Beck Depression Inventory (BDI). Multiple regression analysis was employed, and scores of the obsessive-compulsive subscale of SCL-90-R, BMI, RSES, FAD, BDI and RIELCS were used as predictors of EAT total scores. The second multiple regression analysis was employed with the same independent variables as predictors of the General Symptom Index (GSI) of SCL-90-R. Obsessive-compulsive symptoms were the best p...
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Research Interests: Endocrinology, Psychiatry, Cognition, Medicine, Oxytocin, and 3 moreInternal Medicine, Vasopressin, and NPR
Suicide is a major cause of death in patients with schizophrenia; thus, predicting and preventing suicide in patients with schizophrenia is examined in various studies. Affective temperaments which are accepted as precursors of mood... more
Suicide is a major cause of death in patients with schizophrenia; thus, predicting and preventing suicide in patients with schizophrenia is examined in various studies. Affective temperaments which are accepted as precursors of mood disorders may be an important factor in predicting suicidality. This study investigated the relationship between affective temperaments of relatives of schizophrenia patients and suicidal thoughts and other clinical correlates of patients with schizophrenia. Patients with schizophrenia and their first degree relatives are included to the study. All of the participants were evaluated with Structured Clinical Interview for DSM-IV axis I disorders and relatives with active psychiatric diagnosis were excluded. Positive and Negative Symptom Scale, Clinical Global Impression Scale, Turkish version of cognitive assessment interview were administered congruently to the patients. Relatives of the patients were evaluated with Temperament Evaluation of Memphis, Pis...
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The long-term use of opioids leads alternations in both innate-adaptive immune systems and other diagnostic hematologic cells. The purpose of this study is to evaluate the alterations of these parameters in patients with heroin/opioid... more
The long-term use of opioids leads alternations in both innate-adaptive immune systems and other diagnostic hematologic cells. The purpose of this study is to evaluate the alterations of these parameters in patients with heroin/opioid addictions. Adults, meeting the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria of the American Psychiatric Association regarding opioid use disorder (Heroin Group or HG, n = 51) and healthy controls (Control Group or CG, n = 50), were included in the study. All hematological parameters, inflammation indexes (neutrophil-lymphocyte ratio and platelet-lymphocyte ratio), and iron panel were compared with the controls. Mean corpuscular volume, red blood cell distribution width, mean corpuscular hemoglobin content, unsaturated iron-binding capacity, and total iron-binding capacity were significantly higher in HG compared to CG, while red blood cell count, hemoglobin, hematocrit, and serum iron levels were signific...
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Pregnancy and postpartum periods are the main reproductive periods during which women experience mood disorders. Affective temperaments are known antecedents of mood disorders and their importance is increasing in time for early diagnosis... more
Pregnancy and postpartum periods are the main reproductive periods during which women experience mood disorders. Affective temperaments are known antecedents of mood disorders and their importance is increasing in time for early diagnosis and determining risky groups. But data about affective temperaments during perinatal period is limited. Women during pregnancy and perinatal period and healthy controls who are not in perinatal period are included in the study. 83 pregnant women in 1st trimester, 94 pregnant women in 2nd trimester and 115 pregnant women in 3rd trimester; 32 women in 1st month postpartum and 89 women in 2nd month postpartum; and 88 healthy non-pregnant women with similar ages were evaluated regarding their temperament evaluation of Memphis, Pisa, Paris and San Diego auto-questionnaire (TEMPS-A) scores. Women in perinatal period had higher scores of hyperthymic temperaments than the control group. Women in the 2nd month of postpartum period had also higher anxious te...
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Meperidine hydrochloride is a synthetic opioid and a weak µ receptor agonist. Meperidine use disorder is mostly iatrogenic and is common in health care workers. In addition, it is prescribed in acute and chronic pain complaints, and has a... more
Meperidine hydrochloride is a synthetic opioid and a weak µ receptor agonist. Meperidine use disorder is mostly iatrogenic and is common in health care workers. In addition, it is prescribed in acute and chronic pain complaints, and has a high potential for creating addiction. Treatment of meperidine use disorder is a challenging issue and there is no standardised treatment for meperidine addiction. Buprenorphine is a μ receptor partial agonist, a long-acting synthetic opioid for the treatment of opioid dependence and has a buprenorphine/naloxone (BN) form combined with naloxone. Buprenorphine maintenance therapy is one of the treatment options performed in opiate use disorder. But there is a paucity of data about treatment of meperidine use disorder. Here, a full remission case report is presented with BN maintenance treatment for a patient with meperidine use disorder diagnosis.
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Background:This study investigates the antipsychotic use patterns of patients with schizophrenia and its correlations in their daily drug use patterns.Methods:Patients with schizophrenia who have regular records at two different community... more
Background:This study investigates the antipsychotic use patterns of patients with schizophrenia and its correlations in their daily drug use patterns.Methods:Patients with schizophrenia who have regular records at two different community counselling centres (CCS) were included in the study. Information about their medications and sociodemographic data was recorded through face-to-face interviews and supporting information about their drug use patterns was obtained from their relatives/caregivers/nurse. The Clinical Global Impression Scale (severity of illness) and the General Assessment of Functionality scales were also administered.Results:Patients with schizophrenia used 2.0 ± 0.81 antipsychotics daily and 3.52 ± 2.55 pills (1–18). Seventy-one percent of the patients used two or more kinds of psychotropic drugs. The most frequently used antipsychotics were quetiapine, a second generation antipsychotic, and haloperidol, a typical antipsychotic. Clinical severity, regular visits to...
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Synthetic cannabinoids (SCs) are included in a group of drugs called new psychoactive substances. Effects of SCs on the central nervous system are similar to other cannabinoids, but 2–100 times more potent than marijuana. Thus, addiction... more
Synthetic cannabinoids (SCs) are included in a group of drugs called new psychoactive substances. Effects of SCs on the central nervous system are similar to other cannabinoids, but 2–100 times more potent than marijuana. Thus, addiction and withdrawal symptoms are more severe than natural cannabinoids. Withdrawal symptoms of SCs were reported in the literature previously. But there is no report about SC withdrawal delirium and its treatment. Several studies reported that agonists of CB1 receptors play a role in GABA and glutamatergic neurotransmission, which is similar to the effects of alcohol on GABA and glutamatergic receptors. Previous studies on alcohol delirium cases suggested that elevated creatine kinase (CK) can be a marker of progress. This study reports delirium and high serum CK levels related to SC withdrawal and offers a treatment with benzodiazepine for them. We described two cases treated in our inpatient clinic about SC withdrawal with increase of serum CK level an...
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Olanzapine is a thienobenzodiazepine that blocks especially the serontonin (5-hydroxytryptamine [5-HT]) 5-HT2A and the dopamine D2 receptors as well as muscarinic (M1), histamine (H1), 5-HT2C, 5-HT3 to 5-HT6, adrenergic (α(l)), and D4... more
Olanzapine is a thienobenzodiazepine that blocks especially the serontonin (5-hydroxytryptamine [5-HT]) 5-HT2A and the dopamine D2 receptors as well as muscarinic (M1), histamine (H1), 5-HT2C, 5-HT3 to 5-HT6, adrenergic (α(l)), and D4 receptors. This case report presents an olanzapine abuse. A 48-year-old, primary school graduate, married woman applied to psychiatry clinic with tachycardia, insomnia, and anxiety complaints. In psychiatric evaluations, it was determined that these complaints have been continuing for 15 years at intervals and that she has been using citalopram 40 mg/day and olanzapine 50 mg/day for the last 3 years. As diabetes mellitus was diagnosed in follow-ups, interruption of olanzapine treatment was planned. The patient stated that she started taking the medicine again upon discomfort, increase in anxiety, dysphoria, insomnia, and nervousness, which started just after olanzapine was interrupted. She said that she was feeling dense stress when she did not take the medicine, and she thought that this situation would recover only by taking that medicine and hence she could not discontinue the medicine. In addition to medications with obvious abuse potential such as benzodiazepines and methylphenidate, and other stimulants, abuse of a number of commonly prescribed psychiatric medications has been reported. There are only 2 cases of olanzapine abuse in literature.
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The issue of whether a serotonergic abnormality is involved in poststroke depression (PSD) was investigated in a sample of poststroke patients. The severity of depression was assessed by Hamilton Rating Scale for Depression (HDRS).... more
The issue of whether a serotonergic abnormality is involved in poststroke depression (PSD) was investigated in a sample of poststroke patients. The severity of depression was assessed by Hamilton Rating Scale for Depression (HDRS). Buspirone was administered to 16 depressed poststroke (DPS), 10 non-depressed post-stroke (NDPS) patients, and 10 male healthy controls (HCs), to evaluate serotonin (5-HT) function. The prolactin (PRL) response was significantly blunted in DPS patients compared to HCs. There was no significant relationship between the severity of depression and lesion lateralization. Also, no significant differences in buspirone-induced PRL responses were found between DPS patients with right- and left-sided lesions. The severity of depression in DPS patients was not correlated with the time since stroke. Our results suggest that serotonergic dysfunction may involve in development of poststroke depression. The relatively small sample size and the failure to adequately control for age are major limitations of this study.
Research Interests: Psychology, Depression, Medicine, Serotonin, Stroke, and 15 moreHumans, Prolactin, Internal Medicine, Affective Disorders, Female, Male, Rating Scale, Aged, Middle Aged, Adult, Case Control Studies, Severity of Illness Index, Psychiatric Status Rating Scales, Psychology and Cognitive Sciences, and Medical and Health Sciences
Research Interests: Psychology, Clinical Psychology, Eating Disorders, Family, Evaluation, and 15 moreComparative Study, Medicine, Anorexia Nervosa, Bulimia Nervosa, Humans, Female, Obsessive Compulsive Disorder, Family Functioning, Body Mass Index, Clinical Sciences, Questionnaires, Adult, Eating Disorder, Eating Attitudes Test, and Obsessive Compulsive
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The aim of this study was to examine the relationship between disordered eating and three psychological variables (obsessive and depressive symptoms, self-esteem) and body mass index (BMI) in a sample of male and female college students... more
The aim of this study was to examine the relationship between disordered eating and three psychological variables (obsessive and depressive symptoms, self-esteem) and body mass index (BMI) in a sample of male and female college students in Turkey. Maudsley Obsessive-Compulsive Inventory (MOCI), Beck Depression Inventory (BDI), Rosenberg Self Esteem Scale (RSES), Eating Attitude Test (EAT), and Bulimic Investigatory Test, Edinburgh (BITE) scales were administered to 408 college students (279 women; 129 men). By multiple regression analysis, the scales of MOCI, BDI, RSES and BMI were used as potential predictors of EAT and BITE scores for each gender. Obsessionality and BMI were the strongest predictors of bulimic and anorexic symptoms in women. In men, while the strongest predictors of bulimic symptoms were the depressive and obsessive symptoms, the best predictor of anorexic symptoms was obsession scores. There were significant differences and some similarities between male and female Turkish college students.