SIN3B

SIN3转录调节同源物B（酵母）
SIN3 transcription regulator homolog B (yeast)
SIN3转录调节同源物B（酵母）; SIN3 transcription regulator homolog B (yeast)
	PDB rendering based on 1e91.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1e91, 1pd7, 2cr7, 2czy, 2f05
标识
代号	SIN3B; KIAA0700
扩展标识	遗传学：607777 鼠基因：107158 同源基因：81810 GeneCards: SIN3B Gene
基因本体论描述
分子功能	· chromatin binding; · transcription corepressor activity; · protein binding;
细胞成分	· X chromosome; · Y chromosome; · XY body; · nucleus; · nucleoplasm; · cytoplasm; · autosome;
生物过程	· transcription, DNA-dependent; · skeletal muscle tissue development; · cellular lipid metabolic process; · small molecule metabolic process; · negative regulation of transcription, DNA-dependent; · cardiac muscle tissue development;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	23309
Ensembl	ENSG00000127511
UniProt	O75182
mRNA序列	NM_015260
蛋白序列	NP_056075
基因位置	Chr 19:; 16.94 – 16.99 Mb
PubMed查询	[1]
	查; 论; 编;

成对两亲性螺旋蛋白SIN3B（英语：Paired amphipathic helix protein Sin3b）是一个由人类基因SIN3B编码的蛋白质^[1]^[2]。

互作

SIN3B与HDAC1^[3]^[4]、Zinc finger and BTB domain-containing protein 16^[5]、SUDS3^[6]以及IKZF1^[4]^[7]等蛋白有相互作用。

另见

Transcription coregulator

参考文献

^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. December 1998, 5 (3): 169–76. PMID 9734811. doi:10.1093/dnares/5.3.169.
^ Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast).
^ Zhang, Y; Ng H H, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. (UNITED STATES). August 1999, 13 (15): 1924–35. ISSN 0890-9369. PMC 316920 . PMID 10444591. doi:10.1101/gad.13.15.1924.
^ ^4.0 ^4.1 Koipally, J; Renold A, Kim J, Georgopoulos K. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J. (ENGLAND). June 1999, 18 (11): 3090–100. ISSN 0261-4189. PMC 1171390 . PMID 10357820. doi:10.1093/emboj/18.11.3090.
^ David, G; Alland L, Hong S H, Wong C W, DePinho R A, Dejean A. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. Oncogene (ENGLAND). May 1998, 16 (19): 2549–56. ISSN 0950-9232. PMID 9627120. doi:10.1038/sj.onc.1202043.
^ Alland, Leila; David Gregory, Shen-Li Hong, Potes Jason, Muhle Rebecca, Lee Hye-Chun, Hou Harry, Chen Ken, DePinho Ronald A. Identification of Mammalian Sds3 as an Integral Component of the Sin3/Histone Deacetylase Corepressor Complex. Mol. Cell. Biol. (United States). April 2002, 22 (8): 2743–50. ISSN 0270-7306. PMC 133736 . PMID 11909966. doi:10.1128/MCB.22.8.2743-2750.2002.
^ Koipally, Joseph; Georgopoulos Katia. A molecular dissection of the repression circuitry of Ikaros. J. Biol. Chem. (United States). August 2002, 277 (31): 27697–705. ISSN 0021-9258. PMID 12015313. doi:10.1074/jbc.M201694200.

延伸阅读

Ayer DE, Lawrence QA, Eisenman RN. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell. 1995, 80 (5): 767–76. PMID 7889570. doi:10.1016/0092-8674(95)90355-0.
David G, Alland L, Hong SH; et al. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. Oncogene. 1998, 16 (19): 2549–56. PMID 9627120. doi:10.1038/sj.onc.1202043.
Koipally J, Renold A, Kim J, Georgopoulos K. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J. 1999, 18 (11): 3090–100. PMC 1171390 . PMID 10357820. doi:10.1093/emboj/18.11.3090.
Naruse Y, Aoki T, Kojima T, Mori N. Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes. Proc. Natl. Acad. Sci. U.S.A. 2000, 96 (24): 13691–6. PMC 24126 . PMID 10570134. doi:10.1073/pnas.96.24.13691.
Spronk CA, Tessari M, Kaan AM; et al. The Mad1-Sin3B interaction involves a novel helical fold. Nat. Struct. Biol. 2001, 7 (12): 1100–4. PMID 11101889. doi:10.1038/81944.
Spronk CA, Jansen JF, Tessari M; et al. Sequence-specific assignment of the PAH2 domain of Sin3B free and bound to Mad1. J. Biomol. NMR. 2001, 19 (4): 377–8. PMID 11370785. doi:10.1023/A:1011262214741.
Alland L, David G, Shen-Li H; et al. Identification of Mammalian Sds3 as an Integral Component of the Sin3/Histone Deacetylase Corepressor Complex. Mol. Cell. Biol. 2002, 22 (8): 2743–50. PMC 133736 . PMID 11909966. doi:10.1128/MCB.22.8.2743-2750.2002.
Rayman JB, Takahashi Y, Indjeian VB; et al. E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex. Genes Dev. 2002, 16 (8): 933–47. PMC 152357 . PMID 11959842. doi:10.1101/gad.969202.
Koipally J, Georgopoulos K. A molecular dissection of the repression circuitry of Ikaros. J. Biol. Chem. 2002, 277 (31): 27697–705. PMID 12015313. doi:10.1074/jbc.M201694200.
Yang L, Mei Q, Zielinska-Kwiatkowska A; et al. An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. Biochem. J. 2003, 369 (Pt 3): 651–7. PMC 1223118 . PMID 12398767. doi:10.1042/BJ20020854.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Petrie K, Guidez F, Howell L; et al. The histone deacetylase 9 gene encodes multiple protein isoforms. J. Biol. Chem. 2003, 278 (18): 16059–72. PMID 12590135. doi:10.1074/jbc.M212935200.
Wysocka J, Myers MP, Laherty CD; et al. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Genes Dev. 2003, 17 (7): 896–911. PMC 196026 . PMID 12670868. doi:10.1101/gad.252103.
Ota T, Suzuki Y, Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Dugast-Darzacq C, Pirity M, Blanck JK; et al. Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential. Oncogene. 2004, 23 (55): 8887–99. PMID 15467743. doi:10.1038/sj.onc.1208107.
Gerhard DS, Wagner L, Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Rampalli S, Pavithra L, Bhatt A; et al. Tumor Suppressor SMAR1 Mediates Cyclin D1 Repression by Recruitment of the SIN3/Histone Deacetylase 1 Complex. Mol. Cell. Biol. 2005, 25 (19): 8415–29. PMC 1265755 . PMID 16166625. doi:10.1128/MCB.25.19.8415-8429.2005.
Xu Y, Sengupta PK, Seto E, Smith BD. RFX family proteins differentially interact with HDACs to repress collagen alpha 2(I) gene (COL1A2) expression. J. Biol. Chem. 2006, 281 (14): 9260–70. PMC 1434794 . PMID 16464847. doi:10.1074/jbc.M511724200.

外部链接

医学主题词表（MeSH）：SIN3B+protein,+human

SIN3B引用了美国国家医学图书馆提供的资料，这些资料属于公共领域。

[pmid9734811-1] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. December 1998, 5 (3): 169–76. PMID 9734811. doi:10.1093/dnares/5.3.169.

[entrez-2] Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast).

[pmid10444591-3] Zhang, Y; Ng H H, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. (UNITED STATES). August 1999, 13 (15): 1924–35. ISSN 0890-9369. PMC 316920 . PMID 10444591. doi:10.1101/gad.13.15.1924.

[pmid10357820-4] 4.0 ^4.1 Koipally, J; Renold A, Kim J, Georgopoulos K. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J. (ENGLAND). June 1999, 18 (11): 3090–100. ISSN 0261-4189. PMC 1171390 . PMID 10357820. doi:10.1093/emboj/18.11.3090.

[pmid9627120-5] David, G; Alland L, Hong S H, Wong C W, DePinho R A, Dejean A. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. Oncogene (ENGLAND). May 1998, 16 (19): 2549–56. ISSN 0950-9232. PMID 9627120. doi:10.1038/sj.onc.1202043.

[pmid11909966-6] Alland, Leila; David Gregory, Shen-Li Hong, Potes Jason, Muhle Rebecca, Lee Hye-Chun, Hou Harry, Chen Ken, DePinho Ronald A. Identification of Mammalian Sds3 as an Integral Component of the Sin3/Histone Deacetylase Corepressor Complex. Mol. Cell. Biol. (United States). April 2002, 22 (8): 2743–50. ISSN 0270-7306. PMC 133736 . PMID 11909966. doi:10.1128/MCB.22.8.2743-2750.2002.

[pmid12015313-7] Koipally, Joseph; Georgopoulos Katia. A molecular dissection of the repression circuitry of Ikaros. J. Biol. Chem. (United States). August 2002, 277 (31): 27697–705. ISSN 0021-9258. PMID 12015313. doi:10.1074/jbc.M201694200.

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