SIN3B

SIN3B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1E91, 1PD7, 2CR7, 2CZY, 2F05
Dynodwyr
Cyfenwau	SIN3B, Paired amphipathic helix protein Sin3b, SIN3 transcription regulator family member B
Dynodwyr allanol	OMIM: 607777 HomoloGene: 81810 GeneCards: SIN3B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001106 transcription corepressor activity • histone deacetylase activity • chromatin binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • X chromosome • Y chromosome • autosome • Sin3 complex • nucleoplasm • XY body • cnewyllyn cell • chromatin Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • GO:0045996 negative regulation of transcription, DNA-templated • histone deacetylation • regulation of lipid metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23309	n/a
Ensembl	ENSG00000127511	n/a
UniProt	O75182	n/a
RefSeq (mRNA)	NM_001297595 NM_001297597 NM_015260	n/a
RefSeq (protein)	NP_001284524 NP_001284526 NP_056075	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SIN3B yw SIN3B a elwir hefyd yn SIN3 transcription regulator family member B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.11.

Llyfryddiaeth

• "Sin3B expression is required for cellular senescence and is up-regulated upon oncogenic stress. ". Cancer Res. 2009. PMID 19654306.
• "The human SIN3B corepressor forms a nucleolar complex with leukemia-associated ETO homologues. ". BMC Mol Biol. 2008. PMID 18205948.
• "pH might play a role in regulating the function of paired amphipathic helices domains of human Sin3B by altering structure and thermodynamic stability. ". Biochemistry (Mosc). 2015. PMID 25869359.
• "Stress-mediated Sin3B activation leads to negative regulation of subset of p53 target genes. ". Biosci Rep. 2015. PMID 26181367.
• "Sin3B mediates collagen type I gene repression by interferon gamma in vascular smooth muscle cells.". Biochem Biophys Res Commun. 2014. PMID 24709079.