Restraining the V(D)J recombinase (Q35219034)

7 August 2017

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title

Restraining the V(D)J recombinase (English)

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7 August 2017

David B Roth

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7 August 2017

language of work or name

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1 August 2003

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Nature Reviews Immunology

7 August 2017

published in

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

656-666

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Lymphoid malignancies: the dark side of B-cell differentiation

7 August 2017

cites work

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Unequal access: regulating V(D)J recombination through chromatin remodeling

31 March 2020

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The mechanism and regulation of chromosomal V(D)J recombination

31 March 2020

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The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

31 March 2020

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V(D)J recombination: a functional definition of the joining signals

31 March 2020

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RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

31 March 2020

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Stimulation of V(D)J cleavage by high mobility group proteins

31 March 2020

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Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination

31 March 2020

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Definition of a core region of RAG-2 that is functional in V(D)J recombination

31 March 2020

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Expression and V(D)J recombination activity of mutated RAG-1 proteins

31 March 2020

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Analysis of regions of RAG-2 important for V(D)J recombination

31 March 2020

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Regions of RAG1 protein critical for V(D)J recombination

31 March 2020

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V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

31 March 2020

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Characterization of broken DNA molecules associated with V(D)J recombination

31 March 2020

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Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated

31 March 2020

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Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

31 March 2020

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The RAG proteins in V(D)J recombination: more than just a nuclease

31 March 2020

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V(D)J recombination: RAG proteins, repair factors, and regulation

31 March 2020

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31 March 2020

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VDJ recombination: a transposase goes to work

31 March 2020

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Tn10 transposition via a DNA hairpin intermediate

31 March 2020

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Three-dimensional structure of the Tn5 synaptic complex transposition intermediate

31 March 2020

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Transposition of maize Ac/Ds transposable elements in the yeast Saccharomyces cerevisiae

31 March 2020

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Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage

31 March 2020

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The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

31 March 2020

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The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoire

31 March 2020

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The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo

31 March 2020

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Initiation of V(D)J recombination in vitro obeying the 12/23 rule

31 March 2020

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Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.

31 March 2020

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Cutting edge: targeting of V beta to D beta rearrangement by RSSs can be mediated by the V(D)J recombinase in the absence of additional lymphoid-specific factors.

31 March 2020

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Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells.

31 March 2020

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Novel strand exchanges in V(D)J recombination

31 March 2020

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Unusual immunoglobulin gene rearrangement leads to replacement of recombinational signal sequences

31 March 2020

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V(D)J Recombination in Ku86-Deficient Mice: Distinct Effects on Coding, Signal, and Hybrid Joint Formation

31 March 2020

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Inversions produced during V(D)J rearrangement at IgH, the immunoglobulin heavy-chain locus

31 March 2020

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How to make ends meet in V(D)J recombination

31 March 2020

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Nonhomologous end joining and V(D)J recombination require an additional factor

31 March 2020

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Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

31 March 2020

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Association of terminal deoxynucleotidyl transferase with Ku

31 March 2020

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Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferase

31 March 2020

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Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

31 March 2020

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The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase

31 March 2020

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Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

31 March 2020

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Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair

31 March 2020

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Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

31 March 2020

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Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

31 March 2020

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DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity

31 March 2020

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Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination

31 March 2020

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Joining-deficient RAG1 mutants block V(D)J recombination in vivo and hairpin opening in vitro

31 March 2020

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Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase

31 March 2020

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Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

31 March 2020

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Hairpin coding end opening is mediated by RAG1 and RAG2 proteins

31 March 2020

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DNA hairpin opening mediated by the RAG1 and RAG2 proteins

31 March 2020

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The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

31 March 2020

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VDJ recombination: Artemis and its in vivo role in hairpin opening

31 March 2020

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The RAG1 N-terminal domain is an E3 ubiquitin ligase

31 March 2020

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Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

31 March 2020

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Mechanisms of chromosomal translocations in B cell lymphomas

31 March 2020

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Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes

31 March 2020

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Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells

31 March 2020

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T cell receptor gene trans-rearrangements: chimeric gamma-delta genes in normal lymphoid tissues

31 March 2020

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Assessing the pathogenic potential of the V(D)J recombinase by interlocus immunoglobulin light-chain gene rearrangement

31 March 2020

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Hybrid T cell receptor genes formed by interlocus recombination in normal and ataxia-telangiectasis lymphocytes

31 March 2020

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Initiation of V(D)J recombination in vivo: role of recombination signal sequences in formation of single and paired double-strand breaks

31 March 2020

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Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners

31 March 2020

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Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products

31 March 2020

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V(D)J recombination intermediates and non-standard products in XRCC4-deficient cells

31 March 2020

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Rejoining of DNA by the RAG1 and RAG2 proteins

31 March 2020

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Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

31 March 2020

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DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

31 March 2020

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New insights into V(D)J recombination and its role in the evolution of the immune system

31 March 2020

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In vivo transposition mediated by V(D)J recombinase in human T lymphocytes

31 March 2020

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Targeted transposition by the V(D)J recombinase

31 March 2020

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Restrictions limiting the generation of DNA double strand breaks during chromosomal V(D)J recombination

31 March 2020

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Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development

31 March 2020

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Atm-deficient mice: a paradigm of ataxia telangiectasia

31 March 2020

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Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

31 March 2020

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Sensing of intermediates in V(D)J recombination by ATM.

31 March 2020

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Intermolecular V(D)J recombination is prohibited specifically at the joining step

31 March 2020

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Intermolecular V(D)J recombination

31 March 2020

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Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining

31 March 2020

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Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

31 March 2020

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The importance of repairing stalled replication forks

31 March 2020

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DNA double strand break repair and chromosomal translocation: lessons from animal models

31 March 2020

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Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

31 March 2020

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Sensing and repairing DNA double-strand breaks

31 March 2020

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The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

31 March 2020

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DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus

31 March 2020

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Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

31 March 2020

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Ku70: a candidate tumor suppressor gene for murine T cell lymphoma

31 March 2020

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DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

31 March 2020

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Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

31 March 2020

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Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis

31 March 2020

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The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice.

31 March 2020

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Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions

31 March 2020

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Irradiation promotes V(D)J joining and RAG-dependent neoplastic transformation in SCID T-cell precursors

31 March 2020

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Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents

31 March 2020

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Somatic Cells Efficiently Join Unrelated DNA Segments End-to-End

31 March 2020

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Mechanisms of nonhomologous recombination in mammalian cells

31 March 2020

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Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction

31 March 2020

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Double-strand break repair in Ku86- and XRCC4-deficient cells

31 March 2020

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DNA end-joining catalyzed by human cell-free extracts

31 March 2020

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Amplifying mechanisms of lymphomagenesis

31 March 2020

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Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells

31 March 2020

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RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

31 March 2020

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Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

31 March 2020

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Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends.

31 March 2020

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Cell-free V(D)J recombination

31 March 2020

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A recombinase diversified: new functions of the RAG proteins

31 March 2020

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Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination

31 March 2020

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The V(D)J recombinase efficiently cleaves and transposes signal joints

31 March 2020

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Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination

31 March 2020

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Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL.

31 March 2020

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RAG1/2-mediated resolution of transposition intermediates: two pathways and possible consequences

31 March 2020

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Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs.

31 March 2020

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The C-terminal portion of RAG2 protects against transposition in vitro

31 March 2020

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Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2

31 March 2020

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T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells

31 March 2020

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Single active site catalysis of the successive phosphoryl transfer steps by DNA transposases: insights from phosphorothioate stereoselectivity

31 March 2020

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inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NRI1152

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Dimensions Publication ID

7 August 2017

1036460478

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