Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2 (Q34985886)

5 August 2017

title

Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2 (English)

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5 August 2017

Chia-Lun Tsai

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5 August 2017

David G Schatz

series ordinal

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5 August 2017

language of work or name

English

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publication date

1 April 2003

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5 August 2017

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

1922-1930

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The C-terminal portion of RAG2 protects against transposition in vitro

5 August 2017

cites work

1 reference

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The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development

8 July 2018

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Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination

8 July 2018

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Ordered assembly of the V(D)J synaptic complex ensures accurate recombination

8 July 2018

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V(D)J recombination: RAG proteins, repair factors, and regulation

8 July 2018

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Sensing of intermediates in V(D)J recombination by ATM.

8 July 2018

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Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs.

8 July 2018

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Tn7: smarter than we thought

8 July 2018

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RAG transposase can capture and commit to target DNA before or after donor cleavage

8 July 2018

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How to make ends meet in V(D)J recombination

8 July 2018

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The RAG proteins and V(D)J recombination: complexes, ends, and transposition

8 July 2018

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Definition of minimal domains of interaction within the recombination-activating genes 1 and 2 recombinase complex

8 July 2018

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GTP binding and signaling by Gh/transglutaminase II involves distinct residues in a unique GTP-binding pocket

8 July 2018

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Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination

8 July 2018

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An ATP-ADP switch in MuB controls progression of the Mu transposition pathway

8 July 2018

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DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

8 July 2018

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Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

8 July 2018

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Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly

8 July 2018

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Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

8 July 2018

1 reference

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Transposable element-host interactions: regulation of insertion and excision

8 July 2018

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Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS.

8 July 2018

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Identification of V(D)J recombination coding end intermediates in normal thymocytes

8 July 2018

1 reference

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RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

8 July 2018

1 reference

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Tn10 and IS10 transposition and chromosome rearrangements: mechanism and regulation in vivo and in vitro.

8 July 2018

1 reference

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Definition of a core region of RAG-2 that is functional in V(D)J recombination

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=154477

Gh: a GTP-binding protein with transglutaminase activity and receptor signaling function

8 July 2018

1 reference

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Physiological concentrations of purines and pyrimidines

8 July 2018

1 reference

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New insights into V(D)J recombination and its role in the evolution of the immune system

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=154477

Formation and resolution of double-strand break intermediates in V(D)J rearrangement

8 July 2018

1 reference

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The V(D)J recombination activating gene, RAG-1.

8 July 2018

1 reference

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RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

8 July 2018

1 reference

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The P-loop--a common motif in ATP- and GTP-binding proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=154477

P element transposition in vitro proceeds by a cut-and-paste mechanism and uses GTP as a cofactor.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=154477

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

8 July 2018

1 reference

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Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=154477

Rejoining of DNA by the RAG1 and RAG2 proteins

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=154477

The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=154477

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=154477

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=154477

RAG1/2-mediated resolution of transposition intermediates: two pathways and possible consequences

26 October 2018

1 reference

12 December 2020

The V(D)J recombinase efficiently cleaves and transposes signal joints

1 reference

12 December 2020

V(D)J recombination in mouse thymocytes: Double-strand breaks near T cell receptor δ rearrangement signals

1 reference

12 December 2020

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated

1 reference

12 December 2020

Coding Joint Formation in a Cell-Free V(D)J Recombination System

1 reference

12 December 2020

VDJ recombination: a transposase goes to work

1 reference

12 December 2020

Mobile DNA elements: controlling transposition with ATP-dependent molecular switches

1 reference

12 December 2020

A zinc-binding domain involved in the dimerization of RAG1

1 reference

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/CDG185

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5 August 2017

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5 August 2017

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