Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging (Q24646862)

object named as

Hanna K Sanoff

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author name string

Yan Liu

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Hyunsoon Cho

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Christin E Burd

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Chad Torrice

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Nancy E Thomas

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Norman E Sharpless

INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis

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language of work or name

English

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publication date

August 2009

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439-48

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cites work

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Ink4a/Arf expression is a biomarker of aging

7 April 2017

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7 April 2017

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A common variant on chromosome 9p21 affects the risk of myocardial infarction

7 April 2017

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Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

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Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.

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Cellular senescence in pretransplant renal biopsies predicts postoperative organ function.

27 September 2017

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Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf.

27 September 2017

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Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

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Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21.

27 September 2017

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Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p.

27 September 2017

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27 September 2017

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27 September 2017

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A common variant of the p16(INK4a) genetic region is associated with physical function in older people

27 September 2017

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Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF.

27 September 2017

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Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program

27 September 2017

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27 September 2017

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pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.

27 September 2017

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The regulation of INK4/ARF in cancer and aging

27 September 2017

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p16INK4a induces an age-dependent decline in islet regenerative potential

27 September 2017

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Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets

27 September 2017

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Cancer and ageing: rival demons?

27 September 2017

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27 September 2017

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Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty

27 September 2017

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Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood.

27 September 2017

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Role of the alternative INK4A proteins in human keratinocyte senescence: evidence for the specific inactivation of p16INK4A upon immortalization

27 September 2017

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The rate of telomere sequence loss in human leukocytes varies with age.

27 September 2017

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Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes

27 September 2017

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Telomere Shortening Is Associated with Cell Division in Vitro and in Vivo

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27 September 2017

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The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes.

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Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantation

21 January 2018

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The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

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28 November 2018

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Cellular senescence in aging primates.

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Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney

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Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age

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PubMed

https://pubmed.ncbi.nlm.nih.gov/19485966

12 December 2020

inferred from PubMed ID database lookup

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19485966

12 December 2020

inferred from PubMed ID database lookup

Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19485966

12 December 2020

inferred from PubMed ID database lookup

Estimating the Dimension of a Model

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Crossref

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2009.00489.X

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1111/J.1474-9726.2009.00489.X

1 reference

1 reference

1 reference

PubMed publication ID

19485966

1 reference