Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes (Q28680760)

Andrew T Hattersley

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Alexander S Doney

Alex S F Doney

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Andrew D Morris

Andrew D Morris

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Andrew P Morris

Andrew P Morris

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author name string

Katherine S Elliott

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John R B Perry

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Nigel W Rayner

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Beverley Shields

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Christopher J Groves

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Lorna W Harries

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Jonathan L Marchini

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Katharine R Owen

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Beatrice Knight

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Lon R Cardon

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Mark Walker

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Graham A Hitman

on focus list of Wikimedia project

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language of work or name

English

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publication date

1 June 2007

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published in

Science

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volume

316

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issue

5829

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page(s)

1336-41

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ScienceSource

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cites work

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The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

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Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

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Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1

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Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

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