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Don’t forget these
7 Endocrine Med
4
eS Levothyroxine
e Endocrine
Y, INDICATIONS
* Hypothyroidism
* Myxedema coma
" KEY SIDE EFFECTS
* Palpitation & Tachycardia
* Weight reduction
* Heat intolerance
Ly REMEMBER
* Full therapeutic effect can only see
* after around 6 weeks
What is the difference of T4 and T3
hormone? Pioglitazone
€ Endocrine
Qa INDICATIONS
* Type 2 Diabetes
* Nonalcoholic steatohepatitis
(" KEY SIDE EFFECTS
* Weight gain
* Chronic heart failure
* Peripheral edema
Ly REMEMBER
* This medicine is rarely used due to unfavorable
benefit-to-risk profile
Do you know the boxed warning of
Pioglitazone? Metformin
e Endocrine
Qa INDICATIONS
* Type 2 Diabetes (T2DM)
* Polycystic ovary syndrome
(") KEY SIDE EFFECTS
* Weight loss
* Vitamin B12 deficiency (long-term use)
* Lactic acidosis
Vy REMEMBER
* Temporarily discontinue Metformin for 48
hours before injecting iodinated contrast
9 Why it is contraindicated in severe
LJ renal impairment? Hydrocortisone
e Endocrine
Yn, INDICATIONS
* Adrenal insufficiency
* Anti-inflammatory agent
" KEY SIDE EFFECTS
* Cushingoid features, like moon face
* Osteoporosis
* Gastrointestinal ulcer
Ly REMEMBER
+ After long term use, steroids will cause HPA
suppression and require tapering
Can you name one more side effect
for steroid? Dapagliflozin
e Endocrine
Qa INDICATIONS a
* Type 2 Diabetes en
* (esp in pts with risk in ASCVD)
(") KEY SIDE EFFECTS
* Urinary tract infection
* Acute kidney injury
* Risk of bone fractures
Ly REMEMBER
* Cannot use in severe renal failure (eGFR <30)
9 Why this medicine is not effective in
LA renal failure pts? Oxytocin
e Endocrine
Ya INDICATIONS
* Induction of labor
* Postpartum uterine bleeding
" KEY SIDE EFFECTS
* Cardiac arrhythmia
* Postpartum hemorrhage
* Water intoxication
Ly REMEMBER
* In some conditions, such as partial placenta
previa, do not use oxytocin
1?) What is partial placenta previa? Insulin
Cp Endocrine
Qn INDICATIONS
* Diabetes mellitus (11 & T2)
* Diabetic ketoacidosis (DKA)
(") KEY SIDE EFFECTS
* Hypoglycemia (hypo)
* Hypokalemia
* Lipodystrophy
Ly REMEMBER
* Classified by duration of action as rapid, short,
intermediate, long-acting.
9 Can you name the longest-acting
LJ insulin?
