CRISPR-Cas9 Genome Editing: Md. Qamrul Islam
CRISPR-Cas9 Genome Editing: Md. Qamrul Islam
CRISPR-Cas9 Genome Editing: Md. Qamrul Islam
• Deleted
• Replaced
01
Advancements in Genome Editing
1989 1998 2009
HR mediated ZFNs TALENs
targeting
03
Discovery of CRISPR
• Osaka University researcher Yoshizumi Ishino in
1987.
ENEMIES
FIGHTING FOR
EXISTANCE
04
Components of CRISPR Locus
A CRISPR Locus
Spacers
A CRISPR Array
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Components of CRISPR-Cas9
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Natural Microbial CRISPR System
Phage infection
Spacer Acquisition
4 Steps
crRNA Biogenesis and
Processing
Target Degradation
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Natural Microbial CRISPR System
4. Target Degradation
14
Future Prospects
Ecological Gene therapy Screen for drug
vector control target ID
Pathogen gene
Pathway engineering Crops, animals
disruption
15
Conclusion
• Medical applications
• Crop editing
• Gene drives
• Synthetic biology
• Further investigation
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Thank you
17