#=GF ID CoV_S1
#=GF AC PF01600.21
#=GF DE Coronavirus spike glycoprotein S1
#=GF PI Corona_S1;
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Williams LS;0000-0001-5551-8526
#=GF SE Bateman A
#=GF GA 25.00 25.00;
#=GF TC 46.10 46.10;
#=GF NC 24.90 24.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 81514348 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 26085157
#=GF RT Identification of the Receptor-Binding Domain of the Spike
#=GF RT Glycoprotein of Human Betacoronavirus HKU1.
#=GF RA Qian Z, Ou X, Goes LG, Osborne C, Castano A, Holmes KV,
#=GF RA Dominguez SR;
#=GF RL J Virol. 2015;89:8816-8827.
#=GF RN [2]
#=GF RM 19906932
#=GF RT Recombination, reservoirs, and the modular spike: mechanisms of
#=GF RT coronavirus cross-species transmission.
#=GF RA Graham RL, Baric RS;
#=GF RL J Virol. 2010;84:3134-3146.
#=GF RN [3]
#=GF RM 14647384
#=GF RT Angiotensin-converting enzyme 2 is a functional receptor for the
#=GF RT SARS coronavirus.
#=GF RA Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA,
#=GF RA Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H,
#=GF RA Farzan M;
#=GF RL Nature. 2003;426:450-454.
#=GF RN [4]
#=GF RM 14670965
#=GF RT A 193-amino acid fragment of the SARS coronavirus S protein
#=GF RT efficiently binds angiotensin-converting enzyme 2.
#=GF RA Wong SK, Li W, Moore MJ, Choe H, Farzan M;
#=GF RL J Biol Chem. 2004;279:3197-3201.
#=GF DR INTERPRO; IPR002551;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family represents the spike glycoprotein (S) of
#=GF CC coronaviruses. The spike protein is arranged in trimers on the
#=GF CC surface of the viral membrane and is essential for viral entry.
#=GF CC The spike protein is translated as a large polypeptide that is
#=GF CC subsequently cleaved to the distal S1, responsible for receptor
#=GF CC binding, and the membrane-anchored S2 responsible for membrane
#=GF CC fusion [1]. The coronavirus (SARS-CoV) S1 subunit is composed
#=GF CC of two distinct domains: an N-terminal domain (S1 NTD) and a
#=GF CC receptor-binding domain (S1 RBD) also referred to as the S1 CTD
#=GF CC or domain B. Each of these domains have been implicated in
#=GF CC binding to host receptors. However, most coronaviruses are not
#=GF CC known to utilise both the S1 NTD and S1 RBD for viral entry
#=GF CC [2]. This entry contains spike protein from both alpha and
#=GF CC gamma coronaviruses but excludes the spike protein from
#=GF CC beta-coronaviruses such as SARS-CoV.
#=GF SQ 37
#=GS G1FEY6_9ALPC/266-687 AC G1FEY6.1
#=GS B1PHJ5_9ALPC/221-631 AC B1PHJ5.1
#=GS B6VDW0_9NIDO/47-422 AC B6VDW0.1
#=GS SPIKE_CVPPU/248-668 AC P07946.2
#=GS V5TFD8_BWCOV/445-693 AC V5TFD8.1
#=GS D9J204_9ALPC/237-647 AC D9J204.1
#=GS C6GHB7_9ALPC/267-686 AC C6GHB7.1
#=GS C6GHB7_9ALPC/267-686 DR PDB; 6JX7 B; 267-686;
#=GS C6GHB7_9ALPC/267-686 DR PDB; 6JX7 C; 267-686;
#=GS C6GHB7_9ALPC/267-686 DR PDB; 6JX7 A; 267-686;
#=GS A0A0U1UYV9_9ALPC/218-633 AC A0A0U1UYV9.1
#=GS A0A0U1WJW2_9ALPC/237-631 AC A0A0U1WJW2.1
#=GS H9TEX4_9ALPC/251-675 AC H9TEX4.1
#=GS K4JZP8_9ALPC/219-610 AC K4JZP8.1
#=GS B6VDX8_THCOV/50-450 AC B6VDX8.1
#=GS A0A172AZS6_9ALPC/239-650 AC A0A172AZS6.1
#=GS SPIKE_BC512/225-632 AC Q0Q466.1
#=GS A0A0U1UZD0_9ALPC/190-596 AC A0A0U1UZD0.1
#=GS B6VDY7_9NIDO/49-415 AC B6VDY7.1
#=GS A0A0U1WHB7_9ALPC/222-632 AC A0A0U1WHB7.1
#=GS SPIKE_CVH22/26-430 AC P15423.1
#=GS SPIKE_CVH22/26-430 DR PDB; 7VN9 C; 297-430;
#=GS SPIKE_CVH22/26-430 DR PDB; 7CYC C; 48-430;
#=GS SPIKE_CVH22/26-430 DR PDB; 7VNG D; 299-430;
#=GS SPIKE_CVH22/26-430 DR PDB; 6ATK E; 298-430;
#=GS SPIKE_CVH22/26-430 DR PDB; 7CYC A; 48-430;
#=GS SPIKE_CVH22/26-430 DR PDB; 7VN9 E; 296-430;
#=GS SPIKE_CVH22/26-430 DR PDB; 6U7H A; 37-430;
#=GS SPIKE_CVH22/26-430 DR PDB; 7CYD B; 48-430;
#=GS SPIKE_CVH22/26-430 DR PDB; 7CYD C; 48-430;
#=GS SPIKE_CVH22/26-430 DR PDB; 6ATK D; 305-412;
#=GS SPIKE_CVH22/26-430 DR PDB; 7CYD A; 48-430;
#=GS SPIKE_CVH22/26-430 DR PDB; 6U7H C; 37-430;
#=GS SPIKE_CVH22/26-430 DR PDB; 7CYC B; 48-430;
#=GS SPIKE_CVH22/26-430 DR PDB; 6ATK F; 310-320;
#=GS SPIKE_CVH22/26-430 DR PDB; 6U7H B; 37-430;
#=GS H9BR00_9NIDO/40-461 AC H9BR00.1
#=GS B0LJR1_9ALPC/265-686 AC B0LJR1.1
#=GS A0A0U1UZ37_9ALPC/122-516 AC A0A0U1UZ37.1
#=GS SPIKE_CVHNL/204-611 AC Q6Q1S2.1
#=GS SPIKE_CVHNL/204-611 DR PDB; 5SZS A; 204-611;
#=GS SPIKE_CVHNL/204-611 DR PDB; 3KBH F; 482-602;
#=GS SPIKE_CVHNL/204-611 DR PDB; 3KBH E; 482-602;
#=GS SPIKE_CVHNL/204-611 DR PDB; 3KBH G; 482-602;
#=GS SPIKE_CVHNL/204-611 DR PDB; 5SZS B; 204-611;
#=GS SPIKE_CVHNL/204-611 DR PDB; 3KBH H; 482-602;
#=GS SPIKE_CVHNL/204-611 DR PDB; 7FC3 E; 481-611;
#=GS SPIKE_CVHNL/204-611 DR PDB; 5SZS C; 204-611;
#=GS B2BW33_BWCOV/430-672 AC B2BW33.1
#=GS A0A0E3N634_9NIDO/45-419 AC A0A0E3N634.1
#=GS A0A1L2KGB2_9ALPC/215-623 AC A0A1L2KGB2.1
#=GS A0A0U1WHD9_9ALPC/218-633 AC A0A0U1WHD9.1
#=GS H9BR35_9NIDO/53-470 AC H9BR35.1
#=GS A0A0U1WHB3_9ALPC/221-631 AC A0A0U1WHB3.1
#=GS SPIKE_FIPV/249-673 AC P10033.1
#=GS S0AP48_9ALPC/227-633 AC S0AP48.1
#=GS E3W5J0_9ALPC/268-686 AC E3W5J0.1
#=GS H9BR17_9NIDO/51-466 AC H9BR17.1
#=GS S5YNL4_9ALPC/219-623 AC S5YNL4.1
#=GS H9BR25_9NIDO/40-467 AC H9BR25.1
#=GS E3W5F7_9ALPC/267-688 AC E3W5F7.1
#=GS B1PHK2_9ALPC/232-640 AC B1PHK2.1
#=GS A0A0U1WHD7_9ALPC/215-642 AC A0A0U1WHD7.1
G1FEY6_9ALPC/266-687 .............................................dechss----.-...YCAGYAKNVFVP-LDGKIPE.SFSFSNWFLLSDKSTLVQGRVLSRQPVFVQ...C..LRPVP.....TWSNNTAVV...HFTNDP...---...---............-FCP..NVTADVLRFNLNFSDTDVYT..ASTndDQLHFTFEDNTTASIACYSSANVTDNQpnnnsaSHIPFGKTAH.SYFCFANF.........-SHSVVSRQFLGILPPTVREFAFGKDGSIFINGYKYFSLPPIKSVNFSISSVE....QYGFWTIAYTNYTDVMVDVNGTGITRLFYCD..SPLNRIKCQQLKHELPDGFYSAS..MLVKKNLPKTF.VTMPQFYNWMNVTLHVVLND.....TEKRad.iilAKAPELASLADIHFEIAQANGSvt..nvtSICVQAKQVAL.FYKYTSR....................QGLYTYSnlVEL..QNYDCPFSPQQFNNYLQFETLCFDTS.PAVAGCKWSLVhDVKWRTQFAT--.-...ITVSYKDGSMITTMPK.........................
B1PHJ5_9ALPC/221-631 ...................................................YSVC.D...DCDGFPKYVFAVTEGGEVPP.NFRLDNWFYLTNSSTPISGMFTSVQPFNLS...C..VWTVP.....VLTNNSLPV...YFNMSM..nENV...TCN............GYSNfdVGVVDAMRFSLNFTDNQ--I..IRK..GVISVFTSTNV-YNFSCTNNSVLDGDA......-VIPFGDVAQ.THYCFIKYf......tnITSGESVSQFVGILPPQVKEFVIMRNGDFHLNGYRIFSVDRVESAIFNISTND....GRDFWTVAFANNAEVLTEINATSIQNLLYCN..NPVNSIKCQQLRFNLDDGFYSHT..FDSADNLPRTI.VRLPKYVTHSYINVTVGVNF.....ENGT......-LTNYLVDFAPDGTSIGKDNIT.......TVCVDTTTFTT.RLNVLAF....................-SAFSTA..VDI..QAGTCLFSYNNLNNYLGLVSLCFSTK.P-NGGCMMSVV.ARGYFGEFQKVG.V...LYVSFTKGDNVLGVP-p........................
B6VDW0_9NIDO/47-422 .......................................srvnsnylrdtr----.-...---------LTSLKHGYLTE.DFHI--FSPLSNSTIPISGLLRSYQPLYLA...C..YVQIT.....N---TTLSM...FLEPSTt.fDTA...GCT............GSKY..-QTHDALRLILDLNEESSA-..---..-SINITTTKNILYIFVCSDSQDFSRAH......NSPLLKSRNA.QLYCFINN.........--------TYIGPLPANLTDFTIYHTGQLYANGYYLGVLPDTVKQVRLIQSSI....PSNYTFFALANLTDTLITLSNTTITNVTYCD.rSTLDMLACQISKHYVDDGFYSDP..QKTSLALPRTI.VTLPKVAELEMVNLTINARY.....SAGE......---------ASATININGN--D.......TFCVTKPYFHI.NAKYTCS....................----DCV..LNL..RTDTCSFDINAINNGMSFSQFCLSTK.--SGSCSITLVaTKYWNYQIAQ--.K...LYVTAIEGQTSTGTT-a........................
SPIKE_CVPPU/248-668 .................................................vs--NCtD...QCASYVANVFTTQPGGFIPS.DFSFNNWFLLTNSSTLVSGKLVTKQPLLVN...C..LWPVP.....SFEEAASTF...CFEGAG...-FD...QCN............GAVL..NNTVDVIRFNLNFTTNVQSG..KGA..TVFSLNTTGGVTLEISCYTVSDSSFFS.....yGEIPFGVTDG.PRYCYVHY.........---NGTALKYLGTLPPSVKEIAISKWGHFYINGYNFFSTFPIDCISFNLTTGD....SDVFWTIAYTSYTEALVQVENTAITKVTYCN..SHVNNIKCSQITANLNNGFYPVS..SSEVGLVNKSV.VLLPSFYTHTIVNITIGLGM.....KRSG......YGQPIASTLSNITLPMQDHNTD.......VYCIRSDQFSV.YVHSTCKsalwdn........ifkrncTDVLDAT..AVI..KTGTCPFSFDKLNNYLTFNKFCLSLS.PVGANCKFDVAaRTRTNEQVVR--.S...LYVIYEEGDNIVGVP-s........................
V5TFD8_BWCOV/445-693 lkrvmsvplsmirdviidvkkrvlsidgfpvgsllsdfefrfsilamndty----.-...--------------------.------------------------------...-..-----.....---------...------...---...---............----..--------------------..---..---------------------------......----------.--------.........-----------------------------------------------------....------LAGLKYTTALITFDKGNVRNVIDCNsnSVFDKLRCDLQTDVMSDGFYPVN.iKTNEAEENATF.IDV--ESTLANLSLEVFVSS.....PSHS......-PACLLKSYKCVDTRYFYLQNY......tYSCADNGISND.AAGSAYCegr..............mdtFNKFGVN..GLD..FRGKCPFSASKVNTGLTFDKICFGVY.--EQGCQADKV.------------.-...----------------cnfgfyfddvvfnqygnkvyykr..
D9J204_9ALPC/237-647 ..................................................v-QNC.T..gNCEEYANNIFSTEPGGIIPE.GFSFNNWFVLTNDSTVLDGRFLTRQPLLVN...C..LWPVP.....SFSEISQEF...CFASAD...-FT...QCN............GYKL..NSTADVIRFNLNFTHETAAA..SGT..TFFELNTTGGVVLYISCYNQSRTEAQVs....eGFVPFGNHEG.SLYCYVSY.........---NETLQKFLGVLPPSVKEIAISKDGGFYINGYNYFQTFPIDCISFNLTTGN....TGAFWTIAYTSYTDVMVDVENTAIKRVIYCN..SHINDIRCNQLTPSLPDGFYPVS..PKAIGFINKTF.VTLPANFDHVYVNITGNVNL.....KAER......-GRPYNNG-GNATLSFQG----.......--CIAVSQFTV.NLNHTCTitna...........gssgcTNAYEAN..VYM..TSGSCPFAFDRLNNHMSFSKLCFSTV.PLGDDCRLDLTvQTRYFTGVFA--.H...VYVSYKFGLDIVGLP-t........................
C6GHB7_9ALPC/267-686 ..............................................techt----.D...YCAGYAKNVFV-PIDGKIPE.GFSFSNWFLLTDKSTLVQGRVLSSQPVFVQ...C..LRPVP.....TWSNNTAVV...HFKNDV...---...---............-FCP..NVTADVLRFNLNFSDTDVYTdsTTD..DQLHFTFEDNTTASITCYSSANVTDNQpasgsiSHTPF--VSN.SYLCFANF.........-SHSSVSRQFLGILPPTVREFAFGRDGSIFVNGYKYFSLQPIKSVNFSISSVE....NYGFWTIAYTNYTDVMVDVNGTVITRLFYCD..SPLNRIKCQQLKHELPDGFYSAS..MLVKKDLPKTF.VTMPQFYNWMNVTLHVVLND.....IEKKad.iilAGAPELASLADIHFEIAQANGSvv..nvtSVCVQARQLAL.FYKYTSL....................QGLYTYSnlVQL..QNYDCPFSPQQFNNYLQFETLCFDVS.PAVAGCKWSLVhDVKWRTQFAT--.-...ITVSYKDGAMITTMPK.........................
#=GR C6GHB7_9ALPC/267-686 SS ..............................................-B-SS----.S...S-TT--TT-----SSS---S.S---SS----BSS-B--EEEEEEEEEEEEE...E..EE--B.....SSS---EEE...ESBS-S...---...---............-SSS..S-B-SEE--B-------B---SS--..-SEEEEETTS-EEE-EE--------------------------.-EEEEE--.........-SSS----EEEEEE-S---BEEEESSS-EEETTEEEE----EEEEEE----S-....-SSB-BEEEEEEEEEEEEEESSSEEEEEE--..SHHHHHHHHHT-SS--SEEEEE-..----S---EEE.E-------B--EEEEEEE--.....SSSSS-.GGG--HHHHHHT--EEEEEE-SSSSEE..EES--B--SSEE-E.EEEEEES....................SS--STTS--EE..EESSSSS-GGGTTSS-EEEEEEE-SS.S-S-SEEEEEES-SSS--B-----.-...EEEEEEEEEEEEE-SS.........................
A0A0U1UYV9_9ALPC/218-633 ...................................................YSIC.K...NCSGFPDHVFAVGQDGTIPP.SFGFENWFYLTNSSSPVSGRFSSSQPLQLF...C..LWPIP.....SLLGNTLPV...YFNMSK...NNA...NCN............GFKA..DGVVGSLRFALNFSDER-AF..ARE..GVISLETVGNT-YNFTCTNSSTPSDDS.....sFVLPFGVTDQ.AYYCFMTFy......lnRTADLKTTVFAGMLPPIVREFVVMRNGDFYLNGFRVFSVGQVVSARFNISSND....SRDFWTVAFANNAPVLVDINSTNIQRLLYCN..SPLNIIKCQQLRFNLDNGFYSYA..PETANNLPRSF.VRLPKYMTHSVINVSVAVSY.....DVVNkt..niGLYAWRVSFADHWLGFDRDNRT.......AVCADTASFSV.KLIKGSF....................-SYGDVY..VDI..WSGECPFSFAALNNYLSFGSICFSLV.P-NGGCAMSIV.TRGSYGEPQKFA.A...LYVSFSEGDNVIGVPK.........................
A0A0U1WJW2_9ALPC/237-631 ...................................................YSVC.K...DCNGFPQHVFPVLDGGKIPG.DFSFDNWFLLTNSSTIVNGKIVDIQPLKLL...C..LWPVP.....ALVANDNKI...YFNITG...--A...NCN............GFKD.eNAYADVLRFSLNFTNSQ-VF..NGI..HSVTVNVVGGD-LKFSCSNTSTYAESD......EVLPFGPLSS.VYYCFVNG.........KLGNDTFSRFVGILPPVVKEIVISRYGSFYMNGVKLFEVPYVESVVFNVTSSV....GSDFWTVAYAQNTEVLLEVNSTDIKDILYCD..TPANKLKCQQLSFSLEDGFYPAA..LVTGVEVPRTY.VALPYHATHMFVNLTVHLGN.....SVDA......----------DAYVQINGVN-D.......TVCVNTTQFST.HFQQLDT....................--SNTIS..ALM..QNGDCPFNFDSLNNFLSFDSICFNLQ.PVGSSCTISIM.-KNWMGFKAPWK.S...VYVTFKRGNRITGVK-n........................
H9TEX4_9ALPC/251-675 ...........................................yefcedye----.-...YCTATATNVFAPTVGGYIPD.GFSFNNWFLLTNSSTFVSGRFVTNQPLLVN...C..LWPVP.....SFGVAAQEF...CFEGAQ...-FS...QCN............GMSL..NNTVDVIRFNLNFTADVQSG..MGA..TVFSLNTTGGVILEISCYKDTVSESSFy...syGEIPFGITDG.PRYCYVLY.........---NGTALKYLGTLPPSVKEIAISKWGHFYINGYNFFSTFPIDCISFNLTTGA....SGAFWTIAYTSYTEALVQVENTAIKKVTYCN..SHINNIKCSQLTANLNNGFYPVA..SSEVGLVNKSV.VLLPTFFAHTAFNITIDLGM.....KRSG......YGQPIASTLSNITLPMQDNNTD.......VYCVRSNQFSV.YVHSTCKssswdn........ifnqdcTDVLEAT..AVI..KTGTCPFSFDKLNNYLTFNKFCLSLS.PVGANCKFDVAaHTRTNEQVVR--.S...LYVIYEEGDNIVGVP-s........................
K4JZP8_9ALPC/219-610 ...................................................YSVC.T...ECDGFPKHVFPVLDDGKIPG.DFSFSNWFVLTNSSTVLQGRIVTVQPLKLL...C..LWPVP.....SLNANDKPV...YFNLSL..nSDV...RCN............GHSI..AGYAQALRFSLNFTANQ-VL..NGV..HSIKLFSSNQN-FTFTCSTNGTLE---......-RIPFGRVES.VYKCFVRI.........DAINSTKNLFVGILPPVTKEFVISRYGAVYINGVHIMSLPPLESVIFNVTSSV....GSDFWTVAFADEAEVLLDLNATNIVDILYCD..TLVNKIKCQNLAFSLEDGFYATS..NLIERDIPRSF.ITLPYHVTHSVVGLDVRIYY.....ENEA......----------ASNLTLSPSD--.......PVCVDSSQFST.YFNVTA-....................-DTNGFN..ARI..INVDCPFTFDKLNNYISFESICFSLE.PFAGGCSMRIE.--SFFSSYVRTVgS...LYILFKNGNKITGVT-e........................
B6VDX8_THCOV/50-450 ............................................eepksdg----.-...--------------KGHFTQ.--NVHRFAFLTNGSSPVDQIIRTTQPLLLR...CpqWFGYN.....GSGNWVLKF...NFSESN...---...YCN...........dGYNYngNKVVSHIRLIGAFLASPSVD..Y--..-VFTLQTTSGSTYYLNCSTSQRPVG--......----FDAEMQ.RNYCYVKT.........----ANYTQFIGILPERVADVTFSREGTFYVNGFGMGSFGQLARITVDKGALA....TFNHSWAYFVDEADVLLNITDSQIQGIVYCD.kDLYDHLRCQQSSFSLTDGFYSTA..KYTTNQQRKTIfVTLPKHTYTETISILPNISNpa.ypDGST......NGPALGWWVGTMNVLFNNSQ--.......TLCVNSSFFMV.NITFKCWlkph............ptkpSDEYKCI..GGL..PTAQVKLPDWPFAPYYSFSQLCLSST.-YQVGYSTFYF.-QYWNQGTNKRWeSkplFYYTYQTGTQYTYVTK.........................
A0A172AZS6_9ALPC/239-650 .................................................vs--NCtS...DCSGYAANIFAVETGGFIPS.SFSFNNWFVLTNSSTIVSGKFVSSQPLLVN...C..LTPVP.....SFGDETSII...NFDTVP...--S...QCN............GATV..NGSFDVVRFNLNFTANVASS..SGT..SFLALNTTGGVVLYLSCFNETKTTNLYm...seGALPFGTHEG.ALYCYVSY.........---NETSFKYIGVLPPSVKEIAVSKWGFVYINGYNYFQTFPIDSVAFNLTTGN....SGAFWTIAYTTFTDVLLEVSDTQIKSVTYCN..SHINDIKCSQMSENLPDGFYPVS..QHSLPNVNKTF.VTLPANFEHTSINVTGNVLL.....I-YY......-AHPVFR-SGNVTLHPQGTQ--.......TICVNTTQFTF.NFDSQCHqla.............gggcDGIGASM..ISI..DSGNCPFSPDKLNQHLAFETLCFSTL.PTGSDCAFSLTvQNRYFTRVFA--.H...LFVTYKYGLDHLGVQ-t........................
SPIKE_BC512/225-632 ...................................................YSVCtK...HCTGLADNVFSTDQGGHIPP.IFPYNNWFLLTNTSTLVQGVTRVFQPFLVN...C..LVALP.....KLQGLTTTL...SFDSPLn.vPGF...SCN............GANG..SSSAEAFRFNVNDTK---LF..VGA..GAVTLNTVDGVNVSIVCSNNATQPTRS......NNLQ---EDL.PYYCFTNT.........SSGTNHTVKFLSVFPPIIREFVITKYGNVYVNGYIYLRTRPLTAVHLNASSHSq..dVAGFWTIAATNFTDVLVEVNNTGIQRLLYCD..TPENSVKCSQLSFELEDGFYSMTadNVYAVTKPHTF.VTLPTFNDHGFVNVTVGGNF.....DSSY......--PPKFT--ANGTLVNNGT---.......VVCVTSNQFTL.RHDFMVG....................-YSADMR..KGIfeYSSTCPFNRETINNYLTFGRICFSTS.PADGACELKYY.VWNTIGAVSHLAgT...LYVQHTKGDIITGTPK.........................
A0A0U1UZD0_9ALPC/190-596 ...................................................YTVC.D...RCDGFPHHVFAVQEGGKIPG.SFDFTNWFYLTNTSSPFDGRFVSNQPLQIQ...C..LWPIP.....ALTSTTGII...YFNSSRftdPHQ...RCN............GYNE.vGGLADHLRFAINVTDRGAFQ..L--..GVISLLAVHNA-YNFSCSNISNFVDAT.....tIGVPFGKTYQ.PYYCFVTE.........GYNISANRTFVGVMPSDVREIVVSRYGSVYINGYKIFNVGELYGVVLNFSSLT....GSDFWTVAYANEVNVLVDIEETYITGILYCD..TPLNRLKCQQQRFFMDDGFYSA-..IDLAPPVVQTI.VLLPEYTGLTNITLDVNVTF.....N---......PPSCIQCAPTVNSILLNGESGG.......SVCVSTNRFSV.DFKLTVN....................--SQAYD..IGV..RTGSCPFSYGSLNNFVKFGSICFSLV.D-NGGCPMPIN.AINYIKIEYPIG.V...LYVTHSPGEAITGVPK.........................
B6VDY7_9NIDO/49-415 ......................................isvgslpgyptqh----.-...--------------------.---LELISPLTNSTLPINGLHRSYQPLYFA...C..FTDIV.....NNTLNM-HL...TQNEQA...-TY...NCM............GDAI.rNMSHDALRLFLNLTSANRA-..---..-SIRVIGADNTTYMFVCSEHLNISTAM......ANSTFYSANK.QLYCFTNE.........--------TYLGPLPANLSDITIYRTGQFYVNGY-LLGTLPISVKTVRIETGG...lPAHSTYFALANLTDTLITLANTTITQVTYCE.sSTIDNIACQRSTHTLADGFYSAQ..QDLFQSNVRTV.ITLPKLQEVEVIQVNITATF.....NFG-......--E-----PKVTAITINGND--.......SYCVTKPYFTI.QSNFVCT....................----GCT..LQV..RSSTCNFDLFAINNGMSFSQFCISAT.--AGSCSSKIVaTYVWNYDTGR--.N...LYFTFTEGQMFTGT--st.......................
A0A0U1WHB7_9ALPC/222-632 ...................................................YEVC.A...DCDGFPKYVFAVTDGGAIPP.NFQFDNWFYLTNSSTPISGMFTSVQPFNLS...C..VWPVP.....VLTSNSLPV...HFNMSL..nNGA...HCN............GYSNldVGLVDAMRFSLNFTDSQ--I..IRT..GVISVITSTNV-FNFSCTNSSVFGE-T......NVIPFGDVEK.THYCFINYf......tnITTGESASQFVGILPPQVKEFVIMRNGDFHLNGYRIFSVDSVESVIFNISTKD....GRDFWTVAFANNAEVLTEINATSIQNLLYCN..NPVNSIKCQQLRFNLDDGFYSHT..FDSVDNLPRTI.VRLPKYVTHSIINVTVGINF.....ENKT......-LTNYLIDFAPDDVSIGKDNIT.......TVCVDTTTFTV.RLNVLAF....................-SSFSTA..VDI..QAGTCPFSYNNLNNYLGFGSLCFSTR.P-NGGCMMSVV.ARGYFGEFQKVG.V...LYVSFTKGDNVLGVP-p........................
SPIKE_CVH22/26-430 ...................................................YSVC.N...GCVGYSENVFAVESGGYIPS.DFAFNNWFLLTNTSSVVDGVVRSFQPLLLN...C..LWSVS.....GLRFTTGFV...YFNGTG...-RG...DCK............GFSS..DVLSDVIRYNLNFEENL---..-RR..GTILFKTSYGV-VVFYCTNNTLVSGDA......-HIPFGTVLG.NFYCFVNT.........TIGNETTSAFVGALPKTVREFVISRTGHFYINGYRYFTLGNVEAVNFNVTTAE....TTDFCTVALASYADVLVNVSQTSIANIIYCN..SVINRLRCDQLSFDVPDGFYSTS..PIQSVELPVSI.VSLPVYHKHTFIVLYVDFKP.....Q-SG......GGKCFNCYPAGVNITLANFNETk.....gPLCVDTSHFTT.KYVAVYA....................-NVGRWS..ASI..NTGNCPFSFGKVNNFVKFGSVCFSLK.DIPGGCAMPIV.-ANWAYSKYYTIgS...LYVSWSDGDGITGVPQ.........................
#=GR SPIKE_CVH22/26-430 SS ...................................................XXXX.X...XXXXXX-------TTS---T.T---SSS---BSSSEESSEEEEEEEEEEEE...E..CECEC.....TTSS---EE...ESSSTT...-SS...--T............SSS-..-S--SEEEEEE-STSTT---..-SS..EEEEEEESSEE-EEEEEESSSSSSS--......-----S----.S-EEEEEE.........EETTEEEEEEEES--SS-SEEEEETT-EEEETTEEEEE-S-ECEEEEEE--SS....SS-ESEEEEEEEEEEEEEEETTEEEEEEETT..SHHHHHHHHTTSSS--SEEEEE-..----SS--EEE.E-------EEEEEEEEEEE-.....S--S......SSSBSTSSTEEEEEEETT-BTTT.....CSEE-SSSEEEE.EEEE-ST....................-TSTTEE..EEE..--TSSSS-TTTTTTTEEEEEEEEESS.--TTSEEEEEE.-EEETTTEEEEEEE...EEEEEEEEEEEEEBSS.........................
H9BR00_9NIDO/40-461 ...............................................rmvr----.N...IEGGATERCMYVQEGGFIPD.NFTFPQWFVLTNDSTLLQGELTTSQPLIVNghlC..SW---.....QSNQQYRKY...SFNTSCp.lPAD...GCNptwgsgnlklfkGWNN.tKGLTDNIRINVNISQSD-YR..TSA..GSVGLELEGGGTVNITCTNSSTPVTTY......SLLPWARSSGePIYCFANV.........SSPSQSYIDFMGILPPFVSEIAFDRSGSIYINGYRYFKISPLLNVELQLNFNL....TSDHFSVTWSNYTEVHLNTTNGYIHQIKYCY..DPLDKLACEMNTFQLPDGVYPYT..PAQQQALPETF.VTTPVYANHTTVVVRTQYTV.....SSTG.....iNGPPSWS-----TVELDGAIND.......TLCVNSRQFTV.HLNTTVH...................yTAAHLFG..TEF..VAGTCPFTLPNINNYLTFGSICFSTV.-NNGGCTIHVQ.-KVLRHYRYTFG.T...IYVSYQPGNQITAMPK.........................
B0LJR1_9ALPC/265-686 ..............................................aechs----.E...YCAGYAKNVFV-PIDGKIPE.SFSFSNWFLLSDKSTLVQGRVLSRQPVLVQ...C..LRPVP.....TWSNNSAVV...FFSNDL...---...YCP............GV--..--TAEVLRFNLNFSDSDVYTdlTND..DQFYFTFEDNTTASIACYSSANVTDFQpanssvSHIPLGKTRH.SYFCFANF.........-SHSVVSRQVLGILPPTVREFAFGRDGSVFVNGYKYFSLPPIKSVNFSISSVE....QYGFWTIAYTNYTDVMVDVNGTGISRLFYCD..SPLNRIKCQQLKHVLPDGFYSAS..MLVKNDLPKTF.VTMPQFYNWMHITLHVVLND.....TAKKed.iilAKAPELASLADVHFEILQANGSvv..nvtSLCVQAKQLAL.FYKYTSL....................QGLYTYSnlVEL..QNYDCPFSPQHFNNYLQFETLCFDVN.PAVAGCKWSLVhDVNWRTQFAT--.-...ITVSYKDGAMITTMP-r........................
A0A0U1UZ37_9ALPC/122-516 ...................................................YSVC.K...ECNGFPAHVFPVLDGGKIPG.DFSFDNWFLLTNSSTIVNGKIVDIQPLKLL...C..LWPIP.....ALDSNDDKI...YFNITG...--A...NCN............GFKD.eDAYADVLRFSLNFTNSQ-VF..NGI..HSVTVNVVGGD-LKFSCSNTSTYTAED......EVLPFGPLSS.IYYCFVSG.........QLGNETFSRFVGILPPVVKEIVISRYGSFYMNGVKLFEVPYVESVVFNVTSSV....GSDFWTVAYAQNTEVLLEVNSTDIKDILYCD..TPANKLKCQQLSFSLEDGFYPAA..VVAGVDVPRTY.VALPYHATHSFVNLTVHLGQ.....GVDS......----------AAYAQINGVN-D.......SYCVNTTQFTT.NFEQLDV....................--SNNVK..AVM..QNGDCPFNFDSLNNFLSFDSICFNLQ.PVGSSCTISIM.-RSWMGFNAPWR.S...IYVSFKRGNRITGVK-t........................
SPIKE_CVHNL/204-611 ...................................................YTVC.D...DCNGYTDNIFSVQQDGRIPN.GFPFNNWFLLTNGSTLVDGVSRLYQPLRLT...C..LWPVP.....GLKSSTGFV...YFNATG...SDV...NCN............GYQH..NSVVDVMRYNLNFSANSLDN..LKS..GVIVFKTLQYD-VLFYCSNSSSGVLDT......-TIPFGPSSQ.PYYCFINS.........TINTTHVSTFVGILPPTVREIVVARTGQFYINGFKYFDLGFIEAVNFNVTTAS....ATDFWTVAFATFVDVLVNVSATNIQNLLYCD..SPFEKLQCEHLQFGLQDGFYSAN..FLDDNVLPETY.VALPIYYQHTDINFTATASF.....G---......-GSCYVCKPHQVNISLNGNT--.......SVCVRTSHFSI.RYIYNRVks................gsPGDSSWH..IYL..KSGTCPFSFSKLNNFQKFKTICFSTV.EVPGSCNFPLE.-ATWHYTSYTIVgA...LYVTWSEGNSITGVP-y........................
#=GR SPIKE_CVHNL/204-611 SS ...................................................EEE-.S...--TTHHHH---B-GGG---T.T---TT----BSS----SEEEEEEEEEEEE...E..EEES-.....---TTS--B...-SSS--...TT-...--S............B---..-S--SEEEEEE---S-GGGT..EEE..EEEEEE-SS-E-EEEEEESSS-GGG--......-EEE-EE-SS.--EEEEEE.........EETTEEEEEEEEE--SEE-EEEEETTSEEEETTEEEEE-S--SEEEEEE--SS....STTEEEEEEEEEEEEEEEEETTEEEEEEE--..SHHHHHHHHHT-SS--SEEEEE-..--------EEE.E-S-----EEEEEEEEEEEE.....----......-SSSTTTSESEEEEEETTBS--.......EEE--SSCEEE.EEEEEEGGG................SSTTTTSEE..EEE..---SSSS-GGGTTSS-EEEEEEEESS.--SS-EEEEEE.-EEETTTEEEEEEE...EEEEEEEEEEEEE-S-S........................
B2BW33_BWCOV/430-672 .............plpmvkafiidfkqrqlaidgfpvgaliadfefrfsiv----.-...--------------------.------------------------------...-..-----.....---------...------...---...---............----..--------------------..---..---------------------------......----------.--------.........-----------------------------------------------------....AMPQTFISTLNYTTALVTFDKGNVRSVIDCNseKPFDRLRCDLQTDVVSDGFYPVN.iKTNEAKENTTF.IDVPATLAN--LTLEVFVSS.....PEQS......---PACV--------IKSY---.......-KCVDTRYFYIsDYSYSCAengipndaagaaycrgvldqINNYGVR..GMD..FKGKCPFAGSKVNSGLTFDKICFGVY.--EQGCQSDK-.------------.-...----------------acrfgfyfdnvqfsqygnklyykpq
A0A0E3N634_9NIDO/45-419 ...............................lysrannnfdvgvlpgyptk----.-...--------------------.--NVNLFSPLTNSTLPINGLHRSYQPLMLN...C..LTKIT.....N---HTLSM...YLLPSE..iQTY...SCG............GAMV.kYQTHDAVRIILDLTATDHI-..---..-SVEVVGQHGENYVFVCSEQSTYTTAL......HKSTFFSLNS.ELYCFTNN.........--------TYLGILPPDLTDFTVYRTGQFYANGY-LLGTLPITVNYVRLYRGH...lSANSAHFALANLTDTLITLTNTTISQITYCD.kSVVDSIACQRSSHEVEDGFYSNP..KSAVRARQRTI.VTLPKLPELEVVQLNISAHM.....DFGE......------ARL--DSVTINGNT--.......SYCVTKPYFRL.ETNFMCT....................----GCT..MNL..RTDTCSFDLSAVNNGMSFSQFCLSTE.--SGACEMKIIvTYVWNYLLR--Q.R...LYVTAVEGQTHTGTT-s........................
A0A1L2KGB2_9ALPC/215-623 .................................................fe--PC.Q...NCEGFAENVFAVEASGKIPS.DFSFNNWFLLTNSSSVVDGKVRSLQPLKVL...C..LRAVP.....SLLSTKEVI...SLSGVN...-AD...KCN............GHSI..NETAGALRFNLNFTSNPINA..LAS..GKIFISSSFGN-VTIFCSNSSDPGSSA.....dAFIAMGSTSA.AVYCFANS.........TFGNVTSLDFIGVLPVTVREFVFAATGQIYINGFNYFSLPDILSVDFDVKSDN....VTDFWTVAYTQFVDTLVAVNNTLIQEVLYCD..DVIHKLKCSQLSFDLPDGFYSAS..LVRDERLDKTF.VTLPTHSDHSNVTLYVSFNT.....YSSSt....cTTKPDHVTSCQYNVTIVGENDG.......PVCVKSKQFTP.LLQTSI-....................--PTGYY..VSV..ESGSCPFNFLKLKNYLTFDSLCFSTK.QLPGGCSMLIK.-RSNVNYNSDIG.V...IYVSHSPGNNILGVPQ.........................
A0A0U1WHD9_9ALPC/218-633 ...................................................YSIC.K...NCSGFPDHVFAAGQDGTIPP.SFGFENWFYLTNSSSPVSGRFSSSQPLQLF...C..LWPIP.....ALLGNTLPV...YFNMSK...NNA...NCN............GFKA..DGVVDSLRFALNFSDER-AF..ARE..GVISLETVGNT-YNFTCTNSSTPTDGS.....tFVLPFGVTDQ.AYYCFMTFy......lnRTADLRTTVFAGMLPPVVREFVVMRNGDFYLNGFRVFSVGQVVSARFNISSND....SRDFWTVAFANNAPVLVDINSTNIQRLLYCN..SPLNIIKCQQLRFNLDNGFYSYA..PETANNLPRSF.VRLPKYMTHSVINVSVAVSY.....DVVNkt..niGLHAWRVSFADRWLDYDKDNRT.......AVCADSASFTM.RLIKGSF....................-SYGDVY..VDI..WSGECPFSFAALNNYLSFGSICFSLV.P-NGGCAMSIV.TRGSYGEPQKFA.A...LYVSFSEGDNVIGVPK.........................
H9BR35_9NIDO/53-470 ..............................................tdqii----.-...-LDNNLTRNFHVTNQGNIYG.GSYL--LSYITNNSYPIFGVYRSYQPLLVR...C..VFSFSmngniTGNGKDWVY...TFNPST...TNG...NCN...........sPLQNkyNGTVDAIRFVTNFSAFSSE-..---..-ITSFIFRGEHEVSFSCSNTSNVTAHEhl.livNATTFKSNSN.ILYCYFTS.........NFNGTLSSFYVGPFPPNIADVTIFRSGNIYVNGY-YLGYIGMSIHNFSTHHVGl..tYMSSLRGIFTDQVDVLVNISNSVITNIVYCN.hSLVNQIKCQRHLFDLPDGFYSYS..SVSDVSVPETV.ILLPKEVTYSRVKLTAFAEG.....NIFD......GVSLSSLILSENKTNSNTTFND.......TICVDTTYFNF.YLKFACG....................GGSFRCS..LSC..RSAGCPFDLQGLNNYLSFDHICFSLL.-NNGGCPIQLL.-AYWGSSFSRVLaT...IYVSYSPGTRITGSK-d........................
A0A0U1WHB3_9ALPC/221-631 ...................................................YSVC.D...ECDGFPKYVFAATEGGAIPP.NFQFDNWFYLTNSSTPISGMFTSVQPFNLS...C..VWPIP.....VLTSNSLPV...HFNMSL..nKGA...NCN............GYSNldVGLVDAMRFSLNFTDNQ--I..IRT..GVISVKTGTNV-YNFSCTNSSVFGDI-......SVIPFGDVEQ.THYCFINYf......tnISTGENASQFVGILPPQVKEFVIMRNGDFHLNGYRIFSVDTVESVIFNISTRD....GRDFWTVAFANNAEVLTEINATSIQNLLYCN..NPVNSIKCQQLRFNLDNGFYSHT..FDSADNLPRTI.VRLPKYVTHSYINVTVGVNF.....ENRT......-LTNYLVDFAPDGTSIGKDNIT.......TVCVDTTTFTT.RLNVLAF....................-SAFSTA..VDI..QAGTCPFSYNNLNNYLGFGSLCFSTR.P-NGGCMMSVV.ARGYFGEFQKVG.V...LYVSFTKGDNVLGVP-p........................
SPIKE_FIPV/249-673 ................................................yel---C.EdyeHCTGYATNVFAPTSGGYIPD.GFSFNNWFLLTNSSTFVSGRFVTNQPLLIN...C..LWPVP.....SFGVAAQEF...CFEGAQ...-FS...QCN............GVSL..NNTVDVIRFNLNFTADVQSG..MGA..TVFSLNTTGGVILEISCYSDTVSESSSy...syGEIPFGITDG.PRYCYVLY.........---NGTALKYLGTLPPSVKEIAISKWGHFYINGYNFFSTFPIGCISFNLTTGV....SGAFWTIAYTSYTEALVQVENTAIKNVTYCN..SHINNIKCSQLTANLNNGFYPVA..SSEVGFVNKSV.VLLPSFFTYTAVNITIDLGM.....KLSG......YGQPIASTLSNITLPMQDNNTD.......VYCIRSNQFSV.YVHSTCKsslwdn........ifnqdcTDVLEAT..AVI..KTGTCPFSFDKLNNYLTFNKFCLSLS.PVGANCKFDVAaRTRTNEQVVR--.S...LYVIYEEGDNIVGVP-s........................
S0AP48_9ALPC/227-633 ...................................................YQPC.T..aNCIGYAANVFATEPNGHIPE.GFSFNNWFLLSNDSTLVHGKVVSNQPLLVN...C..LLAIP.....KIYGLGQFF...SFNQTI...-DG...VCN............GAAV..QRAPEALRFNINDTSVI---..LAE..GSIVLHTALGTNFSFVCSNSSNPHLAT......FAIPLGATQV.PYYCFLKV.........DTYNSTVYKFLAVLPPTVREIVITKYGDVYVNGFGYLHLGLLDAVTINFTGHGtdddVSGFWTIASTNFVDALIEVQGTAIQRILYCD..DPVSQLKCSQVAFDLDDGFYPISsrNLLSHEQPISF.VTLPSFNDHSFVNITVSASF.....GGHS......GANLIAS-----DTTINGFS--.......SFCVDTRQFTI.SLFYNVT....................-NSYGYV..SKS..QDSNCPFTLQSVNDYLSFSKFCVSTS.LLASACTIDLF.GYPEFGSGVKFT.S...LYFQFTKGELITGTPK.........................
E3W5J0_9ALPC/268-686 ..............................................eecss----.D...YCAGYAKNVF-VPVDGKIPE.SFTFSNWFLLTDKSTLFQGRVLSSQPVFVQ...C..LRPVP.....TWSNNSAVV...HFNNDE...---...---............-FCP..DVMADVLRFNLNFSDTDVYTdsSKD..DQLYFTFEDNTTASIACYSSANVTDFQpasnsiSHSPFGKTAH.SYYCFANF.........-SSSVVSWQFLGILPPTVREFAFGRDGSIFVNGYKYFMLPPIKSVKFSISSVE....QYGFWTIAYTNYTDVMVDVNGTGITRLFYCD..SPINRIKCQQLKHELPDGFYSAS..MLVKKDLPKTF.VTMPQFYNWMNVTLHVVLND.....TLKQy....dIKAPELASLADIHFEIAQANGSvv..nvtSLCVQTRQLAL.FYKYTSL....................QGLYTYSnlVEL..QNYDCPFSPQHFNNYLQFETLCFDVN.PSVAGCKWSLVhVTTWRTQFAT--.-...ITLSYKDGAKITTMPK.........................
H9BR17_9NIDO/51-466 ......................................lqarnqgnysaic----.-...------------PENGYITStSYDLSKIYYLTDGDYPIDGVYKSLQPLKVT...CvpEWHGNs...nFNDTTGWKH...YFDGRIkqnPNTiwcPCSqsg......pggAQHNaaGNSTEYIRFHSNITTSVSN-..---..-LLRLYAVDNQYYYFGCTPTPTPLTFNlt..seNITLFTAEEQ.VHYCYANI.........----NGTVSYIGVLPPKITELTVGRYGDIFVNGFLYFKIPNV-IEYVQLSHTIp..hNKQFYTVFYANMTQVLLNISMASINRLLYCD.kDSYSSIACAVNQFEPANGFYSTS..AIEKISRKFTF.VTMPTVQNHSYYSINLTIGG.....CGHG......--------------EYPHLSNK.......TGCYRTDASNI.NAKQITFvin.............tythDNWIQWA..HKP..--GNCPWALNKINNYNTAGTLQVVPE.-NQATCCTDNQaSWLYLASWTSVNvK...VCFNYQPGTTISIQPQ.........................
S5YNL4_9ALPC/219-623 ...................................................YQVL.P...DSGEFSDNLFTVGDDGSIPP.SFGFNNWFVLSNSSSIISGTVVSNQPLRLT...C..LWPIP.....SSTGALATI...YFNGTN...-GA...QCN............GFDS..NAPFDAIRFNLNGTLSGHNF..VS-..-GFVLHAANGATLGFSCTNSTDAPYLR......-QIPFGIGDT.PYYCYLNV.........TTDINSTMSFVGALPLNLREIVIASNGDVYMNGYRYFAAGDLSSVDVELPSQQv..fGSTFWTIAFTVFETVLLEVDGTSINRMLYCD..NPLNRVKCSHTQFDLVDGFYPLT..DVDLAVKPFTF.VTLPTFADHSFVYFNFSLMF.....DDLN......----EDFRLQSFNLTINGQL--.......SYCVQSRQFTT.SGSVRTNt..................nHQFGFYT..QRA..ASNGCPFTIDTLNNYLTFGRICFSFG.ESGAGCGVDVMvESQYNMFKVT--.T...IFVSYSEGDIIAGMPK.........................
H9BR25_9NIDO/40-467 ...............................................hyqq----.P...QVRGWTDDI---GVDGRIPA.TYPLTNTFYLSNTTTPVDGVYTSLQPLLIR...C..KFKYV.....NDTVNAGKIltmYFNLTN...NTG...RCD............GNSE.kVGLVDAIRFQINVTTDI-LQ..LTA..GSINFTTPDGELYTLHCLNTTLGVGQDy...ypSQSRTRQSGV.TYHCYMIYrntsyaysaNEYTYRVLQYLGPLPASVREIVAFSNGFIYINGILLSRIPALHKVDFGLVKSA...hTSDYYVILFADMVDVMVNISATEMQSIFYCI..TPFEQVKCSQKQTTLSDGFYSTS..AIEVLQRQRTF.VGLPMAINITTLNFAISYLN.....T---......KANPSLGAPQEVNLTINGFA-D.......QFCVTTSQFMV.TLNVTCLvhnn............tsiiPCPQAYT..AEI..SPGDCPFNFLDVNNYLMFDSICFSPS.PSGDSCQMVIN.-KVWANNRIPMS.S...VYVSYVYGNQIVGVP-r........................
E3W5F7_9ALPC/267-688 ..............................................secrs----.E...YCAGYAKNVF-VPVDGKIPE.SFTFSNWFLLTDKSTLLQGRVLSSQPVFVQ...C..LRPVP.....TWSNNSAVV...HFNNDS...---...---............-FCP..KVAADVLRFNLNFSDIDVYTdsSND..DQLYFTFEDNTTASIACYSSANVTDFQpannsiSHIPFGKTAH.SYYCFANF.........-SHSVVSRQFLGILPPTVREFAFGRDGSIFVNGYKHFMLPPIKSVKFSISSVE....QYGFWTIAYTNYTDVMVDVNGTGITRLFYCD..SPINRIKCQQLKHELPDGFYSAS..MLVKKDLPKTF.VTMPQFYNWMNVTLHVVLND.....TLKRyd.iilAEAPELASLADIHFEIAQANGSvv..nvtSLCVQTRQLAL.FYKYTSL....................QGLYTYSnlVEL..QNYDCPFSPQHFNNYLQFETLCFDVN.PSVAGCKWSLVhDTTWRTQFAT--.-...ITLSYKDGAKITTMPK.........................
B1PHK2_9ALPC/232-640 ...................................................YAIC.D...NCNGYPAHIFPVSEGGLIPA.DFNFSNWFLLTNSSTIVDGRIVSEQPVLLM...C..LWAVP.....GLMSTNSFV...YFNGTA...PNK...QCN............GYAT..DSAFEALRFSLNFTDER-VF..AGS..GSVVLLVSGLQ-YKFSCTNNSEAVIDS......-GIPFGNVVE.PFYCFVSI.........----NGTSIFVGMLPAVLREIVITRYGSIYLNGFSIFQGPPIQGVLFNVTNRG....ATDLWTVALSNFTEVLAEVQSTAIKALLYCD..DPLSQLKCQQLQFSLPDGFYATA..SLFQHELPRTF.VTLPRHFTHSWINLRIKWKN.....GVCY......NCPPASSWIDFVTFNSNGTENVlp...erTLCVNTTQFTT.NLTLIEE....................AFSYSTP..VVV..RADDCPFDFQSLNNYLTFGSICFSLNgTIGKGCTLGIY.-KRASSQYIPIW.N...VWVAYTSGDNILGVR-e........................
A0A0U1WHD7_9ALPC/215-642 ...................................................YTLC.D...NCTGFPQHVFATMENGEIPP.SFNFANWFYLTNSSSPVSSRVVGLQPLLLT...C..LWPIP.....ALLGTATDI...TFDRNG..tSDV...RCN............GFAS..NETADAMRFSLNFTDSA-VF..AKE..GVITLKTLSNT-FKFSCSNSSTYQAPY......-VIPFGHIDQ.PYYCFTTFy......inETAGTTTTSFVGMLPPVVREFVITKTGNVYLNGYRIFTVDDVVSVNFNISSTD....HRDFWTVAFVKNTEVMLDIEDTYIKQLLYCN..TPLNVVKCQQLKFVLDDGFYSYS..SPVDEVLPRTI.VRLPRLMTHNFLNFTIFVSFyfdddK--QarpdggFYECATCAPKYYKLAFVDDWTSavssnvtSICVNYASFTT.RLFTFYA....................GTTAGVH..LGL..ETGTCPFSFDTLNNYLTFGSLCFSLV.-ANGGCTMNIV.TQGPYGLPHTIA.V...LYVSYTEGDNIIGVP-l........................
#=GC SS_cons ...............................................B.SSEEE-.S...S-TTHHCC---B-CCS---T.T---SSS---BSSSEESSEEEEEEEEEEEE...E..EECCC.....TTSTTSEEE...ESSSTT...TTS...--T............CSSS..SSB-SEEEEEE-STSTCCGT.SCCC..EEEEEEESSCEEEEEEEESSSSCCC--......-EEE-CE-SS.SEEEEEEE.........EETTEEEEEEEEEE-SCESEEEEETTSEEEETTEEEEE-S-ECEEEEEE--SS....SSTECEEEEEEEEEEEEEEETTEEEEEEETT..SHHHHHHHHHTSSS--SEEEEE-..----SS--EEE.E-S-----EEEEEEEEEEEE.....SSSSS..GGGSSSCCTCSTCEEEEEETTCSTTCE..EECCEE-SSSEEEE.EEEEEECGG................SSTTTTSEES.EEE..EETSSSS-GGGTTSSEEEEEEEEESS.S-STSEEEEEES-EEETTTEEEEEEE...EEEEEEEEEEEEEBSSS........................
#=GC seq_cons ........................................................p....CsGaspplFss..sGtIPs.sFsFsNWFhLTNoSo.lsGhhhS.QPLhlp...C..LaslP.....shssssthl...hFstst.....s...pCN............Ghs...ssssDslRFsLNFosst..h...tt..sslslpsssss.hphsCossosssstt......thlPFGtssp.saYCFssh............stss.pFlGhLPPsV+Ehsls+pGshYlNGYphFslsslpulpFslooss....stsFWTlAasshs-VLlslssTsIppllYCs..oslNplKCpQlpasLsDGFYSsu...hsttslP+Ta.VsLPpahsashlslslslsh.....s.pt.......hts.hs..sshslslssss.s.......olCVsospFol.phphssh.....................s.hshs..spl..psusCPFohsplNNYLoFsolCFSsp.s.suuCphslh..ttahsphhp...s...lYVoapcGspIsGsP..........................
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