ID D9J204_9ALPC Unreviewed; 1429 AA.
AC D9J204;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 05-FEB-2025, entry version 38.
DE SubName: Full=Spike protein {ECO:0000313|EMBL:ADI80523.1};
OS Mink coronavirus strain WD1133.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Alphacoronavirus; Minacovirus.
OX NCBI_TaxID=766792 {ECO:0000313|EMBL:ADI80523.1, ECO:0000313|Proteomes:UP000132946};
RN [1] {ECO:0000313|EMBL:ADI80523.1, ECO:0000313|Proteomes:UP000132946}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WD1133 {ECO:0000313|EMBL:ADI80523.1};
RX PubMed=21346029; DOI=10.1099/vir.0.025353-0;
RA Vlasova A.N., Halpin R., Wang S., Ghedin E., Spiro D.J., Saif L.J.;
RT "Molecular characterization of a new species in the genus Alphacoronavirus
RT associated with mink epizootic catarrhal gastroenteritis.";
RL J. Gen. Virol. 92:1369-1379(2011).
CC -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum-Golgi intermediate
CC compartment membrane {ECO:0000256|ARBA:ARBA00034689}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004182}.
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DR EMBL; HM245926; ADI80523.1; -; Genomic_RNA.
DR SMR; D9J204; -.
DR Proteomes; UP000132946; Genome.
DR GO; GO:0044173; C:host cell endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:InterPro.
DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:InterPro.
DR GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro.
DR GO; GO:0046813; P:receptor-mediated virion attachment to host cell; IEA:InterPro.
DR CDD; cd22377; TGEV-like_Spike_SD1-2_S1-S2_S2; 1.
DR Gene3D; 1.20.5.300; -; 2.
DR Gene3D; 2.60.40.3130; -; 1.
DR InterPro; IPR043607; CoV_S1_C.
DR InterPro; IPR043473; S2_sf_CoV.
DR InterPro; IPR002551; Spike_S1_CoV.
DR InterPro; IPR002552; Spike_S2_CoV.
DR InterPro; IPR043614; Spike_S2_CoV_C.
DR InterPro; IPR044873; Spike_S2_CoV_HR1.
DR InterPro; IPR044874; Spike_S2_CoV_HR2.
DR Pfam; PF01600; CoV_S1; 1.
DR Pfam; PF19209; CoV_S1_C; 1.
DR Pfam; PF01601; CoV_S2; 1.
DR Pfam; PF19214; CoV_S2_C; 1.
DR SUPFAM; SSF111474; Coronavirus S2 glycoprotein; 2.
DR PROSITE; PS51923; COV_S2_HR1; 1.
DR PROSITE; PS51924; COV_S2_HR2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virulence {ECO:0000256|ARBA:ARBA00023026};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT TRANSMEM 1368..1387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1014..1133
FT /note="Coronavirus spike (S) glycoprotein S2 subunit heptad
FT repeat 1 (HR1) region profile"
FT /evidence="ECO:0000259|PROSITE:PS51923"
FT DOMAIN 1282..1379
FT /note="Coronavirus spike (S) glycoprotein S2 subunit heptad
FT repeat 2 (HR2) region profile"
FT /evidence="ECO:0000259|PROSITE:PS51924"
SQ SEQUENCE 1429 AA; 157873 MW; D2E503C51EA4CF75 CRC64;
MRKMLLILVL IPCVLGDLFP CRTSINSTIG NHWYLIDNFV KNYSVSLPSN SDVVLGDYFP
TVEPWHNCLL EQTNSTVIFD GLRALYWDYN NGQVPVRRYL AVAVYGDPYS VSVYFTLDYE
GPRGAKICLC KGMPQPTHIS GEANCWSSQC KLNHYFPICN NTDHCGHFLY GLKWSQTELF
AYLYGYVYNI KLVNHWFNNA SLALMRAASV GQEGWWFNPV RNLTYYSVYK NSSSTIVQNC
TGNCEEYANN IFSTEPGGII PEGFSFNNWF VLTNDSTVLD GRFLTRQPLL VNCLWPVPSF
SEISQEFCFA SADFTQCNGY KLNSTADVIR FNLNFTHETA AASGTTFFEL NTTGGVVLYI
SCYNQSRTEA QVSEGFVPFG NHEGSLYCYV SYNETLQKFL GVLPPSVKEI AISKDGGFYI
NGYNYFQTFP IDCISFNLTT GNTGAFWTIA YTSYTDVMVD VENTAIKRVI YCNSHINDIR
CNQLTPSLPD GFYPVSPKAI GFINKTFVTL PANFDHVYVN ITGNVNLKAE RGRPYNNGGN
ATLSFQGCIA VSQFTVNLNH TCTITNAGSS GCTNAYEANV YMTSGSCPFA FDRLNNHMSF
SKLCFSTVPL GDDCRLDLTV QTRYFTGVFA HVYVSYKFGL DIVGLPTSDA GLKDLSVLHL
NVCTEYNVYG FSGTGIIRQT NQSIPGGLYY TSLSGDLLGF KNVTTGTVYS ITPCEVSAQA
AVIDGSIVGA ITSVNSELLG LKNHITTPYF YYYSVYNYTA DNVTRSMQKY DVNCTPVISY
SNMGVCANGA LVFINVTHTN GDVQPISTGN VTIPSNFTIS VQMEYVQVST ELVSIDCARY
VCNGNARCGK LLSQYVSACH TIEQALAMGS RLESMELESM ISISANALKL ASVEEFNSSA
MLNPVYNESG NTIGGIYLDG LKDILPRKNK HGSSRSTIED LLFNKVVTTG LGTVDEDYKR
CTKGSDIADL ACAQYYNGIM VLPGVANDGK MSMYTASLSG GISLGALGGG AVAIPFSLAV
QARLNYVALQ TDVLQRNQEI LAASFNQAIG NITIALGKVN NAIYQTSQSL STVAQALTKV
QDVVNSQGKA LNHLTLQLQN NFQAISSSIQ DIYYKLDDIN ADAQVDRLIT GRLAALNAFV
TQTLTRQAEV RASRQLAKEK VNECVRSQSS RFGFCGNGTH LFSLTNAAPN GMVFFHTVLV
PTAYETVTAW SGICASDDSR TFGLIVKDVS LTLFRNHDGK FYLTPRTMYQ PRVATSADFV
QIVDCDVLFV NATILELPSI VPDYIDINKT VQDLLDSYKP NWTVPEFSLD IFNQTYLNIT
NEINDLENRS VVLYNTTKEL ELLIQSINNT LVDLEWLNKI ETYVKWPWYV WVLIALIFLF
VLPMLLFCCL STGCCGCCGC LSSCAAGCCK YGCSRDLSRY EPIEKVHVN
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