ID B2BW33_BWCOV Unreviewed; 1472 AA.
AC B2BW33;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 03-MAY-2023, entry version 54.
DE SubName: Full=Spike protein {ECO:0000313|EMBL:ABW87820.1};
OS Beluga whale coronavirus (strain SW1) (BwCoV).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Gammacoronavirus; Cegacovirus.
OX NCBI_TaxID=694015 {ECO:0000313|EMBL:ABW87820.1, ECO:0000313|Proteomes:UP000125413};
RN [1] {ECO:0000313|EMBL:ABW87820.1, ECO:0000313|Proteomes:UP000125413}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SW1 {ECO:0000313|EMBL:ABW87820.1};
RX PubMed=18353961; DOI=10.1128/JVI.02722-07;
RA Mihindukulasuriya K.A., Wu G., St Leger J., Nordhausen R.W., Wang D.;
RT "Identification of a novel coronavirus from a beluga whale by using a
RT panviral microarray.";
RL J. Virol. 82:5084-5088(2008).
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DR EMBL; EU111742; ABW87820.1; -; Genomic_RNA.
DR RefSeq; YP_001876437.1; NC_010646.1.
DR GeneID; 6264443; -.
DR KEGG; vg:6264443; -.
DR Proteomes; UP000125413; Genome.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:InterPro.
DR GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:InterPro.
DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:InterPro.
DR GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro.
DR GO; GO:0046813; P:receptor-mediated virion attachment to host cell; IEA:InterPro.
DR CDD; cd22372; gammaCoV_Spike_SD1-2_S1-S2_S2; 1.
DR Gene3D; 1.20.5.300; -; 1.
DR InterPro; IPR043473; S2_sf_CoV.
DR InterPro; IPR002551; Spike_S1_CoV.
DR InterPro; IPR002552; Spike_S2_CoV.
DR InterPro; IPR044873; Spike_S2_CoV_HR1.
DR InterPro; IPR044874; Spike_S2_CoV_HR2.
DR Pfam; PF01600; CoV_S1; 1.
DR Pfam; PF01601; CoV_S2; 1.
DR SUPFAM; SSF111474; Coronavirus S2 glycoprotein; 2.
DR PROSITE; PS51923; COV_S2_HR1; 1.
DR PROSITE; PS51924; COV_S2_HR2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000125413};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virulence {ECO:0000256|ARBA:ARBA00023026};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT TRANSMEM 1406..1428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1051..1163
FT /note="Coronavirus spike (S) glycoprotein S2 subunit heptad
FT repeat 1 (HR1) region profile"
FT /evidence="ECO:0000259|PROSITE:PS51923"
FT DOMAIN 1329..1417
FT /note="Coronavirus spike (S) glycoprotein S2 subunit heptad
FT repeat 2 (HR2) region profile"
FT /evidence="ECO:0000259|PROSITE:PS51924"
SQ SEQUENCE 1472 AA; 164843 MW; 2E6FF767250999B0 CRC64;
MVRLSFVIVF LCTMLMNPLL ISAIDEGLWP AGMWYSHLLQ ENNTYTVAAF QEHAILPSYV
NNNWTVITNF TAENATQLEW DDPYYNSTLF SYVNITMVGD NCIGNFTNRT LGELGDIDYF
PFNCTNVTNE FRTNYGYFIQ NVMVARCLSS LCAVIIPKGR VFFEKNEMWW WSWQDRYQPG
NYTFRHERFM SLSQNITVIG LAGNFSLFGL GQTININSAS YDWGTVIRGR LDDRICELQM
TGADLCNLTR VDTSSDAFYT AGLVRPASAA LIADGAYKPI FTGVFHDNET HQVLYENATI
KPSVRSFQVK NNDFDALYVG RKEKFSIDAV TIIFRLKETS TYLDLPFCNE TRVDKSDKAI
IGYLIGGDFY SVDVSSIVIE RYNPPQPNAT SIPTTISTVS TTTSGWEDLR SLNMSCVRFD
YKLKKVMSVP LPMVKAFIID FKQRQLAIDG FPVGALIADF EFRFSIVAMP QTFISTLNYT
TALVTFDKGN VRSVIDCNSE KPFDRLRCDL QTDVVSDGFY PVNIKTNEAK ENTTFIDVPA
TLANLTLEVF VSSPEQSPAC VIKSYKCVDT RYFYISDYSY SCAENGIPND AAGAAYCRGV
LDQINNYGVR GMDFKGKCPF AGSKVNSGLT FDKICFGVYE QGCQSDKACR FGFYFDNVQF
SQYGNKLYYK PQDLGFIDYQ FGTLFKNSLV QSNIIQEGCH DYDIYGYKGT GVVKPFSDYS
YLQTGGLIML DSGGFPSLFR YNFALYEVTQ CTREVAQLAV ASNNAIGYYL PKQVTIDGVN
ASTSCNTTGA FKYCYYDDVI HVGRDVSNVT INVCNPSLMM ENSHCINIQG NFMVNEPAIT
FNSTQYQPLL GVSGDVQLPR TLMLHTTTEF IQTHSPKIVI DCTKYVCGSS ERCRRILVKY
GGFCESIMRL LNGVNMADDV SVTDFLDNFN SFDNISVSLQ NLNASFGQFE GYGFQKFLPK
SFDFDGSDPR DARSTIEDIL FDKVTTVGLG TVDADYDKCT KGLSVADLVC AQYYNGIMVL
PGVADAEKMA MYTGALVGGM VLGGITSAAA IPFATQIQAR VNYLALTQNA IQENQKIIVQ
QFNKAIDSMT SAFQSVNEGF SAVSSAITEV QNAVNAQSQA LTKLLGQLNY NFGATTSSIK
ELYERLAKLE ADVQVDRLIN GRLTALSAFV AARQVEAAKV ASQRVLAAEK INECVKSTSN
RYGFCGNGAH IISFPQNAPN GMLFVHFSLV PNETITVKGI IGLCLNNSIG IVPAKDRGMF
IQCSNGTYCP EFENSFNESK NGNVTFPFAI TSREQYNPRQ ITTGDIQMLT SCNSGYTHIE
WSQLPLVAPP YDDFDKEFDK LYEKWNYTLE ELEKLNVTFP YLNVSEQIDI INSAMENIKS
QIQNLNSSYI DLEWLNKYER YSKWPWWVWL IIVLCFAAFC LLVFWIFICT GCCGGCCNCC
GIPALFGYCK RKAHYERLRM DEEGNLEEIK AD
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