ID B1PHK2_9ALPC Unreviewed; 1375 AA.
AC B1PHK2;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 05-FEB-2025, entry version 47.
DE SubName: Full=Spike protein {ECO:0000313|EMBL:ACA52171.1};
GN Name=S {ECO:0000313|EMBL:ACA52171.1};
OS Miniopterus bat coronavirus HKU8.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Alphacoronavirus; Minunacovirus.
OX NCBI_TaxID=694001 {ECO:0000313|EMBL:ACA52171.1, ECO:0000313|Proteomes:UP000143524};
RN [1] {ECO:0000313|EMBL:ACA52171.1, ECO:0000313|Proteomes:UP000143524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AFCD77 {ECO:0000313|EMBL:ACA52171.1};
RX PubMed=18420807; DOI=10.1099/vir.0.83605-0;
RA Chu D.K., Peiris J.S., Chen H., Guan Y., Poon L.L.;
RT "Genomic characterizations of bat coronaviruses (1A, 1B and HKU8) and
RT evidence for co-infections in Miniopterus bats.";
RL J. Gen. Virol. 89:1282-1287(2008).
CC -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum-Golgi intermediate
CC compartment membrane {ECO:0000256|ARBA:ARBA00034689}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004182}.
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DR EMBL; EU420139; ACA52171.1; -; Genomic_RNA.
DR RefSeq; YP_001718612.1; NC_010438.1.
DR SMR; B1PHK2; -.
DR GeneID; 6020262; -.
DR KEGG; vg:6020262; -.
DR Proteomes; UP000143524; Segment.
DR GO; GO:0044173; C:host cell endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:InterPro.
DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:InterPro.
DR GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro.
DR GO; GO:0046813; P:receptor-mediated virion attachment to host cell; IEA:InterPro.
DR CDD; cd22369; alphaCoV_Spike_SD1-2_S1-S2_S2; 1.
DR Gene3D; 1.20.5.300; -; 2.
DR Gene3D; 2.60.40.3130; -; 1.
DR InterPro; IPR043607; CoV_S1_C.
DR InterPro; IPR043473; S2_sf_CoV.
DR InterPro; IPR002551; Spike_S1_CoV.
DR InterPro; IPR002552; Spike_S2_CoV.
DR InterPro; IPR043614; Spike_S2_CoV_C.
DR InterPro; IPR044873; Spike_S2_CoV_HR1.
DR InterPro; IPR044874; Spike_S2_CoV_HR2.
DR Pfam; PF01600; CoV_S1; 1.
DR Pfam; PF19209; CoV_S1_C; 1.
DR Pfam; PF01601; CoV_S2; 1.
DR Pfam; PF19214; CoV_S2_C; 1.
DR SUPFAM; SSF111474; Coronavirus S2 glycoprotein; 2.
DR PROSITE; PS51923; COV_S2_HR1; 1.
DR PROSITE; PS51924; COV_S2_HR2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000143524};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virulence {ECO:0000256|ARBA:ARBA00023026};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT TRANSMEM 1320..1339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 972..1091
FT /note="Coronavirus spike (S) glycoprotein S2 subunit heptad
FT repeat 1 (HR1) region profile"
FT /evidence="ECO:0000259|PROSITE:PS51923"
FT DOMAIN 1235..1331
FT /note="Coronavirus spike (S) glycoprotein S2 subunit heptad
FT repeat 2 (HR2) region profile"
FT /evidence="ECO:0000259|PROSITE:PS51924"
FT COILED 1261..1309
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1375 AA; 150646 MW; FACD26CB13DD53D2 CRC64;
MKSLLVLSLL ALLATLSVNA QVTGEGGVAE GNYWVNASCA GWSYFYALKL GLPPNASAIV
TGYLPKPKGW ICPRFNGAGI YTRNNANAVF VMYRTKALAF EIGVSSSAGG EQYSAYMAQQ
NGKYLVLRIC KWQNGTLAAP TLQSTSGKDC IVNVKVDNHM FYHAAHDIVG MSWSGDAVRL
YTQTDTKTYY IPNSWDRVSI RCPDKFSCSS QIVTKAITVN VTTFANGTID KYAICDNCNG
YPAHIFPVSE GGLIPADFNF SNWFLLTNSS TIVDGRIVSE QPVLLMCLWA VPGLMSTNSF
VYFNGTAPNK QCNGYATDSA FEALRFSLNF TDERVFAGSG SVVLLVSGLQ YKFSCTNNSE
AVIDSGIPFG NVVEPFYCFV SINGTSIFVG MLPAVLREIV ITRYGSIYLN GFSIFQGPPI
QGVLFNVTNR GATDLWTVAL SNFTEVLAEV QSTAIKALLY CDDPLSQLKC QQLQFSLPDG
FYATASLFQH ELPRTFVTLP RHFTHSWINL RIKWKNGVCY NCPPASSWID FVTFNSNGTE
NVLPERTLCV NTTQFTTNLT LIEEAFSYST PVVVRADDCP FDFQSLNNYL TFGSICFSLN
GTIGKGCTLG IYKRASSQYI PIWNVWVAYT SGDNILGVRE PNVGVRDQSV VHQNVCTSYT
IFGHSGRGII RPANISYIAG VYYTAASGQL LGFKNTTTGE VFSVTPCNPS QQAVVVKDRL
VGVMSSTSTV SIPFNNTIPT PSFYYHSNAT SSCDDPSVVY SSIGICDDGG ITFVNSTRVR
GEPDPAISMG NISVPSNFTV SIQVEYLQMS IRPVSIDCAM YVCNGNPHCT RLLQQYISAC
RTIEEALQLS ARLESFEVNS MLTVSETALD LVNISTFGGD YNLTALLPQG GGKRSVIEDI
LFDKVVTSGL GTVDEDYKRC TNGIGIADVP CAQYYNGIMV LPGVVDEEKM SIYTASLLGG
MTMGGFTPVA ALPFALSVQS RLNYVALQTD VLQKNQQILA NAFNSAIGNI TVAFDQVTTA
VQQTSDAIKT VASALNKVQS VVNSQGQALH QLTKQLASNF QAISASIEDI YNRLDGLAAD
ANVDRLITGR LAALNAFVTQ TLTKYTEVRA SRLLAQEKIN ECVKSQSTRY GFCGNGTHLF
SIPNAAPEGI MLFHTVLVPT EYVSVTAWSG YCHNGVGYAV KDVGNSLFQF NNTFYITPRN
MYQPRTPTSA DFIRISGCNV VYVNITDEQL PQVQPEFIDV NKTLEELMSR LPNNTGPNLP
LDIFNQTYLN ISAEIDALEN KSLELQATAD KLQLTIEQLN ATLVDLEWLN RFEQYVKWPW
WVWLTMIIAL VLLTGLMLWC CLATGCCGCC SCMASTLDFR GSRLQQYEVE KVHIQ
//
