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Background: Currently treatment for prosopagnosia is limited. Methods: We report the reversal of acquired associative-type prosopagnosia (AAP) using quantitative electroencephalography (qEEG)-guided transcranial laser therapy (qGLT) in a... more
Background: Currently treatment for prosopagnosia is limited. Methods: We report the reversal of acquired associative-type prosopagnosia (AAP) using quantitative electroencephalography (qEEG)-guided transcranial laser therapy (qGLT) in a subject with temporal lobe epilepsy (TLE) and mild cognitive impairment (MCI). Results: Objective and subjective measures of improvement in AAP, TLE, and MCI are presented. Additional improvement, measured through qEEG, was found 1-month post-treatment. Conclusions: There was no recurrence of AAP for 1 year. We conclude that further research into the utility of qGLT in the treatment of AAP is warranted.
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Attention Deficit-Hyperactivity Disorder (ADHD) often continues into adulthood. Recent neuroimaging studies found lowered baseline dopamine tone in the brains of affected individuals that may place them at risk for Substance Use Disorder... more
Attention Deficit-Hyperactivity Disorder (ADHD) often continues into adulthood. Recent neuroimaging studies found lowered baseline dopamine tone in the brains of affected individuals that may place them at risk for Substance Use Disorder (SUD). This is an observational case study of the potential for novel management of Adult ADHD with a non-addictive glutaminergic-dopaminergic optimization complex KB200z. Low-resolution electromagnetic tomography (LORETA) was used to evaluate the effects of KB220z on a 72-year-old male with ADHD, at baseline and one hour following administration. The resultant z-scores, averaged across Eyes Closed, Eyes Open and Working Memory conditions, increased for each frequency band, in the anterior, dorsal and posterior cingulate regions, as well as the right dorsolateral prefrontal cortex during Working Memory, with KB220z. These scores are consistent with other human and animal neuroimaging studies that demonstrated increased connectivity volumes in reward...
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ABSTRACT The literature dealing with the behavioral effects produced by ablation of the septum and related medial cortical structures in a large number of species (including rodents, carnivores, and primates) is reviewed. Relevant... more
ABSTRACT The literature dealing with the behavioral effects produced by ablation of the septum and related medial cortical structures in a large number of species (including rodents, carnivores, and primates) is reviewed. Relevant neuroanatomical and electrophysiological data are included when they lend support to a point of view or when they clarify a point of information. It is concluded that septal function cannot be explained in terms of a unitary mechanism, but rather there appears to be a functional anatomical localization within the septum. The posteroventral septum modulates water intake via possible efferents to the supraoptic and paraventricular nuclei, which in turn controls neurosecretion at the neurohypophysis. Increases in water intake and deficits in passive avoidance after septal ablation are not related. The lateral septal nuclei and their afferent connections with the hippocampus and diencephalic connections with the hypothalamus exert control over the formation of conditioned emotional responses. Deficits in passive avoidance and one-way active avoidance, and facilitation in two-way active avoidance after septal ablation are most parsimoniously explained in terms of decreased “fear.” This hypothesis is supported by both behavioral and endocrinological data. The medial septal nucleus and its connections with fields CA1, CA2, and CA3 of the hippocampus regulate motor mechanisms. Overresponding on various operant schedules and deficits in alternation and reversal problems are specific to damage to the medial septal nucleus and are highly correlated with abolition of the hippocampal theta rhythm. An inability to efficiently utilize response-produced proprioceptive feedbac, rather than a response disinhibition model, appears to be the best hypothesis available for an explanation of these deficits. The role of the septum in stimulus processing is also reviewed, and a physiological mechanism for hyperreactivity to sensory stimuli often observed after septal ablation is discussed. Finally, it is hypothesized that the cingulate gyrus is probably not involved in response facilitation but rather with the organization of sequential behavior.
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Research Interests: Cognitive Science, Dementia, Cognition, Electroencephalography, Controller Design, and 15 moreMedicine, Executive Function, Cognitive Aging, Memory, Humans, Cerebral Cortex, Female, Male, Cognitive Process, Cognitive Performance, Aged, Cognitive Function, Age Related Cognitive Decline, Alpha Rhythm, and Cognition disorders
Sixteen-channel topographic brain mapping of electroencephalograms of 25 right-handed males, 9-12 years of age, with attention-deficit-hyperactivity disorder revealed increased theta (4-7.75 Hz) and decreased beta 1 (12.75-21 Hz) when... more
Sixteen-channel topographic brain mapping of electroencephalograms of 25 right-handed males, 9-12 years of age, with attention-deficit-hyperactivity disorder revealed increased theta (4-7.75 Hz) and decreased beta 1 (12.75-21 Hz) when compared with 27 controls matched for age and grade level. The differences were greater when patients were tested for reading and drawing skills, but were decreased when they were at rest during visual fixation. Although the differences in patients with attention-deficit-hyperactivity disorder were generalized, increased theta was more prominent in frontal regions, while beta 1 was significantly decreased in temporal regions. Principal component analysis was used to combine the variables into 2 components which accounted for 82% of the total variance. A discriminant function analysis using these components was able to predict group membership for attention-deficit-hyperactivity disorder patients 80% of the time and 74% for controls. These findings support the use of topographic electroencephalography for further elucidation of the neurophysiology of attention-deficit-hyperactivity disorder.
Research Interests: Cartography, Attention, Electroencephalography, Comparative Study, Medicine, and 15 moreBrain Mapping, Evoked Potentials, Humans, Child, Cerebral Cortex, Male, Exploration, Arousal, Learning Disorders, Neurosciences, Nino, Attention deficit disorder with hyperactivity, Attention deficit hyperactivity disorder, Paediatrics and reproductive medicine, and Macho
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ABSTRACT Damage to the medial and dorsal septal nuclear groups or to the ventral sector of gyrus proreus impaired performance of cats during DRL 40 acquisition. The deficit was diminished during the presentation of a feedback stimulus... more
ABSTRACT Damage to the medial and dorsal septal nuclear groups or to the ventral sector of gyrus proreus impaired performance of cats during DRL 40 acquisition. The deficit was diminished during the presentation of a feedback stimulus signaling the termination of the required delay, but reappeared when feedback was withdrawn. In the absence of feedback, deficient animals generated response distributions correlated with each other, but not correlated with distributions generated by controls. During feedback, all group distributions were correlated. Collateral behavior was evident in all animals during non-feedback periods, and was reduced during feedback. The results support the view that damage to the septum, or frontal cortex impairs the effective utilization of response produced proprioceptive stimuli.
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Research Interests: Engineering, Electrophysiology, Cognition, Attention, Cognitive Neuroscience, and 15 moreMedicine, Humans, EEG Biofeedback, Female, Clinical, Male, Cognitive Performance, Clinical Neurophysiology, Digit span, Adult, Elsevier, Individual Difference, Alpha Rhythm, Brain injuries, and Medical and Health Sciences
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Anat Barnea DSc , Donald Bars PhD , Donald R. Bars PhD , Eugenia Bodenhamer-Davis PhD , Tonya Callaway MS , Grant Bright PhD , Valdeane W. Brown PhD , V. Shannon Burkett MA , John M. Cummins PhD , Robert M. Dickson LPC , Malcolm H.... more
Anat Barnea DSc , Donald Bars PhD , Donald R. Bars PhD , Eugenia Bodenhamer-Davis PhD , Tonya Callaway MS , Grant Bright PhD , Valdeane W. Brown PhD , V. Shannon Burkett MA , John M. Cummins PhD , Robert M. Dickson LPC , Malcolm H. Skolnick PhD and JD , Jeffrey A. Carmen PhD , Marco Congedo PhD , Joel Lubar PhD , David Joffe MS , B. Robert Crago PhD , Lonnie A. Nelson MA , Raymond M. Daly PhD , Bella Lev MSW , Roger deBeus PhD , J. D. Ball PhD , Mary E. deBeus PhD & Richard Herrington PhD Published online: 08 Sep 2008.
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This checklist is intended to encourage robust experimental design and clear reporting for clinical and cognitive-behavioural neurofeedback experiments.
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Research Interests: Cognitive Science, Addiction, Electroencephalography, Emotions, Brain Mapping, and 15 moreBrain, Humans, Personality Assessment Inventory, Cerebral Cortex, EEG Biofeedback, Alcoholism, Female, Male, Electroencephalogram, Applied Psychophysiology, Middle Aged, Adult, Insular Cortex, Low Resolution, and Delta Rhythm
ABSTRACT Poster session
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Research Interests: Cognition, Electroencephalography, Pediatric Neurology, Humans, Child, and 15 moreMale, Reaction Time, Exploration, Modification, Electroencephalogram, Rating Scale, Activity, Performance Indicator, Case Control Study, Neurosciences, Nino, Attention deficit disorder with hyperactivity, Attention deficit hyperactivity disorder, Continuous Performance Test, and Paediatrics and reproductive medicine
A study with three component parts was performed to assess the effectiveness of neurofeedback treatment for Attention Deficit/Hyperactivity Disorder (ADHD). The subject pool consisted of 23 children and adolescents ranging in age from 8... more
A study with three component parts was performed to assess the effectiveness of neurofeedback treatment for Attention Deficit/Hyperactivity Disorder (ADHD). The subject pool consisted of 23 children and adolescents ranging in age from 8 to 19 years with a mean of 11.4 years who participated in a 2- to 3-month summer program of intensive neurofeedback training. Feedback was contingent on the production of 16-20 hertz (beta) activity in the absence of 4-8 hertz (theta) activity. Posttraining changes in EEG activity, T.O.V.A. performance, (ADDES) behavior ratings, and WISC-R performance were assessed. Part I indicated that subjects who successfully decreased theta activity showed significant improvement in T.O.V.A. performance; Part II revealed significant improvement in parent ratings following neurofeedback training; and Part III indicated significant increases in WISC-R scores following neurofeedback training. This study is significant in that it examines the effects of neurofeedback training on both objective and subjective measures under relatively controlled conditions. Our findings corroborate and extend previous research, indicating that neurofeedback training can be an appropriate and efficacious treatment for children with ADHD.
Research Interests: Psychology, Cognitive Science, Nonparametric Statistics, Attention, Electroencephalography, and 11 moreTreatment Outcome, Adolescent, Child Behavior, Humans, Child, Applied, Female, Male, Children and Adolescents, Attention deficit disorder with hyperactivity, and Attention deficit hyperactivity disorder
Neurophysiological correlates of Attention Deficit Disorder with and without Hyperactivity (ADD/HD) and effects of methylphenidate are explored using electroencephalographic (EEG) and auditory eventrelated potentials (ERPs). In the first... more
Neurophysiological correlates of Attention Deficit Disorder with and without Hyperactivity (ADD/HD) and effects of methylphenidate are explored using electroencephalographic (EEG) and auditory eventrelated potentials (ERPs). In the first of four studies, a database of ADD/HD individuals of varying ages and matched adolescent/adult controls is presented. Study 2 compares controls and age-matched children with ADD, and children with ADHD on and
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... The only major change in procedure involved the elimination of the movement of the boxes during the ITI since the animal was re-quired ... was almost complete destruction of nuclei septi lateralis and septi medialis in all sub-jects... more
... The only major change in procedure involved the elimination of the movement of the boxes during the ITI since the animal was re-quired ... was almost complete destruction of nuclei septi lateralis and septi medialis in all sub-jects and no differences in extent of damage between ...
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Research Interests: Neuroscience, Cognitive Science, Psychometrics, Cognition, Anterior Cingulate, and 15 moreAttention, Neurofeedback, Electroencephalography, Adolescent, Prefrontal Cortex, Brain Mapping, Humans, Female, Male, Feedback, Adult, Functional Neuroimaging, Neural pathways, Neurosciences, and Functional Laterality
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Research Interests: Cognition, Electroencephalography, Pediatric Neurology, Humans, Child, and 15 moreMale, Reaction Time, Exploration, Modification, Electroencephalogram, Rating Scale, Activity, Performance Indicator, Case Control Study, Neurosciences, Nino, Attention deficit disorder with hyperactivity, Attention deficit hyperactivity disorder, Continuous Performance Test, and Paediatrics and reproductive medicine
ABSTRACT Rats with septal lesions were compared to non-operated controls in an investigation of gross bodily movement in response to shocks of various intensities. The results of two experiments indicated that septal-operated rats: (a)... more
ABSTRACT Rats with septal lesions were compared to non-operated controls in an investigation of gross bodily movement in response to shocks of various intensities. The results of two experiments indicated that septal-operated rats: (a) display the same detection threshold for electric shock as controls; (b) do not display a greater magnitude of response to supra-threshold shocks although they tend to respond to a greater proportion of shock intensities between the 50 per cent and 100 per cent thresholds; (c) do not display more rapid habituation to repeated shock presentations; and, (d) are more active during the inter-shock interval. These results are discussed with reference to the literature on avoidance learning in septal-operated animals.