Oleamid

Oleamid
	(Z)-Okta-9-decenamid
Drugi nazivi	Oleilamid; 9-Oktadecenamid; (Z)-9-Oktadecenamid; 9,10-Oktadecenoamid; Amid oleinske kiseline; Cis-9,10-oktadecenoamid
Identifikacija
CAS registarski broj	301-02-0
PubChem	5283387
ChemSpider	4446508
UNII	7L25QK8BWO
EINECS broj	206-103-9
ChEBI	116314
ChEMBL	CHEMBL15927
IUPHAR ligand	284
Jmol-3D slike	Slika 1
SMILES
	O=C(N)CCCCCCC\C=C/CCCCCCCC
InChI
	InChI=1S/C18H35NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H2,19,20)/b10-9- ; Kod: FATBGEAMYMYZAF-KTKRTIGZSA-N InChI=1/C18H35NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H2,19,20)/b10-9-; Kod: FATBGEAMYMYZAF-KTKRTIGZBR
Svojstva
Molekulska formula	C18H35NO
Molarna masa	281.48 g mol−1
Agregatno stanje	Kremasta čvrsta materija
Gustina	0,879 g/cm3
Tačka topljenja	102-104 °C
Tačka ključanja	>200 °C
Rastvorljivost u vodi	Nerastvoran je
Opasnost
NFPA 704	0 1 0
Tačka paljenja	>200 °C
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Oleamid je amid oleinske kiseline. On je endogena supstanca, koja se prirodno javlja u telu životinja. On se akumulira u cerebrospinalnom fluidu tokom deprivacije sna i indukuje san kod životinja.^[6] On je izučavan kao potencijalni medicinski tretman za poremećaje raspoloženja i sna, i kanabinoidima regulisane depresije.^[7]^[8]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ ^5,0 ^5,1 ^5,2 ^5,3 ^5,4 Oleamide at chemicalland21.com
↑ Salvador Huitron-Resendiz, Lhys Gombart, Benjamin F. Cravatt, and Steven J. Henriksen (2001). „Effect of Oleamide on Sleep and Its Relationship to Blood Pressure, Body Temperature, and Locomotor Activity in Rats”. Experimental Neurology 172 (1): 235–243. DOI:10.1006/exnr.2001.7792. PMID 11681856.
↑ „Methods of treating anxiety and mood disorders with oleamide - US Patent 6359010”. Arhivirano iz originala na datum 2011-06-12. Pristupljeno 2014-04-11.
↑ Raphael Mechoulam, Ester Fride, Lumír Ondřej Hanuš, Tzviel Sheskin, Tiziana Bisogno, Vincenzo Di Marzo, Michael Bayewitch and Zvi Vogel (1997). „Anandamide may mediate sleep induction”. Nature 389 (6646): 25–26. DOI:10.1038/37891. PMID 9288961.

Povezano

Spoljašnje veze

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[C21-5] 5,0 ^5,1 ^5,2 ^5,3 ^5,4 Oleamide at chemicalland21.com

[6] Salvador Huitron-Resendiz, Lhys Gombart, Benjamin F. Cravatt, and Steven J. Henriksen (2001). „Effect of Oleamide on Sleep and Its Relationship to Blood Pressure, Body Temperature, and Locomotor Activity in Rats”. Experimental Neurology 172 (1): 235–243. DOI:10.1006/exnr.2001.7792. PMID 11681856.

[7] „Methods of treating anxiety and mood disorders with oleamide - US Patent 6359010”. Arhivirano iz originala na datum 2011-06-12. Pristupljeno 2014-04-11.

[8] Raphael Mechoulam, Ester Fride, Lumír Ondřej Hanuš, Tzviel Sheskin, Tiziana Bisogno, Vincenzo Di Marzo, Michael Bayewitch and Zvi Vogel (1997). „Anandamide may mediate sleep induction”. Nature 389 (6646): 25–26. DOI:10.1038/37891. PMID 9288961.

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p r u Neurotransmiteri
Aminokiseline	Alanin • Aspartat • Cikloserin • DMG • GABA • Glutamat • Glicin • Hipotaurin • Kinurenska kiselina (Transtorin) • NAAG (Spaglumska kiselina) • NMG (Sarkozin) • Serin • Taurin • TMG (Betain)
Endokanabinoidi	2-AG • 2-AGE (Noladin etar) • AEA (Anandamid) • NADA • OAE (Virodhamin) • Oleamid
Gasotransmiteri	Ugljen-monoksid • Vodonik-sulfid • Azot-monoksid • Azotsuboksid
Monoamini	Dopamin • Epinefrin (Adrenalin) • Melatonin • NAS (Normelatonin) • Norepinefrin (Noradrenalin) • Serotonin (5-HT)
Purini	Adenozin • ADP • AMP • ATP
Trag amini	3-ITA • 5-MeO-DMT • Bufotenin • DMT • NMT • Oktopamin • Fenetilamin • Sinefrin • Tironamin • Triptamin • Tiramin
Drugi	1,4-BD • Acetilholin • GBL • GHB • Histamin
Vidi isto Neuropeptidi