Leu-enkefalin
Leu-enkefalin | |||
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IUPAC ime |
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Identifikacija | |||
CAS registarski broj | 58822-25-6 | ||
PubChem[1][2] | 10415290 | ||
ChemSpider[3] | 21106451 | ||
IUPHAR ligand | 1613 | ||
Jmol-3D slike | Slika 1 | ||
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Svojstva | |||
Molekulska formula | C28H37N5O7 | ||
Molarna masa | 555.62268 g/mol | ||
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Infobox references |
Leu-enkefalin je endogenni opioidni peptidni neurotransmiter koji se prirodno javlja u mozgu mnogih životinja, uključujući čoveka.[4][5] On je jedna od dve forme enkefalina. Druga forma je met-enkefalin. Za tirozinski ostatak u poziciji 1 se smatra da je analogan sa 3-hidroksilnom grupom morfina.
Leu-enkefalin je peptid sa sekvencom: Tyr - Gly - Gly - Phe - Leu. On proizvodi farmakološke efekte na mi i delta opioidnim receptorima, mada ima veću potentnost na delta receptoru.
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Dudás B, Merchenthaler I (2003). „Topography and associations of leu-enkephalin and luteinizing hormone-releasing hormone neuronal systems in the human diencephalon”. J Clin Endocrinol Metab. 88 (4): 1842-8.
- ↑ Khachaturian, Henry Lewis, Michael E. Watson, Stanley J. (2006). Immunocytochemical studies with antisera against Leu-enkephalin and an enkephalin-precursor fragment (BAM-22P) in the rat brain. Elsevier. DOI:10.1016/0024-3205(82)90233-8. PMID 6759829.