Alazocin

Alazocin
(IUPAC) ime
	(2R,6R,11R)- 6,11-dimethyl- 3-prop- 2-en- 1-yl- 1,2,3,4,5,6-hexahydro- 2,6-methano- 3-benzazocin- 8-ol 2-allyl- 5,9-dimethyl- 2'-hydroxy- 6,7-benzomorphan
Klinički podaci
Identifikatori
CAS broj	14198-28-8
ATC kod	nije dodeljen
PubChem	3036246
ChemSpider	2300306
Hemijski podaci
Formula	C17H23NO
Mol. masa	257.37 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C17H23NO/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17/h4-6,11-12,16,19H,1,7-10H2,2-3H3/t12-,16+,17+/m0/s1 ; Key: LGQCVMYAEFTEFN-JCURWCKSSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Uncontrolled
Način primene	?

Alazocin ((-)-SKF-10,047, (-)-N-alilnormetazocin, (-)-ANMC), je bio prvi lek koji je agonist σ₁ receptora (K_i = 24 nM).^[4]^[5]^[6] On nema značajan afinitet za σ₂ receptor.^[6] Alazocin takođe deluje kao agonist κ-opioidnog receptora (K_i = 0.4 nM), i u znatno manjoj meri kao antagonist NMDA receptora (K_i = 587 nM).^[6]^[7]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Iwamoto ET (February 1981). „Pharmacologic effects of N-allylnormetazocine (SKF-10047)”. NIDA research monograph 34: 82–8. PMID 6783955.
↑ Shearman GT, Herz A (August 1982). „Non-opioid psychotomimetic-like discriminative stimulus properties of N-allylnormetazocine (SKF 10,047) in the rat”. European journal of pharmacology 82 (3-4): 167–72. PMID 6290235.
↑ ^6,0 ^6,1 ^6,2 Chou YC, Liao JF, Chang WY, Lin MF, Chen CF (March 1999). „Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan”. Brain Research 821 (2): 516–9. DOI:10.1016/S0006-8993(99)01125-7. PMID 10064839.
↑ Gharagozlou P, Hashemi E, DeLorey TM, Clark JD, Lameh J (2006). „Pharmacological profiles of opioid ligands at kappa opioid receptors”. BMC Pharmacology 6: 3. DOI:10.1186/1471-2210-6-3. PMC 1403760. PMID 16433932.

Povezano

Benzomorfan

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Iwamoto ET (February 1981). „Pharmacologic effects of N-allylnormetazocine (SKF-10047)”. NIDA research monograph 34: 82–8. PMID 6783955.

[5] Shearman GT, Herz A (August 1982). „Non-opioid psychotomimetic-like discriminative stimulus properties of N-allylnormetazocine (SKF 10,047) in the rat”. European journal of pharmacology 82 (3-4): 167–72. PMID 6290235.

[pmid10064839-6] 6,0 ^6,1 ^6,2 Chou YC, Liao JF, Chang WY, Lin MF, Chen CF (March 1999). „Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan”. Brain Research 821 (2): 516–9. DOI:10.1016/S0006-8993(99)01125-7. PMID 10064839.

[pmid16433932-7] Gharagozlou P, Hashemi E, DeLorey TM, Clark JD, Lameh J (2006). „Pharmacological profiles of opioid ligands at kappa opioid receptors”. BMC Pharmacology 6: 3. DOI:10.1186/1471-2210-6-3. PMC 1403760. PMID 16433932.

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