EGLU

EGLU
(IUPAC) ime
	(2S)-2-amino-2-etilpentandionska kiselina
Klinički podaci
Identifikatori
ATC kod	nije dodeljen
PubChem	5311079
Hemijski podaci
Formula	C7H13NO4
Mol. masa	175,182 g/mol
InChI
	InChI=1S/C7H13NO4/c1-2-7(8,6(11)12)4-3-5(9)10/h2-4,8H2,1H3,(H,9,10)(H,11,12)/t7-/m0/s1 ; Key: QFYBYZLHPIALCZ-ZETCQYMHSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

(2S)-α-Etilglutaminska kiselina (EGLU) je lek koji se koristi u neurološkim istraživanjima. On je bio jedno od prvih jedinjenja za koja je utvrđeno da deluju kao selektivni antagonisti za grupu II metabotropnih glutamatnih receptora (mGluR_2/3), tako da je bio koristan u karakterizaciji i istraživanju ove receptorske familije.^[3]^[4]^[5]^[6]^[7]^[8]^[9]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Jane, DE; Thomas, NK; Tse, HW; Watkins, JC (1996). „Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord”. Neuropharmacology 35 (8): 1029–35. DOI:10.1016/S0028-3908(96)00048-2. PMID 9121605.
↑ Huang, L; Rowan, MJ; Anwyl, R (1999). „Induction of long-lasting depression by (+)-alpha-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro”. European Journal of Pharmacology 366 (2–3): 151–8. DOI:10.1016/S0014-2999(98)00918-2. PMID 10082195.
↑ Palazzo, E; Marabese, I; De Novellis, V; Oliva, P; Rossi, F; Berrino, L; Rossi, F; Maione, S (2001). „Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception”. Neuropharmacology 40 (3): 319–26. DOI:10.1016/S0028-3908(00)00160-X. PMID 11166324.
↑ Iserhot, C; Gebhardt, C; Schmitz, D; Heinemann, U (2004). „Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat”. Brain Research 1027 (1–2): 151–60. DOI:10.1016/j.brainres.2004.08.052. PMID 15494166.
↑ Cahusac, PM; Wan, H (2007). „Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo”. Neuroscience 146 (1): 202–12. DOI:10.1016/j.neuroscience.2007.01.049. PMID 17346894.
↑ Kim, WY; Vezina, P; Kim, JH (2008). „Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment”. Behavioural Brain Research 191 (1): 62–6. DOI:10.1016/j.bbr.2008.03.010. PMID 18433894.
↑ Altinbilek, B; Manahan-Vaughan, D (2009). „A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory”. Neuroscience 158 (1): 149–58. DOI:10.1016/j.neuroscience.2008.07.045. PMID 18722513.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Jane, DE; Thomas, NK; Tse, HW; Watkins, JC (1996). „Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord”. Neuropharmacology 35 (8): 1029–35. DOI:10.1016/S0028-3908(96)00048-2. PMID 9121605.

[4] Huang, L; Rowan, MJ; Anwyl, R (1999). „Induction of long-lasting depression by (+)-alpha-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro”. European Journal of Pharmacology 366 (2–3): 151–8. DOI:10.1016/S0014-2999(98)00918-2. PMID 10082195.

[5] Palazzo, E; Marabese, I; De Novellis, V; Oliva, P; Rossi, F; Berrino, L; Rossi, F; Maione, S (2001). „Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception”. Neuropharmacology 40 (3): 319–26. DOI:10.1016/S0028-3908(00)00160-X. PMID 11166324.

[6] Iserhot, C; Gebhardt, C; Schmitz, D; Heinemann, U (2004). „Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat”. Brain Research 1027 (1–2): 151–60. DOI:10.1016/j.brainres.2004.08.052. PMID 15494166.

[7] Cahusac, PM; Wan, H (2007). „Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo”. Neuroscience 146 (1): 202–12. DOI:10.1016/j.neuroscience.2007.01.049. PMID 17346894.

[8] Kim, WY; Vezina, P; Kim, JH (2008). „Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment”. Behavioural Brain Research 191 (1): 62–6. DOI:10.1016/j.bbr.2008.03.010. PMID 18433894.

[9] Altinbilek, B; Manahan-Vaughan, D (2009). „A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory”. Neuroscience 158 (1): 149–58. DOI:10.1016/j.neuroscience.2008.07.045. PMID 18722513.

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