O-806

O-806
(IUPAC) ime
	(6aR)-3-(6-bromoheks-2-inil)-6,6,9-trimetil-6a,7,10,10a-tetrahidrobenzo[c]hromen-1-ol
Klinički podaci
Identifikatori
ATC kod	nije dodeljen
PubChem	10549140
ChemSpider	26001356
Hemijski podaci
Formula	C22H27BrO2
Mol. masa	403,352 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C22H27BrO2/c1-15-9-10-18-17(12-15)21-19(24)13-16(8-6-4-5-7-11-23)14-20(21)25-22(18,2)3/h9,13-14,17-18,24H,5,7-8,10-12H2,1-3H3/t17-,18-/m1/s1 ; Key: QHFROVGTWNPDOW-QZTJIDSGSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Verzija za štampanje više nije podržana i može davati greške. Podnovite oznake i koristite ugrađenu mogućnost štampanja preglednika.

O-806 je lek koji je kanabinoidni derivat sa primenom u naučnim istraživanjima. On je mešoviti agonist/antagonist kanabinoidnog receptora CB₁. Drugim rečima on deluje kao antagonist kad se dozira zajedno sa potentnijim CB₁ agonistom, dok je slab parcijalni agonist u odsustvu drugog agonist.^[4]^[5]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Griffin, G.; Wray, E.; Rorrer, W.; Crocker, P.; Ryan, W.; Saha, B.; Razdan, R.; Martin, B. i dr.. (1999). „An investigation into the structural determinants of cannabinoid receptor ligand efficacy”. British Journal of Pharmacology 126 (7): 1575–1584. DOI:10.1038/sj.bjp.0702469. PMC 1565939. PMID 10323589.
↑ Griffin, G.; Wray, E.; Martin, B.; Abood, M. (1999). „Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum”. British Journal of Pharmacology 128 (3): 684–688. DOI:10.1038/sj.bjp.0702806. PMC 1571656. PMID 10516649.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Griffin, G.; Wray, E.; Rorrer, W.; Crocker, P.; Ryan, W.; Saha, B.; Razdan, R.; Martin, B. i dr.. (1999). „An investigation into the structural determinants of cannabinoid receptor ligand efficacy”. British Journal of Pharmacology 126 (7): 1575–1584. DOI:10.1038/sj.bjp.0702469. PMC 1565939. PMID 10323589.

[5] Griffin, G.; Wray, E.; Martin, B.; Abood, M. (1999). „Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum”. British Journal of Pharmacology 128 (3): 684–688. DOI:10.1038/sj.bjp.0702806. PMC 1571656. PMID 10516649.

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