Anitha Roy
SAVEETHA UNIVERSITY, Department of Pharmacology, Faculty Member
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Background: Chronic non communicable diseases were interlinked with inflammation and infections should response to starting core of major diseases in both acute and chronic conditions. In drug discovery, development of a drug which acts... more
Background: Chronic non communicable diseases were interlinked with inflammation and infections should response to starting core of major diseases in both acute and chronic conditions. In drug discovery, development of a drug which acts as anti-infective agents (anti-microbial and anti-inflammatory) must be ideal and challenging for management of many chronic diseases. Objective: In this study, six lead pyrazoline hybrids were synthesized by cyclization of chalcones and characterized by various spectroscopic and elemental analysis. All synthesized compounds were screened for anti-inflammatory and anti-microbial activity by computational tools and biological evaluation. Methods: Synthesized pyrazoline analogues were characterized by various spectroscopic techniques and evaluated for prediction of pharmacokinetics, physicochemical properties and Molecular docking studies of various targeted enzymes on microbial and inflammatory mediators. Those compounds were screened by anti-microbia...
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Objective: The objective of the present study was to evaluate the safety and tolerability of autoinjector devices (AIDs) in rabbits by intramuscular (i.m.) administration, using haematological and biochemical markers. Introduction:... more
Objective: The objective of the present study was to evaluate the safety and tolerability of autoinjector devices (AIDs) in rabbits by intramuscular (i.m.) administration, using haematological and biochemical markers. Introduction: Emergency and mass casualty situations require immediate drug delivery for which AIDs are preferred. The tolerability of amikacin as antibacterial and buprenorphine as analgesic AID has been studied in rats by intraperitoneal administration. In the present study, it was evaluated in rabbits by i.m. administration. Methods: Water-filled glass cartridges (2.3–2.4 mL) were converted to amikacin (106 mg/mL) and buprenorphine (0.128 mg/mL) cartridges. Dual dose AID was used for i.m. administration (1.2 mL). The study was done as a crossover design on 12 rabbits. Initially, three rabbits each were given manually or AID, 57 mg/kg amikacin, and three rabbits each by manual or by AID, 0.07 mg/kg buprenorphine for 7 days. After 1 month, the injections were changed ...
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AIM: The aim of the study is to find the antidiabetic activity of piper longum and stevia herbal formulation. INTRODUCTION: Diabetes Mellitus also known as diabetes is a metabolic disorder which is characterised with increased blood... more
AIM: The aim of the study is to find the antidiabetic activity of piper longum and stevia herbal formulation. INTRODUCTION: Diabetes Mellitus also known as diabetes is a metabolic disorder which is characterised with increased blood glucose level. Frequent urination, increased thirst and increased appetite are the common symptoms. Three types of diabetes are there namely type 1, type 2, and gestational diabetes. Piper longum also known as indian long pepper, belongs to the family piperaceae. It belongs to the indo-malaya region and tropical rainforest region. Stevia rebaudiana commonly known as candly leaf, sweet leaf and sugar leaf belongs to the genus stevia. Stevia is a natural sweetener and natural sugar substitute. MATERIALS AND METHOD: lpha-amylase inhibition was determined by quantifying the amount of maltose liberated during the experiment. Different concentration of nanoparticles (10, 20, 30, 40, 50 L.) was pre-incubated with 100 L of amylase solution (1U/mL) at room temper...
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Context: Ajwain oil is an essential oil with thymol as its major constituent which is known for many pharmacological activities.Aims: To evaluate the anti-hyperglycaemic potential of ajwain oil using different in vitro models.Methods and... more
Context: Ajwain oil is an essential oil with thymol as its major constituent which is known for many pharmacological activities.Aims: To evaluate the anti-hyperglycaemic potential of ajwain oil using different in vitro models.Methods and Material: In vitro α-amylase and α-glucosidase inhibitory effect of ajwain oil was carried out by the method of Bernfeld and Shibano et al. 1997 with minor modifications respectively. Cytotoxicity of the ajwain oil was assessed using MTT assay. Glucose uptake potential was assessed in differentiated L6 myotubes using fluorescent tagged 6-NBDG.Results: Ajwain oil showed very good α – amylase inhibitory activity. A maximum inhibition of 88.55 ±0.43 % was achieved at a concentration of 4µL/ml by ajwain oil which was comparable to that of standard acarbose, 90.96 ± 1.81%. The IC50 of the extract was found to be 0.47µL/ml and for acarbose 0.69µL/ml. The maximum in vitro α – glucosidase inhibitory activity was found to be 89 ± 0.72 % and 91.67 ± 1.09% at 4µL/ml for ajwain oil and acarbose. The IC50 of the extract and acarbose were found to be 0.37µL/ml and 0.41µL/ml respectively. Ajwain oil has enhanced glucose uptake in L6 myotubes in a dose dependent manner.Conclusion: The anti-hyperglycaemic activity of the ajwain oil strongly support its ability to decrease sugar level hence it may be further validated for its use as an antidiabetic agent.
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Aim: To evaluate the anti-diabetic activity of cassia fistula. Materials and methods: Cassia fistula extract used in the study here was obtained from Green Chem Herbal extracts and formulations, Bengaluru, India. DMEM, FBS, and... more
Aim: To evaluate the anti-diabetic activity of cassia fistula. Materials and methods: Cassia fistula extract used in the study here was obtained from Green Chem Herbal extracts and formulations, Bengaluru, India. DMEM, FBS, and Pioglitazone, were obtained from Sigma Aldridge co India. Acarbose, dinitrosalicylic acid, DMSO is obtained from Sigma Aldrich co. India. Alpha amylase enzymes were procured from Himedia, Mumbai. All the roger chemicals used in the study were up to analytical grade. The study was carried out as an in vitro study by the method of Bernfeld. Results: cassia fistula showed high alpha amylase inhibitory activity. Conclusion: It can be concluded that cassia fistula shows high alpha amylase inhibitory activity and can be used as medication for diabetes.
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COVID 19 is due to SARS-CoV2 and has a vital role as a causative agent of a potentially fatal disease which targets the human respiratory system. Generalized additive models are used to explore the effect of diurnal temperature, humidity... more
COVID 19 is due to SARS-CoV2 and has a vital role as a causative agent of a potentially fatal disease which targets the human respiratory system. Generalized additive models are used to explore the effect of diurnal temperature, humidity on COVID 19. COVID 19 has played a crucial role in revitalizing the Earth causing enticed changes worldwide. Efforts have been made to prioritize investments for adopting a shift to cleaner energy alternatives, thereby sustaining human lives. COVID 19 has a positive impact on the global climatic conditions making it favorable for the inhabitants. There is a significant reduction in the level of greenhouse gas emissions, the use of fossil fuels, coal, non-renewable resources, relative humidity, air pollution. The global calamity has led to a serious threat to human lives. To control the pandemic, special attention and efforts are taken to protect the person-to-person transmission. Social distancing must be maintained to prevent the spread of the dise...
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Introduction: Nanotechnology is one of the most facilitated technology that has been found in the recent past. It has been used enormously in different fields like medicine, material science and physics. Silver nanoparticles play a vital... more
Introduction: Nanotechnology is one of the most facilitated technology that has been found in the recent past. It has been used enormously in different fields like medicine, material science and physics. Silver nanoparticles play a vital role in nanomedicine. Even though several noble metals were used for different purposes, silver nanoparticles were focused in the application of the diagnosis of cancer. Materials and Methods: Cumin oil mediated silver nanoparticles were prepared using 1 milli molar of silver nitrate. The prepared nanoparticles were confirmed using UV-visible spectrophotometer. The nanoparticles were analysed for its morphological characters using TEM the size and shape of the nanoparticles clearly analysed using this technique. Results: The visual colour change observed in the cumin oil solution shows the presence of silver nanoparticles. Silver nanoparticles were observed from 360 nm to 460 nm in UV-Visible spectroscopy. In TEM the silver nanoparticles observed were spherical in shape with ranging from 2-30 nm. Conclusion: Cumin oil mediated silver nanoparticles can further be used for management of diabetes, high blood pressure, rheumatoid arthritis and to boost immune system as well as for Cancer.
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Nanomaterials represent, materials that are natural, incidental, or manufactured, containing particles in their free state or which exist as aggregates, in which 50% or more of the particles in number, size, distribution, or one or more... more
Nanomaterials represent, materials that are natural, incidental, or manufactured, containing particles in their free state or which exist as aggregates, in which 50% or more of the particles in number, size, distribution, or one or more external dimension is in the size range of 1–100 nm.[1] They offer various physiochemical properties as ultra-small size, large surface area, etc.[2] These properties make them liable to reach and interact with the cellular, subcellular and even molecular level of the human body and hence it helps to achieve maximum therapeutic efficacy with minimal side effects.[3,4] Nanotechnology has developed in such a way that it has a huge horizon of applications such as drug delivery, gene transfection, tissue regeneration, and antibacterial as well as anti-inflammatory applications.[5,6] Research Article
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Deltamethrin (DEL) and other synthetic repellents like N,N‐diethyl benzamide (DEB), N,N‐diethyl phenylacetamide (DEPA), and N,N‐diethyl meta toluamide (DEET) are widely used due their high efficacy against mosquitoes. We evaluated the... more
Deltamethrin (DEL) and other synthetic repellents like N,N‐diethyl benzamide (DEB), N,N‐diethyl phenylacetamide (DEPA), and N,N‐diethyl meta toluamide (DEET) are widely used due their high efficacy against mosquitoes. We evaluated the safe dose on exposure to insecticide and insect repellent individually and in combination in Wistar rats. Rats were administrated with individual chemicals DEL, DEB, DEPA, and DEET and in combination of DEL along DEB, DEPA, and DEET. The reduced glutathione and its detoxifying enzymes were significantly increased in DEL treated rats. Serotonin, dopamine, and noradrenaline were increased in DEL alone and its combination groups. Histopathology revealed that DEL and along with other insect repellants can cause lung toxicities. This study suggests that DEL in combination with other insect repellents showed antagonistic effect against oxidative stress, and there was no significant toxicological effect in the combination groups. The insect repellents with DE...
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Background: Nitric oxide (NO) is an inflammatory agent produced by macrophages. It also acts as a neurotransmitter. However, overproduction of NO results in acute or chronic inflammation. Capsicum is well known for its anti-oxidant,... more
Background: Nitric oxide (NO) is an inflammatory agent produced by macrophages. It also acts as a neurotransmitter. However, overproduction of NO results in acute or chronic inflammation. Capsicum is well known for its anti-oxidant, anti–inflammatory, and anticancer properties. Objective: The objective of this study was to evaluate the effect of capsicum oleoresin on NO production and NO synthase gene expression in lipopolysaccharide (LPS) stimulated RAW 264.7 macrophage cell line. Materials and Methods: Macrophage RAW 264.7 cells were obtained from the National Centre for Cell Science, Pune with Passage no 16. RAW macrophages were treated with 12.5 μg/ml, 25 μg/ml, and 50 μg/ml of Capsicum extract with 1 μg/ml of LPS and incubated for 24 h. Results: When capsicum was added at three different doses of 12.5 μg/ml, 25 μg/ml, and 50 μg/ml, the inducible NO synthase (iNOS) levels was significantly suppressed, compared to that of LPS treatment only. The level of NO increased by LPS induction was significantly decreased in a dose-dependent manner when treated with different concentrations of capsicum extract and capsicum had a suppressing effect on iNOS gene expression in LPS – stimulated RAW 264.7 macrophage. Conclusion: This study concludes that capsicum oleoresin is good enough to suppress iNOS gene expression and NO production. Hence, it may be used in inflammatory conditions with excessive NO production. Abbreviations Used: NO: Nitric oxide, LPS: Lipopolysaccharide, iNOS: Inducible nitric oxide synthase, DMEM: Dulbecco's modified Eagle medium, MTT: 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide for, DMSO: Dimethyl sulfoxide, PBS: Phosphate buffer saline, FBS: Fetal bovine serum.
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Aim: The aim of the study was to synthesise cumin oil mediated silver nanoparticles and to evaluate its effect on oral microbes. Introduction: Silver nanoparticles have been assessed for their catalytic, various optical, magnetic... more
Aim: The aim of the study was to synthesise cumin oil mediated silver nanoparticles and to evaluate its effect on oral microbes. Introduction: Silver nanoparticles have been assessed for their catalytic, various optical, magnetic andantibacterial properties. It has a large application in the various fields such as photography, biosensor, biomolecular detection and in cosmetics. Materials and Methods: The silver nanoparticles were prepared initially using cumin oil and confirmed both visually as well as spectrophotometrically.The antimicrobial activity of the cumin oil mediated silver nanoparticles were then evaluated by agar well diffusion method and the zone of inhibition was recorded against oral pathogens such as Streptococcus mutans, Staphylococcus aureus and E.fecalis. Results: The cumin oil mediated silver nanoparticles showed dose dependent antimicrobial activity with very good zone of inhibition against the tested oral pathogens. Conclusion: This study prove that cumin oil mediated silver nanoparticles can be used for the control of infections caused byStreptococcus mutans, Staphylococcus aureus and E.fecalis.
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published quarterly. The aim of IJPBS is to publish. peer reviewed research and review articles rapidly without delay in the developing field of pharmaceutical and biological sciences
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ABSTRACT Infections with bacteria have become a serious problem in joint arthroplasty. This study reports about in vitro antibacterial activity and in vitro cell compatibility of poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)... more
ABSTRACT Infections with bacteria have become a serious problem in joint arthroplasty. This study reports about in vitro antibacterial activity and in vitro cell compatibility of poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofibers loaded with metallic silver particles of a size of 5-13 nm. In vitro antibacterial activity against Staphylococcus aureus and Klebsiella pneumoniae was studied by microplate proliferation tests. The adhesion, viability, and proliferation properties of fibroblasts (NIH 3T3) and differentiation of osteoblasts (MC3T3-E1) were done to study in vitro cell compatibility of the scaffolds. As the results, only silver-containing PHBV nanofibrous scaffolds showed a high antibacterial activity and an inhibitory effect on the growth of both Staphylococcus aureus and Klebsiella pneumoniae bacteria. The nanofibrous scaffolds having silver nanoparticles <1.0% were free of in vitro cytotoxicity. To sum up, the PHBV nanofibrous scaffolds having nanoparticles <1.0 wt % showed not only good antibacterial activity but also good in vitro cell compatibility. It is considered that the PHBV nanofibrous scaffolds with silver nanoparticles <1.0 wt % have a potential to be used in joint arthroplasty.
Research Interests: Engineering, Chemistry, Manufacturing, Kinetics, Electrospinning, and 15 moreCytotoxicity, Medicine, Biological Sciences, In Vitro, Cell Differentiation, Mice, Animals, Fabrication, Framework, CHEMICAL SCIENCES, Biomaterial, Antibacterial activity, Biocompatible Materials, Biomacromolecules, and Klebsiella pneumoniae
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Introduction: Seaweeds are marine macroscopic algae; they are the raw materials for the production of agar and algin and later they are consumed as foodstuffs. Seaweeds are grouped under three divisions viz., Chlorophyceae, Phaeophyceae,... more
Introduction: Seaweeds are marine macroscopic algae; they are the raw materials for the production of agar and algin and later they are consumed as foodstuffs. Seaweeds are grouped under three divisions viz., Chlorophyceae, Phaeophyceae, and Rhodophyceae which are found in relatively shallow coastal waters. Sargassum, a genus of brown seaweed, and it was commonly known as gulfweed belonging to the family Sargassaceae. The antibacterial activity of a molecule is completely associated with compounds that kill bacteria or slow down their growth rate, without being highly toxic to nearby tissues. The main aim of the study is to prepare and evaluate the potential antibacterial activity of Sargassum species seaweed extract against E. coli. Materials and Methods: The fresh seaweed Sargassum sp. was collected from Tuticorin coastal area, Tamil Nadu. The extract was prepared using ethanol and stored in a shadowy aluminum container at 4ºC for further ana...
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Background: Prostate cancer is the second most common cause of cancer deaths for men. The role of plants in the prevention and treatment of disease has been known from the dawn of civilization. Plants maintain the health and vitality of... more
Background: Prostate cancer is the second most common cause of cancer deaths for men. The role of plants in the prevention and treatment of disease has been known from the dawn of civilization. Plants maintain the health and vitality of individuals and also cure diseases, including cancer without causing toxicity. More than 50% of all modern drugs in clinical use are of natural products, many of which have the ability to control cancer cells. Saraca Asoca (Roxb.), De. Wild or Saraca indica is one of the most ancient trees of India Aim: Aim of this study is to investigate the anti-cancer effects of Saraca Asoca flower extract on prostate cancer cell line. Materials and Methods: The anti-cancer effects of Saraca Asoca extract on prostate cancer cell lines was assessed by cell viability assay, cell and nuclear morphological studies. The multiple concentration of Saraca Asoca extract (0, 20, 40, 60, 80, 100 and 120 µg/ml) was used and IC50 doses were calculated. Results: The MTT (3-[4,5...
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Background: Skin cancers are cancers that develop on the surface of the skin. They occur as a result of the formation of irregular cells with the potential to infiltrate or migrate to other areas of the body. Natural medicinal resources,... more
Background: Skin cancers are cancers that develop on the surface of the skin. They occur as a result of the formation of irregular cells with the potential to infiltrate or migrate to other areas of the body. Natural medicinal resources, such as the traditional herbal remedy Lippia nodiflora, have long been used to treat dermatological disorders including skin inflammation and melanogenesis. Apoptosis serves as a promising pathway in controlling cancer. However there are minimal amounts of studies exploring its proapoptotic activity of Lippia nodiflora in skin cancer cells. Aim: The aim of this present study was to evaluate the pro-apoptotic effect of Lippia nodiflora leaf extract against the skin cancer cell line. Materials and Methods: MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays were used to determine the cytotoxic effect of Lippia nodiflora leaf extract against skin cancer cells (B16-F10). The skin cancer cells were treated with different concentrat...
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Quinoline- and acridine-based drugs are widely used as anti-breast cancer agents. These drugs act through various mechanisms of action; for example, neratinib acts on epidermal growth factor receptor 1 (EGFR) and human epidermal receptor... more
Quinoline- and acridine-based drugs are widely used as anti-breast cancer agents. These drugs act through various mechanisms of action; for example, neratinib acts on epidermal growth factor receptor 1 (EGFR) and human epidermal receptor type 2 (HER2) enzymes, whereas amsacrine and pyrazoloacridine act on topoisomerase II enzymes. The objective of the present study was to explore and compare the interaction mechanism of knowledge-based designed derivatives of FDA-approved quinoline- and acridine-based drugs. The above-stated cancer proteins were collected from PDB, prepared by correcting any broken chains, removing water and adding charges. Docking studies were performed in the PyRx docking tool, and Discovery Studio Visualizer was used to visualize the molecular interactions. The result obtained found that neratinib had a better binding affinity towards EGFR and HER2 but weaker binding affinity towards topoisomerase IIα and topoisomerase IIβ. On the other hand, amsacrine and pyrazoloacridine were found to have better binding scores in topoisomerase IIα and topoisomerase IIβ instead of EGFR and HER2, as already proved experimentally. All the designed molecules have shown better binding affinity to their favourable enzymes and other enzymes involved in breast cancer development. The outcome reveals that the designed quinoline- and acridine-based drugs derivatives could be examined as a potent inhibitory drug of breast cancer for their strong multi-targeted inhibition ability and reactivity. Further synthesis, in vitro and in vivo investigations of designed derivatives may be done to prove their therapeutic potential in breast cancer treatment.
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Background: Lung cancer, also known as bronchogenic carcinoma, is a kind of cancer that begins in the lung parenchyma or inside the bronchi. In the United States, it is one of the top causes of cancer-related fatalities. Lippia nodiflora... more
Background: Lung cancer, also known as bronchogenic carcinoma, is a kind of cancer that begins in the lung parenchyma or inside the bronchi. In the United States, it is one of the top causes of cancer-related fatalities. Lippia nodiflora is a flowering, broadleaf plant native to South America. Lippia nodiflora has been used as a natural medicine for a number of disorders due to its antioxidant, anti-inflammatory, anti-bacterial, and anti-tumor characteristics. Aim of the Study: To evaluate the anticancer effect of Lippia nodiflora leaf extract on lung cancer. Materials and methods: The cytotoxic effect of Lippia nodiflora leaf extract was assessed by an MTT assay. The A-549 cells were treated with different concentrations of Lippia nodiflora leaf extract (10-120 μg) for 24h. Analysis of changes in the cell morphology is examined by phase contrast microscope. For the nuclear morphological changes analysis, DAPI staining was used in lung cancer cells. The apoptotic nuclei were viewed ...
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The immune system is one of nature's most fascinating inventions. It is an amazing protection mechanism designed to defend us against millions of bacteria, viruses, fungi, toxins and parasites. The immune system is very complex. It is... more
The immune system is one of nature's most fascinating inventions. It is an amazing protection mechanism designed to defend us against millions of bacteria, viruses, fungi, toxins and parasites. The immune system is very complex. It is made up of several types of cells and proteins that have different jobs to do in fighting against foreign invaders. If our immune system is working properly we are protected from dangers caused by microbes. If not, we suffer sickness and disease. It is possible to intervene in this process and make our immune system stronger using immune boosters. Immune boosters work in many ways. They increase the number of white blood cells in the immune system army, train them to fight against microbes causing diseases. This review article gives an overall view about some natural herbs like Echinaceae purpurea [Cone flower], Panex ginseng [Asian ginseng], Astragalus mambraneous [Milk vetch], Uncaria tomentosa [Cat’s claw] and Withania somnifera [Aswagandha] tha...
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Nature has been a source of medicinal agents for thousands of years and an impressive number of modern drugs has been isolated from natural sources, many based on their use in traditional medicine.Plant extracts are attractive sources of... more
Nature has been a source of medicinal agents for thousands of years and an impressive number of modern drugs has been isolated from natural sources, many based on their use in traditional medicine.Plant extracts are attractive sources of new drugs and have been shown to produce promising results in the treatment of various diseases.Crataegus oxyacantha Linn., commonly known as Hawthorn, is one of the most widely used herbal plant with diverse pharmacological actions.It possess antioxidant and collagen stabilizing action. Hawthorn is used to treat a wide variety of inflammatory conditions, but primary use is treat hypertension, ischemic heart disease, congestive heart failure and arrhythmia. The chemical composition of Hawthorn includes vitamin C, Flavonoids, Glycosides, Saponins and Tannins,Cratategen, cardiotonic amines, Amygdalin ,pectins etc., Hence the aim of the present article is to compile all the data related to pharmacological aspects of this herbal plant .
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Diabetes mellitus is a chronic metabolic disorder caused by the deficiency of pancreatic hormone insulin (Type1 diabetes mellitus) or due to the resistance of cells to insulin secreted by the body (Type 2 diabetes mellitus). It is a... more
Diabetes mellitus is a chronic metabolic disorder caused by the deficiency of pancreatic hormone insulin (Type1 diabetes mellitus) or due to the resistance of cells to insulin secreted by the body (Type 2 diabetes mellitus). It is a rapidly increasing serious condition which evokes a lot of global concern. Exogenous insulin administration is a commonly used treatment for Type 1diabetes mellitus and for gestational diabetes. The conventional subcutaneous insulin injections cause a lot of suffering to the patient primarily due to pain and secondarily due to dose sensitivity and further complications. Hence alternate delivery systems are an area of endeavor for medical professionals and a convenient alternative system will be a boon to the patients. As a result of the technological advances, various invasive and non-invasive delivery systems have been introduced in the past years. Nanotechnology, particle mediated delivery, pulmonary delivery, buccal spray etc. are the most recent adva...
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Diabetes is a chronic metabolic disorder with altered carbohydrate, fat and protein metabolism characterized by increased fasting and post-prandial blood sugar levels resulting from either insulin insufficiency or insulin dysfunction.... more
Diabetes is a chronic metabolic disorder with altered carbohydrate, fat and protein metabolism characterized by increased fasting and post-prandial blood sugar levels resulting from either insulin insufficiency or insulin dysfunction. There are many herbal remedies suggested for diabetes and diabetic complications. Fruits and vegetables are an important part of the human diet and a major source of biologically active substances such as vitamins and secondary metabolites. As per the studies on diabetic patients, health practitioners prefer including more amount of fibre rich fruits in their diet. These fruits with low sugar concentration help in controlling blood sugar level to a maximum extent. Moreover, intake of fibre rich fruits helps in maintaining cholesterol level which in turn normalizes the metabolic rate of the body. This review gives an insight to the logical use of fruits like Prunus cerasus, Eugenia jambolana, Actinidia deliciosa, Psidium guajava L, Punica granatum and P...
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Root canal treatment is a procedure done to remove the infected pulp of the tooth to prevent infection. Themost important step in root canal treatment is cleaning and shaping which is done to disinfect the root canal.Persistent... more
Root canal treatment is a procedure done to remove the infected pulp of the tooth to prevent infection. Themost important step in root canal treatment is cleaning and shaping which is done to disinfect the root canal.Persistent microorganisms after root canal treatment, can lead to failure of the endodontic treatment. Surveyquestionnaires were prepared, using an online survey portal it was distributed randomly to 100 participantsvia social media application. Responses were tabulated and graphs were plotted. From the survey resultsit was evident that knowledge regarding the recent advancements of root canal disinfection is notable.There was no significant association between the field of practice (specialists / general practitioners) andtheir response to the questions. Overall, the survey showed a good knowledge and awareness among theresponders about the recent advancements in irrigants, used in the root canal treatment
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The aim of the present study is to evaluate the antibacterial activity of ethanolic and aqueous leaf extract of Sesbania grandiflora Linn on selected bacterial species. Sesbania grandiflora (Linn) is a medicinal herb belongs to the family... more
The aim of the present study is to evaluate the antibacterial activity of ethanolic and aqueous leaf extract of Sesbania grandiflora Linn on selected bacterial species. Sesbania grandiflora (Linn) is a medicinal herb belongs to the family Leguminosae .The various parts of the plant like roots, bark, leaves, flower and fruit are known to possess different pharmacological properties. The leaf extract of Sesbania possess good anticonvulsant and anxiolytic activity. The leaves of Sesbania is also found to possess hepatoprotective and potent anti oxidant and anti urolithiatic activity .The Ethanolic and Aqueous extract of leaves were screened for the antimicrobial activity by agar well diffusion method. The test organisms used were Staphylococcus aureus, E.coli, Klebsiella pneumoniae, Psuedomonas aeruginosa and Bacillus subtilus. The results obtained from the study showed that the ethanolic extract has significant antibacterial activity on Staphylococcus aureus and E.coli compared with s...