"Dysferlin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A membrane protein that contains multiple C2 DOMAINS. It is highly expressed in skeletal muscle and functions as a calcium ion sensor in SYNAPTIC VESICLE-PLASMA MEMBRANE fusion, as well as in SARCOLEMMA repair following mechanical stress. Mutations in the dysferlin (DYSF) gene are associated with several hereditary MUSCULAR DYSTROPHIES.
| Descriptor ID |
D000073939
|
| MeSH Number(s) |
D12.776.210.500.248 D12.776.543.225
|
| Concept/Terms |
Dysferlin- Dysferlin
- Fer-1-like Protein 1
- Fer 1 like Protein 1
|
Below are MeSH descriptors whose meaning is more general than "Dysferlin".
Below are MeSH descriptors whose meaning is more specific than "Dysferlin".
This graph shows the total number of publications written about "Dysferlin" by people in this website by year, and whether "Dysferlin" was a major or minor topic of these publications.
Below are the most recent publications written about "Dysferlin" by people in Profiles.
-
The extracellular matrix differentially directs myoblast motility and differentiation in distinct forms of muscular dystrophy: Dystrophic matrices alter myoblast motility. Matrix Biol. 2024 May; 129:44-58.
-
Efficient ssODN-Mediated Targeting by Avoiding Cellular Inhibitory RNAs through Precomplexed CRISPR-Cas9/sgRNA Ribonucleoprotein. Stem Cell Reports. 2021 Apr 13; 16(4):985-996.
-
(-)-Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy. Muscle Nerve. 2021 02; 63(2):239-249.
-
Insights into lipid accumulation in skeletal muscle in dysferlin-deficient mice. J Lipid Res. 2019 12; 60(12):2057-2073.
-
Functional muscle hypertrophy by increased insulin-like growth factor 1 does not require dysferlin. Muscle Nerve. 2019 10; 60(4):464-473.
-
Na+ dysregulation coupled with Ca2+ entry through NCX1 promotes muscular dystrophy in mice. Mol Cell Biol. 2014 Jun; 34(11):1991-2002.
-
Dysferlin is a newly identified binding partner of AβPP and it co-aggregates with amyloid-β42 within sporadic inclusion-body myositis (s-IBM) muscle fibers. Acta Neuropathol. 2013 Nov; 126(5):781-3.
-
Perturbations in skeletal muscle sarcomere structure in patients with heart failure and type 2 diabetes: restorative effects of (-)-epicatechin-rich cocoa. Clin Sci (Lond). 2013 Oct; 125(8):383-9.
-
Assessment of disease activity in muscular dystrophies by noninvasive imaging. J Clin Invest. 2013 May; 123(5):2298-305.
-
GREG cells, a dysferlin-deficient myogenic mouse cell line. Exp Cell Res. 2012 Jan 15; 318(2):127-35.