"Presenilins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.
| Descriptor ID |
D053763
|
| MeSH Number(s) |
D12.776.543.696
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Presenilins".
Below are MeSH descriptors whose meaning is more specific than "Presenilins".
This graph shows the total number of publications written about "Presenilins" by people in this website by year, and whether "Presenilins" was a major or minor topic of these publications.
Below are the most recent publications written about "Presenilins" by people in Profiles.
-
Synapsin-Promoted Caveolin-1 Overexpression Maintains Mitochondrial Morphology and Function in PSAPP Alzheimer's Disease Mice. Cells. 2021 09 20; 10(9).
-
Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens. Differentiation. 2018 Jul - Aug; 102:40-52.
-
Mild cognitive impairment and structural brain abnormalities in a sexagenarian with a history of childhood traumatic brain injury. J Neurosci Res. 2018 04; 96(4):652-660.
-
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein. Biochim Biophys Acta Mol Cell Res. 2017 Jan; 1864(1):217-230.
-
Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3344-9.
-
Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo. Hum Mol Genet. 2013 Oct 01; 22(19):3828-43.
-
New genes and new insights from old genes: update on Alzheimer disease. Continuum (Minneap Minn). 2013 Apr; 19(2 Dementia):358-71.
-
Structure of a presenilin family intramembrane aspartate protease. Nature. 2013 Jan 03; 493(7430):56-61.
-
Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment. Cell Rep. 2012 Nov 29; 2(5):1316-28.
-
Antioxidant proteins TSA and PAG interact synergistically with Presenilin to modulate Notch signaling in Drosophila. Protein Cell. 2011 Jul; 2(7):554-63.