"Hedgehog Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of intercellular signaling proteins that play an important role in regulating the development of many TISSUES and organs. Their name derives from the observation of a hedgehog-like appearance in DROSOPHILA embryos with genetic mutations that block their action.
| Descriptor ID |
D053823
|
| MeSH Number(s) |
D12.644.276.671 D12.776.467.671 D23.529.671
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Hedgehog Proteins".
Below are MeSH descriptors whose meaning is more specific than "Hedgehog Proteins".
This graph shows the total number of publications written about "Hedgehog Proteins" by people in this website by year, and whether "Hedgehog Proteins" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 6 | 6 |
| 1997 | 0 | 8 | 8 |
| 1998 | 0 | 7 | 7 |
| 1999 | 0 | 17 | 17 |
| 2000 | 0 | 18 | 18 |
| 2001 | 0 | 16 | 16 |
| 2002 | 0 | 8 | 8 |
| 2003 | 0 | 16 | 16 |
| 2004 | 0 | 17 | 17 |
| 2005 | 0 | 21 | 21 |
| 2006 | 4 | 26 | 30 |
| 2007 | 12 | 12 | 24 |
| 2008 | 17 | 14 | 31 |
| 2009 | 27 | 13 | 40 |
| 2010 | 28 | 21 | 49 |
| 2011 | 25 | 16 | 41 |
| 2012 | 21 | 17 | 38 |
| 2013 | 16 | 19 | 35 |
| 2014 | 30 | 15 | 45 |
| 2015 | 22 | 18 | 40 |
| 2016 | 13 | 19 | 32 |
| 2017 | 17 | 10 | 27 |
| 2018 | 24 | 12 | 36 |
| 2019 | 21 | 8 | 29 |
| 2020 | 14 | 15 | 29 |
| 2021 | 21 | 5 | 26 |
| 2022 | 5 | 23 | 28 |
| 2023 | 4 | 10 | 14 |
| 2024 | 12 | 7 | 19 |
| 2025 | 2 | 1 | 3 |
Below are the most recent publications written about "Hedgehog Proteins" by people in Profiles.
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Identification of Meibomian gland stem cell populations and mechanisms of aging. Nat Commun. 2025 Feb 15; 16(1):1663.
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Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma. Elife. 2025 Jan 21; 13.
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ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip. Nat Genet. 2025 Jan; 57(1):88-102.
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The Nociceptor Primary Cilium Contributes to Mechanical Nociceptive Threshold and Inflammatory and Neuropathic Pain. J Neurosci. 2024 Nov 20; 44(47).
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Dynamic readout of the Hh gradient in the Drosophila wing disc reveals pattern-specific tradeoffs between robustness and precision. Elife. 2024 Nov 07; 13.
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The G protein-coupled receptor ADGRG6 maintains mouse growth plate homeostasis through IHH signaling. J Bone Miner Res. 2024 Oct 29; 39(11):1644-1658.
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The genomes of all lungfish inform on genome expansion and tetrapod evolution. Nature. 2024 Oct; 634(8032):96-103.
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Fibrinogen inhibits sonic hedgehog signaling and impairs neonatal cerebellar development after blood-brain barrier disruption. Proc Natl Acad Sci U S A. 2024 Jul 30; 121(31):e2323050121.
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Oral Hedgehog Inhibitor, Vismodegib, for Locally Advanced Periorbital and Orbital Basal Cell Carcinoma: A Report by the American Academy of Ophthalmology. Ophthalmology. 2024 Nov; 131(11):1339-1344.
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P4HA2 hydroxylates SUFU to regulate the paracrine Hedgehog signaling and promote B-cell lymphoma progression. Leukemia. 2024 Aug; 38(8):1751-1763.