Proto-Oncogene Proteins c-akt
"Proto-Oncogene Proteins c-akt" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
| Descriptor ID |
D051057
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.755 D12.776.476.565 D12.776.624.664.700.168
|
| Concept/Terms |
Proto-Oncogene Proteins c-akt- Proto-Oncogene Proteins c-akt
- Proto Oncogene Proteins c akt
- c-akt, Proto-Oncogene Proteins
- Protein Kinase B
- Proto-Oncogene Protein RAC
- Proto Oncogene Protein RAC
- RAC, Proto-Oncogene Protein
- Proto-Oncogene Protein Akt
- Akt, Proto-Oncogene Protein
- Proto Oncogene Protein Akt
- Rac Protein Kinase
- akt Proto-Oncogene Protein
- Protein, akt Proto-Oncogene
- Proto-Oncogene Protein, akt
- akt Proto Oncogene Protein
- RAC-PK Protein
- RAC PK Protein
- Related to A and C-Protein
- Related to A and C Protein
- c-akt Proto-Oncogene Protein
- Protein, c-akt Proto-Oncogene
- Proto-Oncogene Protein, c-akt
- c akt Proto Oncogene Protein
- c-akt Protein
- Protein-Serine-Threonine Kinase (Rac)
Proto-Oncogene Proteins c-akt1- Proto-Oncogene Proteins c-akt1
- Proteins c-akt1, Proto-Oncogene
- Proto Oncogene Proteins c akt1
- c-akt1, Proto-Oncogene Proteins
- AKT1 Protein Kinase
- Rac-PK alpha Protein
- Rac PK alpha Protein
- alpha Protein, Rac-PK
- Protein Kinase B alpha
- Akt-alpha Protein
- Akt alpha Protein
Proto-Oncogene Proteins c-akt2- Proto-Oncogene Proteins c-akt2
- Proteins c-akt2, Proto-Oncogene
- Proto Oncogene Proteins c akt2
- c-akt2, Proto-Oncogene Proteins
- Protein Kinase B beta
- Rac-PK beta Protein
- Rac PK beta Protein
- AKT2 Protein Kinase
- Akt-beta Protein
- Akt beta Protein
Proto-Oncogene Proteins c-akt3- Proto-Oncogene Proteins c-akt3
- Proteins c-akt3, Proto-Oncogene
- Proto Oncogene Proteins c akt3
- c-akt3, Proto-Oncogene Proteins
- Akt-gamma Protein
- Akt gamma Protein
- AKT3 Protein Kinase
- Protein Kinase B gamma
|
Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-akt".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-akt".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-akt" by people in this website by year, and whether "Proto-Oncogene Proteins c-akt" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 6 | 6 |
| 1999 | 0 | 15 | 15 |
| 2000 | 0 | 14 | 14 |
| 2001 | 0 | 32 | 32 |
| 2002 | 0 | 53 | 53 |
| 2003 | 1 | 46 | 47 |
| 2004 | 0 | 60 | 60 |
| 2005 | 10 | 64 | 74 |
| 2006 | 27 | 41 | 68 |
| 2007 | 29 | 48 | 77 |
| 2008 | 23 | 62 | 85 |
| 2009 | 38 | 65 | 103 |
| 2010 | 38 | 62 | 100 |
| 2011 | 45 | 67 | 112 |
| 2012 | 30 | 76 | 106 |
| 2013 | 24 | 68 | 92 |
| 2014 | 34 | 65 | 99 |
| 2015 | 37 | 58 | 95 |
| 2016 | 20 | 53 | 73 |
| 2017 | 21 | 40 | 61 |
| 2018 | 9 | 27 | 36 |
| 2019 | 20 | 26 | 46 |
| 2020 | 14 | 19 | 33 |
| 2021 | 11 | 27 | 38 |
| 2022 | 8 | 32 | 40 |
| 2023 | 4 | 24 | 28 |
| 2024 | 19 | 9 | 28 |
| 2025 | 0 | 1 | 1 |
Below are the most recent publications written about "Proto-Oncogene Proteins c-akt" by people in Profiles.
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FBP1 controls liver cancer evolution from senescent MASH hepatocytes. Nature. 2025 Jan; 637(8045):461-469.
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Phase II study of MEK inhibitor trametinib alone and in combination with AKT inhibitor GSK2141795/uprosertib in patients with metastatic triple negative breast cancer. Breast Cancer Res Treat. 2025 Feb; 210(1):179-189.
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Interleukin-2-secreting T helper cells promote extra-follicular B cell maturation via intrinsic regulation of a B cell mTOR-AKT-Blimp-1 axis. Immunity. 2024 12 10; 57(12):2772-2789.e8.
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Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation. Nature. 2025 Jan; 637(8044):205-214.
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An optimized fractionation method reveals insulin-induced membrane surface localization of GLUT1 to increase glycolysis in LβT2 cells. Mol Cell Endocrinol. 2025 Jan 01; 595:112405.
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POU2F2 activates the Akt/mTOR signalling pathway and enhances B lymphocyte function during diabetic kidney disease by promoting PIK3CD transcription. Nephrology (Carlton). 2024 Dec; 29(12):825-837.
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Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer. Cancer Res. 2024 Oct 01; 84(19):3250-3266.
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TSC/mTORC1 mediates mTORC2/AKT1 signaling in c-MYC-induced murine hepatocarcinogenesis via centromere protein M. J Clin Invest. 2024 Sep 26; 134(22).
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The mitochondrial redistribution of ENOS is regulated by AKT1 and dimer status. Nitric Oxide. 2024 Nov 01; 152:90-100.
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Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming. Immunity. 2024 Nov 12; 57(11):2634-2650.e5.