ZA973444B - Transdermally administered dextromethorphan as antitussive agents. - Google Patents
Transdermally administered dextromethorphan as antitussive agents.Info
- Publication number
- ZA973444B ZA973444B ZA9703444A ZA973444A ZA973444B ZA 973444 B ZA973444 B ZA 973444B ZA 9703444 A ZA9703444 A ZA 9703444A ZA 973444 A ZA973444 A ZA 973444A ZA 973444 B ZA973444 B ZA 973444B
- Authority
- ZA
- South Africa
- Prior art keywords
- transdermally administered
- dextromethorphan
- antitussive agents
- administered dextromethorphan
- morphanin
- Prior art date
Links
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 title abstract 3
- 229960001985 dextromethorphan Drugs 0.000 title abstract 3
- 239000003434 antitussive agent Substances 0.000 title 1
- 229940124584 antitussives Drugs 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 2
- 230000000954 anitussive effect Effects 0.000 abstract 2
- 239000003937 drug carrier Substances 0.000 abstract 2
- 239000002207 metabolite Substances 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9601528A SE9601528D0 (sv) | 1996-04-23 | 1996-04-23 | Transdermally administered dextromethorphan as antitissue agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA973444B true ZA973444B (en) | 1997-11-18 |
Family
ID=20402295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9703444A ZA973444B (en) | 1996-04-23 | 1997-04-22 | Transdermally administered dextromethorphan as antitussive agents. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6335030B1 (de) |
| EP (1) | EP0904067B1 (de) |
| JP (1) | JP2000509037A (de) |
| AT (1) | ATE284206T1 (de) |
| AU (1) | AU714942B2 (de) |
| CA (1) | CA2251966C (de) |
| DE (1) | DE69731882T2 (de) |
| DK (1) | DK0904067T3 (de) |
| ES (1) | ES2234012T3 (de) |
| NZ (1) | NZ332215A (de) |
| PT (1) | PT904067E (de) |
| SE (1) | SE9601528D0 (de) |
| WO (1) | WO1997039742A1 (de) |
| ZA (1) | ZA973444B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6846495B2 (en) * | 1999-01-11 | 2005-01-25 | The Procter & Gamble Company | Compositions having improved delivery of actives |
| DE19901085C2 (de) * | 1999-01-14 | 2003-12-18 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit einer selbstklebenden Matrix, enthaltend organische Säure-Additionssalze von Alkaloiden des Morphin- bzw. Morphinantyps |
| GB9920167D0 (en) * | 1999-08-25 | 1999-10-27 | Avery Dennison Corp | Pressure sensitive adhesive compositions |
| US7138133B2 (en) | 2001-10-10 | 2006-11-21 | The Procter & Gamble Company | Orally administered liquid compositions |
| US7662404B2 (en) * | 2002-10-31 | 2010-02-16 | Transpharma Medical Ltd. | Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides |
| IL152574A (en) * | 2002-10-31 | 2009-09-22 | Transpharma Medical Ltd | A system for passing through the skin of dry items or dried medicines |
| US8133505B2 (en) * | 2002-10-31 | 2012-03-13 | Transpharma Medical Ltd. | Transdermal delivery system for dried particulate or lyophilized medications |
| US7383084B2 (en) * | 2002-10-31 | 2008-06-03 | Transpharma Medical Ltd. | Transdermal delivery system for dried particulate or lyophilized medications |
| US8502681B2 (en) * | 2005-06-20 | 2013-08-06 | Biovigil, Llc | Hand cleanliness |
| JP5015620B2 (ja) * | 2007-01-30 | 2012-08-29 | 株式会社クラレ | 皮膚外用剤 |
| US20100160368A1 (en) | 2008-08-18 | 2010-06-24 | Gregory Jefferson J | Methods of Treating Dermatological Disorders and Inducing Interferon Biosynthesis With Shorter Durations of Imiquimod Therapy |
| MX346455B (es) | 2008-12-19 | 2017-03-21 | Medicis Pharmaceutical Corp | Formulaciones de imiquimod de baja concentracion de dosis y regimenes de dosis de corta duracion para tratar queratosis actinica. |
| EP2453747B1 (de) | 2009-07-13 | 2017-08-30 | Medicis Pharmaceutical Corporation | Imiquimod-formulierungen mit geringerer dosisstärke und kurze dosierpläne zur behandlung von warzen im genital- und perianalbereich |
| US8461102B2 (en) * | 2010-03-02 | 2013-06-11 | George E. Royster, JR. | Methods and compositions for treating and preventing symptoms of hormonal variations |
| US10493049B2 (en) | 2016-02-10 | 2019-12-03 | Niracle LLC | Applicator-based transdermal drug delivery system for administration of drugs in combination with topical formulations |
| TWI795446B (zh) * | 2017-10-04 | 2023-03-11 | 美商神經治療股份有限公司 | 右旋美索芬(dextromethorphan)經皮輸送裝置 |
| IL296624A (en) * | 2020-03-30 | 2022-11-01 | Shinkei Therapeutics Inc | Transdermal transfer of dextromethorphan |
| US11844753B2 (en) | 2021-11-08 | 2023-12-19 | Weiyong Li | Transdermal drug delivery system for delivering a drug to a patient |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3275510A (en) * | 1966-09-27 | Topical antitussive preparations | ||
| US2676177A (en) | 1949-11-09 | 1954-04-20 | Hoffmann La Roche | Process for the preparation of optically active 3-methoxy-n-methyl morphinans and salts thereof |
| US4557934A (en) | 1983-06-21 | 1985-12-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one |
| US4645502A (en) * | 1985-05-03 | 1987-02-24 | Alza Corporation | Transdermal delivery of highly ionized fat insoluble drugs |
| JPS6351327A (ja) * | 1986-08-22 | 1988-03-04 | Sato Seiyaku Kk | 液状組成物 |
| US4783450A (en) | 1987-04-13 | 1988-11-08 | Warner-Lambert Company | Use of commercial lecithin as skin penetration enhancer |
| US4888354A (en) | 1987-12-21 | 1989-12-19 | Theratech, Inc. | Skin penetration enhancement using free base and acid addition salt combinations of active agents |
| US4915950A (en) | 1988-02-12 | 1990-04-10 | Cygnus Research Corporation | Printed transdermal drug delivery device |
| US5164406A (en) | 1988-06-02 | 1992-11-17 | Bristol-Myers Squibb Co. | Method for enhancing transdermal penetration and compositions useful therein |
| EP0351897A3 (de) | 1988-06-17 | 1990-03-21 | The Procter & Gamble Company | Hautpenetrierendes System für aminfunktionelle Anrzneistoffsalze |
| US5213568A (en) | 1990-03-30 | 1993-05-25 | Medtronic Inc. | Activity controlled electrotransport drug delivery device |
| WO1991015261A1 (en) | 1990-03-30 | 1991-10-17 | Medtronic, Inc. | Activity controlled electrotransport drug delivery device |
| PL168968B1 (en) * | 1990-10-31 | 1996-05-31 | Procter & Gamble | Method of manufacturing an antitussive drug |
| GB9103302D0 (en) | 1991-02-16 | 1991-04-03 | Smithkline Beecham Plc | Pharmaceutical formulations |
| WO1993007902A1 (en) | 1991-10-16 | 1993-04-29 | Richardson-Vicks, Inc. | Enhanced skin penetration system for improved topical delivery of drugs |
| EG20380A (en) | 1991-10-16 | 1999-02-28 | Richardson Vicks Inc | Enhanced skin penetration system for improved topical delivery of drugs |
| US5260066A (en) | 1992-01-16 | 1993-11-09 | Srchem Incorporated | Cryogel bandage containing therapeutic agent |
| US5756117A (en) * | 1992-04-08 | 1998-05-26 | International Medical Asscociates, Inc. | Multidose transdermal drug delivery system |
| WO1995005416A2 (en) | 1993-08-19 | 1995-02-23 | Cygnus Therapeutic Systems | Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavity |
-
1996
- 1996-04-23 SE SE9601528A patent/SE9601528D0/xx unknown
-
1997
- 1997-03-21 PT PT97915801T patent/PT904067E/pt unknown
- 1997-03-21 AU AU23132/97A patent/AU714942B2/en not_active Ceased
- 1997-03-21 WO PCT/SE1997/000484 patent/WO1997039742A1/en active IP Right Grant
- 1997-03-21 DE DE69731882T patent/DE69731882T2/de not_active Expired - Fee Related
- 1997-03-21 US US09/171,674 patent/US6335030B1/en not_active Expired - Lifetime
- 1997-03-21 NZ NZ332215A patent/NZ332215A/xx unknown
- 1997-03-21 EP EP97915801A patent/EP0904067B1/de not_active Expired - Lifetime
- 1997-03-21 JP JP9537974A patent/JP2000509037A/ja active Pending
- 1997-03-21 CA CA002251966A patent/CA2251966C/en not_active Expired - Fee Related
- 1997-03-21 AT AT97915801T patent/ATE284206T1/de not_active IP Right Cessation
- 1997-03-21 ES ES97915801T patent/ES2234012T3/es not_active Expired - Lifetime
- 1997-03-21 DK DK97915801T patent/DK0904067T3/da active
- 1997-04-22 ZA ZA9703444A patent/ZA973444B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT904067E (pt) | 2005-02-28 |
| US6335030B1 (en) | 2002-01-01 |
| EP0904067A1 (de) | 1999-03-31 |
| JP2000509037A (ja) | 2000-07-18 |
| AU714942B2 (en) | 2000-01-13 |
| NZ332215A (en) | 2000-09-29 |
| CA2251966A1 (en) | 1997-10-30 |
| ES2234012T3 (es) | 2005-06-16 |
| EP0904067B1 (de) | 2004-12-08 |
| CA2251966C (en) | 2008-01-15 |
| DK0904067T3 (da) | 2005-03-14 |
| ATE284206T1 (de) | 2004-12-15 |
| AU2313297A (en) | 1997-11-12 |
| SE9601528D0 (sv) | 1996-04-23 |
| DE69731882T2 (de) | 2005-12-15 |
| DE69731882D1 (de) | 2005-01-13 |
| WO1997039742A1 (en) | 1997-10-30 |
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