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DE69731882D1 - Transdermal verabreichtes dextromethorphan als hustenmittel - Google Patents

Transdermal verabreichtes dextromethorphan als hustenmittel

Info

Publication number
DE69731882D1
DE69731882D1 DE1997631882 DE69731882T DE69731882D1 DE 69731882 D1 DE69731882 D1 DE 69731882D1 DE 1997631882 DE1997631882 DE 1997631882 DE 69731882 T DE69731882 T DE 69731882T DE 69731882 D1 DE69731882 D1 DE 69731882D1
Authority
DE
Germany
Prior art keywords
dextromethorphane
human agent
human
transdermal
delivered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE1997631882
Other languages
English (en)
Other versions
DE69731882T2 (de
Inventor
Ulla Hoeck
Bo Kreilgard
Helle Kristensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Pfizer Health AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Health AB filed Critical Pfizer Health AB
Application granted granted Critical
Publication of DE69731882D1 publication Critical patent/DE69731882D1/de
Publication of DE69731882T2 publication Critical patent/DE69731882T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69731882T 1996-04-23 1997-03-21 Transdermal verabreichtes dextromethorphan als hustenmittel Expired - Fee Related DE69731882T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9601528A SE9601528D0 (sv) 1996-04-23 1996-04-23 Transdermally administered dextromethorphan as antitissue agent
SE9601528 1996-04-23
PCT/SE1997/000484 WO1997039742A1 (en) 1996-04-23 1997-03-21 Transdermally administered dextromethorphan as antitussive agent

Publications (2)

Publication Number Publication Date
DE69731882D1 true DE69731882D1 (de) 2005-01-13
DE69731882T2 DE69731882T2 (de) 2005-12-15

Family

ID=20402295

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69731882T Expired - Fee Related DE69731882T2 (de) 1996-04-23 1997-03-21 Transdermal verabreichtes dextromethorphan als hustenmittel

Country Status (14)

Country Link
US (1) US6335030B1 (de)
EP (1) EP0904067B1 (de)
JP (1) JP2000509037A (de)
AT (1) ATE284206T1 (de)
AU (1) AU714942B2 (de)
CA (1) CA2251966C (de)
DE (1) DE69731882T2 (de)
DK (1) DK0904067T3 (de)
ES (1) ES2234012T3 (de)
NZ (1) NZ332215A (de)
PT (1) PT904067E (de)
SE (1) SE9601528D0 (de)
WO (1) WO1997039742A1 (de)
ZA (1) ZA973444B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6846495B2 (en) * 1999-01-11 2005-01-25 The Procter & Gamble Company Compositions having improved delivery of actives
DE19901085C2 (de) * 1999-01-14 2003-12-18 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit einer selbstklebenden Matrix, enthaltend organische Säure-Additionssalze von Alkaloiden des Morphin- bzw. Morphinantyps
GB9920167D0 (en) * 1999-08-25 1999-10-27 Avery Dennison Corp Pressure sensitive adhesive compositions
US7138133B2 (en) 2001-10-10 2006-11-21 The Procter & Gamble Company Orally administered liquid compositions
IL152574A (en) * 2002-10-31 2009-09-22 Transpharma Medical Ltd A system for passing through the skin of dry items or dried medicines
US7383084B2 (en) * 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
US8133505B2 (en) * 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
US7662404B2 (en) * 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
US8502681B2 (en) * 2005-06-20 2013-08-06 Biovigil, Llc Hand cleanliness
JP5015620B2 (ja) * 2007-01-30 2012-08-29 株式会社クラレ 皮膚外用剤
US20100160368A1 (en) * 2008-08-18 2010-06-24 Gregory Jefferson J Methods of Treating Dermatological Disorders and Inducing Interferon Biosynthesis With Shorter Durations of Imiquimod Therapy
WO2010080345A1 (en) 2008-12-19 2010-07-15 Graceway Pharmaceuticals, Llc Lower dosage strength imiquimod formulations and short dosing regimens for treating actinic keratosis
MX336923B (es) 2009-07-13 2016-02-05 Medicis Pharmaceutical Corp Formulaciones de imiquimod de concentracion de dosificacion inferior y regimenes de dosificacion cortos para tratar verrugas genitales y perianales.
US8461102B2 (en) * 2010-03-02 2013-06-11 George E. Royster, JR. Methods and compositions for treating and preventing symptoms of hormonal variations
US10493049B2 (en) 2016-02-10 2019-12-03 Niracle LLC Applicator-based transdermal drug delivery system for administration of drugs in combination with topical formulations
TWI795446B (zh) * 2017-10-04 2023-03-11 美商神經治療股份有限公司 右旋美索芬(dextromethorphan)經皮輸送裝置
CA3173322A1 (en) * 2020-03-30 2021-10-07 Suresh Borsadia Transdermal delivery of dextromethorphan
US11844753B2 (en) 2021-11-08 2023-12-19 Weiyong Li Transdermal drug delivery system for delivering a drug to a patient

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3275510A (en) * 1966-09-27 Topical antitussive preparations
US2676177A (en) 1949-11-09 1954-04-20 Hoffmann La Roche Process for the preparation of optically active 3-methoxy-n-methyl morphinans and salts thereof
US4557934A (en) 1983-06-21 1985-12-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
US4645502A (en) * 1985-05-03 1987-02-24 Alza Corporation Transdermal delivery of highly ionized fat insoluble drugs
JPS6351327A (ja) * 1986-08-22 1988-03-04 Sato Seiyaku Kk 液状組成物
US4783450A (en) 1987-04-13 1988-11-08 Warner-Lambert Company Use of commercial lecithin as skin penetration enhancer
US4888354A (en) 1987-12-21 1989-12-19 Theratech, Inc. Skin penetration enhancement using free base and acid addition salt combinations of active agents
US4915950A (en) 1988-02-12 1990-04-10 Cygnus Research Corporation Printed transdermal drug delivery device
US5164406A (en) 1988-06-02 1992-11-17 Bristol-Myers Squibb Co. Method for enhancing transdermal penetration and compositions useful therein
EP0351897A3 (de) 1988-06-17 1990-03-21 The Procter & Gamble Company Hautpenetrierendes System für aminfunktionelle Anrzneistoffsalze
US5213568A (en) 1990-03-30 1993-05-25 Medtronic Inc. Activity controlled electrotransport drug delivery device
WO1991015261A1 (en) * 1990-03-30 1991-10-17 Medtronic, Inc. Activity controlled electrotransport drug delivery device
CA2129676C (en) * 1990-10-31 1997-09-30 Ronald Lee Smith Dextromethorphan antitussive compositions
GB9103302D0 (en) * 1991-02-16 1991-04-03 Smithkline Beecham Plc Pharmaceutical formulations
JPH07500113A (ja) 1991-10-16 1995-01-05 リチャードソン、ビックス、インコーポレーテッド 薬物の改善された局所送達用の高皮膚浸透系
EG20380A (en) 1991-10-16 1999-02-28 Richardson Vicks Inc Enhanced skin penetration system for improved topical delivery of drugs
US5260066A (en) 1992-01-16 1993-11-09 Srchem Incorporated Cryogel bandage containing therapeutic agent
US5756117A (en) * 1992-04-08 1998-05-26 International Medical Asscociates, Inc. Multidose transdermal drug delivery system
JPH09504810A (ja) 1993-08-19 1997-05-13 シグナス，インコーポレイテッド 水溶性感圧粘膜接着剤

Also Published As

Publication number Publication date
EP0904067A1 (de) 1999-03-31
DE69731882T2 (de) 2005-12-15
NZ332215A (en) 2000-09-29
WO1997039742A1 (en) 1997-10-30
ES2234012T3 (es) 2005-06-16
PT904067E (pt) 2005-02-28
ZA973444B (en) 1997-11-18
ATE284206T1 (de) 2004-12-15
AU2313297A (en) 1997-11-12
AU714942B2 (en) 2000-01-13
DK0904067T3 (da) 2005-03-14
CA2251966A1 (en) 1997-10-30
CA2251966C (en) 2008-01-15
EP0904067B1 (de) 2004-12-08
US6335030B1 (en) 2002-01-01
JP2000509037A (ja) 2000-07-18
SE9601528D0 (sv) 1996-04-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee