ZA90430B - Bis-aza-bicyclic anxiolytic agents - Google Patents

Bis-aza-bicyclic anxiolytic agents

Info

Publication number: ZA90430B
Authority: ZA; South Africa
Prior art keywords: aza; bis; anxiolytic agents; bicyclic; bicyclic anxiolytic
Prior art date: 1989-01-23

Application number

ZA90430A

Other languages

English (en)

Inventor

Kishor Amratral Desai

Amratral Desai Kishor

Gene Michael Bright

Michael Bright Gene

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-01-23

Filing date

1990-01-22

Publication date

1991-08-28

1990-01-22 Application filed by Pfizer filed Critical Pfizer

1990-08-29 Priority to ZA906885A priority Critical patent/ZA906885B/xx

1991-08-28 Publication of ZA90430B publication Critical patent/ZA90430B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

ZA90430A 1989-01-23 1990-01-22 Bis-aza-bicyclic anxiolytic agents ZA90430B (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
ZA906885A ZA906885B (en)	1990-01-22	1990-08-29	Drying and/or heating device

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1989/000275 WO1990008148A1 (en)	1989-01-23	1989-01-23	Bis-aza-bicyclic anxiolytic agents

Publications (1)

Publication Number	Publication Date
ZA90430B true ZA90430B (en)	1991-08-28

Family

ID=22214801

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA90430A ZA90430B (en)	1989-01-23	1990-01-22	Bis-aza-bicyclic anxiolytic agents

Country Status (38)

Country	Link
US (1)	US5122525A (sv)
EP (1)	EP0380217B1 (sv)
JP (1)	JPH0643427B2 (sv)
KR (1)	KR910009289B1 (sv)
CN (1)	CN1022186C (sv)
AP (1)	AP128A (sv)
AR (1)	AR246969A1 (sv)
AT (1)	ATE82574T1 (sv)
AU (1)	AU614214B2 (sv)
BA (1)	BA98302A (sv)
BG (1)	BG51046A3 (sv)
CA (1)	CA2008108C (sv)
CZ (1)	CZ277698B6 (sv)
DD (1)	DD291560A5 (sv)
DE (1)	DE69000467T2 (sv)
DK (1)	DK0380217T3 (sv)
EG (1)	EG19306A (sv)
ES (1)	ES2053094T3 (sv)
FI (1)	FI95381C (sv)
GR (1)	GR3006925T3 (sv)
HU (1)	HU215154B (sv)
IE (1)	IE62670B1 (sv)
IL (1)	IL93073A (sv)
IS (1)	IS1667B (sv)
MA (1)	MA21735A1 (sv)
MX (1)	MX19222A (sv)
MY (1)	MY104861A (sv)
NO (1)	NO175978C (sv)
NZ (1)	NZ232168A (sv)
OA (1)	OA10041A (sv)
PL (1)	PL163836B1 (sv)
PT (1)	PT92919B (sv)
RO (1)	RO110142B1 (sv)
RU (1)	RU2015977C1 (sv)
SK (1)	SK279339B6 (sv)
WO (2)	WO1990008148A1 (sv)
YU (1)	YU47554B (sv)
ZA (1)	ZA90430B (sv)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990008148A1 (en) *	1989-01-23	1990-07-26	Pfizer Inc.	Bis-aza-bicyclic anxiolytic agents
WO1992000075A1 (en) *	1990-06-29	1992-01-09	Pfizer Inc.	Pyridopyrazine derivatives for treating substance abuse and addiction
ATE120746T1 (de) *	1991-01-31	1995-04-15	Pfizer	Recematspaltung von trans-2-(2-pyrimidinyl)-7- (hydroxymethyl)octahydro-2h-pyrido(1,2-a>- pyrazin.
US5185449A (en) *	1991-02-27	1993-02-09	Pfizer Inc.	Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
US5157034A (en) *	1991-02-27	1992-10-20	Pfizer Inc.	Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines
EP0573464B1 (en) *	1991-02-27	1997-03-19	Pfizer Inc.	Process for preparing trans-piperidine-2,5-dicarboxylates
US5311195A (en) *	1991-08-30	1994-05-10	Etak, Inc.	Combined relative and absolute positioning method and apparatus
ATE146178T1 (de) *	1991-09-25	1996-12-15	Pfizer	Neuroleptisch 2-substituierte perhydro-1h- pyrido(1,2-a>pyrazine
EP0646116B1 (en) *	1992-06-16	1999-10-13	Pfizer Inc.	Process and intermediates for bis-aza-bicyclic anxiolytic agents
AU5291793A (en) *	1992-09-24	1994-04-12	National Institutes Of Health	Aralkyl diazabicycloalkane derivatives for cns disorders
IL104506A (en) *	1993-01-25	1997-11-20	Israel State	Fast changing heating- cooling device and method, particularly for cryogenic and/or surgical use
US5637713A (en) *	1993-08-20	1997-06-10	Pfizer Inc.	Process for preparing trans-piperidine-2,5-dicarboxylates
US5455350A (en) *	1993-10-13	1995-10-03	Pfizer Inc.	Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
IL107460A (en) *	1993-11-01	1999-06-20	Israel State	Controlled cryogenic contact system
JP3287574B2 (ja) *	1994-09-30	2002-06-04	ファイザー・インク	２，７−置換オクタヒドロ−１ｈ−ピリド［１，２−ａ］ピラジン誘導体
US5731307A (en) *	1994-09-30	1998-03-24	Pfizer, Inc.	Neuroleptic 2,7-disubtituted perhydro-1h-pyrido 1, 2-A!pyrazines
US6231833B1 (en) *	1999-08-05	2001-05-15	Pfizer Inc	2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
IL124453A0 (en) *	1995-12-21	1998-12-06	Pfizer	2,7-substituted octahydro-pyrrolo [1,2-A]pyrazine derivatives
BR9710018A (pt) *	1996-07-01	1999-08-10	Pfizer	Preparação de (7S,trans)-2-(2-pirimidinil)-7-(hidroximetil)octa-hidro-2H-pirido[1,2-A]pirazina
PA8469101A1 (es) *	1998-04-09	2000-09-29	Pfizer Prod Inc	Ligandos azabiciclicos de receptores 5ht1
US6251893B1 (en) *	1998-06-15	2001-06-26	Nps Allelix Corp.	Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
HN1999000146A (es) *	1998-09-21	2000-11-11	Pfizer Prod Inc	Agentes farmaceuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas.
US20020016334A1 (en) *	2000-07-31	2002-02-07	Coe Jotham Wadsworth	Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD)
US6670476B2 (en)	2000-11-29	2003-12-30	Pfizer Inc.	Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine
AU2004220327B2 (en) *	2003-03-12	2010-06-24	Pfizer Products Inc.	Pyridyloxymethyl and benzisoxazole azabicyclic derivatives
EP1633756B1 (en)	2003-04-09	2008-12-24	Biogen Idec MA Inc.	A2a adenosine receptor antagonists
JP4864719B2 (ja) *	2003-11-26	2012-02-01	ファイザー・プロダクツ・インク	Ｇｓｋ−３インヒビターとしてのアミノピラゾール誘導体
US20070219201A1 (en) *	2004-05-27	2007-09-20	Warner-Lambert Company Llc	Combination of atomoxetine and a 5ht1a receptor agonist for treating adhd and other disorders
US7658206B2 (en)	2006-12-05	2010-02-09	Kohler Co.	Plumbing valve with stick control handle

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3388128A (en) *	1965-09-03	1968-06-11	Allan R. Day	Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
US4182763A (en) *	1978-05-22	1980-01-08	Mead Johnson & Company	Buspirone anti-anxiety method
US4339579A (en) *	1980-12-29	1982-07-13	American Home Products Corporation	2,6-Bis-(pyrrolopyrazinyl)pyrazines
US4400511A (en) *	1982-05-07	1983-08-23	American Home Products Corporation	2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
US4414389A (en) *	1982-05-25	1983-11-08	American Home Products Corporation	4-Substituted-piperidino carboxamides
US4517187A (en) *	1982-10-18	1985-05-14	Pennwalt Corporation	1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
DE3321969A1 (de) *	1983-06-18	1984-12-20	Troponwerke GmbH & Co KG, 5000 Köln	2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3409440A1 (de) *	1984-03-15	1985-09-26	Bayer Ag, 5090 Leverkusen	Imidazo(1,5-a)pyridyl-methan- und imidazo(1,5-b)pyridazinylmethan-derivate, ihre herstellung und sie enthaltende aufzeichnungsmaterialien
IT1204803B (it) *	1986-02-17	1989-03-10	Acraf	Composto farmacologicamente attivo e composizioni farmaceutiche che lo contengono,procedimento per prepararlo e intermedio utile in detto procedimento
US4788290A (en) *	1987-12-11	1988-11-29	American Home Products Corporation	Serotonergic pyrazine derivatives
JP2668259B2 (ja) *	1988-02-18	1997-10-27	塩野義製薬株式会社	複素環化合物および抗潰瘍剤
WO1990008148A1 (en) *	1989-01-23	1990-07-26	Pfizer Inc.	Bis-aza-bicyclic anxiolytic agents

1989
- 1989-01-23 WO PCT/US1989/000275 patent/WO1990008148A1/en unknown
- 1989-01-23 MX MX1922290A patent/MX19222A/es unknown
- 1989-09-01 HU HU40/90A patent/HU215154B/hu not_active IP Right Cessation
- 1989-09-01 RO RO148053A patent/RO110142B1/ro unknown
- 1989-09-01 WO PCT/US1989/003811 patent/WO1990008144A1/en active IP Right Grant
- 1989-12-13 IS IS3529A patent/IS1667B/is unknown
1990
- 1990-01-12 EP EP90300362A patent/EP0380217B1/en not_active Expired - Lifetime
- 1990-01-12 DE DE9090300362T patent/DE69000467T2/de not_active Expired - Fee Related
- 1990-01-12 ES ES90300362T patent/ES2053094T3/es not_active Expired - Lifetime
- 1990-01-12 AT AT90300362T patent/ATE82574T1/de not_active IP Right Cessation
- 1990-01-12 DK DK90300362.2T patent/DK0380217T3/da active
- 1990-01-16 IL IL9307390A patent/IL93073A/en not_active IP Right Cessation
- 1990-01-18 BG BG090949A patent/BG51046A3/xx unknown
- 1990-01-19 NZ NZ232168A patent/NZ232168A/xx unknown
- 1990-01-19 MY MYPI90000101A patent/MY104861A/en unknown
- 1990-01-19 AR AR90315971A patent/AR246969A1/es active
- 1990-01-19 CA CA002008108A patent/CA2008108C/en not_active Expired - Fee Related
- 1990-01-21 EG EG3290A patent/EG19306A/xx active
- 1990-01-22 DD DD90337249A patent/DD291560A5/de not_active IP Right Cessation
- 1990-01-22 ZA ZA90430A patent/ZA90430B/xx unknown
- 1990-01-22 AP APAP/P/1990/000158A patent/AP128A/en active
- 1990-01-22 SK SK299-90A patent/SK279339B6/sk unknown
- 1990-01-22 IE IE22590A patent/IE62670B1/en not_active IP Right Cessation
- 1990-01-22 AU AU48679/90A patent/AU614214B2/en not_active Ceased
- 1990-01-22 CZ CS90299A patent/CZ277698B6/cs not_active IP Right Cessation
- 1990-01-22 CN CN90100291A patent/CN1022186C/zh not_active Expired - Fee Related
- 1990-01-22 PL PL90283395A patent/PL163836B1/pl not_active IP Right Cessation
- 1990-01-22 YU YU11190A patent/YU47554B/sh unknown
- 1990-01-22 MA MA21996A patent/MA21735A1/fr unknown
- 1990-01-22 PT PT92919A patent/PT92919B/pt not_active IP Right Cessation
- 1990-01-22 KR KR1019900000701A patent/KR910009289B1/ko not_active IP Right Cessation
- 1990-01-23 OA OA59727A patent/OA10041A/en unknown
- 1990-01-23 JP JP2013459A patent/JPH0643427B2/ja not_active Expired - Fee Related
1991
- 1991-07-09 US US07/721,537 patent/US5122525A/en not_active Expired - Lifetime
- 1991-07-22 FI FI913510A patent/FI95381C/sv not_active IP Right Cessation
- 1991-07-22 RU SU915001279A patent/RU2015977C1/ru not_active IP Right Cessation
- 1991-07-22 NO NO912863A patent/NO175978C/no unknown
1993
- 1993-01-28 GR GR930400172T patent/GR3006925T3/el unknown
1998
- 1998-03-30 BA BA980302A patent/BA98302A/bs unknown

Also Published As

Publication number	Publication date
PT92919B (pt)	1995-12-29
CN1022186C (zh)	1993-09-22
WO1990008144A1 (en)	1990-07-26
NO912863D0 (no)	1991-07-22
BG51046A3 (en)	1993-01-15
AU614214B2 (en)	1991-08-22
NO175978B (no)	1994-10-03
EG19306A (en)	1995-01-31
ES2053094T3 (es)	1994-07-16
ATE82574T1 (de)	1992-12-15
FI95381B (sv)	1995-10-13
CA2008108C (en)	1995-08-08
IE62670B1 (en)	1995-03-08
EP0380217B1 (en)	1992-11-19
AP9000158A0 (en)	1990-01-31
MY104861A (en)	1994-06-30
DD291560A5 (de)	1991-07-04
KR900011774A (ko)	1990-08-02
US5122525A (en)	1992-06-16
FI95381C (sv)	1996-01-25
CZ277698B6 (en)	1993-03-17
IS1667B (is)	1997-11-14
YU11190A (sh)	1993-05-28
CS29990A3 (en)	1992-11-18
AP128A (en)	1991-03-20
WO1990008148A1 (en)	1990-07-26
GR3006925T3 (sv)	1993-06-30
NZ232168A (en)	1991-08-27
MX19222A (es)	1993-12-01
OA10041A (en)	1996-10-14
BA98302A (bs)	2001-09-14
CA2008108A1 (en)	1990-07-23
IL93073A (en)	1994-05-30
KR910009289B1 (ko)	1991-11-09
CN1044464A (zh)	1990-08-08
JPH02233681A (ja)	1990-09-17
RU2015977C1 (ru)	1994-07-15
HUT63163A (en)	1993-07-28
SK279339B6 (sk)	1998-10-07
NO175978C (no)	1995-01-11
DK0380217T3 (da)	1992-12-14
EP0380217A1 (en)	1990-08-01
AR246969A1 (es)	1994-10-31
HU215154B (hu)	2000-09-28
AU4867990A (en)	1990-07-26
IE900225L (en)	1990-07-23
DE69000467D1 (de)	1992-12-24
JPH0643427B2 (ja)	1994-06-08
YU47554B (sh)	1995-10-03
MA21735A1 (fr)	1990-10-01
PT92919A (pt)	1990-07-31
RO110142B1 (ro)	1995-10-30
IS3529A7 (is)	1990-07-24
PL163836B1 (pl)	1994-05-31
NO912863L (no)	1991-07-22
DE69000467T2 (de)	1993-04-01
FI913510A0 (sv)	1991-07-22

Publication	Publication Date	Title
AP9000158A0 (en)	1990-01-31	Bis-aza-bicyclic anxiolytic agents
AU108277S (en)	1990-07-16	Hedge-shears
DE3991623D2 (en)	1992-03-12	Frequenzueberwachungsanordnung
EP0405242A3 (en)	1992-05-27	Vip-analogs ii
HU901322D0 (en)	1990-05-28	Herbicid-produces
GB8906867D0 (en)	1989-05-10	Becvem
GB8911764D0 (en)	1989-07-12	Cornerwise
EP0424336A3 (en)	1992-02-19	Subwarhead
GB9003724D0 (en)	1990-04-18	Toychest ii
EP0417400A3 (en)	1991-09-11	Skibrake
GB8900732D0 (en)	1989-03-08	Agents
EP0430866A3 (en)	1992-12-16	Connection piece
GB8927017D0 (en)	1990-01-17	Flowerite
GB9005687D0 (en)	1990-05-09	N-triazinyloxalamides
EP0407707A3 (en)	1991-11-21	Heel-holder
EP0417059A3 (en)	1991-05-02	Bicyclic tetrahydroxylated pyrrolizidines
DE3991686D2 (de)	1992-01-30	Schmuckblende
DE4091102D2 (de)	1992-06-25	Spundlochverschluss
ZA9010357B (en)	1992-08-26	Antipicornaviral pyridazinamines
GB2228286B (en)	1992-06-10	Dead-locks
IL111617A0 (en)	1995-01-24	Oxadiazolinones
CA64463S (en)	1989-10-03	Tapeplayer
IE890799L (en)	1989-09-14	Imidazopyridines
EP0417060A3 (en)	1991-07-24	Bicyclic tetrahydroxypyrrolizidine
IL91679A0 (en)	1990-04-29	Wheel-ladder