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YU47554B - RACEMSKI I OPTIČKI AKTIVNI DERIVATI PIRIDO (1,2-a) PIRAZINA I NJIHOVI INTERMEDIJERI - Google Patents

RACEMSKI I OPTIČKI AKTIVNI DERIVATI PIRIDO (1,2-a) PIRAZINA I NJIHOVI INTERMEDIJERI

Info

Publication number
YU47554B
YU47554B YU11190A YU11190A YU47554B YU 47554 B YU47554 B YU 47554B YU 11190 A YU11190 A YU 11190A YU 11190 A YU11190 A YU 11190A YU 47554 B YU47554 B YU 47554B
Authority
YU
Yugoslavia
Prior art keywords
racemic
active derivatives
pirazine
pirido
intermediates
Prior art date
Application number
YU11190A
Other languages
English (en)
Other versions
YU11190A (sh
Inventor
K.A. Desai
G.M. Bright
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU11190A publication Critical patent/YU11190A/sh
Publication of YU47554B publication Critical patent/YU47554B/sh
Priority to BA980302A priority Critical patent/BA98302A/bs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Racemski i optički aktivni derivati pirido (1,2-a) pirazina formule: ili njegove farmaceutski prihvatljive adicione soli sa kiselinama, gde X predstavlja N ili CH; -Y1(CH2)n supstituisani na atomu ugljenika sa do 2 metil grupe; n je 1 ili 2; i Y1 je CH2 NH ili NCH3. Prijava sadrži još 7 zavisnih zahteva.
YU11190A 1989-01-23 1990-01-22 RACEMSKI I OPTIČKI AKTIVNI DERIVATI PIRIDO (1,2-a) PIRAZINA I NJIHOVI INTERMEDIJERI YU47554B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BA980302A BA98302A (bs) 1989-01-23 1998-03-30 Bis-aza-biciklicna anksioliticka sredstva

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1989/000275 WO1990008148A1 (en) 1989-01-23 1989-01-23 Bis-aza-bicyclic anxiolytic agents
PCT/US1989/003811 WO1990008144A1 (en) 1989-01-23 1989-09-01 Bis-aza-bicyclic anxiolytic agents

Publications (2)

Publication Number Publication Date
YU11190A YU11190A (sh) 1993-05-28
YU47554B true YU47554B (sh) 1995-10-03

Family

ID=22214801

Family Applications (1)

Application Number Title Priority Date Filing Date
YU11190A YU47554B (sh) 1989-01-23 1990-01-22 RACEMSKI I OPTIČKI AKTIVNI DERIVATI PIRIDO (1,2-a) PIRAZINA I NJIHOVI INTERMEDIJERI

Country Status (38)

Country Link
US (1) US5122525A (sh)
EP (1) EP0380217B1 (sh)
JP (1) JPH0643427B2 (sh)
KR (1) KR910009289B1 (sh)
CN (1) CN1022186C (sh)
AP (1) AP128A (sh)
AR (1) AR246969A1 (sh)
AT (1) ATE82574T1 (sh)
AU (1) AU614214B2 (sh)
BA (1) BA98302A (sh)
BG (1) BG51046A3 (sh)
CA (1) CA2008108C (sh)
CZ (1) CZ277698B6 (sh)
DD (1) DD291560A5 (sh)
DE (1) DE69000467T2 (sh)
DK (1) DK0380217T3 (sh)
EG (1) EG19306A (sh)
ES (1) ES2053094T3 (sh)
FI (1) FI95381C (sh)
GR (1) GR3006925T3 (sh)
HU (1) HU215154B (sh)
IE (1) IE62670B1 (sh)
IL (1) IL93073A (sh)
IS (1) IS1667B (sh)
MA (1) MA21735A1 (sh)
MX (1) MX19222A (sh)
MY (1) MY104861A (sh)
NO (1) NO175978C (sh)
NZ (1) NZ232168A (sh)
OA (1) OA10041A (sh)
PL (1) PL163836B1 (sh)
PT (1) PT92919B (sh)
RO (1) RO110142B1 (sh)
RU (1) RU2015977C1 (sh)
SK (1) SK279339B6 (sh)
WO (2) WO1990008148A1 (sh)
YU (1) YU47554B (sh)
ZA (1) ZA90430B (sh)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents
WO1992000075A1 (en) * 1990-06-29 1992-01-09 Pfizer Inc. Pyridopyrazine derivatives for treating substance abuse and addiction
ATE120746T1 (de) * 1991-01-31 1995-04-15 Pfizer Recematspaltung von trans-2-(2-pyrimidinyl)-7- (hydroxymethyl)octahydro-2h-pyrido(1,2-a>- pyrazin.
US5185449A (en) * 1991-02-27 1993-02-09 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
US5157034A (en) * 1991-02-27 1992-10-20 Pfizer Inc. Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines
EP0573464B1 (en) * 1991-02-27 1997-03-19 Pfizer Inc. Process for preparing trans-piperidine-2,5-dicarboxylates
US5311195A (en) * 1991-08-30 1994-05-10 Etak, Inc. Combined relative and absolute positioning method and apparatus
ATE146178T1 (de) * 1991-09-25 1996-12-15 Pfizer Neuroleptisch 2-substituierte perhydro-1h- pyrido(1,2-a>pyrazine
EP0646116B1 (en) * 1992-06-16 1999-10-13 Pfizer Inc. Process and intermediates for bis-aza-bicyclic anxiolytic agents
AU5291793A (en) * 1992-09-24 1994-04-12 National Institutes Of Health Aralkyl diazabicycloalkane derivatives for cns disorders
IL104506A (en) * 1993-01-25 1997-11-20 Israel State Fast changing heating- cooling device and method, particularly for cryogenic and/or surgical use
US5637713A (en) * 1993-08-20 1997-06-10 Pfizer Inc. Process for preparing trans-piperidine-2,5-dicarboxylates
US5455350A (en) * 1993-10-13 1995-10-03 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
IL107460A (en) * 1993-11-01 1999-06-20 Israel State Controlled cryogenic contact system
JP3287574B2 (ja) * 1994-09-30 2002-06-04 ファイザー・インク ２，７−置換オクタヒドロ−１ｈ−ピリド［１，２−ａ］ピラジン誘導体
US5731307A (en) * 1994-09-30 1998-03-24 Pfizer, Inc. Neuroleptic 2,7-disubtituted perhydro-1h-pyrido 1, 2-A!pyrazines
US6231833B1 (en) * 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
IL124453A0 (en) * 1995-12-21 1998-12-06 Pfizer 2,7-substituted octahydro-pyrrolo [1,2-A]pyrazine derivatives
BR9710018A (pt) * 1996-07-01 1999-08-10 Pfizer Preparação de (7S,trans)-2-(2-pirimidinil)-7-(hidroximetil)octa-hidro-2H-pirido[1,2-A]pirazina
PA8469101A1 (es) * 1998-04-09 2000-09-29 Pfizer Prod Inc Ligandos azabiciclicos de receptores 5ht1
US6251893B1 (en) * 1998-06-15 2001-06-26 Nps Allelix Corp. Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
HN1999000146A (es) * 1998-09-21 2000-11-11 Pfizer Prod Inc Agentes farmaceuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas.
US20020016334A1 (en) * 2000-07-31 2002-02-07 Coe Jotham Wadsworth Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD)
US6670476B2 (en) 2000-11-29 2003-12-30 Pfizer Inc. Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine
AU2004220327B2 (en) * 2003-03-12 2010-06-24 Pfizer Products Inc. Pyridyloxymethyl and benzisoxazole azabicyclic derivatives
EP1633756B1 (en) 2003-04-09 2008-12-24 Biogen Idec MA Inc. A2a adenosine receptor antagonists
JP4864719B2 (ja) * 2003-11-26 2012-02-01 ファイザー・プロダクツ・インク Ｇｓｋ−３インヒビターとしてのアミノピラゾール誘導体
US20070219201A1 (en) * 2004-05-27 2007-09-20 Warner-Lambert Company Llc Combination of atomoxetine and a 5ht1a receptor agonist for treating adhd and other disorders
US7658206B2 (en) 2006-12-05 2010-02-09 Kohler Co. Plumbing valve with stick control handle

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3388128A (en) * 1965-09-03 1968-06-11 Allan R. Day Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
US4182763A (en) * 1978-05-22 1980-01-08 Mead Johnson & Company Buspirone anti-anxiety method
US4339579A (en) * 1980-12-29 1982-07-13 American Home Products Corporation 2,6-Bis-(pyrrolopyrazinyl)pyrazines
US4400511A (en) * 1982-05-07 1983-08-23 American Home Products Corporation 2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
US4414389A (en) * 1982-05-25 1983-11-08 American Home Products Corporation 4-Substituted-piperidino carboxamides
US4517187A (en) * 1982-10-18 1985-05-14 Pennwalt Corporation 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3409440A1 (de) * 1984-03-15 1985-09-26 Bayer Ag, 5090 Leverkusen Imidazo(1,5-a)pyridyl-methan- und imidazo(1,5-b)pyridazinylmethan-derivate, ihre herstellung und sie enthaltende aufzeichnungsmaterialien
IT1204803B (it) * 1986-02-17 1989-03-10 Acraf Composto farmacologicamente attivo e composizioni farmaceutiche che lo contengono,procedimento per prepararlo e intermedio utile in detto procedimento
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
JP2668259B2 (ja) * 1988-02-18 1997-10-27 塩野義製薬株式会社 複素環化合物および抗潰瘍剤
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents

Also Published As

Publication number Publication date
PT92919B (pt) 1995-12-29
CN1022186C (zh) 1993-09-22
WO1990008144A1 (en) 1990-07-26
NO912863D0 (no) 1991-07-22
BG51046A3 (en) 1993-01-15
AU614214B2 (en) 1991-08-22
NO175978B (no) 1994-10-03
EG19306A (en) 1995-01-31
ES2053094T3 (es) 1994-07-16
ATE82574T1 (de) 1992-12-15
FI95381B (fi) 1995-10-13
CA2008108C (en) 1995-08-08
IE62670B1 (en) 1995-03-08
EP0380217B1 (en) 1992-11-19
AP9000158A0 (en) 1990-01-31
ZA90430B (en) 1991-08-28
MY104861A (en) 1994-06-30
DD291560A5 (de) 1991-07-04
KR900011774A (ko) 1990-08-02
US5122525A (en) 1992-06-16
FI95381C (fi) 1996-01-25
CZ277698B6 (en) 1993-03-17
IS1667B (is) 1997-11-14
YU11190A (sh) 1993-05-28
CS29990A3 (en) 1992-11-18
AP128A (en) 1991-03-20
WO1990008148A1 (en) 1990-07-26
GR3006925T3 (sh) 1993-06-30
NZ232168A (en) 1991-08-27
MX19222A (es) 1993-12-01
OA10041A (en) 1996-10-14
BA98302A (bs) 2001-09-14
CA2008108A1 (en) 1990-07-23
IL93073A (en) 1994-05-30
KR910009289B1 (ko) 1991-11-09
CN1044464A (zh) 1990-08-08
JPH02233681A (ja) 1990-09-17
RU2015977C1 (ru) 1994-07-15
HUT63163A (en) 1993-07-28
SK279339B6 (sk) 1998-10-07
NO175978C (no) 1995-01-11
DK0380217T3 (da) 1992-12-14
EP0380217A1 (en) 1990-08-01
AR246969A1 (es) 1994-10-31
HU215154B (hu) 2000-09-28
AU4867990A (en) 1990-07-26
IE900225L (en) 1990-07-23
DE69000467D1 (de) 1992-12-24
JPH0643427B2 (ja) 1994-06-08
MA21735A1 (fr) 1990-10-01
PT92919A (pt) 1990-07-31
RO110142B1 (ro) 1995-10-30
IS3529A7 (is) 1990-07-24
PL163836B1 (pl) 1994-05-31
NO912863L (no) 1991-07-22
DE69000467T2 (de) 1993-04-01
FI913510A0 (fi) 1991-07-22

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