ATE120746T1 - Recematspaltung von trans-2-(2-pyrimidinyl)-7- (hydroxymethyl)octahydro-2h-pyrido(1,2-a>- pyrazin. - Google Patents
Recematspaltung von trans-2-(2-pyrimidinyl)-7- (hydroxymethyl)octahydro-2h-pyrido(1,2-a>- pyrazin.Info
- Publication number
- ATE120746T1 ATE120746T1 AT92902650T AT92902650T ATE120746T1 AT E120746 T1 ATE120746 T1 AT E120746T1 AT 92902650 T AT92902650 T AT 92902650T AT 92902650 T AT92902650 T AT 92902650T AT E120746 T1 ATE120746 T1 AT E120746T1
- Authority
- AT
- Austria
- Prior art keywords
- octahydro
- pyrido
- pyrimidinyl
- hydroxymethyl
- trans
- Prior art date
Links
- 238000003776 cleavage reaction Methods 0.000 title 1
- 230000007017 scission Effects 0.000 title 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- ONHPOXROAPYCGT-UHFFFAOYSA-N 2,3,4,6,7,8,9,9a-octahydro-1h-pyrido[1,2-a]pyrazine Chemical compound C1CNCC2CCCCN21 ONHPOXROAPYCGT-UHFFFAOYSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 235000011002 L(+)-tartaric acid Nutrition 0.000 abstract 1
- 239000001358 L(+)-tartaric acid Substances 0.000 abstract 1
- FEWJPZIEWOKRBE-LWMBPPNESA-N L-(+)-Tartaric acid Natural products OC(=O)[C@@H](O)[C@H](O)C(O)=O FEWJPZIEWOKRBE-LWMBPPNESA-N 0.000 abstract 1
- AUONNNVJUCSETH-UHFFFAOYSA-N icosanoyl icosanoate Chemical compound CCCCCCCCCCCCCCCCCCCC(=O)OC(=O)CCCCCCCCCCCCCCCCCCC AUONNNVJUCSETH-UHFFFAOYSA-N 0.000 abstract 1
- 150000003892 tartrate salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64868691A | 1991-01-31 | 1991-01-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE120746T1 true ATE120746T1 (de) | 1995-04-15 |
Family
ID=24601808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92902650T ATE120746T1 (de) | 1991-01-31 | 1991-12-05 | Recematspaltung von trans-2-(2-pyrimidinyl)-7- (hydroxymethyl)octahydro-2h-pyrido(1,2-a>- pyrazin. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0569387B1 (de) |
| JP (1) | JP2609410B2 (de) |
| AT (1) | ATE120746T1 (de) |
| CA (1) | CA2099563C (de) |
| DE (1) | DE69108743T2 (de) |
| DK (1) | DK0569387T3 (de) |
| ES (1) | ES2072141T3 (de) |
| FI (1) | FI100400B (de) |
| GR (1) | GR3015726T3 (de) |
| IE (1) | IE67777B1 (de) |
| PT (1) | PT100061B (de) |
| WO (1) | WO1992013858A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5719286A (en) * | 1992-06-16 | 1998-02-17 | Pfizer Inc. | Process and intermediates for bis-aza-bicyclic anxiolytic agents |
| WO1996010570A1 (en) * | 1994-09-30 | 1996-04-11 | Pfizer Inc. | NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES |
| AU681310B2 (en) * | 1994-09-30 | 1997-08-21 | Pfizer Inc. | 2,7-substituted octahydro-1h-pyrido{1,2-a}pyrazine derivatives |
| CA2259496A1 (en) * | 1996-07-01 | 1998-01-08 | Philip Dietrich Hammen | Preparation of (7s,trans)-2-(2-pyrimidinyl)-7-(hydroxymethyl)octahydro-2h-pyrido[1,2-a]pyrazine |
| DE19821039A1 (de) * | 1998-05-11 | 1999-11-18 | Bayer Ag | Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan |
| US6670476B2 (en) | 2000-11-29 | 2003-12-30 | Pfizer Inc. | Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine |
| PT1337533E (pt) * | 2000-11-29 | 2006-08-31 | Pfizer Prod Inc | Resolucao da trans-7-(hidroxi-metil)octa-hidro-2h-pirido-1,2a)pirazina |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX19222A (es) * | 1989-01-23 | 1993-12-01 | Pfizer | Agentes ansioliticos bis-aza-biciclicos |
-
1991
- 1991-12-05 DK DK92902650.8T patent/DK0569387T3/da active
- 1991-12-05 CA CA002099563A patent/CA2099563C/en not_active Expired - Fee Related
- 1991-12-05 JP JP4502803A patent/JP2609410B2/ja not_active Expired - Fee Related
- 1991-12-05 AT AT92902650T patent/ATE120746T1/de not_active IP Right Cessation
- 1991-12-05 EP EP92902650A patent/EP0569387B1/de not_active Expired - Lifetime
- 1991-12-05 DE DE69108743T patent/DE69108743T2/de not_active Expired - Fee Related
- 1991-12-05 ES ES92902650T patent/ES2072141T3/es not_active Expired - Lifetime
- 1991-12-05 WO PCT/US1991/008314 patent/WO1992013858A1/en active IP Right Grant
-
1992
- 1992-01-29 PT PT100061A patent/PT100061B/pt not_active IP Right Cessation
- 1992-01-30 IE IE920303A patent/IE67777B1/en not_active IP Right Cessation
-
1993
- 1993-07-30 FI FI933422A patent/FI100400B/fi active
-
1995
- 1995-04-10 GR GR950400858T patent/GR3015726T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2099563A1 (en) | 1992-08-01 |
| PT100061A (pt) | 1993-03-31 |
| EP0569387B1 (de) | 1995-04-05 |
| ES2072141T3 (es) | 1995-07-01 |
| FI933422L (fi) | 1993-07-30 |
| PT100061B (pt) | 1999-06-30 |
| DE69108743T2 (de) | 1995-08-17 |
| DK0569387T3 (da) | 1995-07-03 |
| FI933422A0 (fi) | 1993-07-30 |
| IE67777B1 (en) | 1996-04-17 |
| IE920303A1 (en) | 1992-07-29 |
| WO1992013858A1 (en) | 1992-08-20 |
| DE69108743D1 (de) | 1995-05-11 |
| EP0569387A1 (de) | 1993-11-18 |
| GR3015726T3 (en) | 1995-07-31 |
| FI100400B (fi) | 1997-11-28 |
| JPH06502181A (ja) | 1994-03-10 |
| CA2099563C (en) | 1998-09-29 |
| JP2609410B2 (ja) | 1997-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |