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ZA86393B - Process for preparing glucagon or derivatives of fragments thereof in yeast - Google Patents

Process for preparing glucagon or derivatives of fragments thereof in yeast

Info

Publication number
ZA86393B
ZA86393B ZA86393A ZA86393A ZA86393B ZA 86393 B ZA86393 B ZA 86393B ZA 86393 A ZA86393 A ZA 86393A ZA 86393 A ZA86393 A ZA 86393A ZA 86393 B ZA86393 B ZA 86393B
Authority
ZA
South Africa
Prior art keywords
derivatives
yeast
fragments
glucagon
expression
Prior art date
Application number
ZA86393A
Other languages
English (en)
Inventor
Kjeld Norris
Lars Thim
Fanny Norris
Mogens Trier Hansen
Alister James Moody
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Publication of ZA86393B publication Critical patent/ZA86393B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/30—Signal or leader sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Plant Pathology (AREA)
  • Emergency Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA86393A 1985-01-22 1986-01-20 Process for preparing glucagon or derivatives of fragments thereof in yeast ZA86393B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK27885A DK27885A (da) 1985-01-22 1985-01-22 Fremstilling af peptider

Publications (1)

Publication Number Publication Date
ZA86393B true ZA86393B (en) 1987-03-25

Family

ID=8091749

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA86393A ZA86393B (en) 1985-01-22 1986-01-20 Process for preparing glucagon or derivatives of fragments thereof in yeast

Country Status (17)

Country Link
US (1) US4826763A (xx)
EP (1) EP0189998B1 (xx)
JP (2) JPH0720435B2 (xx)
AT (1) ATE48643T1 (xx)
AU (1) AU587218B2 (xx)
CA (1) CA1294232C (xx)
DE (1) DE3667488D1 (xx)
DK (1) DK27885A (xx)
ES (1) ES8708250A1 (xx)
FI (1) FI87800C (xx)
GR (1) GR860149B (xx)
IE (1) IE58726B1 (xx)
MX (1) MX163776B (xx)
NO (1) NO172185C (xx)
NZ (1) NZ214883A (xx)
PT (1) PT81872B (xx)
ZA (1) ZA86393B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5151354A (en) * 1986-08-21 1992-09-29 Cornelius Hollenberg Fermentation processes using amylolytic enzyme producing microorganisms
EP0268772B1 (en) * 1986-09-19 1995-04-26 ZymoGenetics, Inc. Expression of biologically active factor XIII
JPH01187499A (ja) * 1988-01-21 1989-07-26 Science & Tech Agency 原子炉解体用ロボット
ZA90533B (en) * 1989-02-01 1990-10-31 Shionogi & Co A method for the production of glucagon
US6172039B1 (en) 1990-04-16 2001-01-09 Apex Bioscience, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
US5234906A (en) * 1991-01-10 1993-08-10 Amylin Pharmaceuticals, Inc. Hyperglycemic compositions
US5510459A (en) * 1991-01-17 1996-04-23 Zymogenetics, Inc. Glucagon antagonists
US5408037A (en) * 1991-01-17 1995-04-18 Zymogenetics, Inc. Methods for detecting glucagon antagonists
WO1994001215A1 (en) * 1992-07-06 1994-01-20 Beckman Instruments, Inc. Fluid delivery system utilizing multiple port valve
DK144093D0 (xx) * 1993-12-23 1993-12-23 Novo Nordisk As
US5652216A (en) * 1994-05-26 1997-07-29 Novo Nordisk A/S Pharmaceutical preparation
DK0981362T3 (da) * 1997-05-16 2004-03-15 Ontario Inc 1149336 Anvendelse af GLP-2-agonister, der forbedrer funktionen af den øvre mavetarmkanal
CN1732012A (zh) * 2002-12-27 2006-02-08 迪奥贝克斯公司 用于预防和控制胰岛素诱发的低血糖的组合物和方法
US7655618B2 (en) 2002-12-27 2010-02-02 Diobex, Inc. Compositions and methods for the prevention and control of insulin-induced hypoglycemia
MX2011008094A (es) 2009-02-03 2012-02-13 Amunix Operating Inc Polipeptidos recombinantes extendidos y composiciones que comprenden los mismos.
CN102481331B (zh) 2009-06-08 2017-09-22 阿穆尼克斯运营公司 葡萄糖调节多肽及其制备和使用方法
MX366864B (es) 2012-02-27 2019-07-26 Amunix Operating Inc Composiciones de conjugados de xten y métodos para realizarlas.
EP3864032B1 (en) 2018-10-09 2022-11-30 Fresenius Kabi iPSUM S.r.l. Process for the manufacture of glp-1 analogues
EP3753946A1 (en) 2019-06-18 2020-12-23 Fresenius Kabi iPSUM S.r.l. Improved process for the preparation of high purity glucagon
WO2020254479A1 (en) 2019-06-18 2020-12-24 Fresenius Kabi Ipsum S.R.L. Process for the manufacture of glucagon
BR112022009217A2 (pt) 2019-11-13 2022-08-02 Amunix Pharmaceuticals Inc Polipeptídeos xten com código de barras e composições destes, e métodos para produzir e usar os mesmos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401759A (en) * 1980-05-01 1983-08-30 Harvey Rubin Detection and isolation of glucagon mRNA using a synthetic oligodeoxynucleotide
DK283180A (da) * 1980-07-01 1982-01-02 Novo Industri As Polypeptider og derivater deraf
US4546082A (en) * 1982-06-17 1985-10-08 Regents Of The Univ. Of California E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins

Also Published As

Publication number Publication date
MX163776B (es) 1992-06-22
US4826763A (en) 1989-05-02
AU587218B2 (en) 1989-08-10
DK27885A (da) 1986-07-23
PT81872B (pt) 1988-05-27
CA1294232C (en) 1992-01-14
JPH0746986B2 (ja) 1995-05-24
ES8708250A1 (es) 1987-10-01
NO172185C (no) 1993-06-16
JPH06292594A (ja) 1994-10-21
AU5247286A (en) 1986-07-31
DK27885D0 (da) 1985-01-22
IE58726B1 (en) 1993-11-03
FI87800B (fi) 1992-11-13
NZ214883A (en) 1988-04-29
DE3667488D1 (de) 1990-01-18
FI860251A (fi) 1986-07-23
EP0189998A1 (en) 1986-08-06
IE860162L (en) 1986-07-22
EP0189998B1 (en) 1989-12-13
ES551042A0 (es) 1987-10-01
FI87800C (fi) 1993-02-25
ATE48643T1 (de) 1989-12-15
NO172185B (no) 1993-03-08
NO860178L (no) 1986-07-23
JPH0720435B2 (ja) 1995-03-08
JPS61181398A (ja) 1986-08-14
GR860149B (en) 1986-05-21
PT81872A (en) 1986-02-01
FI860251A0 (fi) 1986-01-20

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